Major interaction on record — check this product against your medications before combining. Based on 8 of 11 ingredients. Check your meds →
Dietary supplement

Amino Synergy Raspberry Lemonade Ingredients & Drug Interactions

by Kaged

Powder Category: Botanical With Nutrients
Most serious interaction: Major
The interaction bottom line Most serious interaction: Major

Amino Synergy Raspberry Lemonade is a dietary supplement by Kaged with 11 active ingredients. Its ingredients are commonly taken for skin and hair care, source of dietary fats (mcts), hydration with coconut water.Based on those ingredients, 788 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are L-Arginine, L-Tryptophan, Coconut Water fruit powder. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of Amino Synergy Raspberry Lemonade by Kaged

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 1 of its 11 active ingredients.
  • “EAALPHA Matrix” is a proprietary blend — the label gives one combined amount (3.60 Gram(s)) without saying how much of each component you get.

Amino Synergy Raspberry Lemonade is a powder blend of 11 ingredients, including 9 amino acids (building blocks your body uses to make protein and other compounds) and coconut water fruit powder. The amino acids are L-leucine, L-isoleucine, L-valine, L-arginine, L-methionine, L-lysine hydrochloride, L-phenylalanine, L-histidine, L-threonine, and L-tryptophan.

The product also contains inactive ingredients like citric acid, malic acid, natural flavor, and stevia sweetener for taste.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: muscle recovery and growth support.
  • We looked for evidence on: Athletic performance, Muscle strength, Wound healing, protein synthesis, muscle protein breakdown, exercise recovery.
  • The closest evidence on file: Methionine is rated "Insufficient Reliable Evidence To Rate" for Wound healing (Natural Medicines).
  • Also on file: Lysine is rated "Insufficient Reliable Evidence To Rate" for Athletic performance, Muscle strength.
  • Also on file: L-tryptophan is rated "Insufficient Reliable Evidence To Rate" for Athletic performance.

The product facts don't provide effectiveness ratings for this amino acid blend as a whole. Individual amino acids in the formula have mixed evidence: L-lysine is possibly effective for cold sores; L-methionine is possibly effective for neural tube birth defects; L-histidine is possibly effective for cholera; and L-phenylalanine is rated possibly ineffective for ADHD.

For most other conditions mentioned in the data, evidence is insufficient to rate. If you're considering this product for a specific health goal, we'd recommend discussing it with your pharmacist or doctor.

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 7 of the 8 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 8 of 8.
  • General safety write-ups exist for 8 of 8.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

L-arginine is often well tolerated short-term but can lower blood pressure and may not be safe for everyone—use only under medical supervision. L-tryptophan is generally well tolerated but has a historical safety concern: in 1989, a contaminated batch from Japan was linked to a rare neurological condition called eosinophilia-myalgia syndrome (EMS); this was traced to one manufacturer and led to FDA restrictions, though purified forms are now available.

Common side effects from individual amino acids may include gastrointestinal upset (stomach pain, diarrhea, nausea), headache, and insomnia. L-phenylalanine is not for people with phenylketonuria (PKU), a genetic condition that prevents proper phenylalanine metabolism.

Coconut can rarely trigger allergic reactions, including anaphylaxis, in those with coconut sensitivity.

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 6 of the 8 matched ingredients can interact with medications — Lysine, L-tryptophan, Phenylalanine, L-arginine, Threonine, among others.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications; Parkinson's medications.
  • For scale: 788 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your pharmacist or doctor if you use levodopa (for Parkinson's disease), monoamine oxidase inhibitors (MAOIs—older antidepressants), blood pressure medications (especially ACE inhibitors or ARBs), blood thinners or antiplatelet drugs, diabetes medications, sedating drugs (like benzodiazepines or opioids), serotonergic antidepressants (like SSRIs), NMDA antagonist psychiatric or pain medications, sildenafil (Viagra), isoproterenol, or 5-HT4 agonist gastrointestinal drugs. These are the medication types documented to interact with ingredients in this formula.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Major medication interactions have been identified, and safety information is well characterized.

This amino acid blend is designed to support muscle and protein synthesis, but several ingredients carry documented interactions with common medications—especially blood pressure drugs, blood thinners, diabetes medications, antidepressants, and Parkinson's medication. If you take any prescription medication, check each one with our tool before use.

Talk to your pharmacist about whether this product is right for you, particularly if you have high or low blood pressure, take heart or neurological medications, or have PKU.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 8 of 11 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 24, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Amino Synergy Raspberry Lemonade, straight from the product label.

Brand Kaged
Barcode (UPC) 852253007936
Net contents 7.94 Ounce(s); 225 Gram(s)
Market status On market
Date entered into DSLD Oct 24, 2023
DSLD ID 298708
Product type Botanical With Nutrients
Supplement form Powder
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Amino Synergy Raspberry Lemonade by Kaged, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
7.5 Gram(s)
Maximum serving Sizes:
7.5 Gram(s)
Servings per container
30
UPC/BARCODE
852253007936
IngredientAmount% DV
L-Leucine0 NP--
L-Arginine0 NP--
L-Isoleucine0 NP--
L-Methionine0 NP--
L-Lysine Hydrochloride0 NP--
L-Phenylalanine0 NP--
L-Valine0 NP--
L-Histidine0 NP--
L-Threonine0 NP--
L-Tryptophan0 NP--
Total Sugars1 Gram(s)--
Calories20 Calorie(s)--
Coconut Water fruit powder500 mg--
Total Carbohydrate1 Gram(s)1%
EAALPHA Matrix3.6 Gram(s)--

Other ingredients: Citric Acid, Natural flavor, Malic Acid, Tartaric Acid, Steviol Glycosides, Silicon Dioxide, Sucralose, Vegetable powder

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Helps combat muscle breakdown // Recovery // Growth

Vegan Friendly

Non GMO Gluten Free

Manufactured in the USA from domestic and international ingredients.

Formula

All 9 essential amino acids Kaged Amino Synergy is an advanced full-spectrum essential amino acid (EAA) formula that delivers fermented and vegan-friendly EEAs, Amino Synergy will support protein synthesis and muscle recovery, helping you maximize your muscle growth and retain your muscle mass. Upheld to the Kaged standard, we use a patented amino acid blend that delivers a powerful leucine-enriched EAA matrix to ensure you get the highest quality aminos on the planet.

3.6 grams essential amino acids 500 milligrams coconut water 9 amino acids <1 gram sugar Typical amounts per serving Essential amino acids

Raspberry lemonade Naturally flavored

General Statements

We are Kaged We are Kaged, the elite supplement brand. We provide you with the highest quality formulas in the world to help you lift heavier, be healthier, and evolve into the strongest version of yourself.

Contents may settle during shipping. Sold by weight, not volume.

33.659485, -117.998802 Instagram Facebook Twitter YouTube

Seals/Symbols

Informed Sport We Trust You Trust

Brand IP Statement(s)

Never Stop Evolving

Copyright 2022 Kaged Muscle LLC. EAAlpha US Patent #9,364,463.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Precautions

Contains: Tree nuts (coconut)

Warning: Consult your physician prior to using this product if you are pregnant, nursing, under 18 years of age, taking medication or have a medical condition.

Warning: Consult your physician prior to using this product if you are pregnant, nursing, under 18 years of age, taking medication or have a medical condition.

Immediately discontinue use and contact your physician if any adverse reactions occur.

Keep out of reach of children.

This product contains a silica gel pack. Do not eat.

Suggested/Recommended/Usage/Directions

Directions: Mix 1 scoop with 10-14 oz of water 1-2 times per day.

Storage

Exposure to moisture or heat may cause powder to clump or harden. Store in a cool, dry place, avoid direct sunlight, humidity and high temperature. Replace lid securely after each use.

See for yourself

Amino Synergy Raspberry Lemonade by Kaged label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Amino Synergy Raspberry Lemonade by Kaged

These are the 11 active ingredients this product is made of. Select any to open its full monograph.

Serving size7.5 Gram(s) Dosage formPowder Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Coconut Water fruit powder

Interacts with
86 drugs
500 mg per serving

Coconut is a nutritious tropical food enjoyed as oil, water, milk, and flesh, and it is generally safe to eat in normal food amounts. While some uses...

Coconut Water fruit powder monograph & interactions

EAALPHA Matrix

3.6 Gram(s) per serving

Other (inactive) ingredients: Citric Acid, Natural flavor, Malic Acid, Tartaric Acid, Steviol Glycosides, Silicon Dioxide, Sucralose, Vegetable powder. These complete the product’s ingredient list but are not active constituents.

Interaction report

Amino Synergy Raspberry Lemonade by Kaged Drug Interactions

Want to check YOUR meds against Amino Synergy Raspberry Lemonade?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
788Drugs
256 Major 524 Moderate 8 Minor

Ingredients driving the most interactions

Each ingredient & the kinds of drugs it affects

For each ingredient in Amino Synergy Raspberry Lemonade with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

L-Arginine9 drug types · 403 drugs

Ace Inhibitors (Aceis)

Theoretically, concomitant use of L-arginine and ACE inhibitors may increase the risk for hypotension and hyperkalemia.
Combining L-arginine with some antihypertensive drugs, especially ACE inhibitors, seems to have additive vasodilating and blood pressure-lowering effects. Furthermore, ACE inhibitors can increase potassium levels. Use of L-arginine has been associated with hyperkalemia in some patients. Theoretically, concomitant use of ACE inhibitors with L-arginine may increases the risk of hyperkalemia.

Likelihood Probable Evidence D
Angiotensin Receptor Blockers (Arbs)

Theoretically, concomitant use of L-arginine and ARBs may increase the risk of hypotension and hyperkalemia.
L-arginine increases nitric oxide, which causes vasodilation. Combining L-arginine with ARBs seems to increase L-arginine-induced vasodilation. Furthermore, ARBs can increase potassium levels. Use of L-arginine has been associated with hyperkalemia in some patients. Theoretically, concomitant use of ARBs with L-arginine may increases the risk of hyperkalemia.

Likelihood Probable Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, concomitant use of L-arginine with anticoagulant and antiplatelet drugs might have additive effects and increase the risk of bleeding.
Preliminary research suggests that L-arginine infusions reduce platelet aggregation in humans. The clinical significance of this effect is unclear.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, concomitant use of L-arginine might have additive effects with antidiabetes drugs.
Preliminary clinical research shows that L-arginine decreases blood glucose levels in patients with type 2 diabetes.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, concomitant use of L-arginine and antihypertensive drugs may increase the risk of hypotension.
L-arginine increases nitric oxide, which causes vasodilation. Clinical evidence shows that L-arginine can reduce blood pressure in some individuals with hypertension. Furthermore, combining L-arginine with some antihypertensive drugs seems to have additive vasodilating and blood pressure-lowering effects.

Likelihood Probable Evidence D
Isoproterenol (Isuprel)

Theoretically, concurrent use of isoproterenol and L-arginine might result in additive effects and hypotension.
Preliminary clinical evidence suggests that L-arginine enhances isoproterenol-induced vasodilation in patients with essential hypertension or a family history of essential hypertension.

Likelihood Probable Evidence D
Potassium-Sparing Diuretics

Theoretically concomitant use of potassium-sparing diuretics with L-arginine may increases the risk of hyperkalemia.
Potassium-sparing diuretics can increase potassium levels. Use of L-arginine has been associated with hyperkalemia in some patients.

Likelihood Possible Evidence D
Sildenafil (Viagra)

Theoretically, concurrent use of sildenafil and L-arginine might increase the risk for hypotension.
In vivo, concurrent use of L-arginine and sildenafil has resulted in increased vasodilation. Theoretically, concurrent use might have additive vasodilatory and hypotensive effects. However, in studies evaluating the combined use of L-arginine and sildenafil for erectile dysfunction, hypotension was not reported.

Likelihood Possible Evidence D
Testosterone

Theoretically, concomitant use of L-arginine and testosterone might have additive effects.
In clinical research, L-arginine increases the level of testosterone in male patients with erectile dysfunction. The clinical significance of this finding is unclear.

Likelihood Possible Evidence D

L-Tryptophan2 drug types · 394 drugs

Cns Depressants

Theoretically, concomitant use of L-tryptophan with CNS depressants might cause additive sedative effects.
Clinical research shows that L-tryptophan can cause fatigue and drowsiness.

Likelihood Probable Evidence B
Serotonergic Drugs

Theoretically, combining L-tryptophan with serotonergic drugs might cause additive serotonergic effects.
L-tryptophan is a precursor to serotonin. Theoretically, combining serotonergic drugs with L-tryptophan might increase the risk of serotonergic side effects, including serotonin syndrome and cerebral vasoconstrictive disorders.

Likelihood Possible Evidence D

Coconut Water fruit powder1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, taking coconut with antidiabetes drugs might increase the risk of hypoglycemia.
Animal research suggests that coconut milk might increase insulin levels and/or decrease blood glucose levels.

Likelihood Unlikely Evidence D

L-Phenylalanine3 drug types · 16 drugs

Levodopa

Phenylalanine, especially in high doses, can reduce the effectiveness of levodopa.
Phenylalanine competes with levodopa for carrier-mediated transport into the brain. The resulting reduction in levels of levodopa in the brain can exacerbate tremor, rigidity, and the "on-off" phenomenon in patients with Parkinson disease.

Likelihood Probable Evidence B
Baclofen

Concomitant intake of phenylalanine may reduce the intestinal absorption of baclofen.
Phenylalanine and baclofen share the same intestinal carrier for absorption; phenylalanine competitively inhibits the absorption of baclofen, reducing its plasma levels.

Likelihood Possible Evidence D
Monoamine Oxidase Inhibitors (Maois)

Theoretically, concomitant use of L-phenylalanine and non-selective MAOIs might increase the risk of hypertensive crisis.
L-phenylalanine is metabolized to tyrosine. Some evidence suggests that L-phenylalanine, given with the non-selective MAOI pargyline, might prevent the elimination of tyramine, increasing the risk of hypertensive crisis. However, this was not reported in a small number of patients when using L-phenylalanine with the partially selective MAO-B inhibitor, selegiline.

Likelihood Possible Evidence D

L-Threonine1 drug type · 3 drugs

Nmda Antagonists

Theoretically, threonine might decrease the effects of NMDA antagonists.
Threonine increases central nervous system (CNS) glycine levels. Glycine seems to bind a site on NMDA receptors and enhance the activity of the receptors.

Likelihood Likely Evidence B

L-Lysine Hydrochloride1 drug type · 1 drug

5-Ht4 Agonists

Theoretically, lysine may reduce the effects of 5-HT4 agonists.
Animal research suggests that L-lysine is a partial serotonin receptor 4 (5-HT4) antagonist and inhibits diarrhea induced by the 5-HT4 agonist, 5-hydroxytryptophane.

Likelihood Unlikely Evidence D
The maker

Brand information

Manufacturer and brand details for Amino Synergy Raspberry Lemonade, from the product label.

Kaged

See all Kaged products
Name
Kaged
Street Address
101 Main Street, Suite 360
City
Huntington Beach
State
CA
ZipCode
92648
Phone Number
844.445.2433
Web Address
Kaged.com
Pharmacist Counseling Corner

Amino Synergy Raspberry Lemonade by Kaged: Common Questions

Does Amino Synergy Raspberry Lemonade by Kaged interact with any medications?
Yes. Based on its ingredients, Amino Synergy Raspberry Lemonade has a known interaction with 788 medications, including 256 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Amino Synergy Raspberry Lemonade contains 11 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What are amino acids and why are they in this product?
Amino acids are the building blocks your body uses to make protein and produce important chemicals like neurotransmitters and hormones. This blend contains nine amino acids that support muscle protein synthesis and overall amino acid balance, particularly useful during or after exercise.
Can I take this if I'm on an antidepressant?
It depends on which antidepressant. L-tryptophan in this product can combine with serotonergic antidepressants (like SSRIs, SNRIs, and tricyclics) to increase serotonin effects, which carries a Moderate interaction risk. L-phenylalanine also interacts with MAOIs (an older class of antidepressant). Check your specific medication with the tool on this page or ask your pharmacist.
Is this safe during pregnancy?
The data shows mixed safety ratings across the amino acids. L-arginine and L-methionine are rated possibly safe or likely safe, but L-phenylalanine and L-tryptophan have insufficient or unsafe ratings during pregnancy. You should not take this product during pregnancy without your doctor's approval.
What side effects might I experience?
Common side effects from the amino acids include stomach pain, diarrhea, nausea, headache, and insomnia. L-arginine may lower blood pressure. L-phenylalanine can cause anxiety or constipation. If you have a coconut allergy, this product could trigger allergic reactions.
Can I take this with blood pressure medication?
L-arginine in this formula can lower blood pressure and combines with blood pressure drugs (especially ACE inhibitors and ARBs) to increase the risk of dangerously low blood pressure and high potassium levels. Do not use this product with blood pressure medications without talking to your pharmacist or doctor first.
I have PKU—can I use this?
No. L-phenylalanine is one of the amino acids in this blend, and it's not safe for people with phenylketonuria (PKU). Avoid this product entirely.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Amino Synergy Raspberry Lemonade is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Amino Synergy Raspberry Lemonade label
Go deeper

The Full Monographs Behind Amino Synergy Raspberry Lemonade’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Coconut

Interacts with 86 drugs

Coconut is a nutritious tropical food enjoyed as oil, water, milk, and flesh, and it is generally safe to eat in normal food amounts. While some uses (like skin moisturizing and hydration) h...

Read the full Coconut monograph →
Herb & supplement monograph

L-arginine

Interacts with 403 drugs

L-arginine is an amino acid that the body uses to make nitric oxide, a substance that helps blood vessels relax and widen. It is popularly used for blood pressure, erectile dysfunction, and...

Read the full L-arginine monograph →
Herb & supplement monograph

Methionine

Methionine is an essential amino acid that your body needs for protein building and many basic chemical reactions. Most people get enough from a normal diet, and supplements are generally no...

Read the full Methionine monograph →
Herb & supplement monograph

Lysine

Interacts with 1 drug

Lysine is an essential amino acid your body cannot make on its own, so it must come from food or supplements. People most often take extra lysine to try to prevent or shorten cold sores, but...

Read the full Lysine monograph →
Herb & supplement monograph

Phenylalanine

Interacts with 16 drugs

Phenylalanine is an essential amino acid the body uses to make brain chemicals like dopamine and norepinephrine. Some people take it for mood, vitiligo, or pain, but the evidence is mostly l...

Read the full Phenylalanine monograph →
Herb & supplement monograph

Histidine

Histidine is an essential amino acid your body needs to build proteins and to make compounds like histamine and carnosine. Most people get enough from a normal diet, and good-quality researc...

Read the full Histidine monograph →
Herb & supplement monograph

Threonine

Interacts with 3 drugs

Threonine is an essential amino acid your body needs but cannot make, so you must get it from food or supplements. Most people get plenty from a normal diet, and high-quality evidence for ta...

Read the full Threonine monograph →
Herb & supplement monograph

L-tryptophan

Interacts with 394 drugs

L-tryptophan is an essential amino acid the body uses to make serotonin and melatonin, and people take it to support sleep and mood. The evidence for supplement use is limited and mixed, and...

Read the full L-tryptophan monograph →
Sources

Sources & How We Checked

Amino Synergy Raspberry Lemonade's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 143 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

L-arginine 66 references
  1. Sapienza MA, Kharitonov SA, Horvath I, et al. Effect of inhaled L-arginine on exhaled nitric oxide in normal and asthmatic subjects. Thorax 1998;53:172-5.
  2. Clarkson P, Adams MR, Powe AJ, et al. Oral L-arginine improves endothelium-dependent dilation in hypercholesterolemic young adults. J Clin Invest 1996;97:1989-94. PubMed
  3. Tenenbaum A, Fisman EZ, Motro M. L-arginine: Rediscovery in progress. Cardiology 1998;90:153-9.
  4. Brittenden J, Park KGM, Heys SD, et al. L-Arginine stimulates host defenses in patients with breast cancer. Surgery 1994;115:205-12.
  5. Korting GE, Smith SD, Wheeler MA, et al. A randomized double-blind trial of oral L-arginine for treatment of interstitial cystitis. J Urol 1999;161:558-65. DOI
  6. Rector TS, Bank AJ, Mullen KA, et al. Randomized, double-blind, placebo-controlled study of supplemental oral L-arginine in patients with heart failure. Circulation 1996;93:2135-41.
  7. Siani A, Pagano E, Iacone R, et al. Blood pressure and metabolic changes during dietary L-arginine supplementation in humans. Am J Hypertens 2000;13:547-51. PubMed
  8. Cheng JW, Balwin SN. L-arginine in the management of cardiovascular diseases. Ann Pharmacother 2001;35:755-64. PubMed
  9. Wallace AW, Tom WL. Interaction of L-arginine and phosphodiesterase inhibitors in vasodilation of the porcine internal mammary artery. Anesth Analg 2000;90:840-6. DOI
  10. Huynh NT, Tayek JA. Oral arginine reduces systemic blood pressure in type 2 diabetes: its potential role in nitric oxide generation. J Am Coll Nutr 2002;21:422-7.. PubMed
  11. Staff AC, Berge L, Haugen G, et al. Dietary supplementation with L-arginine or placebo in women with pre-eclampsia. Acta Obstet Gynecol Scand 2004;83:103-7.
  12. Resnick DJ, Softness B, Murphy AR, et al. Case report of an anaphylactoid reaction to arginine. Ann Allergy Asthma Immunol 2002;88:67-8. PubMed
  13. Anon. Arginine hydrochloride injection (marketed as R-Gene 10). FDA Drug Safety Newsletter 2009;2(2):16-18. Available at: www.fda.gov/Drugs/DrugSafety/DrugSafetyNewsletter/default.htm.
  14. Higashi Y, Oshima T, Sasaki S, et. al. Angiotensin-converting enzyme inhibition, but not calcium antagonism, improves a response of the renal vasculature to L-arginine in patients with essential hypertension. Hypertension. 1998 Jul;32(1):16-24.
  15. Facchinetti, F., Longo, M., Piccinini, F., Neri, I., and Volpe, A. L-arginine infusion reduces blood pressure in preeclamptic women through nitric oxide release. J Soc Gynecol.Investig. 1999;6(4):202-207. DOI
  16. de Gouw, H. W., Verbruggen, M. B., Twiss, I. M., and Sterk, P. J. Effect of oral L-arginine on airway hyperresponsiveness to histamine in asthma. Thorax 1999;54(11):1033-1035. PubMed
  17. Komers, R., Komersova, K., Kazdova, L., Ruzickova, J., and Pelikanova, T. Effect of ACE inhibition and angiotensin AT1 receptor blockade on renal and blood pressure response to L-arginine in humans. J Hypertens. 2000;18(1):51-59. PubMed
  18. Cartledge, J. J., Davies, A. M., and Eardley, I. A randomized double-blind placebo-controlled crossover trial of the efficacy of L-arginine in the treatment of interstitial cystitis. BJU.Int. 2000;85(4):421-426.
  19. Sozykin, A. V., Noeva, E. A., Balakhonova, T. V., Pogorelova, O. A., and Men'shikov, M. I. [Effect of L-arginine on platelet aggregation, endothelial function adn exercise tolerance in patients with stable angina pectoris]. Ter.Arkh. 2000;72(8):24-27.
  20. Nagaya, N., Uematsu, M., Oya, H., Sato, N., Sakamaki, F., Kyotani, S., Ueno, K., Nakanishi, N., Yamagishi, M., and Miyatake, K. Short-term oral administration of L-arginine improves hemodynamics and exercise capacity in patients with precapillary pulmona
  21. Stokes, G. S., Barin, E. S., Gilfillan, K. L., and Kaesemeyer, W. H. Interactions of L-arginine, isosorbide mononitrate, and angiotensin II inhibitors on arterial pulse wave. Am J Hypertens. 2003;16(9 Pt 1):719-724.
  22. Park, K. G., Heys, S. D., Blessing, K., Kelly, P., McNurlan, M. A., Eremin, O., and Garlick, P. J. Stimulation of human breast cancers by dietary L-arginine. Clin.Sci.(Lond) 1992;82(4):413-417.
  23. Palloshi, A., Fragasso, G., Piatti, P., Monti, L. D., Setola, E., Valsecchi, G., Galluccio, E., Chierchia, S. L., and Margonato, A. Effect of oral L-arginine on blood pressure and symptoms and endothelial function in patients with systemic hypertension,
  24. Schlaich, M. P., Ahlers, B. A., Parnell, M. M., and Kaye, D. M. beta-Adrenoceptor-mediated, nitric-oxide-dependent vasodilatation is abnormal in early hypertension: restoration by L-arginine. J Hypertens. 2004;22(10):1917-1925. PubMed
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Methionine 12 references
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Phenylalanine 23 references
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Histidine 3 references
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Threonine 4 references
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L-tryptophan 18 references
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Coconut 10 references
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