Major interaction on record — check this product against your medications before combining. Based on 6 of 11 ingredients. Check your meds →
Dietary supplement

CleanStart Cleansing Drink Mix Ingredients & Drug Interactions

by Nature's Sunshine

CleanStart Cleansing Drink Mix label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking CleanStart Cleansing Drink Mix against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

CleanStart Cleansing Drink Mix is a dietary supplement by Nature's Sunshine with 11 active ingredients. Its ingredients are commonly taken for constipation, diarrhea, high cholesterol.Based on those ingredients, 2,101 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Dietary Fiber, Aloe Vera, Sodium Copper Chlorophyllin. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against CleanStart Cleansing Drink Mix by Nature's Sunshine

Ask about any prescription or over-the-counter medication and we check it for interactions with CleanStart Cleansing Drink Mix by Nature's Sunshine — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of CleanStart Cleansing Drink Mix by Nature's Sunshine

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 1 of its 11 active ingredients.
  • “Proprietary Blend” is a proprietary blend — the label gives one combined amount (8.50 Gram(s)) without saying how much of each component you get.

CleanStart contains 10 ingredients. The active components include malic acid (which may help with dry mouth), sodium copper chlorophyllin (a chlorophyll derivative), potassium citrate (a form of potassium), stevia leaf extract (a sweetener), aloe vera, and vegetable fiber.

Several other ingredients—vegetable fiber, natural Wild Berry flavor, hydrated bentonite, psyllium, and carotene extract—are included, though we lack interaction data for some of them.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: Dietary cleansing and detoxifying program.
  • We looked for evidence on: Constipation, Diarrhea, Body odor, Fecal odor, Urinary odor, Flatulence — and 4 related terms.
  • The strongest evidence on file: Black Psyllium is rated "Effective" for Constipation (Natural Medicines).
  • Also on file: Aloe is rated "Possibly Effective" for Constipation.
  • Also on file: Chlorophyllin is rated "Possibly Ineffective" for Urinary odor.

The evidence for this product's ingredients is mixed. Aloe vera shows possibly effective ratings for acne, obesity, diabetes, psoriasis, burns, and constipation.

Malic acid is possibly effective for dry mouth but has insufficient evidence for acne, GERD, fatigue, fibromyalgia, and psoriasis. Stevia and sodium copper chlorophyllin lack established evidence for their intended uses in our data.

No effectiveness data exists for vegetable fiber, psyllium, or carotene extract in the information we hold.

The evidence, ingredient by ingredient Black Psyllium Malic Acid Chlorophyllin Potassium Stevia Aloe

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 6 of the 6 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 6 of 6.
  • General safety write-ups exist for 6 of 6.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Aloe vera by mouth is possibly unsafe in pregnancy and lactation because the latex can stimulate the uterus, act as a strong laxative, and carry limited safety data. Malic acid and potassium citrate are likely safe in pregnancy and lactation, though potassium supplements during pregnancy and lactation should be used only under medical guidance.

Sodium copper chlorophyllin should be avoided in pregnancy due to insufficient safety data, and safety while breastfeeding is unknown. Stevia's safety data in pregnancy and lactation is incomplete.

Aloe is generally well tolerated topically but oral aloe latex can cause abdominal pain, cramps, and diarrhea, especially with long-term use. Malic acid orally appears well tolerated, though gastrointestinal side effects like diarrhea and nausea have been reported in some users.

Stevia commonly causes abdominal bloating, dizziness, headache, nausea, and numbness, though most effects resolve after the first week.

Side effects, ingredient by ingredient Black Psyllium Malic Acid Chlorophyllin Potassium Stevia Aloe

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 6 of the 6 matched ingredients can interact with medications — Black Psyllium, Aloe, Chlorophyllin, Stevia, Potassium, among others.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications; heart-rhythm medications; lithium.
  • For scale: 2,102 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking CleanStart, check your medications against these drug types if you're on them: digoxin (Major severity), blood thinners (anticoagulants, antiplatelet drugs), warfarin, diabetes medications, potassium-sparing diuretics, ACE inhibitors, ARBs, stimulant laxatives, lithium, blood pressure medications, and diuretics. No interactions are documented for the ingredients we could not check.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with clinical evidence supporting its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

If you take digoxin, blood thinners, diabetes medications, diuretics, or lithium, check with your pharmacist before using CleanStart. Pregnant or breastfeeding women should discuss this product with their doctor first, especially due to aloe's possible effects.

The product contains multiple ingredients with interaction potential, so verify your medications against the tool on this page.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 6 of 11 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Mar 25, 2014.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about CleanStart Cleansing Drink Mix, straight from the product label.

Brand Nature's Sunshine
Net contents 56 Packet(s); 84 Capsule(s); 275.1 Gram(s)
Market status On market
Date entered into DSLD Mar 25, 2014
DSLD ID 31160
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for CleanStart Cleansing Drink Mix by Nature's Sunshine, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Cleansing Drink Mix Packet(s)
Maximum serving Sizes:
1 Cleansing Drink Mix Packet(s)
IngredientAmount% DV
Dietary Fiber5 Gram(s)4%
Malic Acid0 NP--
Sodium Copper Chlorophyllin0 NP--
Potassium Citrate0 NP--
Vegetable Fiber0 NP--
Proprietary Blend8.5 Gram(s)--
Stevia leaf extract0 NP--
natural Wild Berry flavor0 NP--
Hydrated Bentonite0 NP--
Aloe Vera0 NP--
Psyllium0 NP--
Carotene extract0 NP--

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

14 DAY PROGRAM

CleanStart(TM) Cleansing Drink Mix

Dietary Cleansing & Detoxifying Program

This carton is sealed for your protection.

Nature's Sunshine uses natural source materials in its products that are subject to color variation.

Product of U.S.A.

~ Complete colon cleanse eliminates toxic waste* ~ Increases energy, improves body balance and harmony* ~ Nourishes and strengthens the waste-filtering process* ~ Nourishes the five main detoxifying organs* ~ Promotes healthy colonic environment*

Environmental pollutants and toxins can build up in the body, slowing the body's natural cleansing and detoxifying process. These herbs were selected for their ability to help support the five primary cleansing and detoxifying eliminatory organs: liver, kidneys, lungs, bowels and skin.

This package contains two types of packets: 28 capsule packets (2 LBS II(R) capsules, 1 Enviro-Detox(TM)) and 28 cleansing drink mix packets (powdered mix). This represents a two-week supply when used as directed.

Natural Wild Berry Flavor

FDA Disclaimer Statement

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Seals/Symbols

Nature's Sunshine(R) QUALITY, SERVICE, INTEGRITY

FDA Statement of Identity

DIETARY SUPPLEMENT

General

Stock No. 3993-8

Precautions

See your health care provider prior to use if: Pregnant or nursing, any medical condition exists or when taking any medication.

Read and follow recommendation carefully. Do not use if diarrhea, loose stools or abdominal pain are present or develop. Use of this product may worsen these conditions and be harmful to your health. Chronic diarrhea can result in serious illness. Do not exceed recommended dose. Not for long term use.

Warning: May cause allergic reaction in persons sensitive to inhaled or ingested psyllium.

Suggested/Recommended/Usage/Directions

Balanced nutrition and regular exercise will maximize the benefits achieved from use of this product.

You can safely cleanse up to 30 days consecutively, if you desire.

RECOMMENDATION Take contents of one cleansing drink mix packet 15-30 minutes before breakfast and 15-30 minutes before dinner. Mix cleansing drink mix packet in 8 ounces of juice or water. Shake, blend or stir vigorously. Drink immediately. It is recommended that an additional glass of water be consumed immediately after drink. Drink plenty of water throughout the day.

Brand IP Statement(s)

(C)2013 Nature's Sunshine Products, Inc.

Formula

~ Supplies 10g of fiber daily*

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

CleanStart Cleansing Drink Mix by Nature's Sunshine label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

CleanStart Cleansing Drink Mix label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in CleanStart Cleansing Drink Mix by Nature's Sunshine

These are the 11 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Cleansing Drink Mix Packet(s) Dosage formCapsule Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Dietary Fiber

Interacts with
2,025 drugs
5 Gram(s) per serving

Black psyllium is a soluble-fiber supplement made from the seeds of a Plantago plant, used mostly to ease constipation and support digestive health. I...

Dietary Fiber monograph & interactions

Proprietary Blend

8.5 Gram(s) per serving
Interaction report

CleanStart Cleansing Drink Mix by Nature's Sunshine Drug Interactions

Want to check YOUR meds against CleanStart Cleansing Drink Mix?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
2,101Drugs
1 Major 643 Moderate 1,457 Minor

Ingredients driving the most interactions

Dietary Fiber 2,025
Aloe Vera 461
Sodium Copper Chlorophyllin 335
Stevia leaf extract 259
Malic Acid 172

Individual Drug Interactions

The ingredients in CleanStart Cleansing Drink Mix interact with 2,101 drugs. Click any drug to see the details.

6 of the 11 ingredients in CleanStart Cleansing Drink Mix interact with drugs. Each result below shows which ingredient is responsible. Dietary Fiber Aloe Vera Sodium Copper Chlorophyllin Stevia leaf extract Malic Acid Potassium Citrate

Each ingredient & the kinds of drugs it affects

For each ingredient in CleanStart Cleansing Drink Mix with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Dietary Fiber7 drug types · 2,025 drugs

Carbamazepine (Tegretol)

Theoretically, black psyllium might reduce the effects of carbamazepine and increase the risk for convulsions.
Theoretically, black psyllium might reduce carbamazepine absorption. A preliminary study using blond psyllium reported decreased carbamazepine bioavailability due to binding of the drug to psyllium, as well as reduction of available fluid in the gut for dissolution of the drug. This interaction may also occur with black psyllium.

Likelihood Probable Evidence D
Lithium

Theoretically, taking black psyllium at the same time as lithium might reduce lithium absorption.
The fiber in black psyllium might reduce lithium absorption and plasma levels. Some case reports describe a reduction in plasma lithium levels with concomitant administration of blond psyllium. This was reversed when psyllium was stopped. This interaction may also occur with black psyllium.

Likelihood Probable Evidence D
Metformin (Glucophage)

Theoretically, black psyllium might increase the therapeutic and adverse effects of metformin.
Animal research shows that concurrent consumption of blond psyllium with metformin slows and increases the absorption of metformin. This interaction may also occur with black psyllium. To avoid changes in absorption, take psyllium 30-60 minutes after metformin.

Likelihood Possible Evidence D
Olanzapine (Zyprexa)

Theoretically, taking black psyllium at the same time as olanzapine might reduce olanzapine absorption.
The fiber in black psyllium might decrease the absorption of olanzapine. A single case report describes a reduction in the effectiveness of olanzapine when it was concomitantly administered with an unspecified type of psyllium 3 grams orally twice daily. This effect was reversed when psyllium was stopped.

Likelihood Possible Evidence D
Digoxin (Lanoxin)

Theoretically, taking black psyllium at the same time as digoxin might reduce digoxin absorption and decrease digoxin levels.
Psyllium might bind digoxin in the gut. However, some clinical evidence suggests that psyllium does not impact digoxin absorption.

Likelihood Unlikely Evidence B
Ethinyl Estradiol

Theoretically, taking black psyllium at the same time as ethinyl estradiol might alter levels of estradiol.
Concurrent use of blond psyllium with ethinyl estradiol results in a slight increase in the extent of ethinyl estradiol absorption and a slower rate of absorption. This is unlikely to be clinically significant.

Likelihood Unlikely Evidence D
Oral Drugs

Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Psyllium seems to have variable effects on drug absorption. To avoid changes in absorption, take psyllium 30-60 minutes after oral medications. Animal research shows that blond psyllium delays and increases the absorption of metformin and ethinyl estradiol. Case reports and animal research suggest that blond psyllium might reduce absorption of lithium, digoxin, olanzapine, and carbamazepine. Finally, some pharmacokinetic studies show that psyllium does not affect the absorption of levothyroxine or warfarin. Although many of these studies evaluated blond psyllium, the fiber content in black psyllium may have similar effects.

Likelihood Possible Evidence B
Dietary Fiber full monograph & interactions

Aloe Vera7 drug types · 461 drugs

Digoxin (Lanoxin)

Theoretically, aloe latex might increase the risk of adverse effects when taken with cardiac glycosides.
Overuse of aloe latex can increase the risk of adverse effects from cardiac glycoside drugs, such as digoxin, due to potassium depletion. Overuse of aloe, along with cardiac glycoside drugs, can increase the risk of toxicity.

Likelihood Probable Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, aloe gel might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
In vitro research shows that aloe gel can inhibit platelet aggregation. This inhibition was greater than that seen with celecoxib, but less than that seen with aspirin.

Likelihood Possible Evidence D
Antidiabetes Drugs

Aloe might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Preliminary clinical research suggests aloe gel might lower blood glucose levels and have additive effects when used with antidiabetes drugs. Monitor blood glucose levels closely.

Likelihood Possible Evidence D
Diuretic Drugs

Theoretically, aloe latex might increase the risk of hypokalemia when taken with diuretic drugs.
Overuse of aloe latex might compound diuretic-induced potassium loss, increasing the risk of hypokalemia.

Likelihood Possible Evidence D
Stimulant Laxatives

Theoretically, aloe latex might increase the risk for fluid and electrolyte loss when taken with stimulant laxatives.
Due to cathartic laxative effects of aloe latex, concomitant use with other stimulant laxatives might compound fluid and electrolyte loss.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, aloe latex might increase the risk of bleeding when taken with warfarin.
Aloe latex has stimulant laxative effects. In some people aloe latex can cause diarrhea. Diarrhea can increase the effects of warfarin, increase international normalized ratio (INR), and increase the risk of bleeding. Advise patients who take warfarin not to take excessive amounts of aloe vera.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, aloe might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research shows that aloe extract induces CYP1A2 enzymes.

Likelihood Possible Evidence D
Aloe Vera full monograph & interactions

Sodium Copper Chlorophyllin1 drug type · 335 drugs

Photosensitizing Drugs

Theoretically, concomitant use of chlorophyllin with photosensitizing drugs may have additive effects.
Chlorophyllin is a semi-synthetic derivative of chlorophyll. Chlorophyll has been reported to cause photosensitization. Orally, chlorophyll has also been associated with the development of pseudoporphyria in multiple case reports.

Likelihood Probable Evidence B
Sodium Copper Chlorophyllin full monograph & interactions

Stevia leaf extract3 drug types · 259 drugs

Lithium

Theoretically, stevia might decrease clearance and increase levels of lithium.
Animal research suggests that stevia extracts might have diuretic activity. Theoretically, increased reabsorption of lithium along with sodium might reduce excretion and increase levels of lithium.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, stevia might increase the risk for hypoglycemia when combined with antidiabetes drugs.
Preliminary clinical research in patients with type 2 diabetes suggests that taking a single dose of stevia extract 1000 mg reduces postprandial blood glucose levels when taken with a meal. However, other clinical research in patients with type 1 or type 2 diabetes suggests that taking stevioside 250 mg three times daily does not significantly affect blood glucose levels or glycated hemoglobin (HbA1C) after three months of treatment.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, combining stevia or stevia constituents with antihypertensive agents might increase the risk of hypotension.
Stevia extract and stevioside might lower blood pressure in patients with hypertension. However, other clinical research suggests that stevioside does not significantly lower blood pressure in patients with hypertension.

Likelihood Possible Evidence D
Stevia leaf extract full monograph & interactions

Malic Acid1 drug type · 172 drugs

Antihypertensive Drugs

Theoretically, malic acid might increase the risk of hypotension when taken with antihypertensive drugs.
Animal research shows that malic acid isolated from tagetes roots can reduce mean arterial blood pressure.

Likelihood Possible Evidence D
Malic Acid full monograph & interactions

Potassium Citrate3 drug types · 62 drugs

Ace Inhibitors (Aceis)

Using ACEIs with high doses of potassium increases the risk of hyperkalemia.
ACEIs block the actions of the renin-angiotensin-aldosterone system and reduce potassium excretion. Concomitant use of these drugs with potassium supplements increases the risk of hyperkalemia. However, concomitant use of these drugs with moderate dietary potassium intake (about 3775-5200 mg daily) does not increase serum potassium levels.

Likelihood Likely Evidence C
Angiotensin Receptor Blockers (Arbs)

Using ARBs with high doses of potassium increases the risk of hyperkalemia.
ARBs block the actions of the renin-angiotensin-aldosterone system and reduce potassium excretion. Concomitant use of these drugs with potassium supplements increases the risk of hyperkalemia. However, concomitant use of these drugs with moderate dietary potassium intake (about 3775-5200 mg daily) does not increase serum potassium levels.

Likelihood Likely Evidence C
Potassium-Sparing Diuretics

Concomitant use increases the risk of hyperkalemia.
Using potassium-sparing diuretics with potassium supplements increases the risk of hyperkalemia.

Likelihood Likely Evidence C
Potassium Citrate full monograph & interactions
The maker

Brand information

Manufacturer and brand details for CleanStart Cleansing Drink Mix, from the product label.

Nature's Sunshine

See all Nature's Sunshine products
Name
Nature's Sunshine Products, Inc
City
Spanish Fork
State
Utah
ZipCode
84660
Phone Number
1-800-223-8225
Web Address
www.naturessunshine.com
Pharmacist Counseling Corner

CleanStart Cleansing Drink Mix by Nature's Sunshine: Common Questions

Does CleanStart Cleansing Drink Mix by Nature's Sunshine interact with any medications?
Yes. Based on its ingredients, CleanStart Cleansing Drink Mix has a known interaction with 2,101 medications, including 1 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
CleanStart Cleansing Drink Mix contains 11 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant?
Aloe vera inside should be avoided during pregnancy because its latex can stimulate the uterus and act as a laxative. Sodium copper chlorophyllin also lacks enough safety data for pregnancy. Malic acid and potassium citrate are likely safe, but talk with your doctor before starting, since this is a combination product.
Is it safe while I'm breastfeeding?
Aloe vera should be avoided while breastfeeding due to limited safety data and laxative effects. Safety data for sodium copper chlorophyllin while breastfeeding is unknown, so avoidance is safer. Check with your pharmacist or doctor about the other ingredients in this product before using it.
What's aloe vera doing in a cleansing drink?
Aloe vera shows possibly effective evidence for several conditions including constipation and has been traditionally used to support digestive health. It's included here as one of the blend's active ingredients, though you'll want to be aware of its interaction risks with certain medications.
Will this actually help me lose weight or cleanse my system?
Aloe rates possibly effective for obesity in our data, but the other ingredients lack established evidence for weight loss or detoxification claims. Cleansing products don't replace your liver and kidneys, which do that naturally. Talk to your doctor about whether this product fits your health goals.
What side effects might I notice?
Aloe can cause abdominal pain, cramps, and diarrhea, especially with long-term use. Stevia commonly causes bloating, dizziness, headache, and nausea, though these usually ease after a week. Malic acid may cause nausea or diarrhea in some people. If you experience severe symptoms, stop and contact your pharmacist.
Does this interact with my potassium-sparing diuretic?
Yes—potassium citrate in this product has a Moderate interaction with potassium-sparing diuretics. Taking them together raises the risk of dangerously high potassium levels. Do not use this product without checking with your doctor or pharmacist first.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

CleanStart Cleansing Drink Mix label
Go deeper

The Full Monographs Behind CleanStart Cleansing Drink Mix’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Black Psyllium

Interacts with 2,025 drugs

Black psyllium is a soluble-fiber supplement made from the seeds of a Plantago plant, used mostly to ease constipation and support digestive health. It is best known and most studied for rel...

Read the full Black Psyllium monograph → Herb & supplement monograph

Malic Acid

Interacts with 172 drugs

Malic acid is a natural acid found in apples and other fruits, often combined with magnesium in supplements marketed for fibromyalgia and muscle pain. The evidence for its health benefits is...

Read the full Malic Acid monograph → Herb & supplement monograph

Chlorophyllin

Interacts with 335 drugs

Chlorophyllin is a water-soluble, semi-synthetic form of chlorophyll most often used to help control body and fecal odor and to support wound healing. The best evidence is for its use as a d...

Read the full Chlorophyllin monograph → Herb & supplement monograph

Potassium

Interacts with 62 drugs

Potassium is an essential mineral your body needs for nerve signals, muscle function, and a steady heartbeat, and most people get enough from a balanced diet rich in fruits and vegetables. P...

Read the full Potassium monograph → Herb & supplement monograph

Stevia

Interacts with 259 drugs

Stevia is a plant-based, calorie-free sweetener that is widely used as a sugar alternative and is considered safe in normal food amounts by major regulators. Purified stevia extracts have a...

Read the full Stevia monograph → Herb & supplement monograph

Aloe

Interacts with 461 drugs

Aloe vera gel is widely used on the skin for minor burns and irritation, and some research suggests it may help. Aloe latex (the yellow part) is a strong laxative that can cause cramping and...

Read the full Aloe monograph →
Sources

Sources & How We Checked

CleanStart Cleansing Drink Mix's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 94 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Black Psyllium 18 references
  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  3. Covington TR, et al. Handbook of Nonprescription Drugs. 11th ed. Washington, DC: American Pharmaceutical Association, 1996.
  4. Etman M. Effect of a bulk forming laxative on the bioavailablility of carbamazepine in man. Drug Dev Ind Pharm 1995;21:1901-6.
  5. Perlman BB. Interaction between lithium salts and ispaghula husk. Lancet 1990;335:416.
  6. Vaswani SK, Hamilton RG, Valentine MD, Adkinson NF. Psyllium laxative-induced anaphylaxis, asthma, and rhinitis. Allergy 1996;51:266-8. PubMed
  7. Lantner RR, Espiritu BR, Zumerchik P, Tobin MC. Anaphylaxis following ingestion of a psyllium-containing cereal. JAMA 1990;264:2534-6. DOI
  8. Kaplan MJ. Anaphylactic reaction to "Heartwise." N Engl J Med 1990;323:1072-3. DOI
  9. Nordstrom M, Melander A, Robertsson E, Steen B. Influence of wheat bran and of a bulk-forming ispaghula cathartic on the bioavailability of digoxin in geriatric in-patients. Drug Nutr Interact 1987;5:67-9..
  10. Robinson DS, Benjamin DM, McCormack JJ. Interaction of warfarin and nonsystemic gastrointestinal drugs. Clin Pharmacol Ther 1971;12:491-5. PubMed
  11. Garcia JJ, Fernandez N, Diez MJ, et al. Influence of two dietary fibers in the oral bioavailability and other pharmacokinetic parameters of ethinyloestradiol. Contraception 2000;62:253-7. PubMed
  12. Fernandez N, Lopez C, Díez R, et al. Drug interactions with the dietary fiber Plantago ovata husk. Expert Opin Drug Metab Toxicol 2012;8(11):1377-86.
  13. Semen plantaginis in: WHO Monographs on Selected Medicinal Plants, volume 1. World Health Organization, Geneva, 1999. Available at http://apps.who.int/medicinedocs/en/d/Js2200e/. Accessed November 26, 1026.
  14. Code of Federal Regulations, Title 21 (21CFR 101.17). Food labeling warning, notice, and safe handling statements. Available at www.ecfr.gov/cgi-bin/text-idx?SID=20f647d3b74161501f46564b915b4048&mc=true&node=se21.2.101_117&rgn=div8. Accessed December 3, 2
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Malic Acid 7 references
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Chlorophyllin 6 references
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Potassium 12 references
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Stevia 10 references
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Aloe 41 references
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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