Major interaction on record — check this product against your medications before combining. Based on 13 of 41 ingredients. Check your meds →
Dietary supplement

NO Shotgun MHF-1 Grape Bubblegum Ingredients & Drug Interactions

by VPX

NO Shotgun MHF-1 Grape Bubblegum label
See full label image
Powder Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking NO Shotgun MHF-1 Grape Bubblegum against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

NO Shotgun MHF-1 Grape Bubblegum is a dietary supplement by VPX with 41 active ingredients. Its ingredients are commonly taken for replacing fluids and electrolytes, preventing dehydration during exercise or illness, treating low blood sodium (under medical care).Based on those ingredients, 1,003 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Caffeine Anhydrous, L-Arginine, Hordenine HCl. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against NO Shotgun MHF-1 Grape Bubblegum by VPX

Ask about any prescription or over-the-counter medication and we check it for interactions with NO Shotgun MHF-1 Grape Bubblegum by VPX — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of NO Shotgun MHF-1 Grape Bubblegum by VPX

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 27, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 1 of its 39 active ingredients.
  • “Protein Hydrolysate Matrix” is a proprietary blend — the label gives one combined amount (9,660 mg) without saying how much of each component you get.
  • “Proprietary Branched Chain Ethyl Ester Amino Acid Matrix” is a proprietary blend — the label doesn't break down how much of each component you get.
  • “MHF-1, NO2 & Insulinotrophic Matrix” is a proprietary blend — the label gives one combined amount (10,055 mg) without saying how much of each component you get.

NO Shotgun MHF-1 is a 39-ingredient powder formulated as a pre-workout supplement. The active ingredients include amino acids (L-leucine, L-isoleucine, L-valine, L-arginine in two forms, L-tyrosine, and L-histidine), two types of whey protein (isolate and hydrolysate), creatine in three forms (monohydrate, gluconate, and magnesium chelate), caffeine anhydrous, hordenine HCl, and several other compounds.

The product also contains inactive ingredients such as natural and artificial flavors, malic acid, sucralose, citric acid, phosphate salts, and glycine.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded its ingredients' overall clinical evidence instead.

Strong

Strong clinical evidence supports its ingredients for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredients' overall clinical evidence instead.
  • On file: Sideroblastic anemia — rated "Effective" (Vitamin B6) (Natural Medicines).
  • On file: Hypophosphatemia — rated "Effective" (Phosphate Salts) (Natural Medicines).
  • On file: Neonatal apnea — rated "Effective" (Caffeine) (Natural Medicines).
  • On file: Phenylketonuria (PKU) — rated "Effective" (Tyrosine) (Natural Medicines).
  • On file: Postoperative headache — rated "Effective" (Caffeine) (Natural Medicines).

Effectiveness data in our database is limited to a few of the individual amino acids and creatine forms. Creatine (in its three formulations) is rated Possibly Effective for muscle strength and athletic performance, and also for sarcopenia (age-related muscle loss).

Whey protein is rated Possibly Effective for athletic performance. Caffeine is rated Likely Effective for mental alertness and athletic performance.

L-tyrosine is rated Possibly Effective for cognitive function and memory. For most of the other ingredients — including the specific L-arginine and hordenine formulations, and many of the amino acids in this product — we hold no effectiveness data.

The product's overall effectiveness for pre-workout performance has not been established in the data we hold.

The evidence, ingredient by ingredient Sodium Whey Protein Casein Peptides L-arginine Creatine Vitamin B6 Histidine Beta-alanine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 11 of the 13 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 12 of 13.
  • General safety write-ups exist for 13 of 13.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Whey protein is generally well tolerated by most healthy adults, though common side effects include bloating, cramps, diarrhea, nausea, and acne in some users. Creatine is generally well tolerated in healthy adults but can cause dehydration, water retention, muscle cramps, and gastrointestinal upset; it should be avoided in pregnancy and lactation.

Caffeine is well tolerated in moderate amounts but can cause anxiety, insomnia, jitteriness, headache, and nausea; high doses carry rare risk of stroke. Vitamin B6 is safe at normal dietary amounts, but high doses over time can damage nerves (sensory neuropathy), especially at doses exceeding 1,000 mg daily.

L-arginine is generally well tolerated short-term but can lower blood pressure, and long-term safety for self-treatment is not well established. Hordenine has very limited human safety data; as a stimulant-like compound, it theoretically carries risk of heart-related side effects.

L-histidine safety at higher supplement doses is not well studied. Sodium is essential in small amounts but excessive intake is linked to high blood pressure and heart strain.

Side effects, ingredient by ingredient Sodium Whey Protein Casein Peptides L-arginine Creatine Vitamin B6 Histidine Beta-alanine

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 10 of the 13 matched ingredients can interact with medications — Phosphate Salts, Whey Protein, L-arginine, Vitamin B6, Caffeine, among others.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications; lithium; Parkinson's medications.
  • For scale: 1,003 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this product, double-check with your doctor or pharmacist if you take levodopa (Parkinson disease), ephedrine, blood pressure medications, blood thinners (anticoagulants or antiplatelet drugs), diabetes medications, heart medications like amiodarone, seizure medications, MAOIs or other antidepressants, clozapine, thyroid hormone, or sildenafil. The whey protein can reduce how well you absorb quinolone and tetracycline antibiotics and bisphosphonate osteoporosis drugs — space these doses apart if you take them.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with strong clinical evidence behind its ingredients' uses. Major medication interactions have been identified, and safety information is well characterized.

This is a multi-ingredient pre-workout powder designed for athletic performance and muscle support, containing creatine, amino acids, whey protein, and caffeine. It carries documented interactions with several common medication classes — most notably with levodopa (if you have Parkinson disease), blood pressure drugs, blood thinners, and stimulants — and should be reviewed by your doctor or pharmacist before you start, especially if you take any prescription medications, have kidney disease, or are pregnant or nursing.

The product is generally well tolerated by healthy adults at recommended doses, though common side effects like bloating and nausea can occur.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 20 of 39 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 25, 2011.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about NO Shotgun MHF-1 Grape Bubblegum, straight from the product label.

Brand VPX
Barcode (UPC) 610764860323
Net contents 672 g; 1.48 lb
Market status On market
Date entered into DSLD Nov 25, 2011
DSLD ID 2014
Product type Other Combinations
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for NO Shotgun MHF-1 Grape Bubblegum by VPX, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
21 g
Maximum serving Sizes:
21 g
Servings per container
28
UPC/BARCODE
610764860323
IngredientAmount% DV
Calories81 {Calories}--
Total Fat0 None--
Vitamin B60 NP250%
Protein20 g40%
Sodium65 mg2.6%
Whey Protein Isolate0 NP--
L-Leucine Ethyl Ester Hydrochloride0 NP--
L-Isoleucine Ethyl Ester Hydrochloride0 NP--
L-Leucine0 NP--
L-Arginine0 NP--
L-Isoleucine0 NP--
Creatine Monohydrate0 NP--
Carbohydrates0 g--
L-Tyrosine0 NP--
L-Valine0 NP--
L-Histidine0 NP--
Caffeine Anhydrous0 NP--
Folate0 NP100%
Hordenine HCl0 NP--
Citrulline Malate0 NP--
Whey Protein hydrolysate0 NP--
L-Arginine Ethyl Ester Dihydrochloride0 NP--
Beta-Phenylethylamine HCl0 NP--
Creatine Gluconate0 NP--
L-Valine Ethyl Ester0 NP--
Guanidinopropionic Acid0 NP--
Creatine Magnesium Chelate0 NP--
L-2-aminopentanoic Acid0 NP--
Gamma-Butyrobetaine Ethyl Ester0 NP--
Protein Hydrolysate Matrix9660 mg--
L-Alanyl Glutamine0 NP--
CEX0 NP--
Creatine Taurinate0 NP--
COP0 NP--
Di-Na Creatine Phosphate Tetrahydrate0 NP--
Di-L-Arginine Malate0 NP--
MTB Pump0 NP--
Bis Picolinato Oxo Vanadium0 NP--
Gamma-Butyrobetaine0 NP--
Beta-Alanine0 NP--
KIC0 NP--
Phosphates0 NP--
Casein Protein Hydolysate0 NP--
Proprietary Branched Chain Ethyl Ester Amino Acid Matrix0 NP--
MHF-1, NO2 & Insulinotrophic Matrix10055 mg--
Power, Speed, Strength and MyoBlast Amplification Matrix0 NP--
Training & Mental Acuity Amplification Matrix377 mg--
R-Beta-Methylphenylethylamine0 NP--

Other ingredients: Natural & Artificial flavors, Malic Acid, Sucralean brand Sucralose, Citric Acid Anhydrous, Monosodium Phosphate Anhydrous, Trisodium Phosphate Dodecahydrate, Glycine

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity

DIETARY SUPPLEMENT

Suggested/Recommended/Usage/Directions

Drink an additional one half (1/2) ounce of water for each pound of body weight daily.

RECOMMENDED USE: Do not use N.O. SHOTGUN MHF-1(TM) with REDLINE(R) or MELTDOWN(R) or any other products containing caffeine or other stimulants. Mix one scoop of N.O. SHOTGUN MHF-1(TM) with 8 to 10 ounces of water or your favorite beverage. Drink N.O. SHOTGUN MHF-1(TM) prior to any type of athletic event or resistance training. For enhanced results consume N.O. SYNTHESIZE MHF-1(TM) during and after training. Unlike other N.O. (Nitric Oxide) Supplements which may require several scoops, N.O. SHOTGUN MHF-1(TM) is extremely powerful and requires only one scoop. The N.O. SHOTGUN MHF-1(TM) and N.O. SYNTHESIZE MHF-1(TM) supplement strategy represents the most advanced and latest research on muscle growth and athletic performance.

Precautions

KEEP OUT OF REACH OF CHILDREN.

Caution: As with all dietary supplements, do not use this product if you are pregnant or nursing or have a medical condition. This product contains caffeine and should not be used with any other caffeine and/or stimulant containing products. This product is intended for use by healthy individuals only.

Phenylketonurics: Contains Phenylalanine.

DO NOT PURCHASE IF SAFETY SEAL IS BROKEN OR MISSING.

Muscle energetic compounds within Shotgun(R) may cause a tingling sensation in lips and skin. Contains no Niacin.

FDA Disclaimer Statement

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Storage

PROTECT FROM HEAT, LIGHT AND MOISTURE.

STORE AT 15-30(0)C (59-86(0)F).

STORE IN A COOL, DRY PLACE.

General Statements

*When combined with resistance training and a sensible diet.

181% More Lean Muscle 1108% Bench Press Increase 54% Leg Press Increase

ALL RIGHTS RESERVED.

AWESOME NEW GRAPE BUBBLEGUM FLAVOR

BEST BY DATE ON BOTTOM

CONTENTS SOLD BY WEIGHT NOT VOLUME; SOME SETTLING MAY OCCUR.

INCREASE MUSCLE GENE PROTEINS UP TO 118.55%

NO-Shotgun vs Placebo 181% More Lean Muscle 1108% Bench Press Increase 54% Leg Press Increase

No-Shotgun vs Placebo in Human subjects with 4 weeks resistance training.

UNCUT, UNADULTERATED! NO WAXI MAIZE, NO SUGAR, NO CARBS, 100% PROTEIN BASED GENE-ALTERING COMPOUNDS!

UNIVERSITY PROVEN

University Proven to Increase Muscle Gene Proteins up to 118.55%

University Research Proven to Increase Lean Muscle by 181% Bench Press by 1108% Leg Press by 54% - in Only 4 Weeks!

WORLDS ONLY MHF-1 MATRIX

Brand IP Statement(s)

©2009 VITAL PHARMACEUTICALS, INC.

COP(R) Creatinol-O-Phosphate

Increases in Muscle Gene Proteins with NO-Shotgun MHF-1(TM) Muscle Myo-D Increase……118.55% Muscle MRF-4 Increase……70.91% Muscle Myf5 Increase…….54.38% Muscle Myogenin Increase…….71.17% Myofibrillar Protein Increase….33.11%

Increases in Muscle Gene Proteins with NO-Shotgun MHF-1(TM) Muscle Myo-D Increase……118.55% Muscle MRF-4 Increase……70.91% Muscle Myf5 Increase…….54.38% Muscle Myogenin Increase…….71.17% Myofibrillar Protein Increase….33.11% Red Bars Represent Placebo

NEW MUSCLE NOW!(TM)

NEW MUSCLE NOW!(TM) MHF-1(TM) MYOGENIC HYPERPLASIA FACTOR-1

NO-Shotgun MHF-1(TM) Highlights -Increases Muscle DNA & Muscle(TM) Gene Proteins to Rapidly Increase Muscle Growth -Increases Myogenic Regulatory Factors -Unparalleled Training Intensity, Mental Acuity & Focus -Increases Whole Body Creatine Retention -Insulin Sensitivity and Responsiveness -Insulin Mediated Lean Mass -Meltdown/Redline-Induced Fat Loss -Muscle Fullness and Blood-Engorged Pumps -Strength, Power, Endurance & Recuperation -Crisp, Water-Free Muscle Separation -Blood Flow & Nitric Oxide (N.O.) Levels

NO-SHOTGUN MHF-1(TM) UNIVERSITY PROVEN TO INCREASE MUSCLE DNA BY 148.65% PLACEBO 148.65% INCREASE IN MUSCLE DNA NO-SHOTGUN MHF-1(TM)

PeptoPro(R)

SUCRALEAN(R) ZERO CALORIE SWEETENER

UNLIMITED GROWTH POTENTIAL University Research Proven to Alter Muscle at the Genetic Level. NO-SHOTGUN MHF-1(TM) Activates Satellite Cell Proliferation to Promote Muscle Hyperplasia - The Birth of New Muscle. NO-SHOTGUN MHF-1(TM) generated the most ground breaking University research in the history of Muscle Science.

WORLD'S ONLY MHF-1(TM) [MYOGENIC HYPERPLASIA FACTOR-1] MATRIX

ZERO CARB(R) TECHNOLOGY ZCT

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

NO Shotgun MHF-1 Grape Bubblegum by VPX label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

NO Shotgun MHF-1 Grape Bubblegum label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in NO Shotgun MHF-1 Grape Bubblegum by VPX

These are the 41 active ingredients this product is made of. Select any to open its full monograph.

Serving size21 g Dosage formPowder Servings per container28 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Protein

20 g per serving

Sodium

Interacts with
205 drugs
65 mg per serving

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets g...

Sodium monograph & interactions

Carbohydrates

0 g per serving

Protein Hydrolysate Matrix

9660 mg per serving Form: BCAA Peptide, EAA's, Glutamine Peptides

Proprietary Branched Chain Ethyl Ester Amino Acid Matrix

0 NP per serving
  • › L-Leucine Ethyl Ester Hydrochloride
  • › L-Isoleucine Ethyl Ester Hydrochloride
  • › L-Leucine
  • › L-Arginine
  • › L-Isoleucine
  • › L-Valine
  • › L-Arginine Ethyl Ester Dihydrochloride
  • › L-Valine Ethyl Ester
  • › L-2-aminopentanoic Acid
  • › L-Alanyl Glutamine

MHF-1, NO2 & Insulinotrophic Matrix

10055 mg per serving

Power, Speed, Strength and MyoBlast Amplification Matrix

0 NP per serving

Training & Mental Acuity Amplification Matrix

377 mg per serving

Other (inactive) ingredients: Natural & Artificial flavors, Malic Acid, Sucralean brand Sucralose, Citric Acid Anhydrous, Monosodium Phosphate Anhydrous, Trisodium Phosphate Dodecahydrate, Glycine. These complete the product’s ingredient list but are not active constituents.

Interaction report

NO Shotgun MHF-1 Grape Bubblegum by VPX Drug Interactions

Want to check YOUR meds against NO Shotgun MHF-1 Grape Bubblegum?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,003Drugs
15 Major 853 Moderate 135 Minor

Ingredients driving the most interactions

Caffeine Anhydrous 655
L-Arginine 403
Hordenine HCl 329
Vitamin B6 210
Sodium 205

Individual Drug Interactions

The ingredients in NO Shotgun MHF-1 Grape Bubblegum interact with 1,003 drugs. Click any drug to see the details.

10 of the 41 ingredients in NO Shotgun MHF-1 Grape Bubblegum interact with drugs. Each result below shows which ingredient is responsible. Caffeine Anhydrous L-Arginine Hordenine HCl Vitamin B6 Sodium R-Beta-Methylphenylethylamine Casein Protein Hydolysate Whey Protein Isolate L-Tyrosine Phosphates

Each ingredient & the kinds of drugs it affects

For each ingredient in NO Shotgun MHF-1 Grape Bubblegum with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Caffeine Anhydrous41 drug types · 655 drugs

Ephedrine

Theoretically, concomitant use might increase the risk for stimulant adverse effects.
Use of ephedrine with caffeine can increase the risk of stimulatory adverse effects. There is evidence that using ephedrine with caffeine might increase the risk of serious life-threatening or debilitating adverse effects such as hypertension, myocardial infarction, stroke, seizures, and death.

Likelihood Probable Evidence D
Adenosine (Adenocard)

Theoretically, caffeine might decrease the vasodilatory effects of adenosine and interfere with its use prior to stress testing.
Some evidence shows that caffeine is a competitive inhibitor of adenosine and can reduce the vasodilatory effects of adenosine in humans. However, other research shows that caffeine does not seem to affect supplemental adenosine because high interstitial levels of adenosine overcome the antagonistic effects of caffeine. It is recommended that methylxanthines and methylxanthine-containing products be stopped 24 hours prior to pharmacological stress tests. However, methylxanthines appear more likely to interfere with dipyridamole (Persantine) than adenosine-induced stress testing.

Likelihood Possible Evidence B
Anticoagulant/Antiplatelet Drugs

Theoretically, caffeine may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Caffeine is reported to have antiplatelet activity. Theoretically, it might increase the risk of bleeding when used concomitantly with these agents; however, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Beta-Adrenergic Agonists

Theoretically, large amounts of caffeine might increase the cardiac inotropic effects of beta-agonists.

Likelihood Probable Evidence D
Carbamazepine (Tegretol)

Theoretically, caffeine might reduce the effects of carbamazepine and increase the risk for convulsions.
Animal research suggests that taking caffeine can lower the anticonvulsant effects of carbamazepine and can induce seizures when taken in doses above 400 mg/kg. Human research has shown that taking caffeine 300 mg in three divided doses along with carbamazepine 200 mg reduces the bioavailability of carbamazepine by 32% and prolongs the plasma half-life of carbamazepine 2-fold in healthy individuals.

Likelihood Possible Evidence D
Cimetidine (Tagamet)

Theoretically, cimetidine might increase the levels and adverse effects of caffeine.
Cimetidine decreases the rate of caffeine clearance by 31% to 42%.

Likelihood Likely Evidence B
Clozapine (Clozaril)

Caffeine might increase the levels and adverse effects of clozapine and acutely exacerbate psychotic symptoms.
Caffeine might increase the effects and toxicity of clozapine. Caffeine doses of 400-1000 mg per day inhibit clozapine metabolism. Clozapine is metabolized by cytochrome P450 1A2 (CYP1A2). Although researchers speculate that caffeine might inhibit CYP1A2, there is no reliable evidence that caffeine affects CYP1A2. There is also speculation that genetic factors might make some patients more sensitive to an interaction between clozapine and caffeine. In one case report, severe, life-threatening clozapine toxicity and multiorgan system failure occurred in a patient with schizophrenia stabilized on clozapine who consumed caffeine 600 mg daily.

Likelihood Possible Evidence B
Dipyridamole (Persantine)

Theoretically, caffeine might decrease the vasodilatory effects of dipyridamole and interfere with its use prior to stress testing.
Caffeine inhibits dipyridamole-induced vasodilation. It is recommended that methylxanthines and methylxanthine-containing products be stopped 24 hours prior to pharmacological stress tests. Methylxanthines appear more likely to interfere with dipyridamole (Persantine) than adenosine-induced stress testing.

Likelihood Probable Evidence B
Disulfiram (Antabuse)

Theoretically, disulfiram use might increase the levels and adverse effects of caffeine.
Disulfiram decreases the rate of caffeine clearance.

Likelihood Probable Evidence B
Diuretic Drugs

Theoretically, using caffeine with diuretic drugs might increase the risk of hypokalemia.
Caffeine, especially in excessive amounts, can reduce potassium levels due to stimulation of the sodium-potassium pump. Diuretics can also cause lower potassium levels.

Likelihood Possible Evidence D
Estrogens

Theoretically, estrogens might increase the levels and adverse effects of caffeine.
Estrogen inhibits caffeine metabolism.

Likelihood Probable Evidence B
Ethosuximide (Zarontin)

Theoretically, caffeine might reduce the effects of ethosuximide and increase the risk for convulsions.
Animal research suggests that caffeine 92.4 mg/kg can decrease the anticonvulsant activity of ethosuximide. However, this effect has not been reported in humans.

Likelihood Possible Evidence D
Felbamate (Felbatol)

Theoretically, caffeine might reduce the effects of felbamate and increase the risk for convulsions.
Animal research suggests that a high dose of caffeine 161.7 mg/kg can decreases the anticonvulsant activity of felbamate. However, this effect has not been reported in humans.

Likelihood Possible Evidence D
Flutamide (Eulexin)

Theoretically, caffeine might increase the levels and adverse effects of flutamide.
In vitro evidence suggests that caffeine can inhibit the metabolism of flutamide. However, this effect has not been reported in humans.

Likelihood Probable Evidence D
Fluvoxamine (Luvox)

Theoretically, fluvoxamine might increase the levels and adverse effects of caffeine.
Fluvoxamine reduces caffeine metabolism.

Likelihood Probable Evidence D
Lithium

Abrupt caffeine withdrawal might increase the levels and adverse effects of lithium.
Caffeine has diuretic activity. When abruptly discontinued, caffeine may alter the clearance of lithium. There are two case reports of lithium tremor that worsened upon abrupt coffee withdrawal and 6 case reports of elevated serum lithium levels after reducing or eliminating caffeine intake. In one case, a male with schizoaffective disorder stabilized on lithium had an elevated lithium level after reducing his caffeine intake by 87%. At a later date, he increased his caffeine intake by 6-fold, resulting in a subtherapeutic lithium level and a recurrence of psychiatric symptoms.

Likelihood Probable Evidence D
Monoamine Oxidase Inhibitors (Maois)

Theoretically, concomitant use might increase the risk of a hypertensive crisis.
Caffeine has been shown to inhibit monoamine oxidase (MAO) A and B in laboratory studies. Concomitant intake of large amounts of caffeine with MAOIs might precipitate a hypertensive crisis. In a case report, a patient that consumed 10-12 cups of caffeinated coffee and took the MAOI tranylcypromine presented with severe hypertension. Hypertension was resolved after the patient switched to drinking decaffeinated coffee.

Likelihood Possible Evidence D
Nicotine

Theoretically, concomitant use might increase the risk of hypertension.
Concomitant use of caffeine and nicotine has been shown to have additive cardiovascular effects, including increased heart rate and blood pressure. Blood pressure was increased by 10.8/12.4 mmHg when the agents were used concomitantly.

Likelihood Probable Evidence B
Pentobarbital (Nembutal)

Theoretically, caffeine might decrease the effects of pentobarbital.
Caffeine might negate the hypnotic effects of pentobarbital.

Likelihood Possible Evidence B
Phenobarbital (Luminal)

Theoretically, caffeine might reduce the effects of phenobarbital and increase the risk for convulsions.
Animal research suggests that caffeine can decrease the anticonvulsant activity of phenobarbital. However, the exact mechanism of this interaction is unclear.

Likelihood Possible Evidence D
Phenylpropanolamine

Theoretically, phenylpropanolamine might increase the risk of hypertension, as well as the levels and adverse effects of caffeine.
Concomitant use of phenylpropanolamine and caffeine might cause an additive increase in blood pressure. Phenylpropanolamine also seems to increase caffeine serum levels.

Likelihood Probable Evidence B
Phenytoin (Dilantin)

Theoretically, caffeine might reduce the effects of phenytoin and increase the risk for convulsions.
Animal research suggests that caffeine can decrease the anticonvulsant activity of phenytoin. The effect does not seem to be related to the seizure threshold-lowering effects of caffeine. However, the exact mechanism of this interaction is unclear.

Likelihood Possible Evidence D
Pioglitazone (Actos)

Theoretically, caffeine might increase the levels and clinical effects of pioglitazone.
Animal research suggests that caffeine can modestly increase the maximum concentration, area under the curve, and half-life of pioglitazone, and also reduce its clearance. This increased the antidiabetic effects of pioglitazone. However, the exact mechanism of this interaction is unclear.

Likelihood Possible Evidence D
Quinolone Antibiotics

Theoretically, quinolone antibiotics might increase the levels and adverse effects of caffeine.
Quinolones (also called fluoroquinolones) can decrease caffeine clearance by inhibiting cytochrome P450 1A2 (CYP1A2) enzyme.

Likelihood Probable Evidence B
Riluzole (Rilutek)

Theoretically, concomitant use might increase the levels and adverse effects of both caffeine and riluzole.
Caffeine and riluzole are both metabolized by cytochrome P450 1A2 (CYP1A2), and concomitant use might reduce the metabolism of one or both agents.

Likelihood Possible Evidence D
Caffeine Anhydrous full monograph & all 41 interactions

L-Arginine9 drug types · 403 drugs

Ace Inhibitors (Aceis)

Theoretically, concomitant use of L-arginine and ACE inhibitors may increase the risk for hypotension and hyperkalemia.
Combining L-arginine with some antihypertensive drugs, especially ACE inhibitors, seems to have additive vasodilating and blood pressure-lowering effects. Furthermore, ACE inhibitors can increase potassium levels. Use of L-arginine has been associated with hyperkalemia in some patients. Theoretically, concomitant use of ACE inhibitors with L-arginine may increases the risk of hyperkalemia.

Likelihood Probable Evidence D
Angiotensin Receptor Blockers (Arbs)

Theoretically, concomitant use of L-arginine and ARBs may increase the risk of hypotension and hyperkalemia.
L-arginine increases nitric oxide, which causes vasodilation. Combining L-arginine with ARBs seems to increase L-arginine-induced vasodilation. Furthermore, ARBs can increase potassium levels. Use of L-arginine has been associated with hyperkalemia in some patients. Theoretically, concomitant use of ARBs with L-arginine may increases the risk of hyperkalemia.

Likelihood Probable Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, concomitant use of L-arginine with anticoagulant and antiplatelet drugs might have additive effects and increase the risk of bleeding.
Preliminary research suggests that L-arginine infusions reduce platelet aggregation in humans. The clinical significance of this effect is unclear.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, concomitant use of L-arginine might have additive effects with antidiabetes drugs.
Preliminary clinical research shows that L-arginine decreases blood glucose levels in patients with type 2 diabetes.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, concomitant use of L-arginine and antihypertensive drugs may increase the risk of hypotension.
L-arginine increases nitric oxide, which causes vasodilation. Clinical evidence shows that L-arginine can reduce blood pressure in some individuals with hypertension. Furthermore, combining L-arginine with some antihypertensive drugs seems to have additive vasodilating and blood pressure-lowering effects.

Likelihood Probable Evidence D
Isoproterenol (Isuprel)

Theoretically, concurrent use of isoproterenol and L-arginine might result in additive effects and hypotension.
Preliminary clinical evidence suggests that L-arginine enhances isoproterenol-induced vasodilation in patients with essential hypertension or a family history of essential hypertension.

Likelihood Probable Evidence D
Potassium-Sparing Diuretics

Theoretically concomitant use of potassium-sparing diuretics with L-arginine may increases the risk of hyperkalemia.
Potassium-sparing diuretics can increase potassium levels. Use of L-arginine has been associated with hyperkalemia in some patients.

Likelihood Possible Evidence D
Sildenafil (Viagra)

Theoretically, concurrent use of sildenafil and L-arginine might increase the risk for hypotension.
In vivo, concurrent use of L-arginine and sildenafil has resulted in increased vasodilation. Theoretically, concurrent use might have additive vasodilatory and hypotensive effects. However, in studies evaluating the combined use of L-arginine and sildenafil for erectile dysfunction, hypotension was not reported.

Likelihood Possible Evidence D
Testosterone

Theoretically, concomitant use of L-arginine and testosterone might have additive effects.
In clinical research, L-arginine increases the level of testosterone in male patients with erectile dysfunction. The clinical significance of this finding is unclear.

Likelihood Possible Evidence D
L-Arginine full monograph & interactions

Hordenine HCl3 drug types · 329 drugs

Monoamine Oxidase Inhibitors (Maois)

Hordenine is structurally similar to tyramine In vitro research shows that hordenine is a selective substrate for monoamine oxidase-B in the liver. Theoretically, concomitant use of hordenine with MAOIs might increase blood pressure, potentially leading to a hypertensive crisis.
Some MAOIs include isocarboxazid (Marplan), phenelzine (Nardil), selegiline (Eldepryl, Emsam, Zelapar), and tranylcypromine (Parnate).

Likelihood Possible Evidence D
Stimulant Drugs

Hordenine is structurally similar to N-methyltyramine and synephrine, constituents in bitter orange known to have stimulant properties. Theoretically, taking hordenine with drugs with stimulant properties might increase the risk of hypertension and other adverse cardiovascular effects.
Some of these drugs include amphetamine, caffeine, methylphenidate, pseudoephedrine, and many others.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Hordenine weakly inhibits cytochrome P450 2D6 (CYP2D6) enzymes in vitro. Theoretically, hordenine might increase the levels of CYP2D6 substrates.
Some of drugs that are CYP2D6 substrates include amitriptyline (Elavil), clozapine (Clozaril), codeine, desipramine (Norpramin), donepezil (Aricept), fentanyl (Duragesic), flecainide (Tambocor), fluoxetine (Prozac), meperidine (Demerol), methadone (Dolophine), metoprolol (Lopressor, Toprol XL), olanzapine (Zyprexa), ondansetron (Zofran), tramadol (Ultram), trazodone (Desyrel), and others.

Likelihood Possible Evidence D
Hordenine HCl full monograph & interactions

Vitamin B65 drug types · 210 drugs

Amiodarone (Cordarone)

Theoretically, vitamin B6 might increase the photosensitivity caused by amiodarone.
Despite initial case reports suggesting that pyridoxine may have a protective effect against amiodarone-induced photosensitivity, preliminary clinical research suggests that pyridoxine may actually exacerbate this adverse effect.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Research in hypertensive rats shows that vitamin B6 can decrease systolic blood pressure. Similarly, clinical research in patients with hypertension shows that taking high doses of vitamin B6 may reduce systolic and diastolic blood pressure, possibly by reducing plasma levels of epinephrine and norepinephrine.

Likelihood Possible Evidence B
Phenobarbital (Luminal)

High doses of vitamin B6 may reduce the levels and clinical effects of phenobarbital.
Preliminary clinical evidence suggests that vitamin B6 200 mg daily can reduce plasma levels of phenobarbital, possibly by increasing metabolism. It is not known whether lower doses have any effect. Advise people taking phenobarbital to avoid high doses of vitamin B6.

Likelihood Possible Evidence D
Phenytoin (Dilantin)

High doses of vitamin B6 may reduce the levels and clinical effects of phenytoin.
Preliminary clinical evidence suggests that vitamin B6 200 mg daily can reduce plasma levels of phenytoin, possibly by increasing metabolism. It is not known whether lower doses have any effect. Advise people taking phenytoin to avoid high doses of vitamin B6.

Likelihood Possible Evidence D
Levodopa

Vitamin B6 may increase the metabolism of levodopa when taken alone, but not when taken in conjunction with carbidopa.
Vitamin B6 (pyridoxine) enhances the metabolism of levodopa, reducing its clinical effects. However, this interaction does not occur when carbidopa is used concurrently with levodopa (Sinemet). Therefore, it is not likely to be a problem in most people.

Likelihood Unlikely Evidence D
Vitamin B6 full monograph & interactions

Sodium7 drug types · 205 drugs

Antihypertensive Drugs

Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
High intake of dietary sodium can increase systolic and diastolic blood pressure. Also, high intake of sodium may necessitate increased use of antihypertensive medications to achieve blood pressure control in some patients, such as those with chronic kidney disease.

Likelihood Probable Evidence A
Corticosteroids

Concomitant use of mineralocorticoids and some glucocorticoids with sodium supplements might increase the risk of hypernatremia.
Mineralocorticoids and some glucocorticoids (corticosteroids) cause sodium retention. This effect is dose-related and depends on mineralocorticoid potency. It is most common with hydrocortisone, cortisone, and fludrocortisone, followed by prednisone and prednisolone.

Likelihood Possible Evidence D
Didanosine (Videx)

Concomitant use of didanosine with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia.
Didanosine formulations contain a significant amount of sodium.

Likelihood Probable Evidence C
Lithium

Altering dietary intake of sodium might alter the levels and clinical effects of lithium.
High sodium intake can reduce plasma concentrations of lithium by increasing lithium excretion. Reducing sodium intake can significantly increase plasma concentrations of lithium and cause lithium toxicity in patients being treated with lithium carbonate. Stabilizing sodium intake is shown to reduce the percentage of patients with lithium level fluctuations above 0.8 mEq/L. Patients taking lithium should avoid significant alterations in their dietary intake of sodium.

Likelihood Probable Evidence B
Sodium Phosphates

Theoretically, concomitant use of sodium phosphate with sodium supplements might increase the risk of hypernatremia.
Use of high doses (> 45 mL in 24 hours) of sodium phosphate, such as those used for bowel cleansing before surgery, can lead to serious electrolyte disturbances, including hypernatremia. The risk of hypernatremia is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Sodium-Containing Drugs

Concomitant use of sodium-containing drugs with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia and long-term sodium-related complications.
The Chronic Disease Risk Reduction (CDRR) intake level of 2.3 grams of sodium daily indicates the intake at which it is believed that chronic disease risk increases for the apparently healthy population. Some medications contain high quantities of sodium. When used in conjunction with sodium supplements or high-sodium diets, the CDRR may be exceeded. Additionally, concomitant use may increase the risk for hypernatremia; this risk is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Tolvaptan (Samsca)

Theoretically, concomitant use of tolvaptan with sodium might increase the risk of hypernatremia.
Tolvaptan is a vasopressin receptor 2 antagonist that is used to increase sodium levels in patients with hyponatremia. Patients taking tolvaptan should use caution with the use of sodium salts such as sodium chloride.

Likelihood Probable Evidence C
Sodium full monograph & interactions

R-Beta-Methylphenylethylamine2 drug types · 187 drugs

Monoamine Oxidase Inhibitors (Maois)

Theoretically, taking phenethylamine concomitantly with MAOIs may increase adverse effects.
In humans, phenethylamine is oxidized by MAO-B to form the inactive metabolite phenylacetic acid. Animal research shows that administering an MAOI prior to phenethylamine increases the amphetamine-like effects of phenethylamine. However, low-quality clinical research has used phenethylamine with selegiline, an MAOI, with apparent safety.

Likelihood Possible Evidence D
Serotonergic Drugs

Theoretically, combining serotonergic drugs with phenethylamine might increase the risk of serotonergic adverse effects.
Animal research shows that phenethylamine increases levels of serotonin, norepinephrine, and dopamine. Theoretically, combining serotonergic drugs with phenethylamine might increase the risk of additive serotonergic adverse effects, including serotonin syndrome and cerebral vasoconstrictive disorders. However, low-quality clinical research has used phenethylamine with selegiline, a monoamine oxidase inhibitor (MAOI), with apparent safety.

Likelihood Possible Evidence D
R-Beta-Methylphenylethylamine full monograph & interactions

Casein Protein Hydolysate1 drug type · 172 drugs

Antihypertensive Drugs

Theoretically, combining these casein peptides with antihypertensive drugs might increase the risk of hypotension.
Clinical research shows that some casein peptides, including the lactotripeptides isoleucine-proline-proline (IPP) and valine-proline-proline (VPP), can modestly reduce blood pressure in patients with hypertension.

Likelihood Probable Evidence B
Casein Protein Hydolysate full monograph & interactions

Whey Protein Isolate4 drug types · 53 drugs

Levodopa

Theoretically, whey protein might decrease levodopa absorption.
Small clinical studies show that concomitant ingestion of protein or high doses of leucine or isoleucine (100 mg/kg) and levodopa can exacerbate tremor, rigidity, and the "on-off" syndrome in patients with Parkinson disease.

Likelihood Probable Evidence D
Bisphosphonates

Theoretically, whey protein might reduce the absorption of bisphosphonates.
Whey protein contains minerals such as calcium that bind bisphosphonates in the gut. Advise patients to take bisphosphonates at least 30 minutes before whey protein, but preferably at a different time of day.

Likelihood Probable Evidence D
Quinolone Antibiotics

Theoretically, whey protein might decrease quinolone absorption.
Whey protein contains minerals, such as calcium, that can bind to quinolones in the gut. To avoid this interaction, advise patients to take oral quinolones at least 2 hours before or 4-6 hours after whey protein.

Likelihood Probable Evidence D
Tetracycline Antibiotics

Theoretically, whey protein might decrease tetracycline absorption.
Whey protein contains minerals, such as calcium, that bind to tetracyclines in the gut. To avoid this interaction, advise patients to take oral tetracyclines at least 2 hours before or 4-6 hours after whey protein.

Likelihood Probable Evidence D
Whey Protein Isolate full monograph & interactions

L-Tyrosine2 drug types · 21 drugs

Levodopa

Theoretically, tyrosine might decrease the effectiveness of levodopa.
Tyrosine and levodopa compete for absorption in the proximal duodenum by the large neutral amino acid (LNAA) transport system. Advise patients to separate doses of tyrosine and levodopa by at least 2 hours.

Likelihood Probable Evidence D
Thyroid Hormone

Theoretically, tyrosine might have additive effects with thyroid hormone medications.
Tyrosine is a precursor to thyroxine and might increase levels of thyroid hormones.

Likelihood Probable Evidence D
L-Tyrosine full monograph & interactions

Phosphates3 drug types · 12 drugs

Erdafitinib (Balversa)

Taking erdafitinib with phosphate salts increases the risk of hyperphosphatemia.
Erdafitinib increases phosphate levels. It is recommended that patients taking erdafitinib restrict phosphate intake to no more than 600-800 mg daily.

Likelihood Probable Evidence A
Futibatinib (Lytgobi)

Taking futibatinib with phosphate salts increases the risk of hyperphosphatemia.
Futibatinib can cause hyperphosphatemia, as reported in 88% of patients in clinical studies. In addition, 77% of patients in clinical studies required use of a phosphate binder to manage hyperphosphatemia. Phosphate salts should generally be avoided by people taking this medication.

Likelihood Likely Evidence A
Bisphosphonates

Theoretically, taking phosphate salts with bisphosphonates might increase the risk of hypocalcemia.
Combining bisphosphonates and phosphate can cause hypocalcemia. In one report, hypocalcemic tetany developed in a patient taking alendronate (Fosamax) who received a large dose of phosphate salts as a pre-operative laxative.

Likelihood Possible Evidence D
Phosphates full monograph & interactions
The maker

Brand information

Manufacturer and brand details for NO Shotgun MHF-1 Grape Bubblegum, from the product label.

VPX

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Web Address
VPXSPORTS.COM
Pharmacist Counseling Corner

NO Shotgun MHF-1 Grape Bubblegum by VPX: Common Questions

Does NO Shotgun MHF-1 Grape Bubblegum by VPX interact with any medications?
Yes. Based on its ingredients, NO Shotgun MHF-1 Grape Bubblegum has a known interaction with 1,003 medications, including 15 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
NO Shotgun MHF-1 Grape Bubblegum contains 41 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does this powder have any calories or sugar?
The product facts we have don't specify calorie or total sugar content. The ingredient list includes sucralose (an artificial sweetener), malic acid, and citric acid for flavor, suggesting it's a low- or no-sugar formulation, but you'll want to check the nutrition label on the package or contact the manufacturer for exact figures.
Can I take this if I'm pregnant or breastfeeding?
Several ingredients have safety concerns in pregnancy and lactation. Creatine safety in pregnancy hasn't been established and is best avoided. Caffeine is rated Possibly Safe in pregnancy in moderate amounts, but high intakes may carry risk. Vitamin B6 is Likely Safe in pregnancy, though high doses should be avoided. L-arginine and L-histidine don't have clear pregnancy/lactation data on file. Talk with your doctor or pharmacist before starting this product if you're pregnant or nursing.
Will this affect how my blood pressure medication works?
Yes — vitamin B6, sodium, L-arginine (in two forms), and caffeine can all affect blood pressure medications, either by lowering blood pressure further (causing dizziness or weakness) or by reducing the medication's effectiveness. Run your specific medication through the checker on this page, and confirm with your doctor or pharmacist before you start.
What's hordenine, and why is it in this product?
Hordenine is a stimulant-like compound structurally similar to substances in bitter orange. It's included to support energy and alertness in a pre-workout formula. However, human safety data on hordenine is very limited, and theoretically it can raise blood pressure and cause heart-related side effects, especially when combined with other stimulants like caffeine.
Is this safe for people with kidney disease?
Creatine should be used with caution in people with kidney issues, since creatine is processed by the kidneys and case reports have raised concerns about kidney injury with high doses. If you have kidney disease or reduced kidney function, talk with your doctor or pharmacist before starting this product.
What are the amino acids in this powder for?
The amino acids — leucine, isoleucine, valine (called BCAAs or branched-chain amino acids), arginine, tyrosine, and histidine — are included to support muscle protein synthesis, energy production, and athletic performance. Creatine is added to support muscle strength and power output during exercise.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

NO Shotgun MHF-1 Grape Bubblegum label
Go deeper

The Full Monographs Behind NO Shotgun MHF-1 Grape Bubblegum’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Sodium

Interacts with 205 drugs

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets get more than enough—often too much—from...

Read the full Sodium monograph → Herb & supplement monograph

Whey Protein

Interacts with 53 drugs

Whey protein is a high-quality, complete protein made from cow's milk that can help people meet protein needs and support muscle growth when combined with exercise. It is generally safe for...

Read the full Whey Protein monograph → Herb & supplement monograph

Casein Peptides

Interacts with 172 drugs

Casein peptides are small protein fragments made from milk casein, often studied for mild blood pressure support and relaxation. The evidence is limited and mostly modest, so they should not...

Read the full Casein Peptides monograph → Herb & supplement monograph

L-arginine

Interacts with 403 drugs

L-arginine is an amino acid that the body uses to make nitric oxide, a substance that helps blood vessels relax and widen. It is popularly used for blood pressure, erectile dysfunction, and...

Read the full L-arginine monograph → Herb & supplement monograph

Creatine

Creatine is one of the most studied sports supplements, with solid evidence that it can boost strength and performance during short, high-intensity activities like weightlifting and sprintin...

Read the full Creatine monograph → Herb & supplement monograph

Vitamin B6

Interacts with 210 drugs

Vitamin B6 (pyridoxine) is an essential water-soluble vitamin that your body needs for metabolism, brain function, and making red blood cells. It is best known for helping with pregnancy-rel...

Read the full Vitamin B6 monograph → Herb & supplement monograph

Histidine

Histidine is an essential amino acid your body needs to build proteins and to make compounds like histamine and carnosine. Most people get enough from a normal diet, and good-quality researc...

Read the full Histidine monograph → Herb & supplement monograph

Beta-alanine

Beta-alanine is an amino acid taken mostly by athletes to raise muscle carnosine, which may help buffer acid and reduce fatigue during short, high-intensity exercise. The evidence is moderat...

Read the full Beta-alanine monograph → Herb & supplement monograph

Phosphate Salts

Interacts with 12 drugs

Phosphate salts are mineral compounds used mainly to correct low phosphate levels, as laxatives, and sometimes by athletes. Most people who eat a normal diet already get plenty of phosphate...

Read the full Phosphate Salts monograph → Herb & supplement monograph

Tyrosine

Interacts with 21 drugs

L-tyrosine is an amino acid your body uses to make brain chemicals like dopamine and norepinephrine. Some studies suggest it may help mental performance during short-term stress, sleep loss,...

Read the full Tyrosine monograph → Herb & supplement monograph

Caffeine

Interacts with 655 drugs

Caffeine is a natural stimulant found in coffee, tea, and many other plants and products. In moderate amounts it can boost alertness and reduce tiredness for most healthy adults, but too muc...

Read the full Caffeine monograph → Herb & supplement monograph

Hordenine

Interacts with 329 drugs

Hordenine is a natural alkaloid found in barley and some cacti that is marketed as a stimulant for energy, focus, and fat loss, but solid human evidence for these benefits is lacking. Its sa...

Read the full Hordenine monograph → Herb & supplement monograph

Phenethylamine (pea)

Interacts with 187 drugs

Phenethylamine (PEA) is a natural compound made in the body and found in foods like chocolate; supplements are marketed for mood, focus, and energy. Reliable human research on the supplement...

Read the full Phenethylamine (pea) monograph →
Sources

Sources & How We Checked

NO Shotgun MHF-1 Grape Bubblegum's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 542 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Vitamin B6 32 references
  1. Hansten PD, Horn JR. Drug Interactions Analysis and Management. Vancouver, WA: Applied Therapeutics Inc., 1997 and updates.
  2. Yates AA, Schlicker SA, Suitor CW. Dietary reference intakes: The new basis for recommendations for calcium and related nutrients, B vitamins, and choline. J Am Diet Assoc 1998;98:699-706. PubMed
  3. Geerling BJ, Dagnelie PC, Badart-Smook A, et al. Diet as a risk factor for the development of ulcerative colitis. Am J Gastroenterol 2000;95:1008-13. PubMed
  4. South M. Neonatal seizures after pyridoxine use -- reply. Lancet 1999;354:2083. PubMed
  5. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  6. Baxter P, Aicardi J. Neonatal seizures after pyridoxine use. Lancet 1999;354:2082-3. PubMed
  7. Bendich A, Cohen M. Vitamin B6 safety issues. Ann N Y Acad Sci 1990;585:321-30.
  8. Schaumburg H, Kaplan J, Windebank A. Sensory neuropathy from pyridoxine abuse. A new megavitamin syndrome. N Engl J Med 1983;309:445-8. PubMed
  9. Gordon N. Pyridoxine dependency: an update. Dev Med Child Neurol 1997;39:63-5. PubMed
  10. Lewis PJ. Pain in the hand and wrist. Pyridoxine supplements may help patients with carpal tunnel syndrome. BMJ 1995;310:1534. PubMed
  11. Kaufman G. Pyridoxine against amiodarone-induced photosensitivity (letter). Lancet 1984;1:51-2. PubMed
  12. Mulrow JP, Mulrow CD, McKenna WJ. Pyridoxine and amiodarone-induced photosensitivity. Ann Intern Med 1985;103:68-9. PubMed
  13. Kawada A, Kashima A, Shiraishi H, et al. Pyridoxine-induced photosensitivity and hypophosphatasia. Dermatology 2000;201:356-60.. PubMed
  14. Vasile A, Goldberg R, Kornberg B. Pyridoxine toxicity: report of a case. J Am Osteopath Assoc 1984;83:790-1. DOI
  15. Hansson O, Sillanpaa M. Pyridoxine and serum concentration of phenytoin and phenobarbitone. Lancet 1976;1:256. DOI
  16. Jansen T, Romiti R, Kreuter A, Altmeyer P. Rosacea fulminans triggered by high-dose vitamins B6 and B12. J Eur Acad Dermatol Venereol 2001;15:484-5..
  17. Chittumma P, Kaewkiattikun K, Wiriyasiriwach B. Comparison of the effectiveness of ginger and vitamin B6 for treatment of nausea and vomiting in early pregnancy: a randomized double-blind controlled trial. J Med Assoc Thai 2007;90:15-20.
  18. Hatzitolios, A., Iliadis, F., Katsiki, N., and Baltatzi, M. Is the anti-hypertensive effect of dietary supplements via aldehydes reduction evidence based? A systematic review. Clin Exp.Hypertens. 2008;30(7):628-639. PubMed
  19. Vasdev, S., Ford, C. A., Parai, S., Longerich, L., and Gadag, V. Dietary vitamin B6 supplementation attenuates hypertension in spontaneously hypertensive rats. Mol.Cell Biochem. 1999;200(1-2):155-162.
  20. de, Vogel S., Dindore, V., van, Engeland M., Goldbohm, R. A., van den Brandt, P. A., and Weijenberg, M. P. Dietary folate, methionine, riboflavin, and vitamin B-6 and risk of sporadic colorectal cancer. J Nutr 2008;138(12):2372-2378. PubMed
  21. Hagen, I., Nesheim, B. I., and Tuntland, T. No effect of vitamin B-6 against premenstrual tension. A controlled clinical study. Acta Obstet.Gynecol.Scand. 1985;64(8):667-670. PubMed
  22. Aybak, M., Sermet, A., Ayyildiz, M. O., and Karakilcik, A. Z. Effect of oral pyridoxine hydrochloride supplementation on arterial blood pressure in patients with essential hypertension. Arzneimittelforschung. 1995;45(12):1271-1273.
  23. Lal, K. J., Dakshinamurti, K., and Thliveris, J. The effect of vitamin B6 on the systolic blood pressure of rats in various animal models of hypertension. J Hypertens. 1996;14(3):355-363. PubMed
  24. Lauritzen CH, Reuter HD, Repges R, Bohnert K, and Schmidt U. Treatment of premenstrual tension syndrome with Vitex agnus castus. Controlled, double-blind study versus pyridoxine. Phytomed 1997;4(3):183-189. PubMed
  25. Fonseca VA, Lavery LA, Thethi TK, et al. Metanx in type 2 diabetes with peripheral neuropathy: A randomized trial. Am J Med 2013;126(2):141-9. PubMed
  26. Hankey GJ, Eikelboom JW, Yi Q, et al. Treatment with B vitamins and incidence of cancer in patients with previous stroke or transient ischemic attack: Results of a randomized placebo-controlled trial. Stroke 2012;43(6):1572-7. PubMed
  27. Hoyer-Kuhn H, Kohbrok S, Volland R, Franklin J, Hero B, Beck BB, Hoppe B. Vitamin B6 in primary hyperoxaluria I: first prospective trial after 40 years of practice. Clin J Am Soc Nephrol. 2014 Mar;9(3):468-77. PubMed
  28. Mahmoud A, Tabassum S, Al Enazi S, et al. Amelioration of levetiracetam-induced behavioral side effects by pyridoxine. A randomized double blind controlled study. Pediatr Neurol 2021;119:15-21. PubMed
  29. Gupta M, Gallante B, Bamberger JN, et al. Prospective randomized evaluation of idiopathic hyperoxaluria treatments. J Endourol 2021;35(12):1844-1851. PubMed
  30. Li H, Chen M, Liang S, et al. Excessive vitamin B6 during treatment is related to poor prognosis of patients with nasopharyngeal carcinoma: A U-shaped distribution suggests low dose supplement. Clin Nutr 2021;40(4):2293-2300. PubMed
  31. Tanigawa J, Nabatame S, Tominaga K, et al. High-dose pyridoxine treatment for inherited glycosylphosphatidylinositol deficiency. Brain Dev 2021;43(6):680-687. PubMed
  32. Committee on Practice Bulletins-Obstetrics. ACOG Practice Bulletin No. 189: Nausea And Vomiting Of Pregnancy. Obstet Gynecol. 2018;131(1):e15-e30. PubMed

See these in context on the Vitamin B6 monograph →

Sodium 38 references
  1. Garabedian-Ruffalo SM, Ruffalo RL. Drug and nutrient interactions. Am Fam Physician 1986;33:165-74.
  2. Food and Drug Administration Science Background: Safety of Sodium Phosphates Oral Solution. September 17, 2001. Available at: http://www.fda.gov/cder/drug/safety/sodiumphospate.htm
  3. Coton T, Mallaret C, Coilliot C, Carre D, Guisset M. Severe acute ulcerated gastritis induced by salt. Presse Med 2009;38(3):499-500. PubMed
  4. Frings-Meuthen P, Buehlmeier J, Baecker N, et al. High sodium chloride intake exacerbates immobilization-induced bone resorption and protein losses. J Appl Physiol 2011;111(2):537-542. PubMed
  5. Frings-Meuthen P, Baecker N, Heer M. Low-grade metabolic acidosis may be the cause of sodium chloride-induced exaggerated bone resorption. J Bone Miner Res 2008;23(4):517-524. PubMed
  6. Alam S, Johnson AG. A meta-analysis of randomised controlled trials (RCT) among healthy normotensive and essential hypertensive elderly patients to determine the effect of high salt (NaCl) diet of blood pressure. J Hum Hypertens 1999;13(6):367-74.
  7. Boudville N, Ward S, Benaroia M, House AA. Increased sodium intake correlates with greater use of antihypertensive agents by subjects with chronic kidney disease. Am J Hypertens 2005;18(10):1300-5. PubMed
  8. Bennett WM. Drug interactions and consequences of sodium restriction. Am J Clin Nutr 1997;65(2 Suppl):678S-681S. PubMed
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  10. Food and Nutrition Board, Institute of Medicine. Dietary reference intakes for water, potassium, sodium, chloride, and sulfate. Washington, DC: National Academy Press, 2005. Available at: http://www.nap.edu/openbook.php?record_id=10925. DOI
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Phosphate Salts 23 references
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Casein Peptides 4 references
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Phenethylamine (pea) 9 references
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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