Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Co-Balamin Ingredients & Drug Interactions

by Home Aide Diagnostics, Inc.

Co-Balamin label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Co-Balamin against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Co-Balamin is a dietary supplement by Home Aide Diagnostics, Inc. with 4 active ingredients. Its ingredients are commonly taken for heart and blood vessel health, antioxidant support, anti-aging.Based on those ingredients, 1,022 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Resveratrol, Ubiquinol, Folic Acid. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Co-Balamin by Home Aide Diagnostics, Inc.

Ask about any prescription or over-the-counter medication and we check it for interactions with Co-Balamin by Home Aide Diagnostics, Inc. — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Co-Balamin by Home Aide Diagnostics, Inc.

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 4 of its 4 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Co-Balamin contains four active ingredients: resveratrol, folic acid, ubiquinol (a reduced form of coenzyme Q10), and methylcobalamin (a form of vitamin B12). The product also includes several inactive ingredients — beeswax, soybean oil, gelatin, water, and glycerol — that serve as the capsule structure and carriers.

Each ingredient plays a different role in the formula; resveratrol and ubiquinol are antioxidants, folic acid supports cell division and DNA, and methylcobalamin supports nerve function and red blood cell formation.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: Increase muscle energy and relieve muscular weakness and fatigue.
  • We looked for evidence on: Fatigue, Chronic fatigue syndrome (CFS), Chemotherapy-related fatigue, Athletic performance, Muscle strength, Energy metabolism — and 1 related terms.
  • The closest evidence on file: Coenzyme Q10 is rated "Possibly Ineffective" for Chemotherapy-related fatigue (Natural Medicines).
  • Also on file: Coenzyme Q10 is rated "Likely Ineffective" for Athletic performance.
  • Also on file: Vitamin B12 is rated "Insufficient Reliable Evidence To Rate" for Fatigue.

Resveratrol is possibly effective for obesity and hay fever (allergic rhinitis), though it appears possibly ineffective for cardiovascular disease and high cholesterol. Folic acid is effective for folate deficiency and likely effective for preventing neural tube birth defects and reducing methotrexate toxicity; it's possibly effective for depression and cognitive impairment.

Ubiquinol (coenzyme Q10) is likely effective for CoQ10 deficiency and possibly effective for fibromyalgia, migraine headaches, congestive heart failure, and diabetic nerve pain. Methylcobalamin is effective for B12 deficiency and Imerslund-Grasbeck disease, likely effective for cyanide poisoning, and possibly effective for canker sores and postherpetic neuralgia (nerve pain after shingles).

The evidence, ingredient by ingredient Resveratrol Folic Acid Coenzyme Q10 Vitamin B12

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Resveratrol is generally well tolerated at typical supplement doses; higher doses may cause digestive upset (diarrhea, loose stools, gastrointestinal discomfort), and long-term safety at high doses isn't fully known. It should be avoided during pregnancy and breastfeeding due to insufficient safety information.

Folic acid is generally safe at recommended doses for most adults and is recommended during pregnancy at standard prenatal amounts to help prevent birth defects; it's considered safe while breastfeeding at normal recommended doses. At high doses (15 mg daily), folic acid can cause sleep disturbances, irritability, confusion, and nausea; large doses can also worsen nerve damage in people deficient in vitamin B12.

Ubiquinol is generally well tolerated, with gastrointestinal side effects (diarrhea, nausea, heartburn) occurring in less than 1% of users; there isn't enough reliable safety data in pregnancy, so it's best avoided unless your doctor advises otherwise, and safety while breastfeeding hasn't been well studied. Methylcobalamin is very safe — excess is removed in urine, with no established upper limit — and is needed and safe in pregnancy and breastfeeding at normal recommended amounts.

Side effects, ingredient by ingredient Resveratrol Folic Acid Coenzyme Q10 Vitamin B12

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 4 of the 4 matched ingredients can interact with medications — Resveratrol, Vitamin B12, Coenzyme Q10, Folic Acid.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 1,023 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your pharmacist before using this product if you take blood thinners (anticoagulants) like warfarin or antiplatelet drugs like aspirin or clopidogrel (due to resveratrol's antiplatelet effects and ubiquinol's warfarin interaction); seizure medications like phenobarbital, phenytoin, or primidone (due to folic acid); methotrexate or chemotherapy drugs like capecitabine, 5-fluorouracil, or alkylating agents (due to folic acid and ubiquinol); or metformin for diabetes (due to methylcobalamin's minor effect on B12 absorption).

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

This four-ingredient supplement combines B vitamins and antioxidants with documented uses in deficiency states and some possible benefits for migraines, heart health, and other conditions. However, it carries moderate interactions with blood thinners, seizure medications, methotrexate, and chemotherapy drugs, and should be avoided in pregnancy and breastfeeding for at least one ingredient.

Talk to your pharmacist or doctor before starting if you take any prescription medications, especially seizure drugs, cancer treatments, or blood thinners.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Dec 18, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Co-Balamin, straight from the product label.

Brand Home Aide Diagnostics, Inc.
Barcode (UPC) 169379200012
Net contents 30 Capsule(s)
Market status On market
Date entered into DSLD Dec 18, 2021
DSLD ID 263552
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Co-Balamin by Home Aide Diagnostics, Inc., sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
30
UPC/BARCODE
169379200012
IngredientAmount% DV
Resveratrol400 mg--
Folic Acid0.8 mg--
Ubiquinol200 mg--
Methylcobalamin5 mg--

Other ingredients: Beeswax, Soybean Oil, Gelatin, Water, Glycerol

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Description: Formulated to increase muscle energy and relieve muscular weakness and fatigue caused by everyday use, as well as providing antioxidant effect to help strengthen the immune system. Co-Balamin is an orally administered prescription dietary supplement and should be administered under the supervision of a licensed medical practitioner.

Notice: This product is produced from natural sourced and contains no yeast, sugar, starch, artificial flavors, or preservatives.

Rx only

Made in China

Suggested/Recommended/Usage/Directions

Suggested use: Take one softgel by mouth daily, or as directed by a licensed medical practitioner.

Precautions

Caution: Do not exceed recommended dose.

Pregnant or nursing mothers, children under the age of 18 and individuals with known medical condition(s) should consult a physician before using this or any dietary supplement.

Pregnant or nursing mothers, children under the age of 18 and individuals with known medical condition(s) should consult a physician before using this or any dietary supplement. Keep out of reach of children.

Do not use if safety seal is damaged or missing.

Folate alone is improper therapy in the treatment of pernicious anemia and other megaloblastic anemias where vitamin B12 is deficient. Folate in doses above 0.1 mg daily may obscure pernicious anemia in that hematologic remission may occur while neurological manifestations progress.

Keep out of reach of children.

Call your medical practitioner about side effects. You man report side effects by calling (800) 015-0116 All prescriptions using this product shall be pursuant to state statues as applicable. This is not an Orange Book product.

Storage

Storage: Store at controlled room temperature 15 degrees-30 degrees C (59 degrees-86 degrees F). Protect from light and moisture.

Keep in a cool, dry place.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

General Statements

NDC: 69379-0200-01

FDA Statement of Identity

Prescription Dietary Supplement

Formula

Ubiquinol 200mg Methylcobalamin 5mg Folic acid 0.8mg Resveratrol 400mg

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Co-Balamin by Home Aide Diagnostics, Inc. label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Co-Balamin label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Co-Balamin by Home Aide Diagnostics, Inc.

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Resveratrol

Interacts with
822 drugs
400 mg per serving

Resveratrol is a plant compound found in red grapes, berries, and peanuts that is popular for heart health, anti-aging, and antioxidant support. While...

Resveratrol monograph & interactions

Folic Acid

Interacts with
40 drugs
0.8 mg per serving

Folic acid is the man-made form of vitamin B9 and is one of the most well-studied supplements, especially for preventing serious birth defects when ta...

Folic Acid monograph & interactions

Ubiquinol

Interacts with
198 drugs
200 mg per serving Form: Coenzyme Q-10

CoQ10 is a vitamin-like substance your body makes naturally that helps cells produce energy and acts as an antioxidant. It is generally well tolerated...

Ubiquinol monograph & interactions

Methylcobalamin

Interacts with
20 drugs
5 mg per serving Form: Vitamin B12

Vitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very h...

Methylcobalamin monograph & interactions

Other (inactive) ingredients: Beeswax, Soybean Oil, Gelatin, Water, Glycerol. These complete the product’s ingredient list but are not active constituents.

Interaction report

Co-Balamin by Home Aide Diagnostics, Inc. Drug Interactions

Want to check YOUR meds against Co-Balamin?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,022Drugs
869 Moderate 153 Minor

Ingredients driving the most interactions

Resveratrol 822
Ubiquinol 198
Folic Acid 40
Methylcobalamin 20

Individual Drug Interactions

The ingredients in Co-Balamin interact with 1,022 drugs. Click any drug to see the details.

4 of the 4 ingredients in Co-Balamin interact with drugs. Each result below shows which ingredient is responsible. Resveratrol Ubiquinol Folic Acid Methylcobalamin

Each ingredient & the kinds of drugs it affects

For each ingredient in Co-Balamin with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Resveratrol5 drug types · 822 drugs

Anticoagulant/Antiplatelet Drugs

Resveratrol may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Resveratrol seems to have antiplatelet effects.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, resveratrol might increase levels of drugs metabolized by CYP1A2.
In vitro research shows that resveratrol can inhibit CYP1A2 enzymes. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, resveratrol might increase levels of drugs metabolized by CYP2C19.
In vitro research shows that resveratrol can inhibit CYP2C19 enzymes. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2E1 (Cyp2E1) Substrates

Resveratrol might increase levels of drugs metabolized by CYP2E1.
In vitro research suggests that resveratrol inhibits CYP2E1 isoenzyme. Also, a pharmacokinetic study shows that taking resveratrol 500 mg daily for 10 days prior to taking a single dose of chlorzoxazone 250 mg increases the maximum concentration of chlorzoxazone by about 54%, the area under the curve of chlorzoxazone by about 72%, and the half-life of chlorzoxazone by about 35%. Chlorzoxazone is used as a probe drug for CYP2E1.

Likelihood Probable Evidence B
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, resveratrol might increase levels of drugs metabolized by CYP3A4.
In vitro research shows that resveratrol can inhibit the CYP3A4 enzyme. However, clinical research shows that taking resveratrol 3000 mg daily for 8 weeks does not necessitate dose adjustments to medications metabolized by CYP3A4.

Likelihood Possible Evidence D
Resveratrol full monograph & interactions

Ubiquinol3 drug types · 198 drugs

Alkylating Agents

Coenzyme Q10 has antioxidant effects. Theoretically, this may reduce the activity of chemotherapy drugs that generate free radicals.
Theoretically, antioxidants such as coenzyme Q10 might protect tumor cells from chemotherapeutic agents that work by inducing oxidative stress, such as alkylating agents (e.g., cyclophosphamide) and radiation therapy. The clinical importance of this interaction is unknown.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Coenzyme Q10 is chemically similar to menaquinone and might have vitamin K-like procoagulant effects, which could decrease the effects of warfarin.
Concomitant use of coenzyme Q10 and warfarin might reduce the anticoagulant effects of warfarin. Four cases of decreased warfarin efficacy thought to be due to coenzyme Q10 have been reported. However, there is some preliminary clinical research that suggests coenzyme Q10 might not significantly decrease the effects of warfarin in patients who have a stable INR.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, coenzyme Q10 might have additive effects with antihypertensive drugs.
Some clinical research shows that coenzyme Q10 can significantly lower blood pressure, although other studies have shown conflicting results.

Likelihood Possible Evidence B
Ubiquinol full monograph & interactions

Folic Acid7 drug types · 40 drugs

5-Fluorouracil

Theoretically, high doses of folic acid might increase the toxicity of 5-fluorouracil.
Increases in gastrointestinal side effects of 5-fluorouracil, such as stomatitis and diarrhea, have been described in two clinical studies when leucovorin, a form of folic acid, was administered with 5-fluorouracil.

Likelihood Possible Evidence D
Capecitabine (Xeloda)

Use of high-dose folic acid might contribute to capecitabine toxicity.
Clinical research suggests that higher serum folate levels are associated with an increased risk for moderate or severe toxicity during capecitabine-based treatment for colorectal cancer. Additionally, in one case report, taking folic acid 15 mg daily might have contributed to increased toxicity, including severe diarrhea, vomiting, edema, hand-foot syndrome, and eventually death, in a patient prescribed capecitabine.

Likelihood Possible Evidence D
Methotrexate (Trexall, Others)

Folic acid might reduce the efficacy of methotrexate as a cancer treatment when given concurrently.
Methotrexate exerts its cytotoxic effects by preventing conversion of folic acid to the active form needed by cells. There is some evidence that folic acid supplements reduce the efficacy of methotrexate in the treatment of acute lymphoblastic leukemia, and theoretically they could reduce its efficacy in the treatment of other cancers. Advise cancer patients to consult their oncologist before using folic acid supplements. In patients treated with long-term, low-dose methotrexate for rheumatoid arthritis (RA) or psoriasis, folic acid supplements can reduce the incidence of side effects, without reducing efficacy.

Likelihood Probable Evidence B
Phenobarbital (Luminal)

Folic acid might have antagonistic effects on phenobarbital and increase the risk for seizures.
Folic acid can have direct convulsant activity in some people, reversing the effects of phenobarbital and worsening seizure control. Monitor closely for increased seizure activity.

Likelihood Probable Evidence B
Phenytoin (Dilantin)

Folic acid might reduce serum levels of phenytoin in some patients.
Folic acid may be a cofactor in phenytoin metabolism. Folic acid, in doses of 1 mg daily or more, can reduce serum levels of phenytoin in some patients. Increases in seizure frequency have been reported. If folic acid supplements are added to established phenytoin therapy, monitor serum phenytoin levels closely. If phenytoin and folic acid are started at the same time and continued together, adverse changes in phenytoin pharmacokinetics are avoided. Note that phenytoin also reduces serum folate levels.

Likelihood Probable Evidence B
Primidone (Mysoline)

Folic acid might have antagonistic effects on primidone and increase the risk for seizures.
Folic acid can have direct convulsant activity in some people, reversing the effects of primidone and worsening seizure control. Monitor closely for increased seizure activity. Note that primidone also reduces serum folate levels.

Likelihood Probable Evidence B
Pyrimethamine (Daraprim)

Folic acid might antagonize the effects of pyrimethamine.
Folic acid can antagonize the antiparasitic effects of pyrimethamine against toxoplasmosis and Pneumocystis carinii pneumonia. Folic acid doesn't antagonize the effects of pyrimethamine in the treatment of malaria, because malarial parasites cannot use exogenous folic acid. Use folinic acid as an alternative to folic acid when indicated.

Likelihood Probable Evidence D
Folic Acid full monograph & interactions

Methylcobalamin1 drug type · 20 drugs

Metformin (Glucophage)

Metformin, a common medication used to manage type 2 diabetes, has been associated with lower vitamin B12 levels in some individuals. Prolonged use of metformin can interfere with the absorption of B12 in the digestive system, potentially leading to a deficiency in this essential vitamin.

Likelihood Possible Evidence A
Methylcobalamin full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Co-Balamin, from the product label.

Home Aide Diagnostics, Inc.

See all Home Aide Diagnostics, Inc. products
Name
Home Aide Diagnostics, Inc.
Street Address
1072 S. Powerline Rd.
City
Deerfield Beach
State
FL
ZipCode
33442
Pharmacist Counseling Corner

Co-Balamin by Home Aide Diagnostics, Inc.: Common Questions

Does Co-Balamin by Home Aide Diagnostics, Inc. interact with any medications?
Yes. Based on its ingredients, Co-Balamin has a known interaction with 1,022 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Co-Balamin contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
Resveratrol should be avoided during pregnancy and breastfeeding — there isn't enough safety information for concentrated supplements. Folic acid is recommended during pregnancy at standard prenatal doses and is safe while breastfeeding. Methylcobalamin (vitamin B12) is needed and safe in both pregnancy and breastfeeding. Ubiquinol (CoQ10) has insufficient safety data in pregnancy, so avoid it unless your doctor advises otherwise, and safety while breastfeeding hasn't been well studied. Talk to your doctor or pharmacist for personalized guidance.
What are the most common side effects?
Resveratrol most commonly causes diarrhea, loose stools, and gastrointestinal discomfort at higher doses. Ubiquinol (CoQ10) may cause gastrointestinal side effects like diarrhea, nausea, and heartburn, though these occur in less than 1% of users. Folic acid at recommended doses is generally well tolerated, but at high doses can cause sleep disturbances, irritability, and nausea. Methylcobalamin is generally very well tolerated with no serious adverse effects at normal doses.
Is this product safe for people with diabetes taking metformin?
The methylcobalamin (B12) in this product has a minor documented interaction with metformin — prolonged use of metformin can lower B12 levels, which is why some doctors monitor or supplement B12 in people on long-term metformin. This product may help, but check with your doctor or pharmacist first, especially since the other ingredients (resveratrol, folic acid, ubiquinol) have other potential medication interactions.
Does this product actually work for what it's supposed to do?
That depends on which benefit you're looking for. Folic acid and methylcobalamin (B12) are effective for their respective deficiencies. Resveratrol is possibly effective for obesity and hay fever, but appears ineffective for heart disease and cholesterol. Ubiquinol (CoQ10) is possibly effective for migraines, fibromyalgia, and heart failure. If you're taking this for a specific condition, talk to your pharmacist about what the evidence actually supports.
What's the difference between the ingredients in this product?
Resveratrol is an antioxidant from red grapes and berries studied for obesity and hay fever. Folic acid is a B vitamin essential for cell division and DNA and required in pregnancy. Ubiquinol (CoQ10) is an antioxidant that helps cells produce energy and is studied for heart and nerve health. Methylcobalamin (B12) is a vitamin needed for nerve function, red blood cells, and energy — it's especially important if you take metformin or have a deficiency.
Will this cause digestive upset?
Resveratrol at higher doses is known to cause diarrhea and loose stools. Ubiquinol (CoQ10) may cause appetite suppression, diarrhea, nausea, or heartburn, though these are uncommon. Folic acid at normal doses is well tolerated; high doses (15 mg daily) can cause nausea. Methylcobalamin is generally well tolerated. If you have a sensitive stomach, taking CoQ10 doses above 100 mg divided throughout the day may help reduce symptoms.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Co-Balamin label
Go deeper

The Full Monographs Behind Co-Balamin’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Resveratrol

Interacts with 822 drugs

Resveratrol is a plant compound found in red grapes, berries, and peanuts that is popular for heart health, anti-aging, and antioxidant support. While lab and animal studies are promising, s...

Read the full Resveratrol monograph → Herb & supplement monograph

Folic Acid

Interacts with 40 drugs

Folic acid is the man-made form of vitamin B9 and is one of the most well-studied supplements, especially for preventing serious birth defects when taken before and during early pregnancy. I...

Read the full Folic Acid monograph → Herb & supplement monograph

Coenzyme Q10

Interacts with 198 drugs

CoQ10 is a vitamin-like substance your body makes naturally that helps cells produce energy and acts as an antioxidant. It is generally well tolerated and is most studied for heart condition...

Read the full Coenzyme Q10 monograph → Herb & supplement monograph

Vitamin B12

Interacts with 20 drugs

Vitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very helpful for people who are deficient — su...

Read the full Vitamin B12 monograph →
Sources

Sources & How We Checked

Co-Balamin's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 150 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Resveratrol 24 references
  1. Soleas GJ, Diamandis EP, Goldberg DM. Resveratrol: a molecule whose time has come? And gone? Clin Biochem 1997;30:91-113.
  2. Pace-Asciak CR, Rounova O, Hahn SE, et al. Wines and grape juices as modulators of platelet aggregation in healthy human subjects. Clin Chim Acta 1996;246:163-82. PubMed
  3. Bertelli AA, Giovannini L, Bernini W, et al. Antiplatelet activity of cis-resveratrol. Drugs Exp Clin Res 1996;22:61-3.
  4. Pace-Asciak CR, Hahn S, Diamandis EP, et al. The red wine phenolics trans-resveratrol and quercetin block human platelet aggregation and eicosanoid synthesis: implications for protection against coronary heart disease. Clin Chim Acta 1995;235:207-19.
  5. Bertelli A, Bertelli AA, Gozzini A, Giovannini L. Plasma and tissue resveratrol concentrations and pharmacological activity. Drugs Exp Clin Res 1998;24:133-8.
  6. Bertelli AA, Giovannini L, Giannessi D, et al. Antiplatelet activity of synthetic and natural resveratrol in red wine. Int J Tissue React 1995;17:1-3.
  7. Piver B, Berthou F, Dreano Y, Lucas D. Inhibition of CYP3A, CYP1A and CYP2E1 activities by resveratrol and other non volatile red wine components. Toxicol Lett 2001;125:83-91. PubMed
  8. Chang, T. K., Chen, J., and Lee, W. B. Differential inhibition and inactivation of human CYP1 enzymes by trans-resveratrol: evidence for mechanism-based inactivation of CYP1A2. J.Pharmacol.Exp.Ther. 2001;299(3):874-882.
  9. Dobrydneva, Y., Williams, R. L., and Blackmore, P. F. trans-Resveratrol inhibits calcium influx in thrombin-stimulated human platelets. Br.J.Pharmacol. 1999;128(1):149-157.
  10. Kirk, R. I., Deitch, J. A., Wu, J. M., and Lerea, K. M. Resveratrol decreases early signaling events in washed platelets but has little effect on platalet in whole food. Blood Cells Mol.Dis. 2000;26(2):144-150.
  11. Zbikowska, H. M. and Olas, B. Antioxidants with carcinostatic activity (resveratrol, vitamin E and selenium) in modulation of blood platelet adhesion. J Physiol Pharmacol. 2000;51(3):513-520.
  12. Olas, B., Wachowicz, B., Saluk-Juszczak, J., and Zielinski, T. Effect of resveratrol, a natural polyphenolic compound, on platelet activation induced by endotoxin or thrombin. Thromb.Res 8-15-2002;107(3-4):141-145. PubMed
  13. Yu, C., Shin, Y. G., Kosmeder, J. W., Pezzuto, J. M., and van Breemen, R. B. Liquid chromatography/tandem mass spectrometric determination of inhibition of human cytochrome P450 isozymes by resveratrol and resveratrol-3-sulfate. Rapid Commun.Mass Spectro PubMed
  14. Ma, Z. H. and Ma, Q. Y. Resveratrol: a medical drug for acute pancreatitis. World J Gastroenterol. 6-7-2005;11(21):3171-3174. PubMed
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Coenzyme Q10 40 references
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Vitamin B12 30 references
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  30. Pegalajar-García MD, Cebolla-Verdugo M, Prados-Carmona Á, Llamas-Segura C, Navarro-Triviño FJ. Systemic allergic dermatitis to cobalt present in cyanocobalamin supplementation. Contact Dermatitis 2023;89(3):203-205. PubMed

See these in context on the Vitamin B12 monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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