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Dietary supplement

Comfrey Leaf Chocolate Flavor Ingredients & Drug Interactions

by TerraVita

Comfrey Leaf Chocolate Flavor label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Comfrey Leaf Chocolate Flavor against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Comfrey Leaf Chocolate Flavor is a dietary supplement by TerraVita with 1 active ingredient. Its ingredients are commonly taken for bruises and sprains, muscle and joint pain, minor wounds and skin irritation.Based on those ingredients, 438 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Comfrey Leaf Glycerite Liquid Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Comfrey Leaf Chocolate Flavor by TerraVita

Ask about any prescription or over-the-counter medication and we check it for interactions with Comfrey Leaf Chocolate Flavor by TerraVita — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Comfrey Leaf Chocolate Flavor by TerraVita

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: Comfrey Leaf Glycerite Liquid Extract. Comfrey is a plant long used in herbal medicine, though modern evidence raises serious safety concerns about taking it by mouth.

The inactive ingredients are glycerin (a preservative and sweetener) and chocolate flavor.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Comfrey's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: comfrey leaf extract for topical and internal use.
  • We looked for evidence on: Back pain, Bruises, Sprains, Osteoarthritis, Muscle pain, Joint pain — and 2 related terms.
  • The closest evidence on file: Comfrey is rated "Insufficient Reliable Evidence To Rate" for Back pain (Natural Medicines).
  • Also on file: Comfrey is rated "Insufficient Reliable Evidence To Rate" for Osteoarthritis, Bruises, Sprains.

The evidence we hold doesn't establish that comfrey works for bronchitis, angina, back pain, cough, or cancer. Each of these uses is rated as having insufficient reliable evidence to rate.

The evidence, ingredient by ingredient Comfrey

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

This is the critical issue: oral comfrey is unsafe. The plant contains compounds called pyrrolizidine alkaloids that can severely damage your liver — causing cirrhosis, fibrosis, fluid buildup, and even liver failure.

Serious effects can show up suddenly (with severe belly pain, vomiting, and swelling) or develop slowly over months or years. Lung damage leading to high blood pressure in the lungs has also been reported.

Because of liver toxicity and possible harm to the baby, you should not use comfrey during pregnancy or while breastfeeding.

Side effects, ingredient by ingredient Comfrey

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Comfrey.
  • The most serious interaction on file is rated Moderate.
  • For scale: 439 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your doctor or pharmacist if you use any drugs that damage the liver or any medication that boosts the CYP3A4 enzyme (such as seizure medications like phenobarbital). Both carry Moderate severity concerns with comfrey.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Given the serious liver risks and lack of proven benefit, oral comfrey isn't recommended. If you're considering this product, talk with your doctor or pharmacist first — especially if you take any medication that affects your liver or any seizure drugs.

This is not a decision to make on your own.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Dec 13, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Comfrey Leaf Chocolate Flavor, straight from the product label.

Brand TerraVita
Barcode (UPC) 064435223205
Net contents 1 Fluid Ounce(s); 30 mL
Market status On market
Date entered into DSLD Dec 13, 2022
DSLD ID 281947
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Comfrey Leaf Chocolate Flavor by TerraVita, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
25 Drop(s)
Maximum serving Sizes:
40 Drop(s)
Servings per container
227
UPC/BARCODE
064435223205
IngredientAmount% DV
Comfrey Leaf Glycerite Liquid Extract0.13 mL--

Other ingredients: Glycerin, Chocolate flavor

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

Copyright 2018 TerraVita - Distributed by ZooScape LLC, All Rights Reserved.

Formula

Chocolate flavored Glycerite liquid extract (1:5)

Formulation

Alcohol free

Suggested/Recommended/Usage/Directions

Suggested Use: Take 25-40 drops of extract in a small amount of warm water 3-4 times daily. Shake well before using.

Precautions

Keep away from children.

Do not use if safety seal around cap is broken or missing.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Comfrey Leaf Chocolate Flavor by TerraVita label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Comfrey Leaf Chocolate Flavor label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Comfrey Leaf Chocolate Flavor by TerraVita

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size25 Drop(s) Dosage formLiquid Servings per container227 Amounts shown are per serving.

Comfrey Leaf Glycerite Liquid Extract

Interacts with
438 drugs
0.13 mL per serving

Comfrey is a traditional herb used mainly on the skin for bruises, sprains, and joint pain, and some topical products show modest benefit for these us...

Comfrey Leaf Glycerite Liquid Extract monograph & interactions

Other (inactive) ingredients: Glycerin, Chocolate flavor. These complete the product’s ingredient list but are not active constituents.

Interaction report

Comfrey Leaf Chocolate Flavor by TerraVita Drug Interactions

Want to check YOUR meds against Comfrey Leaf Chocolate Flavor?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
438Drugs
438 Moderate

Ingredients driving the most interactions

Comfrey Leaf Glycerite Liquid Extract 438

Individual Drug Interactions

The ingredients in Comfrey Leaf Chocolate Flavor interact with 438 drugs. Click any drug to see the details.

1 of the 1 ingredient in Comfrey Leaf Chocolate Flavor interact with drugs. Each result below shows which ingredient is responsible. Comfrey Leaf Glycerite Liquid Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Comfrey Leaf Chocolate Flavor with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Comfrey Leaf Glycerite Liquid Extract2 drug types · 438 drugs

Cytochrome P450 3A4 (Cyp3A4) Inducers

Theoretically, CYP3A4 inducers might increase the risk of adverse effects from the pyrrolizidine alkaloid constituents in comfrey.
CYP3A4 enzymes convert pyrrolizidine alkaloids, constituents of comfrey, to toxic metabolites. Some case reports show that enzyme inducers, such as phenobarbital, seem to enhance the toxicity of comfrey.

Likelihood Possible Evidence D
Hepatotoxic Drugs

Theoretically, comfrey might have additive adverse effects on the liver when used with hepatotoxic drugs.
Due to its pyrrolizidine alkaloid constituents, comfrey can cause hepatotoxic effects, including ascites, cirrhosis, hepatic fibrosis, hepatomegaly, and sinusoidal obstruction syndrome.

Likelihood Possible Evidence D
Comfrey Leaf Glycerite Liquid Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Comfrey Leaf Chocolate Flavor, from the product label.

TerraVita

See all TerraVita products
Name
ZooScape LLC
Phone Number
844-449-0444
Web Address
www.ZooScape.com
Pharmacist Counseling Corner

Comfrey Leaf Chocolate Flavor by TerraVita: Common Questions

Does Comfrey Leaf Chocolate Flavor by TerraVita interact with any medications?
Yes. Based on its ingredients, Comfrey Leaf Chocolate Flavor has a known interaction with 438 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Comfrey Leaf Chocolate Flavor contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is comfrey safe to take by mouth?
No. Oral comfrey is unsafe due to liver toxicity. The plant's pyrrolizidine alkaloid compounds can cause serious liver damage, including cirrhosis and fibrosis, sometimes months or even years after you start taking it.
Can I use this product while pregnant or breastfeeding?
No. Comfrey is likely unsafe during pregnancy because of liver toxicity and possible harm to the baby, and should be avoided while breastfeeding because harmful compounds may pass to the infant.
Does comfrey actually work for back pain, bronchitis, or cough?
The evidence we hold doesn't show that comfrey works for these conditions. All the uses listed — back pain, bronchitis, cough, angina, and cancer — are rated as having insufficient reliable evidence to rate effectiveness.
What are the signs that comfrey is harming my liver?
Sudden symptoms include severe belly pain, vomiting, and abdominal swelling. Slower-onset signs are fatigue, progressive belly bloating, and diarrhea. Some people don't notice anything until liver damage is advanced. If you've taken comfrey and develop any of these, seek medical attention right away.
What's in this product besides the comfrey?
The inactive ingredients are glycerin and chocolate flavor. These are excipients that help preserve and flavor the liquid.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Comfrey Leaf Chocolate Flavor is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Comfrey Leaf Chocolate Flavor label
Go deeper

The Full Monographs Behind Comfrey Leaf Chocolate Flavor’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Comfrey

Interacts with 438 drugs

Comfrey is a traditional herb used mainly on the skin for bruises, sprains, and joint pain, and some topical products show modest benefit for these uses. However, comfrey contains compounds...

Read the full Comfrey monograph →
Sources

Sources & How We Checked

Comfrey Leaf Chocolate Flavor's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 13 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Comfrey 13 references
  1. Stewart MJ, Steenkamp V. Pyrrolizidine poisoning: a neglected area in human toxicology. Ther Drug Monit 2001;23:698-708. PubMed
  2. Food and Drug Administration. FDA Advises Dietary Supplement Manufacturers to Remove Comfrey Products From the Market. July 6, 2001. Available at: http://www.cfsan.fda.gov/~dms/dspltr06.html.
  3. Stickel F, Seitz HK. The efficacy and safety of comfrey. Public Health Nutr 2000;3:501-8. PubMed
  4. Chojkier M. Hepatic sinusoidal-obstruction syndrome: toxicity of pyrrolizidine alkaloids. J Hepatol 2003;39:437-46. PubMed
  5. Wang YP, Yan J, Fu PP, Chou MW. Human liver microsomal reduction of pyrrolizidine alkaloid N-oxides to form the corresponding carcinogenic parent alkaloid. Toxicol Lett 2005;155:411-20. PubMed
  6. Predel, H. G., Giannetti, B., Koll, R., Bulitta, M., and Staiger, C. Efficacy of a comfrey root extract ointment in comparison to a diclofenac gel in the treatment of ankle distortions: results of an observer-blind, randomized, multicenter study. Phytome
  7. Gyorik, S. and Stricker, H. Severe pulmonary hypertension possibly due to pyrrolizidine alkaloids in polyphytotherapy. Swiss.Med.Wkly. 4-4-2009;139(13-14):210-211.
  8. Giannetti, B. M., Staiger, C., Bulitta, M., and Predel, H. G. Efficacy and safety of comfrey root extract ointment in the treatment of acute upper or lower back pain: results of a double-blind, randomised, placebo controlled, multicentre trial. Br.J Spor PubMed
  9. Tanret, I. and Duh, D. [Pharmaceutical sheet. Symphytum officinale L., dermal use (Flexagile cream)]. J Pharm.Belg. 2012;(1):41-42.
  10. Laslett, L. L., Quinn, S. J., Darian-Smith, E., Kwok, M., Fedorova, T., Korner, H., Steels, E., March, L., and Jones, G. Treatment with 4Jointz reduces knee pain over 12 weeks of treatment in patients with clinical knee osteoarthritis: a randomised contr
  11. Frost R, Macpherson H, O'meara S. A critical scoping review of external uses of comfrey (Symphytum spp.). Complement Ther Med. 2013;21(6):724-45. PubMed
  12. Pabst H, Schaefer A, Staiger C, Junker-samek M, Predel HG. Combination of comfrey root extract plus methyl nicotinate in patients with conditions of acute upper or low back pain: a multicentre randomised controlled trial. Phytother Res. 2013;27(6):811-7. PubMed
  13. Smith DB, Jacobson BH. Effect of a blend of comfrey root extract (Symphytum officinale L.) and tannic acid creams in the treatment of osteoarthritis of the knee: randomized, placebo-controlled, double-blind, multiclinical trials. J Chiropr Med. 2011;10(3) PubMed

See these in context on the Comfrey monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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