Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Coenzyme Q-10 with Lipoic Acid Ingredients & Drug Interactions

by Douglas Laboratories

Coenzyme Q-10 with Lipoic Acid label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Coenzyme Q-10 with Lipoic Acid against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Coenzyme Q-10 with Lipoic Acid is a dietary supplement by Douglas Laboratories with 3 active ingredients. Its ingredients are commonly taken for diabetic nerve pain (neuropathy), blood sugar support in diabetes, antioxidant support.Based on those ingredients, 1,136 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Red Wine Grape extract, Alpha-Lipoic Acid, Coenzyme Q10. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Coenzyme Q-10 with Lipoic Acid by Douglas Laboratories

Ask about any prescription or over-the-counter medication and we check it for interactions with Coenzyme Q-10 with Lipoic Acid by Douglas Laboratories — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Coenzyme Q-10 with Lipoic Acid by Douglas Laboratories

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 3 of its 3 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains three active ingredients. Alpha-lipoic acid is an antioxidant compound studied for its effects on blood sugar and nerve damage related to diabetes.

Coenzyme Q10 (also called ubiquinone) is a natural compound your body uses to generate energy in cells and plays a role in heart and muscle function. Red wine grape extract is derived from grape seeds and fruit, used traditionally for circulatory and antioxidant support.

The product also includes inactive ingredients—microcrystalline cellulose, gelatin, silica, vegetable stearate, and magnesium stearate—which serve as capsule material and binders.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded its ingredients' overall clinical evidence instead.

Strong

Strong clinical evidence supports its ingredients for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredients' overall clinical evidence instead.
  • On file: Coenzyme Q10 deficiency — rated "Likely Effective" (Coenzyme Q10) (Natural Medicines).
  • On file: Chronic venous insufficiency (CVI) — rated "Possibly Effective" (Grape) (Natural Medicines).
  • On file: Migraine headache — rated "Possibly Effective" (Coenzyme Q10) (Natural Medicines).
  • On file: Congestive heart failure (CHF) — rated "Possibly Effective" (Coenzyme Q10) (Natural Medicines).
  • On file: Diabetic neuropathy — rated "Possibly Effective" (Alpha-lipoic Acid) (Natural Medicines).

Alpha-lipoic acid is rated possibly effective for diabetic nerve damage (neuropathy), high cholesterol (hyperlipidemia), and weight management. Coenzyme Q10 is rated likely effective for correcting a CoQ10 deficiency and possibly effective for fibromyalgia, migraine headaches, congestive heart failure, and diabetic neuropathy.

Red wine grape extract is rated possibly effective for chronic venous insufficiency (a condition affecting veins in the legs) but possibly ineffective for chemotherapy-related nausea and vomiting, hay fever, and obesity. The evidence supporting these uses varies in strength; talk with your pharmacist about whether this combination matches your health goals.

The evidence, ingredient by ingredient Alpha-lipoic Acid Coenzyme Q10 Grape

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Alpha-lipoic acid is generally well tolerated but can lower blood sugar and should be used under medical guidance. The most common side effects with oral use are headache, heartburn, nausea, and vomiting.

Skin rash and itching have also been reported. A rare concern is insulin autoimmune syndrome, noted in case reports.

There is not enough reliable safety information to recommend alpha-lipoic acid during pregnancy or breastfeeding. Coenzyme Q10 is generally well tolerated when used as directed.

Gastrointestinal side effects such as nausea, vomiting, diarrhea, and heartburn occur in less than 1% of people and can often be minimized by dividing doses above 100 mg. Headache, dizziness, and rarely insomnia or skin itching have been reported.

There is not enough reliable safety data to recommend it during pregnancy; caution is advised while breastfeeding—consult your doctor. Red wine grape extract appears well tolerated; abdominal pain, diarrhea, dry mouth, headache, and nausea are the most common side effects.

Grapes as food are safe during pregnancy and breastfeeding, but concentrated grape supplements and wine should be avoided during pregnancy due to limited safety data and alcohol content; use caution with supplements while breastfeeding.

Side effects, ingredient by ingredient Alpha-lipoic Acid Coenzyme Q10 Grape

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 3 of the 3 matched ingredients can interact with medications — Grape, Alpha-lipoic Acid, Coenzyme Q10.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; cancer treatments; diabetes medications.
  • For scale: 1,137 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your pharmacist if you use blood thinners or antiplatelet drugs—alpha-lipoic acid and grape extract may increase bleeding risk (Moderate). If you're on warfarin specifically, coenzyme Q10 may reduce its effectiveness (Moderate).

Chemotherapy patients should consult their oncologist, as alpha-lipoic acid's antioxidant effects may interfere with alkylating agents and antitumor antibiotics (Moderate). Thyroid medication users should verify with their pharmacist, as alpha-lipoic acid may decrease thyroid hormone effects (Moderate).

People on diabetes drugs should be aware of a theoretical risk of low blood sugar (Minor). Additionally, if you take drugs processed by liver enzymes—including some antidepressants, heart medications, or sedatives—the grape extract may affect their levels, though this has not yet been confirmed in humans (Moderate).

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with strong clinical evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

This product combines ingredients with evidence for nerve pain, heart health, and circulation, but it carries notable drug interactions—especially with blood thinners, chemotherapy, thyroid medication, and several liver-metabolized drugs. If you take any prescription medication, check it against our interaction tool before starting.

Anyone taking warfarin, blood thinners, diabetes drugs, thyroid medication, or chemotherapy should talk with their pharmacist or doctor first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 23, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Coenzyme Q-10 with Lipoic Acid, straight from the product label.

Brand Douglas Laboratories
Barcode (UPC) 310539002322
Net contents 30 Capsule(s)
Market status On market
Date entered into DSLD Aug 23, 2020
DSLD ID 232563
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Coenzyme Q-10 with Lipoic Acid by Douglas Laboratories, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
30
UPC/BARCODE
310539002322
IngredientAmount% DV
Alpha-Lipoic Acid50 mg--
Coenzyme Q1060 mg--
Red Wine Grape extract5 mg--

Other ingredients: Microcrystalline Cellulose, Gelatin, Silica, Vegetable Stearate, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested Usage: As a dietary supplement, adults take 1 capsule, 1-2 times daily or as directed by a health professional.

Precautions

Warning: If you are pregnant, nursing, have any health condition or taking any medication, consult your health professional before using this product.

Keep out of the reach of children.

Use only if safety seal is intact.

Storage

Store in a cool, dry place.

Formulation

Gluten-free, Non-GMO

Energy metabolism and cardiometabolic health

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

General Statements

Scan to learn about our manufacturing excellence Contents may not fill package in order to accommodate required labeling. Please rely on stated quantity.

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Coenzyme Q-10 with Lipoic Acid by Douglas Laboratories label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Coenzyme Q-10 with Lipoic Acid label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Coenzyme Q-10 with Lipoic Acid by Douglas Laboratories

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Alpha-Lipoic Acid

Interacts with
263 drugs
50 mg per serving

Alpha-lipoic acid (ALA) is an antioxidant made naturally by the body and found in small amounts in foods. It is most studied for diabetic nerve pain,...

Alpha-Lipoic Acid monograph & interactions

Coenzyme Q10

Interacts with
198 drugs
60 mg per serving

CoQ10 is a vitamin-like substance your body makes naturally that helps cells produce energy and acts as an antioxidant. It is generally well tolerated...

Coenzyme Q10 monograph & interactions

Red Wine Grape extract

Interacts with
910 drugs
5 mg per serving

Grapes and grape products like grape seed extract contain antioxidant compounds such as resveratrol and proanthocyanidins that may support heart and b...

Red Wine Grape extract monograph & interactions

Other (inactive) ingredients: Microcrystalline Cellulose, Gelatin, Silica, Vegetable Stearate, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Coenzyme Q-10 with Lipoic Acid by Douglas Laboratories Drug Interactions

Want to check YOUR meds against Coenzyme Q-10 with Lipoic Acid?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,136Drugs
911 Moderate 225 Minor

Ingredients driving the most interactions

Red Wine Grape extract 910
Alpha-Lipoic Acid 263
Coenzyme Q10 198

Individual Drug Interactions

The ingredients in Coenzyme Q-10 with Lipoic Acid interact with 1,136 drugs. Click any drug to see the details.

3 of the 3 ingredients in Coenzyme Q-10 with Lipoic Acid interact with drugs. Each result below shows which ingredient is responsible. Red Wine Grape extract Alpha-Lipoic Acid Coenzyme Q10

Each ingredient & the kinds of drugs it affects

For each ingredient in Coenzyme Q-10 with Lipoic Acid with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Red Wine Grape extract9 drug types · 910 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, grape extracts may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
In vitro evidence suggests that grape extracts might decrease platelet aggregation.

Likelihood Possible Evidence D
Cyclosporine (Neoral, Sandimmune)

Ingesting grape juice with cyclosporine can reduce cyclosporine absorption.
A small pharmacokinetic study in healthy young adults shows that intake of purple grape juice 200 mL along with cyclosporine can decrease the absorption of cyclosporine by up to 30% when compared with water. Separate doses of grape juice and cyclosporine by at least 2 hours to avoid this interaction.

Likelihood Possible Evidence B
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, grape juice might reduce the levels of CYP1A2 substrates.
A small pharmacokinetic study in healthy adults shows that ingestion of 200 mL of grape juice decreases phenacetin plasma levels. This is thought to be due to induction of CYP1A2.

Likelihood Possible Evidence B
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, grape seed extract may increase the levels of CYP2D6 substrates.
In vitro evidence suggests that grape seed extract might inhibit CYP2D6 enzymes. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2E1 (Cyp2E1) Substrates

Theoretically, grape seed extract might increase the levels of CYP2E1 substrates.
In vitro and animal research suggests that grape seed proanthocyanidin extract inhibits CYP2E1 enzymes. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

It is unclear if grape seed extract inhibits or induces CYP3A4; research is conflicting.
In vitro evidence suggests that grape seed extract might inhibit CYP3A4 enzymes. However, evidence from animal research shows that grape seed extract may induce CYP3A4 in the liver. So far, these interactions have not been reported in humans.

Likelihood Possible Evidence D
Midazolam (Versed)

Theoretically, long-term intake of grape seed extract might decrease the effects of midazolam.
Animal research shows that subchronic ingestions of grape seed extract can increase the elimination of intravenous midazolam by increasing hepatic CYP3A4 activity. Single doses of grape seed extract do not appear to affect midazolam elimination.

Likelihood Possible Evidence D
Phenacetin

Grape juice might decrease phenacetin absorption.
A small pharmacokinetic study in healthy adults shows that ingestion of 200 mL of grape juice decreases phenacetin plasma levels. This is thought to be due to induction of cytochrome P450 1A2 (CYP1A2).

Likelihood Possible Evidence B
Cytochrome P450 2C9 (Cyp2C9) Substrates

It is unclear if grape juice or grape seed extract inhibits CYP2C9; research is conflicting.
In vitro evidence shows that grape seed extract or grape juice might inhibit CYP2C9 enzymes. However, a small pharmacokinetic study in healthy adults shows that drinking 8 ounces of grape juice once does not affect the clearance of flurbiprofen, a probe-drug for CYP2C9 metabolism. The effects of continued grape juice consumption are unclear.

Likelihood Unlikely Evidence D
Red Wine Grape extract full monograph & interactions

Alpha-Lipoic Acid5 drug types · 263 drugs

Alkylating Agents

Theoretically, the antioxidant effects of alpha-lipoic acid might alter the effectiveness of alkylating agents.
The use of antioxidants like alpha-lipoic acid during chemotherapy is controversial. There are concerns that antioxidants could reduce the activity of chemotherapy drugs that generate free radicals. However, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that might interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effect, if any, antioxidants such as alpha-lipoic acid have on chemotherapy. Advise patients to consult their oncologist before using alpha-lipoic acid.

Likelihood Possible Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, alpha-lipoic acid may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
In vitro, alpha-lipoic acid inhibits platelet aggregation.

Likelihood Possible Evidence D
Antitumor Antibiotics

Theoretically, the antioxidant effects of alpha-lipoic acid might alter the effectiveness of antitumor antibiotics.
The use of antioxidants like alpha-lipoic acid during chemotherapy is controversial. There are concerns that antioxidants could reduce the activity of antitumor antibiotic drugs, which work by generating free radicals. However, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that might interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effect, if any, antioxidants such as alpha-lipoic acid have on chemotherapy involving antitumor antibiotics. Advise patients to consult their oncologist before using alpha-lipoic acid.

Likelihood Possible Evidence D
Thyroid Hormone

Theoretically, alpha-lipoic acid might decrease the effects of thyroid hormone drugs.
Animal research suggests that co-administration of thyroxine with alpha-lipoic acid reduces conversion into the active T3 form.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, taking alpha-lipoic acid with antidiabetes drugs might increase the risk of hypoglycemia.
Although some small clinical studies have suggested that alpha-lipoic acid can lower blood glucose levels, larger clinical studies in patients with diabetes have shown no clinically meaningful effect. Additionally, co-administration of single doses of alpha-lipoic acid and glyburide or acarbose did not cause detectable drug interactions in healthy volunteers.

Likelihood Unlikely Evidence B
Alpha-Lipoic Acid full monograph & interactions

Coenzyme Q103 drug types · 198 drugs

Alkylating Agents

Coenzyme Q10 has antioxidant effects. Theoretically, this may reduce the activity of chemotherapy drugs that generate free radicals.
Theoretically, antioxidants such as coenzyme Q10 might protect tumor cells from chemotherapeutic agents that work by inducing oxidative stress, such as alkylating agents (e.g., cyclophosphamide) and radiation therapy. The clinical importance of this interaction is unknown.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Coenzyme Q10 is chemically similar to menaquinone and might have vitamin K-like procoagulant effects, which could decrease the effects of warfarin.
Concomitant use of coenzyme Q10 and warfarin might reduce the anticoagulant effects of warfarin. Four cases of decreased warfarin efficacy thought to be due to coenzyme Q10 have been reported. However, there is some preliminary clinical research that suggests coenzyme Q10 might not significantly decrease the effects of warfarin in patients who have a stable INR.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, coenzyme Q10 might have additive effects with antihypertensive drugs.
Some clinical research shows that coenzyme Q10 can significantly lower blood pressure, although other studies have shown conflicting results.

Likelihood Possible Evidence B
Coenzyme Q10 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Coenzyme Q-10 with Lipoic Acid, from the product label.

Douglas Laboratories

See all Douglas Laboratories products
Name
Douglas Laboratories
Street Address
600 Boyce Road
City
Pittsburgh
State
PA
ZipCode
15205
Phone Number
1.800.245.4440
Web Address
www.douglaslabs.com
Pharmacist Counseling Corner

Coenzyme Q-10 with Lipoic Acid by Douglas Laboratories: Common Questions

Does Coenzyme Q-10 with Lipoic Acid by Douglas Laboratories interact with any medications?
Yes. Based on its ingredients, Coenzyme Q-10 with Lipoic Acid has a known interaction with 1,136 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Coenzyme Q-10 with Lipoic Acid contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
There is not enough reliable safety information for alpha-lipoic acid during pregnancy or breastfeeding, so it is best to avoid. Coenzyme Q10 should be avoided during pregnancy unless your doctor advises otherwise; use caution while breastfeeding. Red wine grape extract as food is fine, but concentrated supplements should be avoided in pregnancy due to limited safety data. Talk with your doctor or pharmacist for personalized advice on this combination.
What are the most common side effects?
From alpha-lipoic acid: headache, heartburn, nausea, vomiting, and dizziness are most common. From coenzyme Q10: gastrointestinal side effects like nausea, diarrhea, and heartburn occur in less than 1% of people, along with occasional headache or dizziness. From grape extract: abdominal pain, diarrhea, dry mouth, headache, and nausea. Overall, this product is generally well tolerated, but individual responses vary.
Will this help my diabetes or blood sugar?
Alpha-lipoic acid is rated possibly effective for diabetic nerve damage. However, it can lower blood sugar, so if you take diabetes medication, you'll need to watch for hypoglycemia (low blood sugar) and should use it only under medical guidance. Coenzyme Q10 is also possibly effective for diabetic nerve damage. Neither ingredient has strong evidence for managing blood sugar itself in larger clinical studies.
Is this safe to use long-term?
Both alpha-lipoic acid and coenzyme Q10 are generally well tolerated in research, but alpha-lipoic acid can lower blood sugar and works best under medical supervision. Coenzyme Q10 has a good safety profile for ongoing use. Red wine grape extract also appears well tolerated. Any long-term use should be discussed with your pharmacist or doctor, especially if you have other health conditions or take medications.
Can this help with high cholesterol or weight loss?
Alpha-lipoic acid is rated possibly effective for high cholesterol and weight management. Coenzyme Q10 is possibly effective for high cholesterol based on the evidence we hold. Red wine grape extract is rated possibly ineffective for weight loss. Results vary, and these supplements work best alongside diet and lifestyle changes—talk with your doctor about realistic expectations.
What is coenzyme Q10 and why is it in this product?
Coenzyme Q10 (also called ubiquinone) is a natural compound your body uses to make energy in cells and support heart and muscle function. It's included here because it's rated possibly effective for heart conditions like congestive heart failure, migraine headaches, and diabetic nerve damage—making it a complementary ingredient to alpha-lipoic acid, which targets similar conditions.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Coenzyme Q-10 with Lipoic Acid is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Coenzyme Q-10 with Lipoic Acid label
Go deeper

The Full Monographs Behind Coenzyme Q-10 with Lipoic Acid’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Alpha-lipoic Acid

Interacts with 263 drugs

Alpha-lipoic acid (ALA) is an antioxidant made naturally by the body and found in small amounts in foods. It is most studied for diabetic nerve pain, where some evidence suggests it may help...

Read the full Alpha-lipoic Acid monograph → Herb & supplement monograph

Coenzyme Q10

Interacts with 198 drugs

CoQ10 is a vitamin-like substance your body makes naturally that helps cells produce energy and acts as an antioxidant. It is generally well tolerated and is most studied for heart condition...

Read the full Coenzyme Q10 monograph → Herb & supplement monograph

Grape

Interacts with 910 drugs

Grapes and grape products like grape seed extract contain antioxidant compounds such as resveratrol and proanthocyanidins that may support heart and blood vessel health. While the food is he...

Read the full Grape monograph →
Sources

Sources & How We Checked

Coenzyme Q-10 with Lipoic Acid's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 122 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Alpha-lipoic Acid 48 references
  1. Labriola D, Livingston R. Possible interactions between dietary antioxidants and chemotherapy. Oncology 1999;13:1003-8.
  2. Anon. Alpha-lipoic acid. Altern Med Rev 1998;3:308-10.
  3. Konrad T, Vicini P, Kusterer K, et al. Alpha-lipoic acid treatment decreases serum lactate and pyruvate concentrations and improves glucose effectiveness in lean and obese patients with Type 2 diabetes. Diabetes Care 1999;22:280-7. PubMed
  4. Ziegler D, Hanefeld M, Ruhnau KJ, et al. Treatment of symptomatic diabetic peripheral neuropathy with the antioxidant alpha-lipoic acid: A 3-week, multicentre randomized controlled trial (ALADIN Study). Diabetologia 1995;38:1425-33.
  5. Gleiter CH, Schreeb KH, Freudenthaler S, et al. Lack of interaction between thioctic acid, glibenclamide and acarbose. Br J Clin Pharmacol 1999;48:819-25. PubMed
  6. Jacob S, Henriksen EJ, Tritschler HJ, et al. Improvement of insulin-stimulated glucose-disposal in type 2 diabetes after repeated parenteral administration of thioctic acid. Exp Clin Endocrinol Diabet 1996;104:284-8. PubMed
  7. Jacob S, Henriksen EJ, Schiemann AL, et al. Enhancement of glucose disposal in patients with type 2 diabetes by alpha-lipoic acid. Arzneimittelforschung 1995;45:872-4.
  8. Jacob S, Ruus P, Hermann R, et al. Oral administration of RAC-alpha-lipoic acid modulates insulin sensitivity in patients with type-2 diabetes mellitus: a placebo-controlled, pilot trial. Free Rad Biol Med 1999;27:309-14.
  9. Segermann J, Hotze A, Ulrich H, Rao GS. Effect of alpha-lipoic acid on the peripheral conversion of thyroxine to triiodothyronine and on serum lipid-, protein- and glucose levels. Arzneimittelforschung 1991;41:1294-8.
  10. Beitner H. Randomized, placebo controlled, double-blind study on the clinical efficacy of a cream containing 5% alpha-lipoic acid related to photoaging of facial skin. Br J Dermatol 2003;149:841-9.
  11. Ziegler D, Nowak H, Kempler P, et al. Treatment of symptomatic diabetic polyneuropathy with the antioxidant alpha-lipoic acid: A meta-analysis. Diabet Med 2004;21:114-21.
  12. Prasad KN. Rationale for using high-dose multiple dietary antioxidants as an adjunct to radiation therapy and chemotherapy. J Nutr 2004;134:3182S-3S. PubMed
  13. Conklin KA. Cancer chemotherapy and antioxidants. J Nutr 2004;134:3201S-3204S. PubMed
  14. Vincent HK, Bourguignon CM, Vincent KR, Taylor AG. Effects of alpha-lipoic acid supplementation in peripheral arterial disease: a pilot study. J Alt Complement Med 2007;13:577-84. PubMed
  15. Furukawa N, Miyamura N, Nishida K, et al. Possible relevance of alpha lipoic acid contained in a health supplement in a case of insulin autoimmune syndrome. Diabetes Res Clin Pract 2007;75:366-7. PubMed
  16. Ziegler D., Ametov A., Barinov A., Dyck P. J., Gurieva I., Low P. A., Munzel U., Yakhno N., Raz I., Novosadova M., Maus J., Samigullin, R. Oral treatment with alpha-lipoic acid improves symptomatic diabetic polyneuropathy: the SYDNEY 2 trial. Diabetes Car
  17. Gu X. M., Zhang S. S., Wu J. C., Tang Z. Y., Lu Z. Q., Li H., Liu C., Chen L., Ning, G. [Efficacy and safety of high-dose a-lipoic acid in the treatment of diabetic polyneuropathy]. Zhonghua Yi Xue Za Zhi 2010;90(35):2473-2476.
  18. Porasuphatana S., Suddee S., Nartnampong A., Konsil J., Harnwong B., Santaweesuk A. Glycemic and oxidative status of patients with type 2 diabetes mellitus following oral administration of alpha-lipoic acid: a randomized double-blinded placebo-controlled
  19. Ansar H., Mazloom Z., Kazemi F., Hejazi N. Effect of alpha-lipoic acid on blood glucose, insulin resistance and glutathione peroxidase of type 2 diabetic patients. Saudi Med J 2011;32(6):584-588. DOI
  20. de Oliveira A. M., Rondó P. H., Luzia L. A., D'Abronzo F. H., Illison V. K. The effects of lipoic acid and a-tocopherol supplementation on the lipid profile and insulin sensitivity of patients with type 2 diabetes mellitus: a randomized, double-blind, pla
  21. Mazloom Z., Ansar H. The Effect of Alpha-Lipoic Acid on Blood Pressure in Type 2 Diabetics. Iranian Journal of Endocrinology and Metabolism 2009;11(3):245-250.
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See these in context on the Alpha-lipoic Acid monograph →

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See these in context on the Coenzyme Q10 monograph →

Grape 34 references
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  10. Schaefer, E., Peil, H., Ambrosetti, L., and Petrini, O. Oedema protective properties of the red vine leaf extract AS 195 (Folia vitis viniferae) in the treatment of chronic venous insufficiency. A 6-week observational clinical trial. Arzneimittelforschun PubMed
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See these in context on the Grape monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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