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Dietary supplement

Cogni-Spark Ingredients & Drug Interactions

by Health Concerns

Cogni-Spark label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Minor
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Cogni-Spark against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Minor

Cogni-Spark is a dietary supplement by Health Concerns with 1 active ingredient. Its ingredients are commonly taken for memory and learning support, age-related cognitive decline, alzheimer's disease and dementia (under study).Based on those ingredients, 16 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are Glycerylphosphorylcholine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Cogni-Spark by Health Concerns

Ask about any prescription or over-the-counter medication and we check it for interactions with Cogni-Spark by Health Concerns — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Cogni-Spark by Health Concerns

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 1 active ingredient.
  • “Proprietary Blend” is a proprietary blend — the label gives one combined amount (300 mg) without saying how much of each component you get.

Cogni-Spark contains one active ingredient: alpha-GPC (glycerylphosphorylcholine), a compound your brain uses naturally. It's included in inactive ingredients — silicon dioxide, stearic acid, and gelatin — which are the capsule and binders.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: memory and cognitive function support.
  • We looked for evidence on: Alzheimer disease, Cognitive function, Vascular dementia, age-related cognitive decline, learning, mental clarity.
  • The strongest evidence on file: Alpha-gpc is rated "Possibly Effective" for Alzheimer disease (Natural Medicines).
  • Also on file: Alpha-gpc is rated "Insufficient Reliable Evidence To Rate" for Cognitive function, Vascular dementia.

The evidence for alpha-GPC is mixed. It's rated possibly effective for Alzheimer disease.

For cognitive function, vascular dementia, stroke, and brain tumors, the evidence we have is insufficient — we can't yet say whether it works for these uses. If you're considering it for any of those conditions, talk it over with your doctor about what the current evidence supports.

The evidence, ingredient by ingredient Alpha-gpc

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Alpha-GPC is generally well tolerated in short-term studies, but long-term safety data isn't fully established. Serious side effects are rare; however, oral use for at least 2 months has been rarely associated with an elevated risk of stroke compared with non-users.

Mild side effects — dizziness, headache, insomnia, nausea, diarrhea, and heartburn — have been reported rarely. The product facts don't include pregnancy or breastfeeding safety information, so talk with your doctor or pharmacist before taking it if you're pregnant, planning to become pregnant, or breastfeeding.

Side effects, ingredient by ingredient Alpha-gpc

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Alpha-gpc.
  • The most serious interaction on file is rated Minor.
  • For scale: 16 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you start Cogni-Spark, double-check if you take scopolamine patches (Transderm Scop) for motion sickness — alpha-GPC may reduce how well they work. Run all your medications through the checker on this page to see the full picture.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Only minor medication interactions are documented, and safety information is well characterized.

Cogni-Spark may be worth considering if you're exploring support for Alzheimer disease, though the evidence is modest and long-term safety isn't fully known. If you take a scopolamine motion sickness patch or any other medications, check them with the tool below first.

Talk with your doctor or pharmacist about whether this product fits your situation and whether the benefit makes sense for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Feb 25, 2019.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Cogni-Spark, straight from the product label.

Brand Health Concerns
Net contents 30 Capsule(s)
Market status On market
Date entered into DSLD Feb 25, 2019
DSLD ID 184535
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Cogni-Spark by Health Concerns, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
30
IngredientAmount% DV
Proprietary Blend300 mg--
Glycerylphosphorylcholine0 NP--

Other ingredients: Silicon Dioxide, Stearic Acid, Gelatin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested Use: One to two capsules 2 times per day between meals.

Precautions

Notice: This product is not intended for use by pregnant women.

Brand IP Statement(s)

Energetic formulas

Combining modern research and ancient wisdom

Formula

Alpha GPC

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Cogni-Spark by Health Concerns label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Cogni-Spark label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Cogni-Spark by Health Concerns

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Proprietary Blend

300 mg per serving

Other (inactive) ingredients: Silicon Dioxide, Stearic Acid, Gelatin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Cogni-Spark by Health Concerns Drug Interactions

Want to check YOUR meds against Cogni-Spark?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
16Drugs
16 Minor

Ingredients driving the most interactions

Glycerylphosphorylcholine 16

Individual Drug Interactions

The ingredients in Cogni-Spark interact with 16 drugs. Click any drug to see the details.

1 of the 1 ingredient in Cogni-Spark interact with drugs. Each result below shows which ingredient is responsible. Glycerylphosphorylcholine

Each ingredient & the kinds of drugs it affects

For each ingredient in Cogni-Spark with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Glycerylphosphorylcholine1 drug type · 16 drugs

Scopolamine (Transderm Scop)

Theoretically, alpha-GPC might decrease the effects of scopolamine.
A small clinical study shows that alpha-GPC can partially counteract the attention and memory impairment effects caused by scopolamine given intramuscularly. Whether alpha-GPC can decrease the beneficial anti-motion sickness effects of the scopolamine patch (Transderm Scop) is unclear.

Likelihood Possible Evidence B
Glycerylphosphorylcholine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Cogni-Spark, from the product label.

Health Concerns

See all Health Concerns products
Name
Health Concerns
Street Address
8001 Capwell Drive
City
Oakland
State
CA
ZipCode
94621
Phone Number
(800) 233-9355
Web Address
www.healthconcerns.com/pro
Pharmacist Counseling Corner

Cogni-Spark by Health Concerns: Common Questions

Does Cogni-Spark by Health Concerns interact with any medications?
Yes. Based on its ingredients, Cogni-Spark has a known interaction with 16 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Cogni-Spark contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does alpha-GPC actually improve memory or brain function?
The evidence varies by use. It's rated possibly effective for Alzheimer disease, but for general cognitive function, the evidence we hold is insufficient to say it works. Talk with your doctor about your specific situation.
What are the side effects?
Most people tolerate alpha-GPC well. Rare side effects include dizziness, headache, insomnia, nausea, diarrhea, and heartburn. A more serious but rare concern is that oral use for 2 months or longer has been rarely linked to an elevated stroke risk — something to discuss with your doctor before starting, especially if you have stroke risk factors.
Is it safe to take long-term?
Long-term safety data isn't fully established, so it's not something to take indefinitely without talking to your doctor first. The long-term stroke risk mentioned above is important to weigh in that conversation.
Can I take this while pregnant or breastfeeding?
The product facts don't include safety information for pregnancy or breastfeeding. Talk with your doctor or pharmacist before using Cogni-Spark in either situation so they can give you personalized advice.
What is alpha-GPC?
Alpha-GPC (glycerylphosphorylcholine) is a compound your brain naturally contains. It's thought to support communication between brain cells, which is why it's studied for memory and cognitive support.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Cogni-Spark is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Cogni-Spark label
Go deeper

The Full Monographs Behind Cogni-Spark’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Alpha-gpc

Interacts with 16 drugs

Alpha-GPC is a choline-containing compound used mainly for memory, brain health, and as a choline source. There is some evidence it may help cognition in people with dementia, but evidence i...

Read the full Alpha-gpc monograph →
Sources

Sources & How We Checked

Cogni-Spark's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 4 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Alpha-gpc 4 references
  1. Di Perri R, Coppola G, Ambrosio LA, et al. A multicentre trial to the evaluate the efficacy and tolerability of alpha-glycerylphosphorylcholine versus cytosine diphosphocholine in patients with vascular dementia. J Int Med Res 1991;19:330-41.
  2. Barbagallo Sangiorgi G, Barbagallo M, Giordano M, et al. Alpha-glycerophosphocholine in the mental recovery of cerebral ischemic attacks: An Italian multicenter clinical trial. Ann N Y Acad Sci 1994;717:253-69. PubMed
  3. Canal N, Franceschi M, Alberoni M, et al. Effect of L-alpha-glyceryl-phosphorylcholine on amnesia caused by scopolamine. Int J Clin Pharmacol Ther Toxicol 1991;29:103-7.
  4. Lee G, Choi S, Chang J, et al. Association of L-a glycerylphosphorylcholine with subsequent stroke risk after 10 Years. JAMA Netw Open 2021;4(11):e2136008.

See these in context on the Alpha-gpc monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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