Interactions on record — worth a quick check against your medications. Based on 2 of 3 ingredients. Check your meds →
Dietary supplement

CLA Ingredients & Drug Interactions

by MusclePharm MP Essentials

CLA label
See full label image
Softgel Capsule Category: Fat/fatty Acid
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking CLA against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

CLA is a dietary supplement by MusclePharm MP Essentials with 3 active ingredients. Its ingredients are commonly taken for heart health, high blood pressure, high cholesterol.Based on those ingredients, 2 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Avocado Oil. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against CLA by MusclePharm MP Essentials

Ask about any prescription or over-the-counter medication and we check it for interactions with CLA by MusclePharm MP Essentials — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of CLA by MusclePharm MP Essentials

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 3 active ingredients.
  • “MusclePharm” is listed as a grouped ingredient — the label gives one combined amount (1,000 mg) without saying how much of each component you get.

This softgel contains 3 active ingredients: conjugated linoleic acid (a fatty acid often called CLA), avocado oil, and extra virgin olive oil, plus a small amount of gelatin, glycerol, and water as binders and capsule material. CLA is the main active ingredient, though we don't have enough data on file to tell you what role it plays in the body.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: Stimulant-free weight management.
  • We looked for evidence on: Obesity, Metabolic syndrome, Weight loss, Body composition.
  • The closest evidence on file: Olive is rated "Insufficient Reliable Evidence To Rate" for Metabolic syndrome (Natural Medicines).
  • Also on file: Avocado is rated "Insufficient Reliable Evidence To Rate" for Obesity, Metabolic syndrome.

We don't hold established effectiveness data for conjugated linoleic acid. Avocado oil shows possibly effective evidence for high cholesterol (hypercholesterolemia) — meaning some clinical work suggests it may help, but we'd need stronger evidence to be sure.

Extra virgin olive oil hasn't been rated for any condition in our database. If you're considering this product for a specific reason, it's worth talking through with your doctor or pharmacist whether the evidence supports that use.

The evidence, ingredient by ingredient Olive Avocado

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Avocado oil is generally well tolerated when taken by mouth in the amounts used in clinical studies. The most common side effect is topical itching if it's in a cream with vitamin B12, though that's not how this product is formulated.

Rarely, avocado can trigger a serious allergic reaction in people with a latex allergy, or cause a gastrointestinal hypersensitivity called FPIES — marked by severe vomiting and diarrhea — though this is uncommon and most often seen in infants and young children. Extra virgin olive oil as food is very safe, but concentrated supplements haven't been as well studied; headache and stomach discomfort have been reported in some trials, and rarely, skin reactions.

Olive pollen can trigger seasonal respiratory allergies in sensitive people. The safety of concentrated supplements during pregnancy or breastfeeding isn't well established — talk with your doctor or pharmacist if you're pregnant, nursing, or planning to be.

Side effects, ingredient by ingredient Olive Avocado

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Avocado.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 2 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take warfarin (Coumadin) or any other blood thinner, check with your doctor or pharmacist before starting this product — avocado oil may reduce how well your blood thinner works. We could not check conjugated linoleic acid, so if you take any prescription medications, run them through the search tool on this page to be thorough.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

This product may be worth considering if you're interested in CLA and tolerate avocado and olive oil well — especially if you're looking at avocado oil for cholesterol support. If you take warfarin or any blood thinner, check with your doctor or pharmacist first.

Pregnant or breastfeeding? The safety data on concentrated supplements isn't clear, so discuss it with your own healthcare provider before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 16, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about CLA, straight from the product label.

Brand MusclePharm MP Essentials
Net contents 180 Softgel(s)
Market status On market
Date entered into DSLD Jun 16, 2022
DSLD ID 267274
Product type Fat/fatty Acid
Supplement form Softgel Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for CLA by MusclePharm MP Essentials, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
1 Softgel(s)
Servings per container
180
IngredientAmount% DV
Calories10 Calorie(s)--
extra virgin Olive Oil0 NP--
Total Fat1 Gram(s)2%
Avocado Oil0 NP--
MusclePharm1000 mg--
Conjugated Linoleic Acid0 NP--

Other ingredients: Gelatin, Glycerol, Water

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Storage

Storage: Store at room temperature. Exposure to heat, light or air can have negative effects related to product quality. Therefore keep out of direct light or heat. Keep sealed when not in use.

Precautions

Warning: This product is only intended for use by healthy adults over 18 years of age.

Consult your physician before using this product if you are taking any prescription or over the counter medications or supplements. Do not use this product if you are pregnant, expect to become pregnant or are nursing. Do not use this product if you are at risk or are being treated for any medical condition or if you are taking a MAO inhibitor.

Keep out of reach of children.

Allergen Warning: This product was produced in a facility that may also process ingredients containing milk, eggs, fish, shellfish, tree nuts, peanuts, wheat and soybeans.

Formula

1,000 milligram blend of CLA, extra virgin olive oil, and avocado oil per serving

MusclePharm CLA features a 1,000 mg blend of Conjugated Linoleic Acid, extra virgin olive oil, and avocado oil per serving to help support weight loss and maintain lean muscle. Conjugated Linoleic acid, commonly referred to as a "healthy fat", is a naturally-occurring fatty acid found in several foods and has been shown in many clinical studies to support lean body composition.

1,000 mg blend of CLA, extra virgin olive oil, and avocado oil

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Formulation

Made in a cGMP Registered Facility

Stimulant-free weight management

Key features Supports weight loss Maintain lean muscle

Weight loss support

General Statements

What are you waiting for?

Seals/Symbols

Banned substance tested Informed-Choice.org Trusted by sport

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested Use: Consume one serving (1 softgel) of MusclePharm CLA with morning, noon, and evening meals or use as directed by a physician or licensed nutritionist. Use as part of a healthy diet and exercise program.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

CLA by MusclePharm MP Essentials label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

CLA label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in CLA by MusclePharm MP Essentials

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Servings per container180 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

MusclePharm

1000 mg per serving Form: Conjugated Linoleic Acid

Other (inactive) ingredients: Gelatin, Glycerol, Water. These complete the product’s ingredient list but are not active constituents.

Interaction report

CLA by MusclePharm MP Essentials Drug Interactions

Want to check YOUR meds against CLA?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
2Drugs
2 Moderate

Ingredients driving the most interactions

Avocado Oil 2

Individual Drug Interactions

The ingredients in CLA interact with 2 drugs. Click any drug to see the details.

1 of the 3 ingredients in CLA interact with drugs. Each result below shows which ingredient is responsible. Avocado Oil

Each ingredient & the kinds of drugs it affects

For each ingredient in CLA with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Avocado Oil1 drug type · 2 drugs

Warfarin (Coumadin)

Avocado may antagonize the anticoagulant effects of warfarin.
Avocado may antagonize the anticoagulant effects of warfarin; however, there has been only one case report of this interaction.

Likelihood Unlikely Evidence D
Avocado Oil full monograph & interactions
The maker

Brand information

Manufacturer and brand details for CLA, from the product label.

MusclePharm MP Essentials

See all MusclePharm MP Essentials products
Name
MusclePharm Corp.
Street Address
4400 Vanowen Street
City
Burbank
State
CA
ZipCode
91505
Pharmacist Counseling Corner

CLA by MusclePharm MP Essentials: Common Questions

Does CLA by MusclePharm MP Essentials interact with any medications?
Yes. Based on its ingredients, CLA has a known interaction with 2 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
CLA contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does this product actually work for building muscle or losing weight?
We don't have effectiveness evidence on file for conjugated linoleic acid. Avocado oil is possibly effective for high cholesterol, but we don't have rated evidence for muscle gain or weight loss. If that's your goal, talk with your doctor or pharmacist about whether this product matches what you're trying to do.
Can I take this if I'm on a blood thinner?
No, not without talking to your doctor or pharmacist first. Avocado oil may weaken warfarin (Coumadin), a common blood thinner — your blood might not stay as thin as your medication is supposed to make it. If you take warfarin or any other blood thinner, check with your own healthcare provider before starting.
What are the most common side effects?
Avocado oil is generally well tolerated. Extra virgin olive oil may cause headache or stomach discomfort in some people, though these were reported in only a small number of trial participants. Serious reactions like allergic responses are rare.
Is this safe during pregnancy or breastfeeding?
The safety of concentrated avocado and olive oil supplements during pregnancy and breastfeeding isn't well known. Talk with your doctor or pharmacist for advice tailored to your situation before starting.
What is conjugated linoleic acid?
It's a fatty acid — the main active ingredient in this product. We don't have detailed effectiveness or safety information on it in our database, so if you want to know more about what it does or whether it's right for you, ask your doctor or pharmacist.
I'm allergic to latex. Is this safe for me?
Avocado can rarely trigger allergic cross-sensitivity in people with latex allergies. If you have a latex allergy, talk with your doctor or pharmacist before taking this product to make sure it's safe for you.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if CLA is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

CLA label
Go deeper

The Full Monographs Behind CLA’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Olive

Olive comes from the same tree that gives us olives and olive oil, and its leaf and fruit contain antioxidant compounds like oleuropein and hydroxytyrosol. Olive oil as part of a Mediterrane...

Read the full Olive monograph → Herb & supplement monograph

Avocado

Interacts with 2 drugs

Avocado is a nutritious fruit rich in healthy monounsaturated fats, fiber, and potassium, and eating it as part of a balanced diet may support heart health. A specific extract called avocado...

Read the full Avocado monograph →
Sources

Sources & How We Checked

CLA's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 12 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Olive 2 references
  1. Liccardi G, D'Amato M, D'Amato G. Oleaceae pollinosis: a review. Int Arch Allergy Immunol 1996;111:210-7. PubMed
  2. Somerville V, Moore R, Braakhuis A. The effect of olive leaf extract on upper respiratory illness in high school athletes: A randomised control trial. Nutrients. 2019;11(2). pii: E358. PubMed

See these in context on the Olive monograph →

Avocado 10 references
  1. Blickstein D, Shaklai M, Inbal A. Warfarin antagonism by avocado. Lancet 1991;337:914-5. PubMed
  2. Blanco C, Diaz-Perales A, Collada C, et al. Class I chitinases as potential panallergens involved in the latex-fruit syndrome. J Allergy Clin Immunol 1999;103(3 Pt 1):507-13. PubMed
  3. Diaz-Perales A, Collada C, Blanco C, et al. Cross-reactions in the latex-fruit syndrome: A relevant role of chitinases but not of complex asparagine-linked glycans. J Allergy Clin Immunol 1999;104:681-7. PubMed
  4. Stucker M, Memmel U, Hoffmann M, et al. Vitamin B(12) cream containing avocado oil in the therapy of plaque psoriasis. Dermatology 2001;203:141-7.
  5. Ahlroth, M., Alenius, H., Turjanmaa, K., Makinen-Kiljunen, S., Reunala, T., and Palosuo, T. Cross-reacting allergens in natural rubber latex and avocado. J.Allergy Clin.Immunol. 1995;96(2):167-173. PubMed
  6. de Groot, A. C., van der Meeren, H. L., and Weyland, J. W. Contact allergy to avocado oil in a sunscreen. Contact Dermatitis 1987;16(2):108-109. PubMed
  7. Blanco, C., Carrillo, T., Castillo, R., Quiralte, J., and Cuevas, M. Avocado hypersensitivity. Allergy 1994;49(6):454-459. PubMed
  8. Crisi, G. and Belsito, D. V. Contact urticaria from latex in a patient with immediate hypersensitivity to banana, avocado and peach. Contact Dermatitis 1993;28(4):247-248.
  9. Cherian S, Neupert K, Varshney P. Avocado as an emerging trigger for food protein-induced enterocolitis syndrome. Ann Allergy Asthma Immunol. 2018;121(3):369-71. PubMed
  10. Lichtenstein AH, Kris-Etherton PM, Petersen KS, et al. Effect of Incorporating 1 Avocado Per Day Versus Habitual Diet on Visceral Adiposity: A Randomized Trial. J Am Heart Assoc 2022;11(14):e025657.

See these in context on the Avocado monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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