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Dietary supplement

CLA 3000 Ingredients & Drug Interactions

by Metabolic Nutrition

CLA 3000 label
See full label image
Softgel Capsule Category: Fat/fatty Acid
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking CLA 3000 against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

CLA 3000 is a dietary supplement by Metabolic Nutrition with 1 active ingredient. Its ingredients are commonly taken for heart and cholesterol support, skin moisturizing, menstrual cramps.Based on those ingredients, 208 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Safflower Oil. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against CLA 3000 by Metabolic Nutrition

Ask about any prescription or over-the-counter medication and we check it for interactions with CLA 3000 by Metabolic Nutrition — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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Computed from our clinical databases

HelloPharmacist Scorecard of CLA 3000 by Metabolic Nutrition

Four independent checks of what is known — a summary of the available information, not a grade of the product itself.

Evidence for Intended Use
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

None of the active ingredients could be matched to our evidence database, so intended use can't be graded.

Why this rating?
  • None of the active ingredients could be matched to a HelloPharmacist monograph, so intended use can't be graded against our evidence data.
Ingredient Transparency
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • “Safflower Oil” is listed as a grouped ingredient — the label gives one combined amount (3,000 mg) without saying how much of each component you get.
Known Interaction Concern
Not assessable

None of the active ingredients could be matched to our interaction database.

Why this rating?
  • We couldn't match any ingredient to a HelloPharmacist monograph, so there was nothing to check interactions against.
Safety Information
Unable to assess

None of the active ingredients could be matched to our safety data.

Why this rating?
  • We couldn't match any ingredient to a HelloPharmacist monograph, so there was no safety data to measure.

HelloPharmacist summaryFully disclosed formula with no assessable stated purpose. Medication interactions could not be assessed, and safety information could not be assessed.

Assessment coverage: 0 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Oct 24, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about CLA 3000, straight from the product label.

Brand Metabolic Nutrition
Barcode (UPC) 764779312091
Net contents 90 Softgel(s)
Market status On market
Date entered into DSLD Oct 24, 2022
DSLD ID 275476
Product type Fat/fatty Acid
Supplement form Softgel Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for CLA 3000 by Metabolic Nutrition, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
3 Softgel(s)
Maximum serving Sizes:
6 Softgel(s)
Servings per container
30
UPC/BARCODE
764779312091
IngredientAmount% DV
Total Fat3 Gram(s)4%
Safflower Oil3000 mg--
Calories30 Calorie(s)--
Conjugated Linoleic Acid2520 mg--
Total Carbohydrates3 Gram(s)1%
Calories from Fat15 Calorie(s)--

Other ingredients: Gelatin, Glycerin, Water, Caramel color

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Health & wellness solution

CLA 3000 is an ultra-cold pressed non-GMO safflower oil, providing the highest quality, un-denatured, pure extract of CLA omega-6 fatty acids.

This product does not contain: Gluten, dairy, egg, peanut, fish, soy, shellfish, wheat, yeast, fillers, binders, preservatives, artifiical ingredients.

Health & wellness solution Promotes fast & efficient weight loss Increase overall body calorie expenditure Boosts immune system & reduces inflammation Supports healthy cholesterol & blood sugar levels

Formula

Ultra cold-pressed conjugated linoleic acid CLA 3000 is an ultra-cold pressed non-GMO safflower oil, providing the highest quality, un-denatured, pure extract of CLA omega-6 fatty acids.

CLA 3000 is 100% derived from vegetables to fit across various lifestyles and provides a class-leading 3,000 mg of safflower oil containing fatty acids which help the body support a healthy metabolism and better control of weight management.

Specifically developed for those individuals who want to maximize their health and wellness.

3,000 mg maximum dose

Precautions

This product does not contain: Gluten, dairy, egg, peanut, fish, soy, shellfish, wheat, yeast, fillers, binders, preservatives, artifiical ingredients. Produced in a facility that processes other ingredients containing these allergens.

Caution: Do not exceed the recommended dose.

Not intended for pregnant or nursing mothers.

Not intended for children under 18 years of age.

If you are taking any medications, have a known medical condition, or are planning a medical procedure, consult your doctor before use.

Discontinue use and consult your doctor if any adverse reactions occur.

Usage warning: Keep out of reach of children and pets.

Do not use if packaging has been tampered with.

California residents only: Warning: Consuming this product can expose you to chemicals including [lead and cadmium], which is [are] known to the state of California o cause cancer and birth defects or other reproductive harm. For more information go to www.P65Watnings.ca.gov/food.

Storage

Store in a cool dry place away from direct sunlight. Avoid excess heat.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Seals/Symbols

GMP Quality Good Manufacturing Practice Certification Made in FDA inspected facility Made in USA

Brand IP Statement(s)

Copyright 2019 Metabolic Nutrition, Inc. All rights reserved.

Metabolic Nutrition Unleash Your Superhero

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions for use: As a dietary supplement, take one serving (3 softgels) daily with food. Do not exceed 6 softgels daily. For best results combine with proper nutrition and training program.

General Statements

Questions? 800-626-1022 Metabolicnutrition.com Follow Us Facebook Instagram Twitter YouTube

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

CLA 3000 by Metabolic Nutrition label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

CLA 3000 label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in CLA 3000 by Metabolic Nutrition

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size3 Softgel(s) Dosage formSoftgel Capsule Servings per container30 Amounts shown are per serving.

Safflower Oil

Interacts with
208 drugs
3000 mg per serving

Safflower is a thistle-like plant used mainly for its seed oil (a common cooking oil) and its colorful flowers. Safflower oil is a reasonable source o...

Safflower Oil monograph & interactions
  • › Conjugated Linoleic Acid

Other (inactive) ingredients: Gelatin, Glycerin, Water, Caramel color. These complete the product’s ingredient list but are not active constituents.

Interaction report

CLA 3000 by Metabolic Nutrition Drug Interactions

CLA 3000 contains a single active ingredient, and it has known interactions with 208 medications. Here’s the picture, then you can look up your own drug.

Want to check YOUR meds against CLA 3000?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
208Drugs
208 Moderate

Ingredients driving the most interactions

Safflower Oil 208

Individual Drug Interactions

The ingredients in CLA 3000 interact with 208 drugs. Click any drug to see the details.

1 of the 1 ingredient in CLA 3000 interact with drugs. Each result below shows which ingredient is responsible. Safflower Oil

Each ingredient & the kinds of drugs it affects

For each ingredient in CLA 3000 with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Safflower Oil3 drug types · 208 drugs

Anticoagulant/Antiplatelet Drugs

High doses of safflower oil might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Small clinical studies show that taking safflower oil, approximately 55 grams daily for 2-3 weeks, decreases platelet aggregation. However, taking lower doses of safflower oil, such as 5 grams daily for 4 weeks, does not seem to affect platelet function. In one case report, a 74-year-old male stabilized on warfarin developed urinary tract bleeding and an elevated INR after taking a safflower extract 20 grams daily for 14 days.

Likelihood Possible Evidence B
Antidiabetes Drugs

Theoretically, safflower oil might alter the effects of antidiabetes drugs.
Some clinical research shows that taking safflower oil 10 grams daily for 3 weeks can increase fasting blood glucose in patients with type 2 diabetes. However, clinical research in patients with metabolic syndrome with or without impaired glucose tolerance shows that taking safflower oil 8 grams daily for 12 weeks reduces fasting glucose levels by around 8 mg/dL. Some clinical research also shows that taking safflower oil 8 grams daily for 16 weeks does not affect fasting glucose levels in patients with type 2 diabetes.

Likelihood Possible Evidence B
Warfarin

Theoretically, safflower oil might increase the risk of bleeding when taken with warfarin.
In one case report, a 74-year-old male stabilized on warfarin developed urinary tract bleeding and an elevated INR after taking a safflower extract 20 grams daily for 14 days.

Likelihood Possible Evidence D
Safflower Oil full monograph & interactions
The maker

Brand information

Manufacturer and brand details for CLA 3000, from the product label.

Metabolic Nutrition

See all Metabolic Nutrition products
Name
Metabolic Nutrition
City
Fort Lauderdale
State
FL
Phone Number
800-626-1022
Web Address
metabolicnutrition.com
Pharmacist Counseling Corner

CLA 3000 by Metabolic Nutrition: Common Questions

Does CLA 3000 by Metabolic Nutrition interact with any medications?
Yes. Based on its ingredients, CLA 3000 has a known interaction with 208 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
CLA 3000 contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if CLA 3000 is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

CLA 3000 label
Go deeper

The Full Monographs Behind CLA 3000’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Safflower

Interacts with 208 drugs

Safflower is a thistle-like plant used mainly for its seed oil (a common cooking oil) and its colorful flowers. Safflower oil is a reasonable source of unsaturated fats, but strong proof tha...

Read the full Safflower monograph →
Sources

Sources & How We Checked

CLA 3000's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 14 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Safflower 14 references
  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  3. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  4. Borkman M, Chisholm DJ, Furler SM, et al. Effects of fish oil supplementation on glucose and lipid metabolism in NIDDM. Diabetes 1989;38:1314-9.. PubMed
  5. Amato, P. and Quercia, R. A. A historical perspective and review of the safety of lipid emulsion in pregnancy. Nutr Clin Pract. 1991;6(5):189-192. PubMed
  6. Demke, D. M., Peters, G. R., Linet, O. I., Metzler, C. M., and Klott, K. A. Effects of a fish oil concentrate in patients with hypercholesterolemia. Atherosclerosis 1988;70(1-2):73-80. PubMed
  7. Kaji, K., Yoshida, S., Nagata, N., Yamashita, T., Mizukoshi, E., Honda, M., Kojima, Y., and Kaneko, S. An open-label study of administration of EH0202, a health-food additive, to patients with chronic hepatitis C. J Gastroenterol. 2004;39(9):873-878. PubMed
  8. Kwon, J. S., Snook, J. T., Wardlaw, G. M., and Hwang, D. H. Effects of diets high in saturated fatty acids, canola oil, or safflower oil on platelet function, thromboxane B2 formation, and fatty acid composition of platelet phospholipids. Am.J.Clin.Nutr. PubMed
  9. Lloyd-Still, J. D., Simon, S. H., Wessel, H. U., and Gibson, L. E. Negative effects of oral fatty acid supplementation on sweat chloride in cystic fibrosis. Pediatrics 1979;64(1):50-52. DOI
  10. Challen, A. D., Branch, W. J., and Cummings, J. H. The effect of aspirin and linoleic acid on platelet aggregation, platelet fatty acid composition and haemostasis in man. Hum Nutr Clin Nutr 1983;37(3):197-208.
  11. Asp ML, Collene AL, Norris LE, Cole RM, Stout MB, Tang SY, Hsu JC, Belury MA. Time-dependent effects of safflower oil to improve glycemia, inflammation and blood lipids in obese, post-menopausal women with type 2 diabetes: a randomized, double-masked, cro
  12. Liu Y, Liu S, Shi Y, et al. Effects of safflower injection on the pharmacodynamics and pharmacokinetics of warfarin in rats. Xenobiotica. 2017 Oct 25:1-6. [Epub ahead of print] PubMed
  13. de Ataide EC, Reges Perales S, de Oliveira Peres MA, et al. Acute liver failure induced by Carthamus tinctorius oil: Case reports and literature review. Transplant Proc. 2018;50(2):476-477. PubMed
  14. Ruyvaran M, Zamani A, Mohamadian A, et al. Safflower (Carthamus tinctorius L.) oil could improve abdominal obesity, blood pressure, and insulin resistance in patients with metabolic syndrome: a randomized, double-blind, placebo-controlled clinical trial. PubMed

See these in context on the Safflower monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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