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Dietary supplement

Coltsfoot & Wormwood Ingredients & Drug Interactions

by TerraVita

Coltsfoot & Wormwood label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Coltsfoot & Wormwood against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Coltsfoot & Wormwood is a dietary supplement by TerraVita with 1 active ingredient. Its ingredients are commonly taken for cough, sore throat, bronchitis and congestion.Based on those ingredients, 1,121 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Coltsfoot & Wormwood Glycerite Liquid Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Coltsfoot & Wormwood by TerraVita

Ask about any prescription or over-the-counter medication and we check it for interactions with Coltsfoot & Wormwood by TerraVita — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Coltsfoot & Wormwood by TerraVita

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 2 active ingredients.
  • “Coltsfoot & Wormwood Glycerite Liquid Extract” is listed as a grouped ingredient — the label gives one combined amount (0.13 mL) without saying how much of each component you get.

This product contains 2 active ingredients: coltsfoot glycerite liquid extract and wormwood glycerite liquid extract. Both are concentrated plant extracts delivered in glycerin, a common carrier for herbal supplements.

The only other ingredient listed is glycerin itself, which serves as the base.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded its ingredients' overall clinical evidence instead.

Moderate

Some clinical evidence supports its ingredients for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredients' overall clinical evidence instead.
  • On file: Allergic rhinitis (hay fever) — rated "Possibly Effective" (Sweet Annie) (Natural Medicines).

The data we hold shows wormwood may be possibly effective for allergic rhinitis (hay fever), though evidence is limited. For wormwood's other proposed uses — nonalcoholic fatty liver disease, malaria, and osteoarthritis — the evidence isn't established enough to rate.

We hold no effectiveness ratings for coltsfoot in our data.

The evidence, ingredient by ingredient Coltsfoot Sweet Annie

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Coltsfoot carries serious safety concerns. It contains pyrrolizidine alkaloids (liver-toxic compounds) that can cause liver and lung injury with chronic use, including a condition called veno-occlusive disease with symptoms like belly pain, vomiting, diarrhea, and fluid buildup.

Only certified pyrrolizidine-alkaloid-free products should be considered, if at all. The safety data advises against coltsfoot during pregnancy and while breastfeeding due to potential liver toxicity and harm to the baby.

Wormwood is generally well tolerated at typical doses, though nausea and vomiting occur in some users. Rare cases of liver injury have been reported.

There isn't enough safety information to know whether wormwood is safe while breastfeeding, and the safety data advises against it during pregnancy. Wormwood is meant for short-term use and shouldn't replace proven treatments.

Side effects, ingredient by ingredient Coltsfoot Sweet Annie

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Coltsfoot, Sweet Annie.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 1,122 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check your medications against these categories: blood thinners and antiplatelet drugs (Moderate risk of bleeding), blood pressure medications (Moderate risk of interference), drugs that induce CYP3A4 (Moderate risk of worsening liver toxicity), and drugs metabolized by CYP3A4 or CYP2B6 (Moderate risk of altered drug levels). Also flag any other medications that affect the liver or are processed by your liver, since both ingredients carry hepatotoxicity risk.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

This product carries serious interactions with blood thinners and multiple other drug categories, plus genuine concerns about liver and lung toxicity from coltsfoot's alkaloid content. If you take any medications — especially blood thinners, blood pressure drugs, or anything metabolized by your liver — check with your pharmacist before using it.

It should not be used during pregnancy or breastfeeding.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 22, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Coltsfoot & Wormwood, straight from the product label.

Brand TerraVita
Barcode (UPC) 064435223120
Net contents 1 Fluid Ounce(s); 30 mL
Market status On market
Date entered into DSLD Nov 22, 2022
DSLD ID 280025
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Coltsfoot & Wormwood by TerraVita, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
25 Drop(s)
Maximum serving Sizes:
40 Drop(s)
Servings per container
227
UPC/BARCODE
064435223120
IngredientAmount% DV
Coltsfoot Glycerite Liquid Extract0 NP--
Wormwood Glycerite Liquid Extract0 NP--
Coltsfoot & Wormwood Glycerite Liquid Extract0.13 mL--

Other ingredients: Glycerin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

Copyright 2018 TerraVita - Distributed by ZooScape LLC, All Rights Reserved.

Formula

Glycerite liquid extract (1:5)

Formulation

Alcohol free No flavor

Suggested/Recommended/Usage/Directions

Suggested Use: Take 25-40 drops of extract in a small amount of warm water 3-4 times daily. Shake well before using.

Precautions

Keep away from children.

Do not use if safety seal around cap is broken or missing.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Coltsfoot & Wormwood by TerraVita label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Coltsfoot & Wormwood label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Coltsfoot & Wormwood by TerraVita

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size25 Drop(s) Dosage formLiquid Servings per container227 Amounts shown are per serving.

Coltsfoot & Wormwood Glycerite Liquid Extract

Interacts with
374 drugs
0.13 mL per serving

Coltsfoot is a traditional herb long used to soothe coughs and clear mucus, but solid human evidence for these uses is lacking. More importantly, the...

Coltsfoot & Wormwood Glycerite Liquid Extract monograph & interactions

Other (inactive) ingredients: Glycerin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Coltsfoot & Wormwood by TerraVita Drug Interactions

Want to check YOUR meds against Coltsfoot & Wormwood?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,121Drugs
1,121 Moderate

Ingredients driving the most interactions

Coltsfoot & Wormwood Glycerite Liquid Extract 374

Individual Drug Interactions

The ingredients in Coltsfoot & Wormwood interact with 1,121 drugs. Click any drug to see the details.

1 of the 1 ingredient in Coltsfoot & Wormwood interact with drugs. Each result below shows which ingredient is responsible. Coltsfoot & Wormwood Glycerite Liquid Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Coltsfoot & Wormwood with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Coltsfoot & Wormwood Glycerite Liquid Extract3 drug types · 374 drugs

Anticoagulant/Antiplatelet Drugs

Concomitant use might increase the risk of bleeding due to decreased platelet aggregation. Coltsfoot has been reported to inhibit platelet aggregation; avoid concomitant use. Some of these drugs include aspirin, clopidogrel (Plavix), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, ticlopidine (Ticlid), warfarin (Coumadin), and others.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, excessive doses of coltsfoot may interfere with antihypertensive or cardiovascular therapy.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Inducers

Hepatotoxic pyrrolizidine alkaloids (PA) are substrates of cytochrome P450 3A4 (CYP3A4). Theoretically, drugs that induce CYP3A4 might increase the conversion of PAs to toxic metabolites. Some drugs that induce CYP3A4 include carbamazepine (Tegretol), phenobarbital, phenytoin (Dilantin), rifampin, rifabutin (Mycobutin), and others.

Likelihood Possible Evidence D
Coltsfoot & Wormwood Glycerite Liquid Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Coltsfoot & Wormwood, from the product label.

TerraVita

See all TerraVita products
Name
ZooScape LLC
Phone Number
844-449-0444
Web Address
www.ZooScape.com
Pharmacist Counseling Corner

Coltsfoot & Wormwood by TerraVita: Common Questions

Does Coltsfoot & Wormwood by TerraVita interact with any medications?
Yes. Based on its ingredients, Coltsfoot & Wormwood has a known interaction with 1,121 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Coltsfoot & Wormwood contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm on a blood thinner like warfarin or aspirin?
No — coltsfoot inhibits platelet aggregation and increases bleeding risk with these drugs. Avoid concomitant use. Talk to your pharmacist or doctor before using this product if you take any blood thinner or antiplatelet medication.
Is this safe during pregnancy or breastfeeding?
No. The safety data advises against coltsfoot during pregnancy due to potential liver toxicity and harm to the baby, and against it while breastfeeding because toxic alkaloids may pass into breast milk. Wormwood should also be avoided during pregnancy and while breastfeeding due to insufficient safety data.
What's the main safety concern with coltsfoot in this product?
Coltsfoot contains liver-toxic pyrrolizidine alkaloids that can cause liver and lung injury, especially with chronic use. This can lead to a serious condition called veno-occlusive disease with symptoms like belly pain, vomiting, diarrhea, and liver enlargement. Use only certified pyrrolizidine-alkaloid-free products, if at all.
Does wormwood work for anything?
The data shows wormwood is possibly effective for allergic rhinitis (hay fever), though evidence is limited. For other uses like liver disease or malaria, the evidence isn't established enough to rate.
What are the common side effects?
Wormwood typically causes nausea and vomiting in some users. Serious liver injury is rare but has been reported. Coltsfoot's main concern is liver and lung damage from its alkaloid content rather than acute side effects.
Can I use this long-term?
No. Wormwood should not be used long-term — it's meant for short-term use only. Coltsfoot also carries cumulative liver and lung risks with chronic exposure and should not be used without certified pyrrolizidine-alkaloid-free certification, if at all.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Coltsfoot & Wormwood label
Go deeper

The Full Monographs Behind Coltsfoot & Wormwood’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Coltsfoot

Interacts with 374 drugs

Coltsfoot is a traditional herb long used to soothe coughs and clear mucus, but solid human evidence for these uses is lacking. More importantly, the raw plant can contain liver-toxic pyrrol...

Read the full Coltsfoot monograph → Herb & supplement monograph

Sweet Annie

Interacts with 889 drugs

Sweet Annie (Artemisia annua) is the source of artemisinin, a compound used in prescription antimalarial drugs. While the purified drug is well studied for malaria, the herb itself as a supp...

Read the full Sweet Annie monograph →
Sources

Sources & How We Checked

Coltsfoot & Wormwood's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 19 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Coltsfoot 8 references
  1. Roulet M, Laurini R, Rivier L, Calame A. Hepatic veno-occlusive disease in newborn infant of a woman drinking herbal tea. J Pediatr 1988;112:433-6. PubMed
  2. WHO working group. Pyrrolizidine alkaloids. Environmental Health Criteria, 80. WHO: Geneva, 1988.
  3. Chojkier M. Hepatic sinusoidal-obstruction syndrome: toxicity of pyrrolizidine alkaloids. J Hepatol 2003;39:437-46. PubMed
  4. Roeder E. Medicinal plants in Europe containing pyrrolizidine alkaloids. Pharmazie 1995;50:83-98.
  5. Wilson BE, Hobbs WN. Case report: pseudoephedrine-associated thyroid storm: thyroid hormone-catecholamine interactions. Am J Med Sci 1993;306:317-9. PubMed
  6. Wang YP, Yan J, Fu PP, Chou MW. Human liver microsomal reduction of pyrrolizidine alkaloid N-oxides to form the corresponding carcinogenic parent alkaloid. Toxicol Lett 2005;155:411-20. PubMed
  7. Hwang SB, Chang MN, Garcia ML, et al. L-652,469--a dual receptor antagonist of platelet activating factor and dihydropyridines from Tussilago farfara L. Eur J Pharmacol 1987;141:269-81. PubMed
  8. Freshour JE, Odle B, Rikhye S, Stewart DW. Coltsfoot as a potential cause of deep vein thrombosis and pulmonary embolism in a patient also consuming kava and blue vervain. J Diet Suppl 2012;9:149-54. PubMed

See these in context on the Coltsfoot monograph →

Sweet Annie 11 references
  1. Mueller MS, Karhagomba IB, Hirt HM, Wemakor E. The potential of Artemisia annua L. as a locally produced remedy for malaria in the tropics: agricultural, chemical and clinical aspects. J Ethnopharmacol 2000;73:487-93. PubMed
  2. Rath K, Taxis K, Walz G, et al. Pharmacokinetic study of artemisinin after oral intake of a traditional preparation of Artemisia annua L. (annual wormwood). Am J Trop Med Hyg 2004;70:128-32. DOI
  3. Centers for Disease Control and Prevention (CDC). Hepatitis temporally associated with an herbal supplement containing artemisinin-Washington, 2008. MMWR Morb Mortal Wkly Rep 2009;58:854-8.
  4. Xing J, Kirby BJ, Whittington D, et al. Evaluation of P450 inhibition and induction by artemisinin antimalarials in human liver microsomes and primary human hepatocytes. Drug Metabl Dispos 2012;40(9):1757-64. PubMed
  5. Savage RL, Hill GR, Barnes J, Kenyon SH, Tatley MV. Suspected hepatotoxicity with a supercritical carbon dioxide extract of Artemisia annua in grapeseed oil used in New Zealand. Front Pharmacol. 2019;10:1448. PubMed
  6. Ruperti-Repilado FJ, Haefliger S, Rehm S, et al. Danger of herbal tea: a case of acute cholestatic hepatitis due to Artemisia annua tea. Front Med (Lausanne). 2019;6:221. PubMed
  7. Yang J, Shen Z, Liu L, et al. Clinical efficacy and safety of Artesimia annua-Sublingual immunotherapy in seasonal allergic rhinitis patients based on different intervention time. Int Arch Allergy Immunol 2022;183(8):852-859.
  8. Kane NF, Kiani BH, Desrosiers MR, Towler MJ, Weathers PJ. Artemisia extracts differ from artemisinin effects on human hepatic CYP450s 2B6 and 3A4 in vitro. J Ethnopharmacol 2022. DOI
  9. Feng Y, Cao Y, Liu Y, et al. Clinical efficacy and safety of coseasonal initiation of Artemisia annua sublingual immunotherapy on patients with Artemisia-induced rhinoconjunctivitis. Am J Otolaryngol 2023;44(5):103942. PubMed
  10. Yang J, Wang W, Shen Z, et al. Efficacy and safety of Artemisia annua sublingual immunotherapy in patients with seasonal allergic rhinoconjunctivitis over two pollen seasons. Eur Arch Otorhinolaryngol. 2023;280(11):4939-4947. PubMed
  11. Shen Z, Zhang P, Kang W, et al. Clinical efficacy in one-year treatment with Artemisia annua-SLIT drops in monosensitized and polysensitized individuals. Am J Otolaryngol 2023;44(6):104002. PubMed

See these in context on the Sweet Annie monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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