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Dietary supplement

Citrulline Unflavored Ingredients & Drug Interactions

by Kaged

Citrulline Unflavored label
See full label image
Powder Category: Amino Acid/protein
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Citrulline Unflavored against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Citrulline Unflavored is a dietary supplement by Kaged with 1 active ingredient. Its ingredients are commonly taken for exercise performance, muscle soreness and fatigue, blood flow and circulation.Based on those ingredients, 178 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are L-Citrulline. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Citrulline Unflavored by Kaged

Ask about any prescription or over-the-counter medication and we check it for interactions with Citrulline Unflavored by Kaged — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Citrulline Unflavored by Kaged

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: L-citrulline, an amino acid your body naturally makes and uses to help relax blood vessels and improve blood flow. There are no other active ingredients, and no inactive fillers are included.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: blood flow athletic endurance cardiovascular support.
  • We looked for evidence on: Athletic performance, Cardiovascular disease (CVD), Heart failure, Pulmonary hypertension, Endothelial function, Vasodilation — and 2 related terms.
  • The strongest evidence on file: L-citrulline is rated "Possibly Effective" for Athletic performance (Natural Medicines).
  • Also on file: L-citrulline is rated "Insufficient Reliable Evidence To Rate" for Cardiovascular disease (CVD), Heart failure, Postoperative pulmonary hypertension, Pulmonary hypertension.

L-citrulline is possibly effective for athletic performance — some evidence supports its use for that purpose. For sarcopenia (age-related muscle loss), the data suggests it's possibly ineffective.

For heart disease, heart failure, Reye syndrome, and diabetes, we don't have enough reliable evidence to know whether it works. Talk with your doctor about whether this ingredient matches what you're trying to achieve.

The evidence, ingredient by ingredient L-citrulline

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

L-citrulline is generally well tolerated in healthy adults, though long-term safety hasn't been fully studied. The most common side effects are gastrointestinal: heartburn, stomach discomfort, and general digestive upset.

A small number of people with pulmonary hypertension reported cough. There isn't enough safety data to know whether it's okay during pregnancy, so the recommendation is to avoid it then.

Safety while breastfeeding is also unknown, so supplemental use isn't advised. Talk with your doctor or pharmacist before taking this if you're pregnant, planning pregnancy, or breastfeeding.

Side effects, ingredient by ingredient L-citrulline

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — L-citrulline.
  • The most serious interaction on file is rated Moderate.
  • For scale: 178 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check with your doctor or pharmacist if you take blood pressure medications or erectile dysfunction drugs — both have Moderate interactions with L-citrulline and could amplify each other's blood-pressure-lowering effects.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Citrulline Unflavored is a single-ingredient supplement aimed mostly at athletic performance. If you take blood pressure medication or erectile dysfunction medication, check with your doctor or pharmacist before starting — both can interact with L-citrulline.

If you're pregnant, breastfeeding, or planning pregnancy, this isn't the right choice. For other questions about whether it fits your goals, talk it over with your own healthcare provider.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Sep 25, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Citrulline Unflavored, straight from the product label.

Brand Kaged
Barcode (UPC) 013189942122
Net contents 7.05 Ounce(s); 200 Gram(s)
Market status On market
Date entered into DSLD Sep 25, 2023
DSLD ID 298710
Product type Amino Acid/protein
Supplement form Powder
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Citrulline Unflavored by Kaged, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Gram(s)
Maximum serving Sizes:
2 Gram(s)
Servings per container
100
UPC/BARCODE
013189942122
IngredientAmount% DV
L-Citrulline2 Gram(s)--

Other ingredients: None

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Bloodflow Athletic endurance Cardiovascular support

Kaged L-Citrulline is 100% plant-based, non-GMO, gluten-free, and third-party tested.

This product is certified and 3rd party tested to be safer for athletes.

Vegan Friendly

Non GMO Gluten Free

Pump

Formula

Clean Pumps L-Citrulline is an amino acid that raises nitric oxide levels and vasodilation in the body, helping you increase blood flow and muscle pumps during exercise. Kaged L-Citrulline is 100% plant-based, non-GMO, gluten-free, and third-party tested. Mix Kaged L-Citrulline with BCAAs, Glutamine, Creatine, and Hydra-Charge for a muscle-building performance matrix.

General Statements

We Are Kaged We are Kaged, the elite supplement brand. We provide you with the highest quality formulas in the world to help you lift heavier, be healthier, and evolve into the strongest version of yourself.

Contents may settle during shipping. Sold by weight, not volume. 33 659485 117 998802

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Seals/Symbols

Informed Sport We Test You Trust Banned Substance Tested Every Batch

Micropure Quality Guarantee

Brand IP Statement(s)

Never Stop Evolving

Copyright 2022 Kaged Muscle LLC.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Third-party tested for purity and potency.

Directions: Mix one rounded scoop in your favorite beverage or protein shake twice a day. Mix Your Own System Mix Citrulline with BCAAs, Glutamine, and Hydra-Charge to create your own pre and post-workout drinks.

Precautions

Consult your physician prior to using this product if you are pregnant, nursing, under 18 years of age, take medication or have a medical condition.

Consult your physician prior to using this product if you are pregnant, nursing, under 18 years of age, take medication or have a medical condition. Keep out of reach of children.

Immediately discontinue use and contact your physician if any adverse reactions occur.

This product contains a silica gel pack. Do not eat.

Storage

Store in a cool, dry place away from excessive heat.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Citrulline Unflavored by Kaged label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Citrulline Unflavored label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Citrulline Unflavored by Kaged

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Gram(s) Dosage formPowder Servings per container100 Amounts shown are per serving.

L-Citrulline

Interacts with
178 drugs
2 Gram(s) per serving

L-citrulline is an amino acid that the body turns into L-arginine to help make nitric oxide, which relaxes blood vessels and may improve blood flow. I...

L-Citrulline monograph & interactions

Other (inactive) ingredients: None. These complete the product’s ingredient list but are not active constituents.

Interaction report

Citrulline Unflavored by Kaged Drug Interactions

Want to check YOUR meds against Citrulline Unflavored?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
178Drugs
178 Moderate

Ingredients driving the most interactions

L-Citrulline 178

Individual Drug Interactions

The ingredients in Citrulline Unflavored interact with 178 drugs. Click any drug to see the details.

1 of the 1 ingredient in Citrulline Unflavored interact with drugs. Each result below shows which ingredient is responsible. L-Citrulline

Each ingredient & the kinds of drugs it affects

For each ingredient in Citrulline Unflavored with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

L-Citrulline2 drug types · 178 drugs

Antihypertensive Drugs

Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
L-citrulline is converted to L-arginine, which can increase nitric oxide and cause vasodilation. However, a meta-analysis of 5 small clinical studies suggests that taking L-citrulline 3-6 grams daily for 1-8 weeks does not lower blood pressure when compared with control.

Likelihood Possible Evidence B
Phosphodiesterase-5 Inhibitors

Theoretically, concurrent use of phosphodiesterase-5 (PDE-5) inhibitors and L-citrulline might result in additive vasodilation.
L-citrulline is converted to L-arginine, which can increase nitric oxide and cause vasodilation. Theoretically, taking L-arginine with PDE-5 inhibitors might have additive vasodilatory and hypotensive effects. However, in studies evaluating the combined use of L-arginine and sildenafil for erectile dysfunction, hypotension was not reported.

Likelihood Possible Evidence D
L-Citrulline full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Citrulline Unflavored, from the product label.

Kaged

See all Kaged products
Name
Kaged Muscle
Street Address
101 Main Street, Suite 360
City
Huntington Beach
State
CA
ZipCode
92648
Phone Number
(844) 445-2433
Web Address
kaged.com
Pharmacist Counseling Corner

Citrulline Unflavored by Kaged: Common Questions

Does Citrulline Unflavored by Kaged interact with any medications?
Yes. Based on its ingredients, Citrulline Unflavored has a known interaction with 178 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Citrulline Unflavored contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this with my blood pressure medication?
Not without checking first. L-citrulline can lower blood pressure on its own, and combining it with blood pressure drugs might drop your pressure too much. Talk with your doctor or pharmacist about your specific medications before starting.
What's L-citrulline actually for?
Your body uses it to make nitric oxide, which relaxes blood vessels and improves blood flow. It's possibly effective for athletic performance, but evidence for other conditions like heart disease or diabetes isn't strong enough to rate.
What side effects should I watch for?
Most people tolerate it well. Heartburn, stomach discomfort, and other digestive upset are the most common complaints. A few people have reported cough, though that was rare and mainly in patients with lung disease.
Is this safe if I'm pregnant or breastfeeding?
There isn't enough data to say it's safe either way, so the advice is to avoid it during pregnancy and while breastfeeding. Talk with your doctor if you have questions about what to take instead.
How long does it take to work?
The product facts we have don't specify how quickly you might notice a difference. That's a question for your doctor, who can tell you what timeline to expect based on what you're using it for.
Can I take this with ED medication?
Not without checking first. Both L-citrulline and drugs like sildenafil or tadalafil work by relaxing blood vessels, and together they might lower your blood pressure too much. Check with your doctor or pharmacist before combining them.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Citrulline Unflavored is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Citrulline Unflavored label
Go deeper

The Full Monographs Behind Citrulline Unflavored’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

L-citrulline

Interacts with 178 drugs

L-citrulline is an amino acid that the body turns into L-arginine to help make nitric oxide, which relaxes blood vessels and may improve blood flow. It is popular for exercise performance an...

Read the full L-citrulline monograph →
Sources

Sources & How We Checked

Citrulline Unflavored's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 8 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

L-citrulline 8 references
  1. Cheng JW, Balwin SN. L-arginine in the management of cardiovascular diseases. Ann Pharmacother 2001;35:755-64. PubMed
  2. Schwedhelm E, Maas R, Freese R, et al. Pharmacokinetic and pharmacodynamic properties of oral L-citrulline and L-arginine: impact on nitric oxide metabolism. Br J Clin Pharmacol 2008;65:51-9. PubMed
  3. Romero MJ, Platt DH, Caldwell RB, Caldwell RW. Therapeutic use of citrulline in cardiovascular disease. Cardiovasc Drug Rev 2006;24:275-90. PubMed
  4. Balderas-Munoz K, Castillo-Martínez L, Orea-Tejeda A, et al. Improvement of ventricular function in systolic heart failure patients with oral L-citrulline supplementation. Cardiol J 2012;19:612-7. PubMed
  5. Sharif Kashani B, Tahmaseb Pour P, Malekmohammad M, et al. Oral l-citrulline malate in patients with idiopathic pulmonary arterial hypertension and Eisenmenger Syndrome: a clinical trial. J Cardiol 2014;64:231-5. PubMed
  6. Pérez-Guisado J, Jakeman PM. Citrulline malate enhances athletic anaerobic performance and relieves muscle soreness. J Strength Cond Res 2010;24:1215-22. PubMed
  7. Mirenayat MS, Moradi S, Mohammadi H, Rouhani MH. Effect of L-citrulline supplementation on blood pressure: a systematic review and meta-analysis of clinical trials. Curr Hypertens Rep. 2018;20(11):98. PubMed
  8. Xu Z, Liu C, Liu S, Zhou Z. Comparison of efficacy and safety of daily oral L-arginine and PDE5Is alone or combination in treating erectile dysfunction: A systematic review and meta-analysis of randomised controlled trials. Andrologia. 2021:e14007. PubMed

See these in context on the L-citrulline monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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