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Dietary supplement

Cran-Max 500 mg Ingredients & Drug Interactions

by International Vitamin Corporation

Cran-Max 500 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Cran-Max 500 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Cran-Max 500 mg is a dietary supplement by International Vitamin Corporation with 1 active ingredient. Its ingredients are commonly taken for urinary tract infection prevention, bladder health, antioxidant support.Based on those ingredients, 714 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Cran-Max Cranberry (Vaccinium macrocarpon) concentrate. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Cran-Max 500 mg by International Vitamin Corporation

Ask about any prescription or over-the-counter medication and we check it for interactions with Cran-Max 500 mg by International Vitamin Corporation — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Cran-Max 500 mg by International Vitamin Corporation

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Cran-Max 500 mg is a single-ingredient supplement: cranberry (Vaccinium macrocarpon) concentrate, delivering 500 mg per capsule. The capsule itself contains inactive ingredients — a cellulose-based capsule material, silicon dioxide, and magnesium stearate as a processing aid.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: support healthier urinary tract health.
  • We looked for evidence on: Urinary tract infections (UTIs), Overactive bladder, Urinary odor, Catheter-related infections, Radiation-induced cystitis, Bladder health — and 3 related terms.
  • The strongest evidence on file: Cranberry is rated "Possibly Effective" for Urinary tract infections (UTIs) (Natural Medicines).
  • Also on file: Cranberry is rated "Insufficient Reliable Evidence To Rate" for Urinary odor, Overactive bladder, Catheter-related infections, Radiation-induced cystitis.

The evidence is strongest for urinary tract infections (UTIs), where cranberry is rated possibly effective — meaning it has shown promise but isn't a replacement for medical care if you have an active infection. For other conditions listed — age-related cognitive decline, benign prostatic hyperplasia (enlarged prostate), cancer prevention, fatty liver disease, and chronic fatigue — the evidence is insufficient to say one way or the other.

If you're considering cranberry for any of these other uses, talk it over with your doctor to see if it's worth trying for your situation.

The evidence, ingredient by ingredient Cranberry

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Cranberry is generally well tolerated as a food or in normal amounts. The most common side effects from oral cranberry are diarrhea and stomach upset.

In very high doses — like 3 to 4 liters of juice daily — these effects become more likely, especially in young children. Nausea, vomiting, and abdominal discomfort have been reported in trials even at moderate doses.

One rare report noted skin redness and itching. The safety data we hold describes concentrated supplement doses as not well studied, so it's worth asking your provider before starting, especially if you're pregnant, nursing, or have a sensitive stomach.

Side effects, ingredient by ingredient Cranberry

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Cranberry.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 715 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take warfarin or another blood thinner, atorvastatin or another statin, nifedipine or another blood pressure or heart medication processed through the liver, or diclofenac or similar pain relievers, talk to your doctor or pharmacist before adding Cran-Max — cranberry may raise the levels of these drugs in your body.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Cran-Max may be worth considering if you're dealing with recurrent UTIs and want to add a supplement alongside standard medical care — never as a replacement for antibiotics when you have an active infection. Be cautious if you take a blood thinner like warfarin, a statin, or a blood pressure medication; these are the main concerns.

Check your own medications with your doctor or pharmacist before you start, and stop and let them know if you experience stomach upset or diarrhea.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jul 25, 2017.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Cran-Max 500 mg, straight from the product label.

Brand International Vitamin Corporation
Barcode (UPC) 636652916811
Net contents 60 Veggie Capsule(s)
Market status On market
Date entered into DSLD Jul 25, 2017
DSLD ID 76641
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Cran-Max 500 mg by International Vitamin Corporation, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
UPC/BARCODE
636652916811
IngredientAmount% DV
Cran-Max Cranberry (Vaccinium macrocarpon) concentrate500 mg--

Other ingredients: Cran-Max Cranberry concentrate, Hydroxypropyl Methylcellulose, Silicon Dioxide, Magnesium Stearate, Contains 2% or less of:

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

Cran-Max is the original, clinically proven, one per day cranberry supplement.

You benefit from two exclusive feature found only in Cran-Max: ~ Bio-Shield is a patented system that helps protect the Cranberry actives through the harsh digestive environment.

No other Cranberry supplement can come close to the high level of PACs found in Cran-Max.

Cran-Max and Bio-Shield are registered trademarks of Pharmachem Labs, Inc.

International Vitamin Corporation. All Rights Reserved.

~ Patented Bio-Shield protects cranberry actives to deliver maximum efficacy

Cran-Max is the original, clinically proven, one per day cranberry supplement.

No other Cranberry supplement can come close to the high level of PACs found in Cran-Max.

Bio-Shield a patented system

General Statements

When it comes to supporting a healthier urinary tract, no other Cranberry supplement has more successful clinical studies.

~ PACs (proanthocyanidins) provide the beneficial antioxidant activity found in Cranberries that help support the urinary tract, fight free radicals and boost the immune system.

Clinical strength

For healthy urinary tract

Questions? Comments? Call 1-888-698-5032 weekdays 8:30 a.m.- 5:00 p.m. (Eastern Time)

~ Contains higher antioxidant (PAC) levels than other Cranberry supplements

When it comes to supporting a healthier urinary tract, no other Cranberry supplement has more successful clinical studies.

202935/550084/IVC646887

Formula

Cranberry concentrate

2 exclusive features found only in Cran-Max: ~ Bio-Shield is a patented system that helps protect the Cranberry actives through the harsh digestive environment. ~ PACs (proanthocyanidins) provide the beneficial antioxidant activity found in Cranberries that help support the urinary tract, fight free radicals and boost the immune system.

Formulation

100% Vegetarian

Suggested/Recommended/Usage/Directions

One per day

Directions: Adults - Take one capsule daily with food as a dietary supplement.

~ Clinical strength, just one per day

FDA Statement of Identity

Dietary Supplement

Precautions

Warning: Pregnant or nursing women, individuals taking medication(s) or persons who have a health condition should consult their physician before using this product.

Safety sealed. Do not use if printed seal under cap is cut, torn, or missing.

Keep out of the reach of children.

Storage

Store at 15(0)-30(0)C (59(0)-86(0)F).

FDA Disclaimer Statement

These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

General

136927 550084 IVC646887

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Cran-Max 500 mg by International Vitamin Corporation label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Cran-Max 500 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Cran-Max 500 mg by International Vitamin Corporation

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Amounts shown are per serving.

Cran-Max Cranberry (Vaccinium macrocarpon) concentrate

Interacts with
714 drugs
500 mg per serving Form: Proanthocyanidins

Cranberry is best known for helping to prevent repeated urinary tract infections (UTIs) in some people, and the evidence here is moderate but mixed. I...

Cran-Max Cranberry (Vaccinium macrocarpon) concentrate monograph & interactions

Other (inactive) ingredients: Cran-Max Cranberry concentrate, Hydroxypropyl Methylcellulose, Silicon Dioxide, Magnesium Stearate, Contains 2% or less of:. These complete the product’s ingredient list but are not active constituents.

Interaction report

Cran-Max 500 mg by International Vitamin Corporation Drug Interactions

Want to check YOUR meds against Cran-Max 500 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
714Drugs
645 Moderate 69 Minor

Ingredients driving the most interactions

Cran-Max Cranberry (Vaccinium macrocarpon) concentrate 714

Individual Drug Interactions

The ingredients in Cran-Max 500 mg interact with 714 drugs. Click any drug to see the details.

1 of the 1 ingredient in Cran-Max 500 mg interact with drugs. Each result below shows which ingredient is responsible. Cran-Max Cranberry (Vaccinium macrocarpon) concentrate

Each ingredient & the kinds of drugs it affects

For each ingredient in Cran-Max 500 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Cran-Max Cranberry (Vaccinium macrocarpon) concentrate6 drug types · 714 drugs

Atorvastatin (Lipitor)

Theoretically, cranberry might increase levels and adverse effects of atorvastatin.
In one case report, a patient taking atorvastatin experienced upper back pain, rhabdomyolysis, and abnormal liver function after drinking cranberry juice 16 ounces daily for 2 weeks. Theoretically, this may have been caused by inhibition of cytochrome P450 3A4 (CYP3A4) enzymes by cranberry juice, as atorvastatin is a CYP3A4 substrate. Creatinine kinase and liver enzymes normalized within 2 weeks of stopping cranberry juice. Patients taking atorvastatin should avoid large quantities of cranberry juice.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
A case of upper back pain, rhabdomyolysis, and abnormal liver function has been reported for a patient taking atorvastatin, a CYP3A4 substrate, in combination with cranberry juice 16 ounces daily for 2 weeks. Creatinine kinase and liver enzymes normalized within 2 weeks of stopping cranberry juice. Also, animal research suggests that cranberry juice, administered intraduodenally 30 minutes prior to nifedipine, a CYP3A4 substrate, inhibits nifedipine metabolism and increases the area under the concentration-time curve by 1.6-fold compared to control.

Likelihood Possible Evidence D
Nifedipine (Procardia)

Theoretically, cranberry might increase the levels and adverse effects of nifedipine.
Animal research suggests that cranberry juice, administered intraduodenally 30 minutes prior to nifedipine treatment, inhibits nifedipine metabolism and increases the area under the concentration-time curve by 1.6-fold compared to control. This interaction has not been reported in humans.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, cranberry might increase the levels and adverse effects of warfarin. However, research is conflicting.
There is contradictory evidence about the effect of cranberry juice on warfarin. Case reports have linked cranberry juice consumption to increases in the international normalized ratio (INR) in patients taking warfarin, resulting in severe spontaneous bleeding and excessive postoperative bleeding. Daily consumption of cranberry sauce for one week has also been linked to an increase in INR in one case report. In a small study in healthy young males, taking a high dose of 3 grams of cranberry juice concentrate capsules, equivalent to 57 grams of fruit daily, for 2 weeks produced a 30% increase in the area under the INR-time curve after a single 25-mg dose of warfarin. However, 3 very small clinical studies in patients stabilized on warfarin reported that cranberry juice 250 mL once or twice daily for 7 days (27% cranberry juice or pure cranberry juice) or 240 mL once daily for 14 days does not significantly increase INR or affect plasma warfarin levels. The reasons for these discrepant findings are unclear. It is possible that the form and dose of cranberry may play a role, as cranberry extracts and juices contain different constituents. Additionally, an in vitro study evaluating 5 different cranberry juices found varying effects, with only a cranberry concentrate, and not diluted cranberry juices, inhibiting CYP2C9. However, this concentrate did not inhibit CYP2C9 activity in humans.

Likelihood Possible Evidence B
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, cranberry might increase the levels and adverse effects of CYP2C9 substrates. However, research is conflicting.
There is contradictory evidence about the effect of cranberry on CYP2C9 enzymes. In vitro evidence suggests that flavonoids in cranberry inhibit CYP2C9 enzymes. However, clinical research shows that cranberry juice does not significantly affect the levels, metabolism, or elimination of the CYP2C9 substrates flurbiprofen or diclofenac. Also, in patients stabilized on warfarin, drinking cranberry juice 250 mL daily for 7 days does not significantly increase the anticoagulant activity of warfarin, a CYP2C9 substrate. Additional pharmacokinetic research shows that cranberry juice does not increase peak plasma concentrations or area under the concentration-time curve of warfarin.

Likelihood Unlikely Evidence B
Diclofenac (Voltaren, Others)

Theoretically, cranberry might modestly increase the levels and adverse effects of diclofenac.
In vitro evidence suggests that cranberry juice inhibits diclofenac metabolism by human liver microsomes. However, drinking cranberry juice does not seem to affect diclofenac metabolism in humans.

Likelihood Unlikely Evidence B
Cran-Max Cranberry (Vaccinium macrocarpon) concentrate full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Cran-Max 500 mg, from the product label.

International Vitamin Corporation

See all International Vitamin Corporation products
Name
International Vitamin Corporation
Street Address
500 Halls Mill Road
City
Freehold
State
NJ
ZipCode
07728
Phone Number
1-888-698-5032
Web Address
www.ivcinc.com
Pharmacist Counseling Corner

Cran-Max 500 mg by International Vitamin Corporation: Common Questions

Does Cran-Max 500 mg by International Vitamin Corporation interact with any medications?
Yes. Based on its ingredients, Cran-Max 500 mg has a known interaction with 714 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Cran-Max 500 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does cranberry actually work for UTIs?
For urinary tract infections, cranberry is rated possibly effective — it has shown promise in research. That said, it's not a substitute for antibiotics if you have an active UTI. It may be worth trying alongside your doctor's treatment plan, or as a preventive if you get them often.
What are the side effects I might notice?
Most common are diarrhea and stomach discomfort. Nausea, vomiting, and abdominal upset have also been reported in trials. Very high doses make these more likely. If you have a sensitive stomach, start low and see how you do, and let your doctor know if side effects don't settle.
Can I take this if I'm pregnant or breastfeeding?
Cranberry in normal food amounts is rated likely safe during pregnancy and lactation. That said, the data we hold doesn't cover concentrated supplement doses well — talk with your provider first to make sure a supplement is right for you.
Is this the same as drinking cranberry juice?
It's a concentrated form, so it's much more potent than juice. The safety data is stronger for food amounts of cranberry than for concentrated supplements, so ask your doctor before starting — they can advise whether the supplement form is a good fit for you.
Will this help with other things, like memory or prostate health?
The evidence isn't established in the data we hold for age-related memory loss, enlarged prostate, cancer prevention, or fatty liver disease. If you're interested in cranberry for one of those reasons, talk it over with your doctor to weigh whether it's worth trying.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Cran-Max 500 mg label
Go deeper

The Full Monographs Behind Cran-Max 500 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Cranberry

Interacts with 714 drugs

Cranberry is best known for helping to prevent repeated urinary tract infections (UTIs) in some people, and the evidence here is moderate but mixed. It is not a reliable treatment for an act...

Read the full Cranberry monograph →
Sources

Sources & How We Checked

Cran-Max 500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 33 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Cranberry 33 references
  1. Anon. Possible interaction between warfarin and cranberry juice. Current Problems in Pharmacovigilance 2003;29:8. PubMed
  2. Greenblatt DJ, von Moltke LL, Perloff ES, et al. Interaction of flurbiprofen with cranberry juice, grape juice, tea, and fluconazole: in vitro and clinical studies. Clin Pharmacol Ther 2006;79:125-33. PubMed
  3. Hodek P, Trefil P, Stiborova M. Flavonoids-potent and versatile biologically active compounds interacting with cytochromes P450. Chem Biol Interact 2002;139:1-21.. PubMed
  4. Grant P. Warfarin and cranberry juice: An interaction? J Heart Valve Dis 2004;13:25-6.
  5. Suvarna R, Pirmohamed M, Henderson L. Possible interaction between warfarin and cranberry juice. BMJ 2003;327:1454. PubMed
  6. Li Z, Seeram NP, Carpenter CL, et al. Cranberry does not affect prothrombin time in male subjects on warfarin. J Am Diet Assoc 2006;106:2057-61. PubMed
  7. Lilja JJ, Backman JT, Neuvonen PJ. Effects of daily ingestion of cranberry juice on the pharmacokinetics of warfarin, tizanidine, and midazolam - probes of CYP2C9, CYP1A2 and CYP3A4. Clin Pharmacol The 2007:81:833-9. PubMed
  8. Wing DA, Rumney PJ, Preslicka CW, Chung JH. Daily cranberry juice for the prevention of asymptomatic bacteriuria in pregnancy: a randomized, controlled pilot study. J Urol 2008;180:1367-72. PubMed
  9. Mohammed Abdul MI, Jiang X, Williams KM, et al. Pharmacodynamic interaction of warfarin with cranberry but not with garlic in healthy subjects. Br J Pharmacol 2008;154:1691-700. PubMed
  10. McMurdo MET, Argo I, Phillips G, et al. Cranberry or trimethoprim for the prevention of recurrently urinary tract infections? A randomized controlled trial in older women. J Antimicrob Chemother 2009;63:389-95.
  11. Mergenhagen KA, Sherman O. Elevated International Normalized Ratio after concurrent ingestion of cranberry sauce and warfarin. Am J Health-Syst Pharm 2008;65:2113-6. PubMed
  12. Ansell J, McDonough M, Zhao Y, et al. The absence of an interaction between warfarin and cranberry juice: a randomized, double-blind trial. J Clin Pharmacol 2009;49:824-30. PubMed
  13. Haber SL, Cauthon KA, Raney EC. Cranberry and warfarin interaction: a case report and review of the literature. Consult Pharm 2012;27:58-65. PubMed
  14. Hamann GL, Campbell JD, George CM. Warfarin-cranberry juice interaction. Ann Pharmacother 2011;45:e17. PubMed
  15. Roberts D, Flanagan P. Case report: Cranberry juice and warfarin. Home Healthc Nurse 2011;29:92-7.
  16. Garcia-Calatayud, S., Larreina Cordoba, J. J., and Lozano De La Torre MJ. [Severe cranberry juice poisoning]. An.Esp.Pediatr. 2002;56(1):72-73.
  17. Patel, D. A., Gillespie, B., Sobel, J. D., Leaman, D., Nyirjesy, P., Weitz, M. V., and Foxman, B. Risk factors for recurrent vulvovaginal candidiasis in women receiving maintenance antifungal therapy: results of a prospective cohort study. Am J Obstet.Gy PubMed
  18. Isele, H. [Fatal bleeding under warfarin plus cranberry juice. Is it due to salicylic acid?]. MMW.Fortschr.Med 3-11-2004;146(11):13.
  19. Linsenmeyer, T. A., Harrison, B., Oakley, A., Kirshblum, S., Stock, J. A., and Millis, S. R. Evaluation of cranberry supplement for reduction of urinary tract infections in individuals with neurogenic bladders secondary to spinal cord injury. A prospecti
  20. McMurdo, M. E., Bissett, L. Y., Price, R. J., Phillips, G., and Crombie, I. K. Does ingestion of cranberry juice reduce symptomatic urinary tract infections in older people in hospital? A double-blind, placebo-controlled trial. Age Ageing 2005;34(3):256- PubMed
  21. Sylvan, L. and Justice, N. P. Possible interaction between warfarin and cranberry juice. Am Fam.Physician 9-15-2005;72(6):1000.
  22. Niklasson, A. and Andren, L. [Interaction between Waran and cranberry juice]. Lakartidningen 3-15-2006;103(11):853-854.
  23. Rindone, J. P. and Murphy, T. W. Warfarin-cranberry juice interaction resulting in profound hypoprothrombinemia and bleeding. Am J Ther 2006;13(3):283-284. PubMed
  24. Uesawa, Y. and Mohri, K. Effects of cranberry juice on nifedipine pharmacokinetics in rats. J Pharm Pharmacol 2006;58(8):1067-1072. PubMed
  25. Valentova, K., Stejskal, D., Bednar, P., Vostalova, J., Cihalik, C., Vecerova, R., Koukalova, D., Kolar, M., Reichenbach, R., Sknouril, L., Ulrichova, J., and Simanek, V. Biosafety, antioxidant status, and metabolites in urine after consumption of dried
  26. Royer, D. J., George, J. N., and Terrell, D. R. Thrombocytopenia as an adverse effect of complementary and alternative medicines, herbal remedies, nutritional supplements, foods, and beverages. Eur J Haematol 2010;84(5):421-429. PubMed
  27. Stapleton, A. E., Dziura, J., Hooton, T. M., Cox, M. E., Yarova-Yarovaya, Y., Chen, S., and Gupta, K. Recurrent urinary tract infection and urinary Escherichia coli in women ingesting cranberry juice daily: a randomized controlled trial. Mayo.Clin.Proc. PubMed
  28. Doad GJ, Kabange W. Cranberry juice, atorvastatin and back pain. J Med Assoc Ga 2014;103(1):14.
  29. Griffiths AP, Beddall A, Pegler S. Fatal haemopericardium and gastrointestinal haemorrhage due to possible interaction of cranberry juice with warfarin. J R Soc Promot Health 2008;128(6):324-6. PubMed
  30. Mellen CK, Ford M, Rindone JP. Effect of high-dose cranberry juice on the pharmacodynamics of warfarin in patients. Br J Clin Pharmacol 2010;70(1):139-42. PubMed
  31. Ushijima K, Tsuruoka S, Tsuda H, Hasegawa G, Obi Y, Kaneda T, Takahashi M, Maekawa T, Sasaki T, Koshimizu TA, Fujimura A. Cranberry juice suppressed the diclofenac metabolism by human liver microsomes, but not in healthy human subjects. Br J Clin Pharmaco PubMed
  32. Ngo N, Brantley SJ, Carrizosa DR, et al. The warfarin-cranberry juice interaction revisited: A systematic in vitro-in vivo evaluation. J Exp Pharmacol. 2010;2010(2):83-91.
  33. Williams G, Stothart CI, Hahn D, Stephens JH, Craig JC, Hodson EM. Cranberries for preventing urinary tract infections. Cochrane Database Syst Rev 2023;11(11):CD001321. PubMed

See these in context on the Cranberry monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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