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Dietary supplement

CLA 1250 Ingredients & Drug Interactions

by NatureWise

CLA 1250 label
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Softgel Capsule Category: Fat/fatty Acid
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking CLA 1250 against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

CLA 1250 is a dietary supplement by NatureWise with 1 active ingredient. Its ingredients are commonly taken for heart and cholesterol support, skin moisturizing, menstrual cramps.Based on those ingredients, 208 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Safflower Oil. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against CLA 1250 by NatureWise

Ask about any prescription or over-the-counter medication and we check it for interactions with CLA 1250 by NatureWise — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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Computed from our clinical databases

HelloPharmacist Scorecard of CLA 1250 by NatureWise

Four independent checks of what is known — a summary of the available information, not a grade of the product itself.

Evidence for Intended Use
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

None of the active ingredients could be matched to our evidence database, so intended use can't be graded.

Why this rating?
  • None of the active ingredients could be matched to a HelloPharmacist monograph, so intended use can't be graded against our evidence data.
Ingredient Transparency
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • “Safflower Oil” is listed as a grouped ingredient — the label gives one combined amount (1.25 Gram(s)) without saying how much of each component you get.
Known Interaction Concern
Not assessable

None of the active ingredients could be matched to our interaction database.

Why this rating?
  • We couldn't match any ingredient to a HelloPharmacist monograph, so there was nothing to check interactions against.
Safety Information
Unable to assess

None of the active ingredients could be matched to our safety data.

Why this rating?
  • We couldn't match any ingredient to a HelloPharmacist monograph, so there was no safety data to measure.

HelloPharmacist summaryFully disclosed formula with no assessable stated purpose. Medication interactions could not be assessed, and safety information could not be assessed.

Assessment coverage: 0 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Sep 24, 2019.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about CLA 1250, straight from the product label.

Brand NatureWise
Net contents 180 Softgel(s)
Market status Off market
Date entered into DSLD Sep 24, 2019
DSLD ID 206406
Product type Fat/fatty Acid
Supplement form Softgel Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for CLA 1250 by NatureWise, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s), 3 Softgel(s)
Maximum serving Sizes:
1 Softgel(s), 3 Softgel(s)
Servings per container
60
IngredientAmount% DV
Calories15 Calorie(s), 45 Calorie(s)--
Calories from Fat10 Calorie(s), 30 Calorie(s)--
Total Fat1.25 Gram(s), 3.75 Gram(s)2%, 6%
Safflower Oil1.25 Gram(s), 3.75 Gram(s)--
Conjugated Linoleic Acid1 Gram(s), 3 Gram(s)--

Other ingredients: Softgel Capsule

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Weight Managment

Doctor formulated

Live healthy. Live happy.

At NatureWise we believe that when you increase health & happiness in the world, it benefits everyone. From our products and customer support to the way we give back, it's all part of our mission to help people live healthier, happier lives.

Good for people Our products don't just benefit our customers. Every NatureWise purchase you make generates a 1-for-1 donation of life-changing nutrients to a child or mother in need for an entire year. Scan the code below to find out how you can double the donation - at no cost! Together we're making a world of difference.

Good for the Earth We care about our planet's health, too. That's why we source our ingredients responsibly and package out products using only recycled materials and renewable energy. We are also a leading supporter of PINA, the Permaculture Institute of North America.

We are 100% real This product is guaranteed authentic. Scan the code to learn more about your product, its ingredients, and why we chose them. We're committed to sharing an unprecedented level of detail about our products.

Weight management

Non-stimulating

Servings per container: 180 60

Formula

CLA 1250 Conjugated linoleic acid (CLA) is a unique fatty acid that has become a popular weight management supplement because of its potential ability to reduce body fat. CLA is typically found in beef and dairy. However changes in farming and food processing have led to a significant reduction in the amount of CLA the average person consumes. NatureWise CLA 1250 is derived from non-GMO safflower oil and standardized to a minimum of 80% potency. NatureWise CLA 1250, along with a balanced diet and regular exercise, is a great way to support your overall weight management plan.

Derived from safflower oil

1,000 mg of active CLA

Formulation

100% non-GMO No artificial ingredients Glute-free

This product does not contain: Wheat, gluten, dairy, soy, eggs, tree nuts, peanuts, fish, or shellfish.

Seals/Symbols

Bottled in USA GMP Certified good manufacturing practice

100% Pure laboratory tested 3rd party certified for purity & potency

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Standard Serving: Adults take 1 softgel three times daily with meals. Maximum Serving: Adults take 3 softgels three times daily with meals.

NatureWise CLA 1250 should always be taken in conjunction with a healthy diet and regular exercise program.

Precautions

Caution: As with any dietary supplement, you should consult your healthcare provider before use, especially if pregnant, nursing, have a medical condition, taking medications, or have known adverse reactions or allergies.

Caution: As with any dietary supplement, you should consult your healthcare provider before use, especially if pregnant, nursing, have a medical condition, taking medications, or have known adverse reactions or allergies.

Keep out of the reach of children.

Do not use if safety seal is damaged or missing.

Storage

Store in a cool, dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Brand IP Statement(s)

2016 NatureWise. All rights reserved.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

CLA 1250 by NatureWise label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

CLA 1250 label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in CLA 1250 by NatureWise

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Servings per container60 Amounts shown are per serving.

Safflower Oil

Interacts with
208 drugs
1.25 Gram(s) per serving

Safflower is a thistle-like plant used mainly for its seed oil (a common cooking oil) and its colorful flowers. Safflower oil is a reasonable source o...

Safflower Oil monograph & interactions
  • › Conjugated Linoleic Acid

Other (inactive) ingredients: Softgel Capsule. These complete the product’s ingredient list but are not active constituents.

Interaction report

CLA 1250 by NatureWise Drug Interactions

CLA 1250 contains a single active ingredient, and it has known interactions with 208 medications. Here’s the picture, then you can look up your own drug.

Want to check YOUR meds against CLA 1250?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
208Drugs
208 Moderate

Ingredients driving the most interactions

Safflower Oil 208

Individual Drug Interactions

The ingredients in CLA 1250 interact with 208 drugs. Click any drug to see the details.

1 of the 1 ingredient in CLA 1250 interact with drugs. Each result below shows which ingredient is responsible. Safflower Oil

Each ingredient & the kinds of drugs it affects

For each ingredient in CLA 1250 with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Safflower Oil3 drug types · 208 drugs

Anticoagulant/Antiplatelet Drugs

High doses of safflower oil might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Small clinical studies show that taking safflower oil, approximately 55 grams daily for 2-3 weeks, decreases platelet aggregation. However, taking lower doses of safflower oil, such as 5 grams daily for 4 weeks, does not seem to affect platelet function. In one case report, a 74-year-old male stabilized on warfarin developed urinary tract bleeding and an elevated INR after taking a safflower extract 20 grams daily for 14 days.

Likelihood Possible Evidence B
Antidiabetes Drugs

Theoretically, safflower oil might alter the effects of antidiabetes drugs.
Some clinical research shows that taking safflower oil 10 grams daily for 3 weeks can increase fasting blood glucose in patients with type 2 diabetes. However, clinical research in patients with metabolic syndrome with or without impaired glucose tolerance shows that taking safflower oil 8 grams daily for 12 weeks reduces fasting glucose levels by around 8 mg/dL. Some clinical research also shows that taking safflower oil 8 grams daily for 16 weeks does not affect fasting glucose levels in patients with type 2 diabetes.

Likelihood Possible Evidence B
Warfarin

Theoretically, safflower oil might increase the risk of bleeding when taken with warfarin.
In one case report, a 74-year-old male stabilized on warfarin developed urinary tract bleeding and an elevated INR after taking a safflower extract 20 grams daily for 14 days.

Likelihood Possible Evidence D
Safflower Oil full monograph & interactions
The maker

Brand information

Manufacturer and brand details for CLA 1250, from the product label.

NatureWise

See all NatureWise products
Name
NatureWise
City
Ashland
State
OR
ZipCode
97520
Phone Number
800-510-7207
Web Address
www.naturewise.com
Pharmacist Counseling Corner

CLA 1250 by NatureWise: Common Questions

Does CLA 1250 by NatureWise interact with any medications?
Yes. Based on its ingredients, CLA 1250 has a known interaction with 208 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
CLA 1250 contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if CLA 1250 is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

CLA 1250 label
Go deeper

The Full Monographs Behind CLA 1250’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Safflower

Interacts with 208 drugs

Safflower is a thistle-like plant used mainly for its seed oil (a common cooking oil) and its colorful flowers. Safflower oil is a reasonable source of unsaturated fats, but strong proof tha...

Read the full Safflower monograph →
Sources

Sources & How We Checked

CLA 1250's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 14 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Safflower 14 references
  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  3. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  4. Borkman M, Chisholm DJ, Furler SM, et al. Effects of fish oil supplementation on glucose and lipid metabolism in NIDDM. Diabetes 1989;38:1314-9.. PubMed
  5. Amato, P. and Quercia, R. A. A historical perspective and review of the safety of lipid emulsion in pregnancy. Nutr Clin Pract. 1991;6(5):189-192. PubMed
  6. Demke, D. M., Peters, G. R., Linet, O. I., Metzler, C. M., and Klott, K. A. Effects of a fish oil concentrate in patients with hypercholesterolemia. Atherosclerosis 1988;70(1-2):73-80. PubMed
  7. Kaji, K., Yoshida, S., Nagata, N., Yamashita, T., Mizukoshi, E., Honda, M., Kojima, Y., and Kaneko, S. An open-label study of administration of EH0202, a health-food additive, to patients with chronic hepatitis C. J Gastroenterol. 2004;39(9):873-878. PubMed
  8. Kwon, J. S., Snook, J. T., Wardlaw, G. M., and Hwang, D. H. Effects of diets high in saturated fatty acids, canola oil, or safflower oil on platelet function, thromboxane B2 formation, and fatty acid composition of platelet phospholipids. Am.J.Clin.Nutr. PubMed
  9. Lloyd-Still, J. D., Simon, S. H., Wessel, H. U., and Gibson, L. E. Negative effects of oral fatty acid supplementation on sweat chloride in cystic fibrosis. Pediatrics 1979;64(1):50-52. DOI
  10. Challen, A. D., Branch, W. J., and Cummings, J. H. The effect of aspirin and linoleic acid on platelet aggregation, platelet fatty acid composition and haemostasis in man. Hum Nutr Clin Nutr 1983;37(3):197-208.
  11. Asp ML, Collene AL, Norris LE, Cole RM, Stout MB, Tang SY, Hsu JC, Belury MA. Time-dependent effects of safflower oil to improve glycemia, inflammation and blood lipids in obese, post-menopausal women with type 2 diabetes: a randomized, double-masked, cro
  12. Liu Y, Liu S, Shi Y, et al. Effects of safflower injection on the pharmacodynamics and pharmacokinetics of warfarin in rats. Xenobiotica. 2017 Oct 25:1-6. [Epub ahead of print] PubMed
  13. de Ataide EC, Reges Perales S, de Oliveira Peres MA, et al. Acute liver failure induced by Carthamus tinctorius oil: Case reports and literature review. Transplant Proc. 2018;50(2):476-477. PubMed
  14. Ruyvaran M, Zamani A, Mohamadian A, et al. Safflower (Carthamus tinctorius L.) oil could improve abdominal obesity, blood pressure, and insulin resistance in patients with metabolic syndrome: a randomized, double-blind, placebo-controlled clinical trial. PubMed

See these in context on the Safflower monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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