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Dietary supplement

Coptis Alcohol Free Ingredients & Drug Interactions

by Herbal Terra

Coptis Alcohol Free label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Coptis Alcohol Free against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Coptis Alcohol Free is a dietary supplement by Herbal Terra with 1 active ingredient. Its ingredients are commonly taken for digestive upset and diarrhea, mouth sores and sore throat, inflammation.Based on those ingredients, 643 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Coptis Root Extract, Dry. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Coptis Alcohol Free by Herbal Terra

Ask about any prescription or over-the-counter medication and we check it for interactions with Coptis Alcohol Free by Herbal Terra — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Coptis Alcohol Free by Herbal Terra

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: Coptis Root Extract, Dry. Coptis is a traditional herb whose main active compound is berberine.

The product also contains two inactive ingredients — glycerin and water — which serve as the liquid base and preservative.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Goldthread product and its label doesn't state a use — see Goldthread's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

We hold no effectiveness data for Coptis Root Extract in our files. That doesn't mean it doesn't work; it means the evidence we have on file isn't established enough to rate it.

If you're considering this for a specific condition, ask your pharmacist or doctor whether any clinical evidence supports that use.

The evidence, ingredient by ingredient Goldthread

How safe is it?

Some data gaps
Safety Information · database check
Some gaps

Safety data exists for these ingredients, but with some important gaps.

Why this rating?
  • We hold adverse-effect (side-effect) data for 0 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Human safety data for coptis are limited, and quality can vary between products, so use it short-term only and with caution. Berberine can pass into breast milk and may harm infants, so avoid coptis while breastfeeding.

Berberine may also harm the fetus, so coptis should be avoided during pregnancy.

Side effects, ingredient by ingredient Goldthread

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Goldthread.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: immunosuppressants / transplant drugs.
  • For scale: 644 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this product, check your medications against two categories: drugs metabolized by CYP3A4 (a major liver pathway — these include many common medications) and cyclosporine. Both interactions are Moderate.

Use the medication checker on this page to see if any of yours are affected.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and some safety-information gaps remain.

Coptis Alcohol Free is worth considering if you're looking for a traditional herbal option and your medications don't interact with CYP3A4 substrates or cyclosporine. If you take any prescription drugs — especially immunosuppressants or cholesterol medications — check with your pharmacist first.

Because human safety data are limited, use it short-term and talk with your pharmacist about whether it's right for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Nov 22, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Coptis Alcohol Free, straight from the product label.

Brand Herbal Terra
Barcode (UPC) 7386004998936
Net contents 2 Fluid Ounce(s); 60 mL
Market status On market
Date entered into DSLD Nov 22, 2024
DSLD ID 324112
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Coptis Alcohol Free by Herbal Terra, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 mL
Maximum serving Sizes:
1 mL
Servings per container
60
UPC/BARCODE
7386004998936
IngredientAmount% DV
Coptis Root Extract, Dry1156 mg--

Other ingredients: Glycerin, Water

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Shake well before use. Adults take up to 30 drops (1 mL, one full squeeze of the dropper bulb) in 3-4 fl. oz. of juice or water up to 4 times a day.

Precautions

We recommend to seek expert medical advice before taking. May have contraindications and cause adverse reaction.

Consult a physician before giving to children under 18, before using during pregnancy, if nursing, or if you are on any medications.

Consult a physician before giving to children under 18, before using during pregnancy, if nursing, or if you are on any medications. Keep out of the reach of children!

Do not use if you are allergic to any ingredients.

Storage

Store in a cool, dry, dark place.

FDA Disclaimer Statement

This product has not been evaluated by the FDA and is not intended to diagnose, treat, cure or prevent any disease.

Formulation

cGMP Made in compliance with cGMP 21 CFR 111 in an FDA registered and inspected facility.

Sugar free

Expertly extracted 100% natural Premium product

No alcohol (ethyl), artificial ingredients, color additives, fillers or binders.

Natural Gluten free

Formula

Coptis chinensis

FDA Statement of Identity

Herbal Supplement

Seals/Symbols

Made in USA

General Statements

Organic raw material.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Coptis Alcohol Free by Herbal Terra label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Coptis Alcohol Free label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Coptis Alcohol Free by Herbal Terra

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 mL Dosage formLiquid Servings per container60 Amounts shown are per serving.

Coptis Root Extract, Dry

Interacts with
643 drugs
1156 mg per serving Form: Coptis chinensis Root Extract, Dry

Goldthread is a traditional Chinese and East Asian herb whose root is rich in berberine, a compound being studied for blood sugar, cholesterol, and an...

Coptis Root Extract, Dry monograph & interactions

Other (inactive) ingredients: Glycerin, Water. These complete the product’s ingredient list but are not active constituents.

Interaction report

Coptis Alcohol Free by Herbal Terra Drug Interactions

Want to check YOUR meds against Coptis Alcohol Free?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
643Drugs
643 Moderate

Ingredients driving the most interactions

Coptis Root Extract, Dry 643

Individual Drug Interactions

The ingredients in Coptis Alcohol Free interact with 643 drugs. Click any drug to see the details.

1 of the 1 ingredient in Coptis Alcohol Free interact with drugs. Each result below shows which ingredient is responsible. Coptis Root Extract, Dry

Each ingredient & the kinds of drugs it affects

For each ingredient in Coptis Alcohol Free with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Coptis Root Extract, Dry2 drug types · 643 drugs

Cyclosporine (Neoral, Sandimmune)

Berberine, a constituent of goldthread, can reduce metabolism of cyclosporine and increase serum levels. It might inhibit cytochrome P450 3A4 (CYP3A4), which metabolizes cyclosporine.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

There's very preliminary evidence that berberine, a constituent of goldthread, might inhibit cytochrome P450 3A4 (CYP3A4) enzyme. So far, this interaction has not been reported in humans. However, watch for an increase in the levels of drugs metabolized by CYP3A4 in patients taking goldthread. Some drugs metabolized by CYP3A4 include lovastatin (Mevacor), clarithromycin (Biaxin), indinavir (Crixivan), sildenafil (Viagra), triazolam (Halcion), and numerous others. Use goldthread cautiously or avoid in patients taking these drugs.

Likelihood Possible Evidence D
Coptis Root Extract, Dry full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Coptis Alcohol Free, from the product label.

Herbal Terra

See all Herbal Terra products
Name
Herbal Terra LLC
Phone Number
+18083857868
Web Address
herbalterra.com
Pharmacist Counseling Corner

Coptis Alcohol Free by Herbal Terra: Common Questions

Does Coptis Alcohol Free by Herbal Terra interact with any medications?
Yes. Based on its ingredients, Coptis Alcohol Free has a known interaction with 643 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Coptis Alcohol Free contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take Coptis Alcohol Free while I'm pregnant or breastfeeding?
No. The berberine in coptis may harm the fetus during pregnancy and can pass into breast milk and harm infants. Avoid it during both pregnancy and breastfeeding.
What is berberine, and why does it matter for drug interactions?
Berberine is the active compound in coptis. It can slow down a major liver enzyme called CYP3A4 that breaks down many medications, causing those drugs to build up in your body.
Has anyone actually had a problem taking coptis with their medications?
Not that we've documented in humans so far. But the evidence shows berberine can inhibit CYP3A4, so the risk is real — it just hasn't been reported in patients yet. That's why we flag it.
Is this product safe to use long-term?
We recommend short-term use only. Human safety data are limited, and product quality varies between brands, so stick to short-term use and chat with your pharmacist about duration.
Why does the interaction with cyclosporine matter specifically?
Cyclosporine is an immunosuppressant that your body needs to clear at a steady rate. Coptis can slow that clearance and raise cyclosporine levels dangerously. If you take it, you'll need to check with your pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Coptis Alcohol Free is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Coptis Alcohol Free label
Go deeper

The Full Monographs Behind Coptis Alcohol Free’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Goldthread

Interacts with 643 drugs

Goldthread is a traditional Chinese and East Asian herb whose root is rich in berberine, a compound being studied for blood sugar, cholesterol, and antimicrobial effects. Strong human eviden...

Read the full Goldthread monograph →
Sources

Sources & How We Checked

Coptis Alcohol Free's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 3 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Goldthread 3 references
  1. Chan E. Displacement of bilirubin from albumin by berberine. Biol Neonate 1993;63:201-8. PubMed
  2. Wu X, Li Q, Xin H, Yu A, Zhong M. Effects of berberine on the blood concentration of cyclosporin A in renal transplanted recipients: clinical and pharmacokinetic study. Eur J Clin Pharmacol 2005;61:567-72. PubMed
  3. Chuang CH, Doyle P, Wang JD, et al. Herbal medicines used during the first trimester and major congenital malformations: an analysis of data from a pregnancy cohort study. Drug Saf 2006;29:537-48. PubMed

See these in context on the Goldthread monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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