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Dietary supplement

Coptis Spp. Goldthread Ingredients & Drug Interactions

by Wise Woman Herbals

Coptis Spp. Goldthread label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Coptis Spp. Goldthread against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Coptis Spp. Goldthread is a dietary supplement by Wise Woman Herbals with 1 active ingredient. Its ingredients are commonly taken for digestive upset and diarrhea, mouth sores and sore throat, inflammation.Based on those ingredients, 643 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Goldthread. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Coptis Spp. Goldthread by Wise Woman Herbals

Ask about any prescription or over-the-counter medication and we check it for interactions with Coptis Spp. Goldthread by Wise Woman Herbals — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Coptis Spp. Goldthread by Wise Woman Herbals

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 1 active ingredient.
  • “Proprietary Blend” is a proprietary blend — the label gives one combined amount (3 mL) without saying how much of each component you get.

This is a liquid herbal extract containing one active ingredient: goldthread (Coptis species), a traditional plant used in herbal medicine. It's a one-ingredient product.

The liquid is prepared with spring water, organic alcohol, and glycerine as inactive ingredients.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Goldthread product and its label doesn't state a use — see Goldthread's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

We don't have effectiveness information on file for goldthread in the product facts we hold. If you're considering this herb for a specific health goal, talk with your pharmacist or doctor — they can help you understand what the evidence shows.

The evidence, ingredient by ingredient Goldthread

How safe is it?

Some data gaps
Safety Information · database check
Some gaps

Safety data exists for these ingredients, but with some important gaps.

Why this rating?
  • We hold adverse-effect (side-effect) data for 0 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Goldthread is poorly studied in humans, and quality varies between products, so we recommend caution and short-term use only if you do take it. The safety data advises against this supplement during pregnancy and breastfeeding — berberine can harm the fetus or newborn and passes into breast milk.

If you're pregnant, planning pregnancy, or nursing, avoid goldthread entirely.

Side effects, ingredient by ingredient Goldthread

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Goldthread.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: immunosuppressants / transplant drugs.
  • For scale: 644 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check before taking if you use cyclosporine or any medication broken down by the CYP3A4 liver enzyme — this includes many cholesterol drugs, blood pressure medications, and others. Use the medication checker on this page to verify your exact prescriptions.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no assessable stated purpose. Moderate medication interactions have been identified, and some safety-information gaps remain.

Goldthread interacts with cyclosporine and potentially with a broad group of CYP3A4-metabolized drugs. If you take any prescription medication, check it against the interaction tool before starting.

Pregnant people and those breastfeeding should avoid it. Talk to your pharmacist before adding this to your routine.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated May 24, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Coptis Spp. Goldthread, straight from the product label.

Brand Wise Woman Herbals
Barcode (UPC) 748840022317
Net contents 2 Fluid Ounce(s); 60 mL
Market status On market
Date entered into DSLD May 24, 2023
DSLD ID 284797
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Coptis Spp. Goldthread by Wise Woman Herbals, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
10 Drop(s)
Maximum serving Sizes:
60 Drop(s)
Servings per container
20
UPC/BARCODE
748840022317
IngredientAmount% DV
Proprietary Blend3 mL--
Goldthread0 NP--

Other ingredients: spring Water, organic Alcohol, Glycerine

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested use: Shake well. Add 10-60 drops to water, 1-4 times per day.

Formulation

The presence of particulate matter in this product is normal.

Precautions

Caution: Not recommended during pregnancy.

Keep out of the reach of children.

General Statements

Botanical formula

FDA Statement of Identity

Dietary Supplement

Storage

Store in a cool, dry area away from direct sunlight with the lid tightly sealed.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Coptis Spp. Goldthread by Wise Woman Herbals label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Coptis Spp. Goldthread label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Coptis Spp. Goldthread by Wise Woman Herbals

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size10 Drop(s) Dosage formLiquid Servings per container20 Amounts shown are per serving.

Proprietary Blend

3 mL per serving

Other (inactive) ingredients: Spring Water, Organic Alcohol, Glycerine. These complete the product’s ingredient list but are not active constituents.

Interaction report

Coptis Spp. Goldthread by Wise Woman Herbals Drug Interactions

Want to check YOUR meds against Coptis Spp. Goldthread?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
643Drugs
643 Moderate

Ingredients driving the most interactions

Goldthread 643

Individual Drug Interactions

The ingredients in Coptis Spp. Goldthread interact with 643 drugs. Click any drug to see the details.

1 of the 1 ingredient in Coptis Spp. Goldthread interact with drugs. Each result below shows which ingredient is responsible. Goldthread

Each ingredient & the kinds of drugs it affects

For each ingredient in Coptis Spp. Goldthread with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Goldthread2 drug types · 643 drugs

Cyclosporine (Neoral, Sandimmune)

Berberine, a constituent of goldthread, can reduce metabolism of cyclosporine and increase serum levels. It might inhibit cytochrome P450 3A4 (CYP3A4), which metabolizes cyclosporine.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

There's very preliminary evidence that berberine, a constituent of goldthread, might inhibit cytochrome P450 3A4 (CYP3A4) enzyme. So far, this interaction has not been reported in humans. However, watch for an increase in the levels of drugs metabolized by CYP3A4 in patients taking goldthread. Some drugs metabolized by CYP3A4 include lovastatin (Mevacor), clarithromycin (Biaxin), indinavir (Crixivan), sildenafil (Viagra), triazolam (Halcion), and numerous others. Use goldthread cautiously or avoid in patients taking these drugs.

Likelihood Possible Evidence D
Goldthread full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Coptis Spp. Goldthread, from the product label.

Wise Woman Herbals

See all Wise Woman Herbals products
Name
Wise Woman Herbals
City
Creswell
State
OR
ZipCode
97426
Phone Number
541.895.5152
Web Address
wisewomanherbals.com
Pharmacist Counseling Corner

Coptis Spp. Goldthread by Wise Woman Herbals: Common Questions

Does Coptis Spp. Goldthread by Wise Woman Herbals interact with any medications?
Yes. Based on its ingredients, Coptis Spp. Goldthread has a known interaction with 643 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Coptis Spp. Goldthread contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take goldthread while pregnant or breastfeeding?
No. The safety data rates goldthread as likely unsafe in pregnancy and while breastfeeding — berberine can harm the fetus or newborn and passes into breast milk. Avoid it during both periods.
I take cyclosporine for my transplant. Is this safe for me?
No. Berberine in goldthread can slow how your body clears cyclosporine and raise its levels, which is a Moderate-severity interaction. Talk to your transplant team before considering any goldthread supplement.
Does this product have any fillers or other stuff in it?
The active ingredient is goldthread. It's prepared with spring water, organic alcohol, and glycerine — those are the inactive ingredients that make it a liquid.
Why do I need to check my medications if goldthread might interact with CYP3A4?
Because CYP3A4 metabolizes over 600 medications — cholesterol drugs, blood pressure meds, immunosuppressants, and many others. The interaction checker on this page will tell you if any of your exact drugs are affected.
Is this herb tested in humans?
Human safety data for goldthread are limited, and product quality varies. The interaction with cyclosporine is based on preliminary evidence and hasn't been seen in actual patients yet, but it's something we watch for.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Coptis Spp. Goldthread is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Coptis Spp. Goldthread label
Go deeper

The Full Monographs Behind Coptis Spp. Goldthread’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Goldthread

Interacts with 643 drugs

Goldthread is a traditional Chinese and East Asian herb whose root is rich in berberine, a compound being studied for blood sugar, cholesterol, and antimicrobial effects. Strong human eviden...

Read the full Goldthread monograph →
Sources

Sources & How We Checked

Coptis Spp. Goldthread's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 3 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Goldthread 3 references
  1. Chan E. Displacement of bilirubin from albumin by berberine. Biol Neonate 1993;63:201-8. PubMed
  2. Wu X, Li Q, Xin H, Yu A, Zhong M. Effects of berberine on the blood concentration of cyclosporin A in renal transplanted recipients: clinical and pharmacokinetic study. Eur J Clin Pharmacol 2005;61:567-72. PubMed
  3. Chuang CH, Doyle P, Wang JD, et al. Herbal medicines used during the first trimester and major congenital malformations: an analysis of data from a pregnancy cohort study. Drug Saf 2006;29:537-48. PubMed

See these in context on the Goldthread monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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