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Dietary supplement

Coptis chinensis Extract Powder 500 mg Ingredients & Drug Interactions

by BulkSupplements.com

Coptis chinensis Extract Powder 500 mg label
See full label image
Powder Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Coptis chinensis Extract Powder 500 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Coptis chinensis Extract Powder 500 mg is a dietary supplement by BulkSupplements.com with 1 active ingredient. Its ingredients are commonly taken for digestive upset and diarrhea, mouth sores and sore throat, inflammation.Based on those ingredients, 643 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Coptis chinensis Root Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Coptis chinensis Extract Powder 500 mg by BulkSupplements.com

Ask about any prescription or over-the-counter medication and we check it for interactions with Coptis chinensis Extract Powder 500 mg by BulkSupplements.com — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Coptis chinensis Extract Powder 500 mg by BulkSupplements.com

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: Coptis chinensis Root Extract at 500 mg per serving. Goldthread, as it's commonly known, is a traditional herb whose main active compound is berberine.

The powder also includes dextrin as an inactive ingredient to aid mixing and delivery.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Goldthread product and its label doesn't state a use — see Goldthread's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

We hold no effectiveness ratings for Coptis chinensis Extract Powder in our data, so I can't tell you what the evidence shows for its intended use.

The evidence, ingredient by ingredient Goldthread

How safe is it?

Some data gaps
Safety Information · database check
Some gaps

Safety data exists for these ingredients, but with some important gaps.

Why this rating?
  • We hold adverse-effect (side-effect) data for 0 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Human safety data for goldthread are limited, and product quality varies between manufacturers, so use it short-term only and with caution. Goldthread should be avoided during pregnancy because berberine may harm the fetus.

It should also be avoided while breastfeeding because berberine can pass into breast milk and may harm the infant.

Side effects, ingredient by ingredient Goldthread

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Goldthread.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: immunosuppressants / transplant drugs.
  • For scale: 644 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check before starting if you take cyclosporine (an immunosuppressant) or any medication metabolized by the CYP3A4 enzyme in your liver, including many statins, heart medications, and other common drugs. The CYP3A4 interaction hasn't been confirmed in humans yet, but it's worth discussing with your pharmacist to be safe.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and some safety-information gaps remain.

Goldthread has moderate interaction potential with cyclosporine and possibly with a large group of other drugs broken down by your liver. If you take any prescription medication — especially immunosuppressants, statins, or heart drugs — talk with your pharmacist before adding this supplement.

Pregnant or breastfeeding? Skip it.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated May 21, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Coptis chinensis Extract Powder 500 mg, straight from the product label.

Brand BulkSupplements.com
Barcode (UPC) X002KUPJ9B
Net contents 1 Kilogram(s); 35.3 Ounce(s)
Market status On market
Date entered into DSLD May 21, 2025
DSLD ID 330637
Product type Botanical
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Coptis chinensis Extract Powder 500 mg by BulkSupplements.com, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
500 mg
Maximum serving Sizes:
500 mg
Servings per container
2000
UPC/BARCODE
X002KUPJ9B
IngredientAmount% DV
Coptis chinensis Root Extract500 mg--

Other ingredients: Dextrin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Coptis chinensis Extract Powder 500 mg per serving

Brand IP Statement(s)

BulkSupplements.com Clean & pure bulk supplements

Formulation

Color may vary

Free of: Added sugar, soy, dairy, yeast, gluten

FDA Disclaimer Statement

Warning: This product is not intended to diagnose, treat, cure, or prevent any disease.

Precautions

Always consult a physician before taking any dietary supplement.

Keep out of reach of children.

If pregnant, consult physician before using this product.

Suggested/Recommended/Usage/Directions

Suggested use: As a dietary supplement, take 500 mg (about 1/5 tsp) up to three times daily, or as directed by a physician.

Storage

Store in a dry, cool place Contents are sold by weight, not volume. Settling may occur.

General Statements

Use an accurate milligram scale. New

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Coptis chinensis Extract Powder 500 mg by BulkSupplements.com label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Coptis chinensis Extract Powder 500 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Coptis chinensis Extract Powder 500 mg by BulkSupplements.com

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size500 mg Dosage formPowder Servings per container2000 Amounts shown are per serving.

Coptis chinensis Root Extract

Interacts with
643 drugs
500 mg per serving

Goldthread is a traditional Chinese and East Asian herb whose root is rich in berberine, a compound being studied for blood sugar, cholesterol, and an...

Coptis chinensis Root Extract monograph & interactions

Other (inactive) ingredients: Dextrin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Coptis chinensis Extract Powder 500 mg by BulkSupplements.com Drug Interactions

Want to check YOUR meds against Coptis chinensis Extract Powder 500 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
643Drugs
643 Moderate

Ingredients driving the most interactions

Coptis chinensis Root Extract 643

Individual Drug Interactions

The ingredients in Coptis chinensis Extract Powder 500 mg interact with 643 drugs. Click any drug to see the details.

1 of the 1 ingredient in Coptis chinensis Extract Powder 500 mg interact with drugs. Each result below shows which ingredient is responsible. Coptis chinensis Root Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Coptis chinensis Extract Powder 500 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Coptis chinensis Root Extract2 drug types · 643 drugs

Cyclosporine (Neoral, Sandimmune)

Berberine, a constituent of goldthread, can reduce metabolism of cyclosporine and increase serum levels. It might inhibit cytochrome P450 3A4 (CYP3A4), which metabolizes cyclosporine.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

There's very preliminary evidence that berberine, a constituent of goldthread, might inhibit cytochrome P450 3A4 (CYP3A4) enzyme. So far, this interaction has not been reported in humans. However, watch for an increase in the levels of drugs metabolized by CYP3A4 in patients taking goldthread. Some drugs metabolized by CYP3A4 include lovastatin (Mevacor), clarithromycin (Biaxin), indinavir (Crixivan), sildenafil (Viagra), triazolam (Halcion), and numerous others. Use goldthread cautiously or avoid in patients taking these drugs.

Likelihood Possible Evidence D
Coptis chinensis Root Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Coptis chinensis Extract Powder 500 mg, from the product label.

BulkSupplements.com

See all BulkSupplements.com products
Name
BulkSupplements.com
Street Address
7511 Eastgate Rd
City
Henderson
State
NV
ZipCode
89011
Web Address
BulkSupplements.com
Pharmacist Counseling Corner

Coptis chinensis Extract Powder 500 mg by BulkSupplements.com: Common Questions

Does Coptis chinensis Extract Powder 500 mg by BulkSupplements.com interact with any medications?
Yes. Based on its ingredients, Coptis chinensis Extract Powder 500 mg has a known interaction with 643 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Coptis chinensis Extract Powder 500 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while pregnant or breastfeeding?
No. The safety data advise against goldthread during pregnancy because berberine may harm the fetus, and while breastfeeding because it can pass into breast milk and harm the infant. Talk with your doctor about alternatives.
What is goldthread used for?
Goldthread is a traditional herb, but we don't hold effectiveness data in our system, so I can't tell you what the scientific evidence shows for its intended use.
Does this product have fillers or other inactive ingredients?
Yes — it contains dextrin, which is an inactive ingredient used to help the powder mix and deliver properly.
Why does this interact with so many medications?
The berberine in goldthread may block a liver enzyme (CYP3A4) that breaks down over 600 different medications. Even though the interaction hasn't been confirmed in humans yet, it's a wide net, so it's important to check your exact drugs.
Is goldthread safe for long-term use?
Human safety data are limited, and product quality varies between brands. Use it short-term only and under caution. Talk with your pharmacist about how long is appropriate for you.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Coptis chinensis Extract Powder 500 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Coptis chinensis Extract Powder 500 mg label
Go deeper

The Full Monographs Behind Coptis chinensis Extract Powder 500 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Goldthread

Interacts with 643 drugs

Goldthread is a traditional Chinese and East Asian herb whose root is rich in berberine, a compound being studied for blood sugar, cholesterol, and antimicrobial effects. Strong human eviden...

Read the full Goldthread monograph →
Sources

Sources & How We Checked

Coptis chinensis Extract Powder 500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 3 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Goldthread 3 references
  1. Chan E. Displacement of bilirubin from albumin by berberine. Biol Neonate 1993;63:201-8. PubMed
  2. Wu X, Li Q, Xin H, Yu A, Zhong M. Effects of berberine on the blood concentration of cyclosporin A in renal transplanted recipients: clinical and pharmacokinetic study. Eur J Clin Pharmacol 2005;61:567-72. PubMed
  3. Chuang CH, Doyle P, Wang JD, et al. Herbal medicines used during the first trimester and major congenital malformations: an analysis of data from a pregnancy cohort study. Drug Saf 2006;29:537-48. PubMed

See these in context on the Goldthread monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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