Interactions on record — worth a quick check against your medications. Based on 4 of 5 ingredients. Check your meds →
Dietary supplement

Colon Optimizer Ingredients & Drug Interactions

by Yes You Can!

Colon Optimizer label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Colon Optimizer against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Colon Optimizer is a dietary supplement by Yes You Can! with 5 active ingredients. Its ingredients are commonly taken for digestive and gut health, source of soluble fiber, constipation or bowel regularity.Based on those ingredients, 2,197 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Acacia, Ginger (root) extract, Peppermint (leaf) extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Colon Optimizer by Yes You Can!

Ask about any prescription or over-the-counter medication and we check it for interactions with Colon Optimizer by Yes You Can! — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Colon Optimizer by Yes You Can!

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 5 active ingredients.
  • “Proprietary Blend” is a proprietary blend — the label gives one combined amount (200 mg) without saying how much of each component you get.

Colon Optimizer contains 5 active ingredients in a proprietary blend. Acacia (gum arabic) is a soluble fiber that's been used as a food additive for centuries.

Psyllium is another fiber type, though we hold no interaction data for it. Ginger root extract provides a warming herbal component traditionally used for digestive comfort.

Peppermint leaf extract offers a cooling effect and is often used in formulas for bowel health. Bacillus coagulans is a spore-forming probiotic — a live organism intended to support digestive flora.

The capsules are filled with rice bran, gelatin, and medium chain triglycerides as inactive ingredients.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: Colon and digestive health support.
  • We looked for evidence on: Abdominal pain, Antibiotic-associated diarrhea, Clostridioides difficile infection, Constipation, Diarrhea, Dyspepsia — and 4 related terms.
  • The strongest evidence on file: Peppermint is rated "Likely Effective" for Irritable bowel syndrome (IBS) (Natural Medicines).
  • Also on file: Peppermint is rated "Possibly Effective" for Dyspepsia.
  • Also on file: Bacillus Coagulans is rated "Possibly Effective" for Constipation, Irritable bowel syndrome (IBS).

The evidence for acacia is limited: our data shows insufficient reliable evidence to rate it for metabolic syndrome, kidney failure, sickle cell disease, obesity, gingivitis, or peristomal lesions. Ginger root has some support — it's rated Possibly Effective for pregnancy-related nausea, vomiting, dysmenorrhea (menstrual pain), and osteoarthritis, though it was rated Possibly Ineffective for muscle soreness from exercise.

Peppermint leaf is Likely Effective for irritable bowel syndrome (IBS) and Possibly Effective for indigestion, nausea from chemotherapy, and reducing colon spasms during barium enema or endoscopy. Bacillus coagulans is Possibly Effective for constipation and IBS, though evidence for antibiotic-associated diarrhea is insufficient.

Overall, peppermint and the probiotic have the strongest data for bowel function.

The evidence, ingredient by ingredient Gum Arabic Ginger Peppermint Bacillus Coagulans

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Acacia is generally recognized as safe as a food additive; however, supplemental doses haven't been well studied. The main side effects are gastrointestinal — bloating, flatulence, diarrhea, nausea, and vomiting — which occurred in a small study at varying rates but often subsided within 2 weeks.

Ginger is generally well tolerated at typical amounts, though doses above 5 grams per day increase side effects. Common mild effects include heartburn, diarrhea, burping, and a pepper-like mouth irritation; these may be reduced by taking encapsulated ginger.

Peppermint is generally well tolerated in food and tea amounts, but concentrated oil should be used cautiously. Side effects can include abdominal pain, anal burning, heartburn, and nausea.

Bacillus coagulans is generally well tolerated in healthy adults, but there is concern it could cause infection in severely ill or immunocompromised patients with central lines. Pregnancy and lactation safety data are limited for acacia and Bacillus coagulans; ginger is rated Likely Safe in pregnancy and lactation; peppermint is Likely Safe in pregnancy and lactation.

Side effects, ingredient by ingredient Gum Arabic Ginger Peppermint Bacillus Coagulans

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 4 of the 4 matched ingredients can interact with medications — Gum Arabic, Peppermint, Ginger, Bacillus Coagulans.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 2,198 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Colon Optimizer, check with your pharmacist if you take blood thinners like warfarin or phenprocoumon, blood pressure medications (especially nifedipine or losartan), diabetes drugs, antibiotics (especially amoxicillin — separate by 2 hours), cancer medications, cyclosporine, or any drug metabolized by liver enzymes CYP3A4, CYP2C19, or CYP2C9. No interactions are documented for psyllium, the ingredient we could not check.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

If you're dealing with constipation or irritable bowel symptoms, the peppermint and probiotic in this formula have decent evidence behind them. However, you'll want to double-check your medications first — especially blood thinners, diabetes drugs, antibiotics, and any CYP3A4 or CYP2C substrates — because several ingredients here can interact.

If you take amoxicillin, space it 2 hours away from this product. Talk to your pharmacist about your full medication list before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Mar 24, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Colon Optimizer, straight from the product label.

Brand Yes You Can!
Barcode (UPC) 804879580317
Net contents 30 Capsule(s)
Market status On market
Date entered into DSLD Mar 24, 2020
DSLD ID 215674
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Colon Optimizer by Yes You Can!, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
30
UPC/BARCODE
804879580317
IngredientAmount% DV
Proprietary Blend200 mg--
Acacia0 NP--
Psyllium0 NP--
Ginger (root) extract0 NP--
Peppermint (leaf) extract0 NP--
Bacillus coagulans0 NP--

Other ingredients: Rice Bran, Gelatin, Medium Chain Triglycerides

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Seals/Symbols

Manufactured in the USA with imported and domestic ingredients

Suggested/Recommended/Usage/Directions

Directions: Take one (1) capsule with your first meal of the day and a full glass of water, or as recommended by a healthcare practitioner

Precautions

Warning: Do not use if pregnant, nursing, or under the age of 18. Consult your doctor prior to use, especially if you are taking any medications or dietary supplements, or if you have or suspect you may have any medical condition.

Immediately discontinue use and consult your doctor if any adverse reactions occur.

Warning: Do not use if pregnant, nursing, or under the age of 18. Keep out of reach of children.

Do not exceed recommended serving.

Do not use if seal is broken or damaged.

Storage

Keep tightly closed in a cool dry place, and do not expose to excessive heat.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Brand IP Statement(s)

2017 Yes You Can! All rights reserved.

FDA Statement of Identity

Dietary Supplement

Formulation

Promotes healthy digestive function

General Statements

Platinum YesYouCan! Guarantee

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Colon Optimizer by Yes You Can! label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Colon Optimizer label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Colon Optimizer by Yes You Can!

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Blend

200 mg per serving

Bacillus coagulans

Interacts with
182 drugs
0 NP per serving

Bacillus coagulans is a spore-forming probiotic that survives stomach acid well and may help with some digestive problems such as IBS, constipation, a...

Bacillus coagulans monograph & interactions

Other (inactive) ingredients: Rice Bran, Gelatin, Medium Chain Triglycerides. These complete the product’s ingredient list but are not active constituents.

Interaction report

Colon Optimizer by Yes You Can! Drug Interactions

Want to check YOUR meds against Colon Optimizer?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
2,197Drugs
2,193 Moderate 4 Minor

Ingredients driving the most interactions

Acacia 2,022
Ginger (root) extract 1,007
Peppermint (leaf) extract 796
Bacillus coagulans 182

Individual Drug Interactions

The ingredients in Colon Optimizer interact with 2,197 drugs. Click any drug to see the details.

4 of the 5 ingredients in Colon Optimizer interact with drugs. Each result below shows which ingredient is responsible. Acacia Ginger (root) extract Peppermint (leaf) extract Bacillus coagulans

Each ingredient & the kinds of drugs it affects

For each ingredient in Colon Optimizer with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Acacia2 drug types · 2,022 drugs

Amoxicillin (Amoxil, Trimox)

Gum arabic can reduce the absorption of amoxicillin.
A small study in healthy volunteers shows that taking amoxicillin and gum arabic concurrently significantly reduces the absorption of amoxicillin. Separate doses of amoxicillin from gum arabic by at least 2 hours.

Likelihood Probable Evidence B
Oral Drugs

Theoretically, gum arabic can alter the absorption of oral drugs due to its fiber content.
Gum arabic has been used as a suspending osmotic agent in drug formulations. It might improve bioavailability of water-insoluble drugs like naproxen, but reduce absorption of polar drugs like amoxicillin. To avoid changes in absorption, take gum arabic 30-60 minutes after oral medications.

Likelihood Possible Evidence B
Acacia full monograph & interactions

Ginger (root) extract14 drug types · 1,007 drugs

Anticoagulant/Antiplatelet Drugs

Ginger may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs. However, research is conflicting.
Laboratory research suggests that ginger inhibits thromboxane synthetase and decreases platelet aggregation. However, this has not been demonstrated unequivocally in humans, with mixed results from clinical trials. Theoretically, excessive amounts of ginger might increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.

Likelihood Possible Evidence B
Antidiabetes Drugs

Theoretically, taking ginger with antidiabetes drugs might increase the risk of hypoglycemia.
Animal and human research suggests that ginger might increase insulin levels and/or decrease blood glucose levels.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Ginger might increase or decrease the levels of CYP3A4 substrates.
In vitro research and some case reports suggest that ginger inhibits CYP3A4 activity. Three case reports from the World Health Organization (WHO) adverse drug reaction database describe increased toxicity in patients taking ginger and cancer medications that are CYP3A4 substrates (imatinib, dabrafenib, and crizotinib). However, the causality of this interaction is unclear due to the presence of multiple interacting drugs and routes of administration.
Conversely, other in vitro research suggests that ginger induces CYP3A4 activity, leading to reduced levels of CYP3A4 substrates. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Losartan (Cozaar)

Theoretically, ginger might increase levels of losartan and the risk of hypotension.
In animal research, ginger increased the levels and hypotensive effects of a single dose of losartan. It is not clear if ginger alters the concentration or effects of losartan when taken continuously. Additionally, this interaction has not been shown in humans.

Likelihood Possible Evidence D
Nifedipine (Procardia)

Ginger may have antiplatelet effects and increase the risk of bleeding if used with nifedipine.
Clinical research shows that combined treatment with ginger 1 gram plus nifedipine 10 mg significantly inhibits platelet aggregation when compared to nifedipine or ginger alone.

Likelihood Possible Evidence B
P-Glycoprotein Substrates

Ginger might increase the absorption and blood levels of P-glycoprotein (P-gp) substrates.
In vitro research and case reports suggest that ginger inhibits drug efflux by P-gp, potentially increasing absorption and serum levels of P-gp substrates. Two case reports from the World Health Organization (WHO) adverse drug reaction database describe increased toxicity in patients taking ginger and cancer medications that are P-gp substrates (trametinib, crizotinib). However, the causality of this interaction is unclear due to the presence of multiple interacting drugs and routes of administration.

Likelihood Possible Evidence D
Phenprocoumon (Marcoumar, Others)

Ginger might increase the risk of bleeding with phenprocoumon.
Phenprocoumon, a warfarin-related anticoagulant, might increase the international normalized ratio (INR) when taken with ginger. There is one case report of a 76-year-old woman with a stable INR on phenprocoumon that increased to greater than 10 when she began consuming dried ginger and ginger tea.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Ginger might increase the risk of bleeding with warfarin.
Laboratory research suggests that ginger might inhibit thromboxane synthetase and decrease platelet aggregation. In one case report, ginger increased the INR when taken with phenprocoumon, which has similar pharmacological effects as warfarin. In another case report, ginger increased the INR when taken with a combination of warfarin, hydrochlorothiazide, and acetaminophen. A longitudinal analysis suggests that taking ginger increases the risk of bleeding in patients taking warfarin for at least 4 months. However, research in healthy people suggests that ginger has no effect on INR, or the pharmacokinetics or pharmacodynamics of warfarin. Until more is known, monitor INRs closely in patients taking large amounts of ginger.

Likelihood Possible Evidence B
Calcium Channel Blockers

Theoretically, taking ginger with calcium channel blockers might increase the risk of hypotension.
Some animal and in vitro research suggests that ginger has hypotensive and calcium channel-blocking effects. Another animal study shows that concomitant administration of ginger and the calcium channel blocker amlodipine leads to greater reductions in blood pressure when compared with amlodipine alone.

Likelihood Unlikely Evidence D
Cyclosporine (Neoral, Sandimmune)

Theoretically, when taken prior to cyclosporine, ginger might decrease cyclosporine levels.
In an animal model, ginger juice taken 2 hours prior to cyclosporine administration reduced the maximum concentration and area under the curve of cyclosporine by 51% and 40%, respectively. This effect was not observed when ginger juice and cyclosporine were administered at the same time.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, ginger might increase the levels of CYP1A2 substrates.
In vitro research shows that ginger inhibits CYP1A2 activity. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2B6 (Cyp2B6) Substrates

Theoretically, ginger might increase the levels of CYP2B6 substrates.
In vitro research shows that ginger inhibits CYP2B6 activity. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, ginger might increase the levels of CYP2C9 substrates.
In vitro research shows that ginger inhibits CYP2C9 activity. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Metronidazole (Flagyl)

Theoretically, ginger might increase levels of metronidazole.
In an animal model, ginger increased the absorption and plasma half-life of metronidazole. In addition, the elimination rate and clearance of metronidazole was significantly reduced.

Likelihood Possible Evidence D
Ginger (root) extract full monograph & interactions

Peppermint (leaf) extract5 drug types · 796 drugs

Cyclosporine (Neoral, Sandimmune)

Theoretically, peppermint oil might increase the levels and adverse effects of cyclosporine.
In animal research, peppermint oil inhibits cyclosporine metabolism and increases cyclosporine levels. Inhibition of cytochrome P450 3A4 (CYP3A4) may be partially responsible for this interaction. An interaction between peppermint oil and cyclosporine has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, peppermint might increase the levels of CYP2C19 substrates.
In vitro research shows that peppermint oil inhibits CYP2C19. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, peppermint might increase the levels of CYP2C9 substrates.
In vitro research shows that peppermint oil inhibits CYP2C9. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, peppermint might increase the levels of CYP3A4 substrates.
Clinical research in healthy volunteers shows that a single dose of peppermint oil 600 mg inhibits CYP3A4 enzymes and increases the AUC of felodipine, a CYP3A4 substrate. However, in vitro research suggests that peppermint oil only inhibits CYP3A4 at very high concentrations.

Likelihood Possible Evidence B
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, peppermint might increase the levels of CYP1A2 substrates.
In vitro and animal research shows that peppermint oil and peppermint leaf inhibit CYP1A2. However, in clinical research, peppermint tea did not significantly affect the metabolism of caffeine, a CYP1A2 substrate. It is possible that the 6-day duration of treatment may have been too short to identify a difference.

Likelihood Possible Evidence B
Peppermint (leaf) extract full monograph & interactions

Bacillus coagulans1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking antibiotics with Bacillus coagulans might decrease the effectiveness of B. coagulans.
B. coagulans preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. coagulans preparations by at least two hours.

Likelihood Probable Evidence D
Bacillus coagulans full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Colon Optimizer, from the product label.

Yes You Can!

See all Yes You Can! products
Name
Chaban Wellness LLC,
Street Address
657 South Drive, Suite 403
City
Miami Springs
State
FL
ZipCode
33166
Web Address
YesYouCan.com
Pharmacist Counseling Corner

Colon Optimizer by Yes You Can!: Common Questions

Does Colon Optimizer by Yes You Can! interact with any medications?
Yes. Based on its ingredients, Colon Optimizer has a known interaction with 2,197 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Colon Optimizer contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this with my antibiotic amoxicillin?
Not at the same time. The acacia in this product can reduce amoxicillin absorption, making it less effective. Take amoxicillin at least 2 hours before or after Colon Optimizer. Check with your doctor or pharmacist for the best timing.
Will this help my IBS?
The peppermint and fiber may help. Peppermint is rated Likely Effective for irritable bowel syndrome, and Bacillus coagulans (the probiotic) is Possibly Effective for IBS. Results vary by person — it's worth a try, but give it time and talk to your doctor if you don't see improvement.
What are the most common side effects?
Gum arabic and ginger can both cause bloating, gas, diarrhea, nausea, and heartburn. Peppermint may add abdominal pain or anal irritation. These are usually mild and often settle down within a couple of weeks. If they don't, stop and tell your pharmacist.
Is this safe during pregnancy?
Ginger is rated Likely Safe and peppermint Likely Safe in pregnancy and lactation, which is reassuring. However, acacia and Bacillus coagulans don't have enough safety data in pregnancy. Talk with your doctor or midwife before starting if you're pregnant or nursing — they know your full picture.
Can I take this with my blood thinner?
Not without checking first. The ginger in this product may increase bleeding risk when combined with blood thinners like warfarin or phenprocoumon. This is a Moderate interaction, so talk to your pharmacist or doctor before adding this supplement.
What's the probiotic in here for?
Bacillus coagulans is a live microorganism meant to support healthy gut bacteria. It's Possibly Effective for constipation and IBS. However, don't take it at the same time as antibiotics — they'll kill the bacteria. Separate them by a few hours.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Colon Optimizer label
Go deeper

The Full Monographs Behind Colon Optimizer’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Gum Arabic

Interacts with 2,022 drugs

Gum arabic is a soluble dietary fiber from the acacia tree that is widely used as a safe food additive and is sometimes taken as a supplement for digestive health and as a prebiotic. Early s...

Read the full Gum Arabic monograph → Herb & supplement monograph

Ginger

Interacts with 1,007 drugs

Ginger is a widely used culinary spice with a long history in traditional medicine, and it has the strongest evidence for helping with nausea and vomiting, including from motion sickness, pr...

Read the full Ginger monograph → Herb & supplement monograph

Peppermint

Interacts with 796 drugs

Peppermint is a popular herb with the best evidence supporting enteric-coated peppermint oil for easing IBS symptoms. It is generally well tolerated for most adults, but it can cause heartbu...

Read the full Peppermint monograph → Herb & supplement monograph

Bacillus Coagulans

Interacts with 182 drugs

Bacillus coagulans is a spore-forming probiotic that survives stomach acid well and may help with some digestive problems such as IBS, constipation, and certain types of diarrhea. The eviden...

Read the full Bacillus Coagulans monograph →
Sources

Sources & How We Checked

Colon Optimizer's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 133 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Gum Arabic 8 references
  1. Jensen CD, Spiller GA, Gates JE, et al. The effect of acacia gum and a water-soluble dietary fiber mixture on blood lipids in humans. J Am Coll Nutr 1993;12:147-54. PubMed
  2. Eltayeb IB, Awad AI, Elderbi MA, Shadad SA. Effect of gum arabic on the absorption of a single oral dose of amoxicillin in healthy Sudanese volunteers. J Antimicrob Chemother 2004;54:577-8. PubMed
  3. Babiker R, Merghani TH, Elmusharaf K, et al. Effects of gum Arabic ingestion on body mass index and body fat percentage in healthy adult females: two-arm randomized, placebo controlled, double-blind trial. Nutr J 2012;11:111. PubMed
  4. Babiker R, Elmusharaf K, Keogh MB, Banaga AS, Saeed AM. Metabolic effect of gum Arabic (Acacia senegal) in patients with type 2 diabetes mellitus (T2DM): randomized, placebo controlled double blind trial. Functional Foods in Health and Disease. 2017;7(3): DOI
  5. Beneke CE, Viljoen AM, Hamman JH. Polymeric plant-derived excipients in drug delivery. Molecules. 2009;14(7):2602-20. PubMed
  6. Ali NE, Kaddam LA, Alkarib SY, et al. Gum Arabic (Acacia Senegal) Augmented Total Antioxidant Capacity and Reduced C-Reactive Protein among Haemodialysis Patients in Phase II Trial. Int J Nephrol. 2020;2020:7214673.
  7. Mortensen A, Aguilar F, Crebelli R, et al. Re-evaluation of acacia gum (E 414) as a food additive. EFSA J. 2017;15(4):e04741. PubMed
  8. Larson R, Nelson C, Korczak R, et al. Acacia Gum Is Well Tolerated While Increasing Satiety and Lowering Peak Blood Glucose Response in Healthy Human Subjects. Nutrients 2021;13(2):618. PubMed

See these in context on the Gum Arabic monograph →

Ginger 64 references
  1. Fischer-Rasmussen W, Kjaer SK, Dahl C, Asping U. Ginger treatment of hyperemesis gravidarum. Eur J Obstet Gynecol Reprod Biol 1991;38:19-24. PubMed
  2. Jewell D, Young G. Interventions for nausea and vomiting in early pregnancy. Cochrane Database Syst Rev 2000;(2):CD000145. PubMed
  3. Vutyavanich T, Kraisarin T, Ruangsri R. Ginger for nausea and vomiting in pregnancy: randomized, double-masked, placebo-controlled trial. Obstet Gynecol 2001;97:577-82. DOI
  4. Backon J. Ginger in preventing nausea and vomiting of pregnancy; a caveat due to its thromboxane synthetase activity and effect on testosterone binding. Eur J Obstet Gynecol Reprod Biol 1991;42:163-4. PubMed
  5. Srivastava KC. Effect of onion and ginger consumption on platelet thromboxane production in humans. Prostaglandins Leukot Essent Fatty Acids 1989;35:183-5. PubMed
  6. Stewart JJ, Wood MJ, Wood CD, Mims ME. Effects of ginger on motion sickness susceptibility and gastric function. Pharmacology 1991;42:111-20. PubMed
  7. Smith C, Crowther C, Willson K, et al. A randomized controlled trial of ginger to treat nausea and vomiting in pregnancy. Obstet Gynecol 2004;103:639-45. PubMed
  8. Portnoi G, Chng LA, Karimi-Tabesh L, et al. Prospective comparative study of the safety and effectiveness of ginger for the treatment of nausea and vomiting in pregnancy. Am J Obstet Gynecol 2003;189:1374-7.. PubMed
  9. Wigler I, Grotto I, Caspi D, Yaron M. The effects of Zintona EC (a ginger extract) on symptomatic gonarthritis. Osteoarthritis Cartilage 2003;11:783-9. PubMed
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Peppermint 41 references
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Bacillus Coagulans 20 references
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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