Interactions on record — worth a quick check against your medications. Based on 2 of 7 ingredients. Check your meds →
Dietary supplement

12 Gauge Shotgun Grape Bubblegum Ingredients & Drug Interactions

by VPX

12 Gauge Shotgun Grape Bubblegum label
See full label image
Powder Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking 12 Gauge Shotgun Grape Bubblegum against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

12 Gauge Shotgun Grape Bubblegum is a dietary supplement by VPX with 7 active ingredients. Its ingredients are commonly taken for morning sickness in pregnancy, premenstrual syndrome (pms), preventing or treating b6 deficiency.Based on those ingredients, 243 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Vitamin B6, Sodium. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against 12 Gauge Shotgun Grape Bubblegum by VPX

Ask about any prescription or over-the-counter medication and we check it for interactions with 12 Gauge Shotgun Grape Bubblegum by VPX — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of 12 Gauge Shotgun Grape Bubblegum by VPX

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 7 of its 7 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

12 Gauge Shotgun Grape Bubblegum is a 7-ingredient pre-workout powder. The active ingredients we can identify are vitamin B6 (a B vitamin that supports energy and nerve function) and sodium (an electrolyte).

The product also lists proprietary blends—a Muscle Volumizing, NO2, Insulinotrophic & Amino Acid Blend; a Power, Speed, Strength and Endurance Matrix; a Friction Energy & Meltdown Fat Oxidation Technology blend; and a Carbonx Novel High Molecular Weight Carb Blend—but their exact doses and components aren't broken out. It also contains folate.

Inactive ingredients (fillers and flavorings) include malic acid, citric acid, natural and artificial flavors, sucralose, and acesulfame potassium.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: Muscle strength power energy and endurance.
  • We looked for evidence on: Cognitive function, Athletic performance, Muscle power, Exercise endurance, Training intensity.
  • The closest evidence on file: Vitamin B6 is rated "Insufficient Reliable Evidence To Rate" for Cognitive function (Natural Medicines).

Vitamin B6 in this product is effective for sideroblastic anemia and B6 deficiency, likely effective for lowering homocysteine levels, and possibly effective for pregnancy-induced nausea. We have no effectiveness data in our records for sodium as a supplement.

The effectiveness of the proprietary blends and folate cannot be assessed from the data we hold.

The evidence, ingredient by ingredient Vitamin B6 Sodium

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Vitamin B6 is well tolerated at doses under 100 mg daily. At higher doses taken over time, it can harm nerves (sensory neuropathy), especially at very high intakes.

Common side effects at normal doses are rare and mild—abdominal pain, headache, heartburn, nausea. Sodium is safe at normal dietary amounts but too much sodium increases blood pressure and heart strain.

The product carries cautions: vitamin B6 at high doses is not advised without medical oversight; sodium should not be supplemented in high amounts without a doctor's approval. Pregnancy: vitamin B6 is likely safe but possibly unsafe (conflicting data), and should only be used under a doctor's guidance if you're pregnant.

Sodium in pregnancy is likely safe but possibly unsafe. We hold no pregnancy or breastfeeding data for folate or the proprietary blends.

Side effects, ingredient by ingredient Vitamin B6 Sodium

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Vitamin B6, Sodium.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: lithium; Parkinson's medications.
  • For scale: 243 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your medications against this product if you take blood pressure drugs (antihypertensives), seizure medications (phenytoin/Dilantin, phenobarbital/Luminal), amiodarone (Cordarone) for heart rhythm, levodopa for Parkinson's, corticosteroids, lithium for bipolar disorder, didanosine (Videx) for HIV, tolvaptan (Samsca), sodium phosphate bowel prep, or any other sodium-containing drugs. These are all Moderate severity interactions.

Use the medication checker below with your exact drug names and doses.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

This is a pre-workout powder with ingredients that can interact with blood pressure, seizure, heart rhythm, mood, and other common medications. If you take any prescription drugs—especially for blood pressure, seizures, or mood—check them against this product before you buy.

Talk to your pharmacist or doctor about whether the doses of vitamin B6 and sodium in your serving fit your health needs.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 7 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 25, 2013.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about 12 Gauge Shotgun Grape Bubblegum, straight from the product label.

Brand VPX
Barcode (UPC) 610764860743
Net contents 392 Gram(s); 13.82 oz.
Market status On market
Date entered into DSLD Feb 25, 2013
DSLD ID 18870
Product type Other Combinations
Supplement form Powder
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for 12 Gauge Shotgun Grape Bubblegum by VPX, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
7 Gram(s)
Maximum serving Sizes:
14 Gram(s)
Servings per container
28
UPC/BARCODE
610764860743
IngredientAmount% DV
Calories16 {Calories}--
Total Carbohydrates4 g2%
Vitamin B6100 mcg5%
Sodium5 mg--
Folate40 mcg10%
Proprietary Muscle Volumizing, NO2, Insulinotrophic & Amino Acid Blend5752 mg--
Power, Speed, Strength and Endurance Matrix1315 mg--
Friction Energy & Meltdown Fat Oxidation Technology500 mg--
Carbonx Novel High Molecular Weight Carb Blend4000 mg--

Other ingredients: Malic Acid, Natural and Artificial flavors, Citric Acid Anhydrous, Sucralean brand Sucralose, Acesulfame Potassium

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Physiological Function: Rapid ATP Resynthesis, CNS Stimulator, Increases Whole Body Creatine Retention & Intramuscular Carnosine, pH Stabilizer/Fatigue Inhibitor, Blood-Engorging Muscle Matrix, Explosive Power & Intense Energy!

- Unparalleled Training Intensity, Mental Acuity & Focus - Increases Whole Body Creatine Retention - Muscle Fullness & Blood-Engorged Pumps - Strength, Power, Endurance 7 Recuperation - Crisp, Water-Free Muscle Separation - Blood Flow & Nitric Oxide (N.O.) Levels

- 1,3 DMAA Free! - Fully Dosed, Researched-Backed (1,300+ Studies) Amounts of Creatine

Product contains heat and moisture sensitive materials which can cause clumping and settling. SHAKE WELL BEFORE OPENING.

NEW 12 GAUGE FORMULA

{4 red shotgun shells}

According to the NIH's biomedical database, a search of 'creatine supplementation' turns up over 1,300 plus scientific studies. When combined with resistance training and a sensible diet.

BEST BY DATE ON BOTTOM

Brand IP Statement(s)

Myogenic Regulatory Factor (MRF) Igniter! 12 GAUGE SHOTGUN(R) and FRICTION(TM) are the only products in the world to contain VPX's Patent Pending Covalently Bonded Creatine/Leucine Peptide! The NEW 12 GAUGE SHOTGUN(R) delivers the extreme mental acuity and intense energy required for explosive workouts in they gym and on the field. Increases in Myogenic Regulatory Factors up to 515% are proven by a study conducted at Baylor University on VPX's original NO-Shotgun(R) MHF-1(TM) formula. This same foundational University Proven Science has been used to develop the NEW cutting-edge 12 GAUGE SHOTGUN(R) formula. 12 GAUGE SHOTGUN(R) with caution. While similar products may require 3 scoops (servings), it is strictly prohibited and unnecessary to use more than one serving of 12 GAUGE SHOTGUN(R) due to its extreme potency. The all new 12 GAUGE SHOTGUN(R) has a far more powerful stimulant and "pump" or muscle volumizing effect than it's predecessor, NO-SHOTGUN(R) MHF-1(TM). Therefore, some individuals who did not desire such a powerful stimulant or muscle pump effect may still prefer the original NO-SHOTGUN(R) MHF-1(TM) - a scientific breakthrough backed by three studies at Baylor University and Florida State University. WHY USE 12 GAUGE SHOTGUN(R)?

- Patent Pending Convalex(TM) Covalently Bonded Creatine/Leucine Peptide

CARBONX(TM) REVOLUTIONARY SUPER CARB MATRIX(TM)

COVALEX(TM) PATENT PENDING COVALENT BONDED CREATINE{image}GLUTAMINE PEPTIDE!

COP(R) Creatinol-O-Phosphate

NATURAL & ARTIFICIAL FLAVORS

For maximum results VPX recommends the following stacking strategy: Combine 12 GAUGE SHOTGUN(R) with the CARBONX(TM) Super Carb Matrix pre-workout for rapid ATP Resynthesis, enhanced performance, and endurance. Sip POWER SHOCK(TM) Amino Acid Nitrates during your workout for increased protein synthesis. Then, drink NO-SYNTHESIZE(R) - post-workout. This supplement strategy represents the most advanced muscle building and performance-enhancing research! This protocol WAS developed by Jack Owoc allows you to take advantage of the pre-, post-, and intra-workout windows for increases in muscle gene proteins and protein synthesis. you can learn more detail by reading Jack Owoc's new book: MELTDOWN(R) and using the new VIVO 360(0) workout, nutrition, and supplement smart phone app.

(C)2012 VITAL PHARMACEUTICALS, INC. ALL RIGHTS RESERVED

Precautions

Tested athletes must contact their governing organization prior to using this product. Tested athletes and consumers assume total liability if product is used in a manner inconsistent with the label guidelines. Do not purchase if safety seal is broken or missing.

KEEP OUT OF REACH OF CHILDREN

Manufactured in a facility that processes milk, egg, soy, wheat, and shellfish.

Caution: As with all dietary supplements, do not use this product if you are pregnant or nursing or have a medical condition. This product contains caffeine and should not be used with any other caffeine and/or stimulant containing products. This product is intended for use by healthy individuals only. Warning Statement: Too much caffeine may cause nervousness, irritability, sleeplessness, and, occasionally, rapid heartbeat.

Not recommended for use by children under 18 years of age.

KEEP OUT OF REACH OF CHILDREN.

Muscle energetic compounds within 12 GAUGE SHOTGUN(R) may cause a tingling sensation in lips and skin. Contains no Niacin. Drink an additional one half (1/2) ounce of water for each pound of weight.

Storage

Store container between 15(0)C to 25(0)C (59(0)F to 77(0)F).

Formulation

1,3 DMAA FREE

Formula

AGMATINE 500mg

28 ULTRA POTENT SERVINGS

One serving of 12 GAUGE SHOTGUN(R) provides 250 mg of caffeine which is less than three cups of coffee.

FDA Statement of Identity

DIETARY SUPPLEMENT

Suggested/Recommended/Usage/Directions

RECOMMENDED USE: Do not use 12 GAUGE SHOTGUN(R) with REDLINE(R), FRICTION(TM), MELTDOWN(R), or any other products containing caffeine or other stimulants. Mix one scoop of 12 GAUGE SHOTGUN(R) with 8 to 10 ounces of water or your favorite beverage. Start with 1/2 to 3/4 scoops to assess tolerance. Drink 12 GAUGE SHOTGUN(R) 30-45 minutes prior to any type of athletic event or resistance training. Unlike other pre-workout supplements which may require several scoops, 12 GAUGE SHOTGUN(R) is extremely powerful and requires only one scoop.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

General

V001

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

12 Gauge Shotgun Grape Bubblegum by VPX label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

12 Gauge Shotgun Grape Bubblegum label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in 12 Gauge Shotgun Grape Bubblegum by VPX

These are the 7 active ingredients this product is made of. Select any to open its full monograph.

Serving size7 Gram(s) Dosage formPowder Servings per container28 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Vitamin B6

Interacts with
210 drugs
100 mcg per serving Form: Pyridoxine Hydrochloride

Vitamin B6 (pyridoxine) is an essential water-soluble vitamin that your body needs for metabolism, brain function, and making red blood cells. It is b...

Vitamin B6 monograph & interactions

Sodium

Interacts with
205 drugs
5 mg per serving

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets g...

Sodium monograph & interactions

Folate

40 mcg per serving Form: Folic Acid

Proprietary Muscle Volumizing, NO2, Insulinotrophic & Amino Acid Blend

5752 mg per serving Form: Agmatine Sulfate, COP(R), Covalex(TM), Creatine Monohydrate, Gamma Butyrobetaine HCl, L-Citrulline Malate, L-Norvaline, L-Taurine

Power, Speed, Strength and Endurance Matrix

1315 mg per serving Form: Beta-Alanine, Betaine Anhydrous, Monosodium Phosphate Anhydrous

Friction Energy & Meltdown Fat Oxidation Technology

500 mg per serving Form: Beta-Phenylethylamine HCl, Caffeine Anhydrous, Evodia, Halostachine HCl, Isopropyloctopamine

Carbonx Novel High Molecular Weight Carb Blend

4000 mg per serving Form: Cluster Dextrin, Hydroxypropyl Distarch Phosphate

Other (inactive) ingredients: Malic Acid, Natural and Artificial flavors, Citric Acid Anhydrous, Sucralean brand Sucralose, Acesulfame Potassium. These complete the product’s ingredient list but are not active constituents.

Interaction report

12 Gauge Shotgun Grape Bubblegum by VPX Drug Interactions

Want to check YOUR meds against 12 Gauge Shotgun Grape Bubblegum?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
243Drugs
238 Moderate 5 Minor

Ingredients driving the most interactions

Vitamin B6 210
Sodium 205

Individual Drug Interactions

The ingredients in 12 Gauge Shotgun Grape Bubblegum interact with 243 drugs. Click any drug to see the details.

2 of the 7 ingredients in 12 Gauge Shotgun Grape Bubblegum interact with drugs. Each result below shows which ingredient is responsible. Vitamin B6 Sodium

Each ingredient & the kinds of drugs it affects

For each ingredient in 12 Gauge Shotgun Grape Bubblegum with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Vitamin B65 drug types · 210 drugs

Amiodarone (Cordarone)

Theoretically, vitamin B6 might increase the photosensitivity caused by amiodarone.
Despite initial case reports suggesting that pyridoxine may have a protective effect against amiodarone-induced photosensitivity, preliminary clinical research suggests that pyridoxine may actually exacerbate this adverse effect.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Research in hypertensive rats shows that vitamin B6 can decrease systolic blood pressure. Similarly, clinical research in patients with hypertension shows that taking high doses of vitamin B6 may reduce systolic and diastolic blood pressure, possibly by reducing plasma levels of epinephrine and norepinephrine.

Likelihood Possible Evidence B
Phenobarbital (Luminal)

High doses of vitamin B6 may reduce the levels and clinical effects of phenobarbital.
Preliminary clinical evidence suggests that vitamin B6 200 mg daily can reduce plasma levels of phenobarbital, possibly by increasing metabolism. It is not known whether lower doses have any effect. Advise people taking phenobarbital to avoid high doses of vitamin B6.

Likelihood Possible Evidence D
Phenytoin (Dilantin)

High doses of vitamin B6 may reduce the levels and clinical effects of phenytoin.
Preliminary clinical evidence suggests that vitamin B6 200 mg daily can reduce plasma levels of phenytoin, possibly by increasing metabolism. It is not known whether lower doses have any effect. Advise people taking phenytoin to avoid high doses of vitamin B6.

Likelihood Possible Evidence D
Levodopa

Vitamin B6 may increase the metabolism of levodopa when taken alone, but not when taken in conjunction with carbidopa.
Vitamin B6 (pyridoxine) enhances the metabolism of levodopa, reducing its clinical effects. However, this interaction does not occur when carbidopa is used concurrently with levodopa (Sinemet). Therefore, it is not likely to be a problem in most people.

Likelihood Unlikely Evidence D
Vitamin B6 full monograph & interactions

Sodium7 drug types · 205 drugs

Antihypertensive Drugs

Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
High intake of dietary sodium can increase systolic and diastolic blood pressure. Also, high intake of sodium may necessitate increased use of antihypertensive medications to achieve blood pressure control in some patients, such as those with chronic kidney disease.

Likelihood Probable Evidence A
Corticosteroids

Concomitant use of mineralocorticoids and some glucocorticoids with sodium supplements might increase the risk of hypernatremia.
Mineralocorticoids and some glucocorticoids (corticosteroids) cause sodium retention. This effect is dose-related and depends on mineralocorticoid potency. It is most common with hydrocortisone, cortisone, and fludrocortisone, followed by prednisone and prednisolone.

Likelihood Possible Evidence D
Didanosine (Videx)

Concomitant use of didanosine with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia.
Didanosine formulations contain a significant amount of sodium.

Likelihood Probable Evidence C
Lithium

Altering dietary intake of sodium might alter the levels and clinical effects of lithium.
High sodium intake can reduce plasma concentrations of lithium by increasing lithium excretion. Reducing sodium intake can significantly increase plasma concentrations of lithium and cause lithium toxicity in patients being treated with lithium carbonate. Stabilizing sodium intake is shown to reduce the percentage of patients with lithium level fluctuations above 0.8 mEq/L. Patients taking lithium should avoid significant alterations in their dietary intake of sodium.

Likelihood Probable Evidence B
Sodium Phosphates

Theoretically, concomitant use of sodium phosphate with sodium supplements might increase the risk of hypernatremia.
Use of high doses (> 45 mL in 24 hours) of sodium phosphate, such as those used for bowel cleansing before surgery, can lead to serious electrolyte disturbances, including hypernatremia. The risk of hypernatremia is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Sodium-Containing Drugs

Concomitant use of sodium-containing drugs with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia and long-term sodium-related complications.
The Chronic Disease Risk Reduction (CDRR) intake level of 2.3 grams of sodium daily indicates the intake at which it is believed that chronic disease risk increases for the apparently healthy population. Some medications contain high quantities of sodium. When used in conjunction with sodium supplements or high-sodium diets, the CDRR may be exceeded. Additionally, concomitant use may increase the risk for hypernatremia; this risk is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Tolvaptan (Samsca)

Theoretically, concomitant use of tolvaptan with sodium might increase the risk of hypernatremia.
Tolvaptan is a vasopressin receptor 2 antagonist that is used to increase sodium levels in patients with hyponatremia. Patients taking tolvaptan should use caution with the use of sodium salts such as sodium chloride.

Likelihood Probable Evidence C
Sodium full monograph & interactions
The maker

Brand information

Manufacturer and brand details for 12 Gauge Shotgun Grape Bubblegum, from the product label.

VPX

See all VPX products
Web Address
VPXSPORTS.COM
Pharmacist Counseling Corner

12 Gauge Shotgun Grape Bubblegum by VPX: Common Questions

Does 12 Gauge Shotgun Grape Bubblegum by VPX interact with any medications?
Yes. Based on its ingredients, 12 Gauge Shotgun Grape Bubblegum has a known interaction with 243 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
12 Gauge Shotgun Grape Bubblegum contains 7 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does this powder have side effects?
Vitamin B6 at normal doses is well tolerated; side effects are uncommon but can include headache, nausea, or heartburn. At very high doses over time, it may cause nerve damage. Sodium in normal amounts is fine, but excess sodium raises blood pressure and strains your heart.
Is it safe to take if I'm pregnant?
The vitamin B6 in this product has conflicting safety data in pregnancy—it's marked both likely safe and possibly unsafe—so it should only be used under a doctor's guidance. Sodium is likely safe but possibly unsafe in pregnancy. Talk to your OB/GYN or pharmacist before taking it.
What does the vitamin B6 in this do?
Vitamin B6 is a B vitamin that supports energy, nerve function, and immune health. In this pre-workout context, it may help with muscle recovery and stamina, though the product facts don't claim that specifically.
Why is there sodium in a pre-workout powder?
Sodium is an electrolyte that helps with hydration and muscle function during exercise. It's common in sports supplements, but if you take medications that are sensitive to sodium (like blood pressure drugs or lithium), the extra sodium in this product matters.
Can I take this if I'm on blood pressure medication?
Maybe, but you need to check with your pharmacist first. Both the vitamin B6 and the sodium can affect how blood pressure drugs work, and the interaction depends on your specific medication and dose. Don't start it without confirming it's safe for you.
What are the proprietary blends in this?
The product lists a Muscle Volumizing blend, a Power/Speed/Strength matrix, a Friction Energy & Fat Oxidation blend, and a Carb Blend, but the exact ingredients and amounts in each aren't shown on the label—they're kept proprietary by the maker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if 12 Gauge Shotgun Grape Bubblegum is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

12 Gauge Shotgun Grape Bubblegum label
Go deeper

The Full Monographs Behind 12 Gauge Shotgun Grape Bubblegum’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Vitamin B6

Interacts with 210 drugs

Vitamin B6 (pyridoxine) is an essential water-soluble vitamin that your body needs for metabolism, brain function, and making red blood cells. It is best known for helping with pregnancy-rel...

Read the full Vitamin B6 monograph → Herb & supplement monograph

Sodium

Interacts with 205 drugs

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets get more than enough—often too much—from...

Read the full Sodium monograph →
Sources

Sources & How We Checked

12 Gauge Shotgun Grape Bubblegum's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 70 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Vitamin B6 32 references
  1. Hansten PD, Horn JR. Drug Interactions Analysis and Management. Vancouver, WA: Applied Therapeutics Inc., 1997 and updates.
  2. Yates AA, Schlicker SA, Suitor CW. Dietary reference intakes: The new basis for recommendations for calcium and related nutrients, B vitamins, and choline. J Am Diet Assoc 1998;98:699-706. PubMed
  3. Geerling BJ, Dagnelie PC, Badart-Smook A, et al. Diet as a risk factor for the development of ulcerative colitis. Am J Gastroenterol 2000;95:1008-13. PubMed
  4. South M. Neonatal seizures after pyridoxine use -- reply. Lancet 1999;354:2083. PubMed
  5. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  6. Baxter P, Aicardi J. Neonatal seizures after pyridoxine use. Lancet 1999;354:2082-3. PubMed
  7. Bendich A, Cohen M. Vitamin B6 safety issues. Ann N Y Acad Sci 1990;585:321-30.
  8. Schaumburg H, Kaplan J, Windebank A. Sensory neuropathy from pyridoxine abuse. A new megavitamin syndrome. N Engl J Med 1983;309:445-8. PubMed
  9. Gordon N. Pyridoxine dependency: an update. Dev Med Child Neurol 1997;39:63-5. PubMed
  10. Lewis PJ. Pain in the hand and wrist. Pyridoxine supplements may help patients with carpal tunnel syndrome. BMJ 1995;310:1534. PubMed
  11. Kaufman G. Pyridoxine against amiodarone-induced photosensitivity (letter). Lancet 1984;1:51-2. PubMed
  12. Mulrow JP, Mulrow CD, McKenna WJ. Pyridoxine and amiodarone-induced photosensitivity. Ann Intern Med 1985;103:68-9. PubMed
  13. Kawada A, Kashima A, Shiraishi H, et al. Pyridoxine-induced photosensitivity and hypophosphatasia. Dermatology 2000;201:356-60.. PubMed
  14. Vasile A, Goldberg R, Kornberg B. Pyridoxine toxicity: report of a case. J Am Osteopath Assoc 1984;83:790-1. DOI
  15. Hansson O, Sillanpaa M. Pyridoxine and serum concentration of phenytoin and phenobarbitone. Lancet 1976;1:256. DOI
  16. Jansen T, Romiti R, Kreuter A, Altmeyer P. Rosacea fulminans triggered by high-dose vitamins B6 and B12. J Eur Acad Dermatol Venereol 2001;15:484-5..
  17. Chittumma P, Kaewkiattikun K, Wiriyasiriwach B. Comparison of the effectiveness of ginger and vitamin B6 for treatment of nausea and vomiting in early pregnancy: a randomized double-blind controlled trial. J Med Assoc Thai 2007;90:15-20.
  18. Hatzitolios, A., Iliadis, F., Katsiki, N., and Baltatzi, M. Is the anti-hypertensive effect of dietary supplements via aldehydes reduction evidence based? A systematic review. Clin Exp.Hypertens. 2008;30(7):628-639. PubMed
  19. Vasdev, S., Ford, C. A., Parai, S., Longerich, L., and Gadag, V. Dietary vitamin B6 supplementation attenuates hypertension in spontaneously hypertensive rats. Mol.Cell Biochem. 1999;200(1-2):155-162.
  20. de, Vogel S., Dindore, V., van, Engeland M., Goldbohm, R. A., van den Brandt, P. A., and Weijenberg, M. P. Dietary folate, methionine, riboflavin, and vitamin B-6 and risk of sporadic colorectal cancer. J Nutr 2008;138(12):2372-2378. PubMed
  21. Hagen, I., Nesheim, B. I., and Tuntland, T. No effect of vitamin B-6 against premenstrual tension. A controlled clinical study. Acta Obstet.Gynecol.Scand. 1985;64(8):667-670. PubMed
  22. Aybak, M., Sermet, A., Ayyildiz, M. O., and Karakilcik, A. Z. Effect of oral pyridoxine hydrochloride supplementation on arterial blood pressure in patients with essential hypertension. Arzneimittelforschung. 1995;45(12):1271-1273.
  23. Lal, K. J., Dakshinamurti, K., and Thliveris, J. The effect of vitamin B6 on the systolic blood pressure of rats in various animal models of hypertension. J Hypertens. 1996;14(3):355-363. PubMed
  24. Lauritzen CH, Reuter HD, Repges R, Bohnert K, and Schmidt U. Treatment of premenstrual tension syndrome with Vitex agnus castus. Controlled, double-blind study versus pyridoxine. Phytomed 1997;4(3):183-189. PubMed
  25. Fonseca VA, Lavery LA, Thethi TK, et al. Metanx in type 2 diabetes with peripheral neuropathy: A randomized trial. Am J Med 2013;126(2):141-9. PubMed
  26. Hankey GJ, Eikelboom JW, Yi Q, et al. Treatment with B vitamins and incidence of cancer in patients with previous stroke or transient ischemic attack: Results of a randomized placebo-controlled trial. Stroke 2012;43(6):1572-7. PubMed
  27. Hoyer-Kuhn H, Kohbrok S, Volland R, Franklin J, Hero B, Beck BB, Hoppe B. Vitamin B6 in primary hyperoxaluria I: first prospective trial after 40 years of practice. Clin J Am Soc Nephrol. 2014 Mar;9(3):468-77. PubMed
  28. Mahmoud A, Tabassum S, Al Enazi S, et al. Amelioration of levetiracetam-induced behavioral side effects by pyridoxine. A randomized double blind controlled study. Pediatr Neurol 2021;119:15-21. PubMed
  29. Gupta M, Gallante B, Bamberger JN, et al. Prospective randomized evaluation of idiopathic hyperoxaluria treatments. J Endourol 2021;35(12):1844-1851. PubMed
  30. Li H, Chen M, Liang S, et al. Excessive vitamin B6 during treatment is related to poor prognosis of patients with nasopharyngeal carcinoma: A U-shaped distribution suggests low dose supplement. Clin Nutr 2021;40(4):2293-2300. PubMed
  31. Tanigawa J, Nabatame S, Tominaga K, et al. High-dose pyridoxine treatment for inherited glycosylphosphatidylinositol deficiency. Brain Dev 2021;43(6):680-687. PubMed
  32. Committee on Practice Bulletins-Obstetrics. ACOG Practice Bulletin No. 189: Nausea And Vomiting Of Pregnancy. Obstet Gynecol. 2018;131(1):e15-e30. PubMed

See these in context on the Vitamin B6 monograph →

Sodium 38 references
  1. Garabedian-Ruffalo SM, Ruffalo RL. Drug and nutrient interactions. Am Fam Physician 1986;33:165-74.
  2. Food and Drug Administration Science Background: Safety of Sodium Phosphates Oral Solution. September 17, 2001. Available at: http://www.fda.gov/cder/drug/safety/sodiumphospate.htm
  3. Coton T, Mallaret C, Coilliot C, Carre D, Guisset M. Severe acute ulcerated gastritis induced by salt. Presse Med 2009;38(3):499-500. PubMed
  4. Frings-Meuthen P, Buehlmeier J, Baecker N, et al. High sodium chloride intake exacerbates immobilization-induced bone resorption and protein losses. J Appl Physiol 2011;111(2):537-542. PubMed
  5. Frings-Meuthen P, Baecker N, Heer M. Low-grade metabolic acidosis may be the cause of sodium chloride-induced exaggerated bone resorption. J Bone Miner Res 2008;23(4):517-524. PubMed
  6. Alam S, Johnson AG. A meta-analysis of randomised controlled trials (RCT) among healthy normotensive and essential hypertensive elderly patients to determine the effect of high salt (NaCl) diet of blood pressure. J Hum Hypertens 1999;13(6):367-74.
  7. Boudville N, Ward S, Benaroia M, House AA. Increased sodium intake correlates with greater use of antihypertensive agents by subjects with chronic kidney disease. Am J Hypertens 2005;18(10):1300-5. PubMed
  8. Bennett WM. Drug interactions and consequences of sodium restriction. Am J Clin Nutr 1997;65(2 Suppl):678S-681S. PubMed
  9. Okusa MD, Crystal LJ. Clinical manifestations and management of acute lithium intoxication. Am J Med 1994;97(4):383-9. PubMed
  10. Food and Nutrition Board, Institute of Medicine. Dietary reference intakes for water, potassium, sodium, chloride, and sulfate. Washington, DC: National Academy Press, 2005. Available at: http://www.nap.edu/openbook.php?record_id=10925. DOI
  11. D'Elia L, Rossi G, Ippolito R, Cappuccio FP, Strazzullo P. Habitual salt intake and risk of gastric cancer: a meta-analysis of prospective studies. Clin Nutr 2012;31(4):489-98. PubMed
  12. Goldsmith SR. Hyponatremia in heart failure: time for a trial. J Card Fail 2013;19(6):398-400. PubMed
  13. Willocks L, Brettle R, Keen J, Valentine C, Pinching AJ. Formulations of didanosine (ddI) and salt overload. Lancet 1992;339(8786):190.
  14. Chen L, Zhang Z, Chen W, Whelton PK, Appel LJ. Lower Sodium Intake and Risk of Headaches: Results From the Trial of Nonpharmacologic Interventions in the Elderly. Am J Public Health. 2016;106(7):1270-5. PubMed
  15. Cook NR, Appel LJ, Whelton PK. Lower levels of sodium intake and reduced cardiovascular risk. Circulation. 2014;129(9):981-9. PubMed
  16. Cook NR, Appel LJ, Whelton PK. Sodium Intake and All-Cause Mortality Over 20 Years in the Trials of Hypertension Prevention. J Am Coll Cardiol. 2016;68(15):1609-1617. PubMed
  17. Mente A, O'Donnell M, Rangarajan S, et al. Associations of urinary sodium excretion with cardiovascular events in individuals with and without hypertension: a pooled analysis of data from four studies. Lancet. 2016;388(10043):465-75. PubMed
  18. Moosavian SP, Haghighatdoost F, Surkan PJ, Azadbakht L. Salt and obesity: a systematic review and meta-analysis of observational studies. Int J Food Sci Nutr. 2017;68(3):265-277. PubMed
  19. O'Donnell M, Mente A, Rangarajan S, et al. Urinary sodium and potassium excretion, mortality, and cardiovascular events. N Engl J Med. 2014;371(7):612-23. DOI
  20. Poggio R, Gutierrez L, Matta MG, Elorriaga N, Irazola V, Rubinstein A. Daily sodium consumption and CVD mortality in the general population: systematic review and meta-analysis of prospective studies. Public Health Nutr. 2015;18(4):695-704. PubMed
  21. Stallings VA, Harrison M, Oria M; Committee to Review the Dietary Reference Intakes for Sodium and Potassium, Food and Nutrition Board, Health and Medicine Division, National Academies of Sciences, Engineering, and Medicine. Washington (DC): National Acad
  22. Mahtani KR, Heneghan C, Onakpoya I, et al. Reduced Salt Intake for Heart Failure: A Systematic Review. JAMA Intern Med. 2018 Dec 1;178(12):1693-1700. PubMed
  23. Yancy CW. Sodium Restriction in Heart Failure: Too Much Uncertainty-Do the Trials. JAMA Intern Med. 2018 Dec 1;178(12):1700-1701. PubMed
  24. He FJ, Campbell NRC, Ma Y, MacGregor GA, Cogswell ME, Cook NR. Errors in estimating usual sodium intake by the Kawasaki formula alter its relationship with mortality: implications for public health. Int J Epidemiol. 2018;47(6):1784-1795. PubMed
  25. Murthy K, Ondrey GJ, Malkani N, et al. THE EFFECTS OF HYPONATREMIA ON BONE DENSITY AND FRACTURES: A SYSTEMATIC REVIEW AND META-ANALYSIS. Endocr Pract. 2019;25(4):366-378. PubMed
  26. Messerli FH, Hofstetter L, Syrogiannouli L, et al. Sodium intake, life expectancy, and all-cause mortality. Eur Heart J 2021;42(21):2103-2112. PubMed
  27. Graudal NA, Hubeck-Graudal T, Jurgens G. Effects of low sodium diet versus high sodium diet on blood pressure, renin, aldosterone, catecholamines, cholesterol, and triglyceride. Cochrane Database Syst Rev 2020;12(12):CD004022. PubMed
  28. Giatti S, Santos RB, Aielo AN, et al. Association of sodium with obstructive sleep apnea. The ELSA-Brasil study. Ann Am Thorac Soc 2021;18(3):502-510. PubMed
  29. Nan X, Lu H, Wu J, et al. The interactive association between sodium intake, alcohol consumption and hypertension among elderly in northern China: a cross-sectional study. BMC Geriatr 2021;21(1):135. PubMed
  30. Kyozuka H, Fukusda T, Murata T, et al. Impact of preconception sodium intake on hypertensive disorders of pregnancy: The Japan Environment and Children's study. Pregnancy Hypertens 2021;23:66-72. PubMed
  31. Zhao L, Ogden CL, Yang Q, et al. Association of usual sodium intake with obesity among US children and adolescents, NHANES 2009-2016. Obesity (Silver Spring) 2021;29(3):587-594. PubMed
  32. Ma Y, He FJ, Sun Q, et al. 24-Hour urinary sodium and potassium excretion and cardiovascular risk. N Engl J Med 2022;386(3):252-263. PubMed
  33. Liu J, Yang X, Zhang P, et al. Association of urinary sodium excretion and left ventricular hypertrophy in people with type 2 diabetes mellitus: A cross-sectional study. Front Endocrinol (Lausanne) 2021;12:728493. PubMed
  34. Filippini T, Malavolti M, Whelton PK, Vinceti M. Sodium intake and risk of hypertension: A systematic review and dose-response meta-analysis of observational cohort studies. Curr Hypertens Rep 2022;24(5):133-144. PubMed
  35. Wang DD, Li Y, Nguyen XT, et al. Dietary sodium and potassium intake and risk of non-fatal cardiovascular diseases: The million veteran program. Nutrients 2022;14(5):1121. PubMed
  36. Kwak JH, Park CH, Eun CS, et al. The associations of dietary intake of high sodium and low zinc with gastric cancer mortality: A prospective cohort study in Korea. Nutr Cancer 2022;74(10):3501-3508. PubMed
  37. George S, Maiti R, Mishra BR, Jena M, Mohapatra D. Effect of regulated add-on sodium chloride intake on stabilization of serum lithium concentration in bipolar disorder: A randomized controlled trial. Bipolar Disord 2023;25(1):66-75. PubMed
  38. Zhou TL, Schütten MTJ, Kroon AA, et al. Urinary Sodium Excretion and Salt Intake Are Not Associated With Blood Pressure Variability in a White General Population. J Am Heart Assoc 2023;12(1):e026578. PubMed

See these in context on the Sodium monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team