Curamin Extra Strength Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Curamin Extra Strength against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Curamin Extra Strength is a dietary supplement by Terry Naturally with 5 active ingredients. Its ingredients are commonly taken for heart and circulatory health, blood clot prevention, high blood pressure.Based on those ingredients, 1,126 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Boswellia (Boswellia serrata) gum resin extract, Nattokinase. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Curamin Extra Strength by Terry Naturally
Ask about any prescription or over-the-counter medication and we check it for interactions with Curamin Extra Strength by Terry Naturally — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Curamin Extra Strength by Terry Naturally
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
Curamin Extra Strength has 4 active ingredients. Nattokinase is an enzyme derived from fermented soy (natto) that works on blood clotting.
Boswellia serrata gum resin extract comes from a tree traditionally used in Ayurvedic medicine, and it contains compounds called boswellic acids. DL-phenylalanine is an amino acid, and BCM-95 Curcugreen is a curcumin formulation — curcumin is the active compound in turmeric.
The tablet also contains inactive ingredients (cellulose, stearic acid, silica, magnesium stearate, croscarmellose sodium, and ethylcellulose) that give it shape and help it break down in your digestive system.
Does it work?
Moderate evidence
For Boswellia serrata, the evidence shows it is possibly effective for osteoarthritis. The data we hold does not establish reliable evidence for the other uses listed — allergic rhinitis (hay fever), Alzheimer disease, asthma, and cluster headache.
For nattokinase and the other ingredients in this product, we hold insufficient evidence to rate their effectiveness for the conditions this supplement targets. The evidence on curcumin and DL-phenylalanine isn't established in our data.
How safe is it?
Well-documented data
Nattokinase is generally well tolerated over the short term, but because it thins the blood, it carries risk if you have bleeding disorders or a history of bleeding. Rare reports include allergic reactions (even anaphylaxis) in people sensitive to natto, with symptoms appearing within 2 hours of taking it.
Boswellia serrata is generally well tolerated short-term; common side effects are mild — abdominal pain, diarrhea, headache, heartburn, nausea, and dizziness. Rarely, very large amounts can form a bezoar (a mass in the stomach).
For pregnancy: nattokinase is not recommended — not enough safety data exists. Boswellia serrata carries insufficient data as well, so do not take it while pregnant or breastfeeding without talking to your doctor or pharmacist.
Safety data for DL-phenylalanine and BCM-95 Curcugreen is not on file.
Meds to double-check
Moderate interaction found
Before taking Curamin Extra Strength, check with your doctor or pharmacist if you take blood thinners or antiplatelet drugs (aspirin, warfarin, clopidogrel) — nattokinase raises bleeding risk at Moderate severity, and there is a documented case of brain bleeding when nattokinase was combined with aspirin. Also confirm any antihypertensive (blood pressure) medications, as nattokinase may lower blood pressure further.
If you take medications that rely on liver enzymes to be broken down (a very long list including many antidepressants, beta-blockers, and statins), Boswellia serrata may raise their levels — discuss this with your pharmacist before starting.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
This product may be worth considering if you're looking for joint support and have discussed it with your doctor — Boswellia has some evidence for osteoarthritis — but it carries real interaction risks. If you take blood thinners, blood pressure medications, or drugs your liver metabolizes heavily, you need to check with your doctor or pharmacist before starting.
Avoid it if you're pregnant or breastfeeding. Talk it over with your healthcare provider to make sure it fits your situation.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 2 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 23, 2023.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Curamin Extra Strength, straight from the product label.
| Brand | Terry Naturally |
|---|---|
| Barcode (UPC) | 367703112066 |
| Net contents | 60 Tablet(s) |
| Market status | On market |
| Date entered into DSLD | Aug 23, 2023 |
| DSLD ID | 300073 |
| Product type | Other Combinations |
| Supplement form | Tablet Or Pill |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Vegan, Vegetarian, Adult (18 - 50 Years), Kosher, Halal, Gluten Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Curamin Extra Strength by Terry Naturally, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Calories | 20 Calorie(s) | -- |
| Total Carbohydrates | 2 Gram(s) | 1% |
| Total Fat | 1 Gram(s) | 1% |
| Protein | 1 Gram(s) | 2% |
| Nattokinase | 0 NP | -- |
| DL-Phenylalanine | 0 NP | -- |
| Boswellia (Boswellia serrata) gum resin extract | 0 NP | -- |
| Proprietary Complex | 2706 mg | -- |
| BCM-95 Curcugreen | 0 NP | -- |
Other ingredients: Cellulose, Powder, Stearic Acid, Silica, Magnesium Stearate, Croscarmellose Sodium, Ethylcellulose
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements
Money-Back Guarantee
When pain is the problem, Curamin is the answer!
Visit Curamin.com to read what others have experienced.
Formulation
Four Powerhouse Ingredients. One Award-Winning Formula
Vegan
Non-GMO
Extra Strength Pain Relief For your good health
No sugar, salt, yeast, wheat, gluten, corn, dairy products, artificial coloring, artificial flavoring, or artificial preservatives.
Color variations are normal.
Formula
Curamin Extra Strength combines clinically proven curcumin and boswellia with DLPA and nattokinase to create a product that has been recognized throughout the natural foods industry for pain relief.
cRc Kosher 328
H Halal
Clinically studied Curcumin with Turmerones
Suggested/Recommended/Usage/Directions
Recommendations: Three tablets daily. May be taken as 1 tablet, 3 times daily.
Precautions
If pregnant or nursing, consult a healthcare practitioner before use.
All ingredients established in human studies for safety and effectiveness. Does not interfere with stomach, liver or kidney function. Occasional muscle pain due to exercise or overuse
Contains soy (less than 5 parts per million)
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Seals/Symbols
cRc Kosher 328 H Halal
FDA Statement of Identity
Dietary Supplement
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Curamin Extra Strength by Terry Naturally label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Curamin Extra Strength by Terry Naturally
These are the 5 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Tablet(s) Dosage formTablet Or Pill Servings per container20 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Protein
Proprietary Complex
- › Nattokinase
- › DL-Phenylalanine
- › Boswellia (Boswellia serrata) gum resin extract
- › BCM-95 Curcugreen
Other (inactive) ingredients: Cellulose, Powder, Stearic Acid, Silica, Magnesium Stearate, Croscarmellose Sodium, Ethylcellulose. These complete the product’s ingredient list but are not active constituents.
Curamin Extra Strength by Terry Naturally Drug Interactions
HelloPharmacist Interaction Report
Curamin Extra Strength by Terry Naturally contains nattokinase and Boswellia serrata, both of which carry documented interactions with medications.
The most serious concern is nattokinase's Moderate risk of bleeding when combined with blood thinners and antiplatelet drugs (like aspirin or warfarin) — there is a case report of brain bleeding in a patient who added nattokinase to low-dose aspirin. Nattokinase may also lower blood pressure, creating a Moderate risk if you're already taking antihypertensive drugs.
Read the full breakdown — every affected drug type, severity by severity
Boswellia serrata poses Moderate interactions through its effects on how your liver breaks down certain medications. It inhibits five major enzyme systems (CYP3A4, CYP2D6, CYP2C19, CYP2C9, and CYP1A2), which means it could raise levels of drugs that depend on these enzymes — potentially making them stronger than intended.
Additionally, Boswellia might theoretically alter how immunosuppressant drugs work.
We could not check DL-phenylalanine or BCM-95 Curcugreen; no interaction data is on file for them. Altogether, these interactions span 1,127 individual medications.
Before you start this product, run your current medications through the interaction checker on this page, and talk with your doctor or pharmacist about any blood thinners, blood pressure drugs, or enzyme-dependent medications you take.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Curamin Extra Strength?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Curamin Extra Strength interact with 1,126 drugs. Click any drug to see the details.
2 of the 5 ingredients in Curamin Extra Strength interact with drugs. Each result below shows which ingredient is responsible. Boswellia (Boswellia serrata) gum resin extract Nattokinase
Acetaminophen, Chlorpheniramine, Dextromethorphan, PseudoephedrineChildren's Tylenol Cold Plus Cough, Tylenol Cold Ex Strength
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interacts with Curamin Extra Strength — through 1 ingredient. Tap an ingredient for the detail:
Boswellia (boswellia Serrata) Gum Resin ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates +1 Moderate
Interaction Summary
Theoretically, Boswellia serrata might increase or decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Boswellia (boswellia Serrata) Gum Resin Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interactionAcetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, SalicylamideRhinogesic GG
How Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interacts with Curamin Extra Strength — through 1 ingredient. Tap an ingredient for the detail:
Boswellia (boswellia Serrata) Gum Resin ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, Boswellia serrata might increase the levels of CYP1A2 substrates.
Read the full Boswellia (boswellia Serrata) Gum Resin Extract + Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interactionAcetaminophen, Chlorpheniramine, PhenylephrineAlka-Seltzer PLUS, Histex SR, Protid
How Acetaminophen, Chlorpheniramine, Phenylephrine interacts with Curamin Extra Strength — through 1 ingredient. Tap an ingredient for the detail:
Boswellia (boswellia Serrata) Gum Resin ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, Boswellia serrata might increase the levels of CYP1A2 substrates.
Read the full Boswellia (boswellia Serrata) Gum Resin Extract + Acetaminophen, Chlorpheniramine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, Phenylephrine, SalicylamideRhinogesic, Rhinogesic JR
How Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interacts with Curamin Extra Strength — through 1 ingredient. Tap an ingredient for the detail:
Boswellia (boswellia Serrata) Gum Resin ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, Boswellia serrata might increase the levels of CYP1A2 substrates.
Read the full Boswellia (boswellia Serrata) Gum Resin Extract + Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interactionAcetaminophen, Chlorpheniramine, PhenylpropanolamineAlumadrine, Conex, Sinadrin Max Strength, Sinulin
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine interacts with Curamin Extra Strength — through 1 ingredient. Tap an ingredient for the detail:
Boswellia (boswellia Serrata) Gum Resin ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, Boswellia serrata might increase the levels of CYP1A2 substrates.
Read the full Boswellia (boswellia Serrata) Gum Resin Extract + Acetaminophen, Chlorpheniramine, Phenylpropanolamine interactionAcetaminophen, Chlorpheniramine, Phenylpropanolamine, OpiumHista-Derfule
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium interacts with Curamin Extra Strength — through 1 ingredient. Tap an ingredient for the detail:
Boswellia (boswellia Serrata) Gum Resin ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, Boswellia serrata might increase or decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Boswellia (boswellia Serrata) Gum Resin Extract + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium interactionAcetaminophen, Chlorpheniramine, Phenylpropanolamine, PhenyltoloxamineNorel Plus
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Phenyltoloxamine interacts with Curamin Extra Strength — through 1 ingredient. Tap an ingredient for the detail:
Boswellia (boswellia Serrata) Gum Resin ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, Boswellia serrata might increase the levels of CYP1A2 substrates.
Read the full Boswellia (boswellia Serrata) Gum Resin Extract + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Phenyltoloxamine interactionAcetaminophen, Chlorpheniramine, PseudoephedrineAlka-Seltzer PLUS Liquid Gels, Children's Tylenol Cold, Codimal, Comtrex, Extra Strength Tylenol Allergy Sinus, Lorsin +3 more
How Acetaminophen, Chlorpheniramine, Pseudoephedrine interacts with Curamin Extra Strength — through 1 ingredient. Tap an ingredient for the detail:
Boswellia (boswellia Serrata) Gum Resin ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, Boswellia serrata might increase or decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Boswellia (boswellia Serrata) Gum Resin Extract + Acetaminophen, Chlorpheniramine, Pseudoephedrine interactionAcetaminophen, ChlorzoxazoneAcetazone Forte, Extra Strength Tylenol Aches & Strains, Parafon Forte
How Acetaminophen, Chlorzoxazone interacts with Curamin Extra Strength — through 1 ingredient. Tap an ingredient for the detail:
Boswellia (boswellia Serrata) Gum Resin ExtractCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, Boswellia serrata might increase the levels of CYP1A2 substrates.
Read the full Boswellia (boswellia Serrata) Gum Resin Extract + Acetaminophen, Chlorzoxazone interactionAcetaminophen, Chlorzoxazone, CodeineAcetazone Forte C8, Parafon Forte C8
How Acetaminophen, Chlorzoxazone, Codeine interacts with Curamin Extra Strength — through 1 ingredient. Tap an ingredient for the detail:
Boswellia (boswellia Serrata) Gum Resin ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, Boswellia serrata might increase the levels of CYP1A2 substrates.
Read the full Boswellia (boswellia Serrata) Gum Resin Extract + Acetaminophen, Chlorzoxazone, Codeine interactionAcetaminophen, CodeineTylenol No.3, Tylenol w/ Codeine
How Acetaminophen, Codeine interacts with Curamin Extra Strength — through 1 ingredient. Tap an ingredient for the detail:
Boswellia (boswellia Serrata) Gum Resin ExtractCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, Boswellia serrata might increase the levels of CYP2D6 substrates.
Read the full Boswellia (boswellia Serrata) Gum Resin Extract + Acetaminophen, Codeine interactionAcetaminophen, Codeine, DoxylamineMersyndol
How Acetaminophen, Codeine, Doxylamine interacts with Curamin Extra Strength — through 1 ingredient. Tap an ingredient for the detail:
Boswellia (boswellia Serrata) Gum Resin ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, Boswellia serrata might increase the levels of CYP1A2 substrates.
Read the full Boswellia (boswellia Serrata) Gum Resin Extract + Acetaminophen, Codeine, Doxylamine interactionAcetaminophen, Codeine, MethocarbamolAcetaminophen, Codeine, Methocarbamol, Robaxacet 8
How Acetaminophen, Codeine, Methocarbamol interacts with Curamin Extra Strength — through 1 ingredient. Tap an ingredient for the detail:
Boswellia (boswellia Serrata) Gum Resin ExtractCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, Boswellia serrata might increase the levels of CYP2D6 substrates.
Read the full Boswellia (boswellia Serrata) Gum Resin Extract + Acetaminophen, Codeine, Methocarbamol interactionAcetaminophen, Dexbrompheniramine, PseudoephedrineSinadrin Plus
How Acetaminophen, Dexbrompheniramine, Pseudoephedrine interacts with Curamin Extra Strength — through 1 ingredient. Tap an ingredient for the detail:
Boswellia (boswellia Serrata) Gum Resin ExtractCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, Boswellia serrata might increase the levels of CYP1A2 substrates.
Read the full Boswellia (boswellia Serrata) Gum Resin Extract + Acetaminophen, Dexbrompheniramine, Pseudoephedrine interactionAcetaminophen, DextromethorphanTylenol Cough Ex Strength
How Acetaminophen, Dextromethorphan interacts with Curamin Extra Strength — through 1 ingredient. Tap an ingredient for the detail:
Boswellia (boswellia Serrata) Gum Resin ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, Boswellia serrata might increase the levels of CYP1A2 substrates.
Read the full Boswellia (boswellia Serrata) Gum Resin Extract + Acetaminophen, Dextromethorphan interactionAcetaminophen, Dextromethorphan, Doxylamine, PseudoephedrineVicks NyQuil
How Acetaminophen, Dextromethorphan, Doxylamine, Pseudoephedrine interacts with Curamin Extra Strength — through 1 ingredient. Tap an ingredient for the detail:
Boswellia (boswellia Serrata) Gum Resin ExtractCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, Boswellia serrata might increase the levels of CYP2D6 substrates.
Read the full Boswellia (boswellia Serrata) Gum Resin Extract + Acetaminophen, Dextromethorphan, Doxylamine, Pseudoephedrine interactionAcetaminophen, Dextromethorphan, Guaifenesin, PhenylephrineConar-A
How Acetaminophen, Dextromethorphan, Guaifenesin, Phenylephrine interacts with Curamin Extra Strength — through 1 ingredient. Tap an ingredient for the detail:
Boswellia (boswellia Serrata) Gum Resin ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, Boswellia serrata might increase or decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Boswellia (boswellia Serrata) Gum Resin Extract + Acetaminophen, Dextromethorphan, Guaifenesin, Phenylephrine interactionAcetaminophen, Dextromethorphan, Guaifenesin, PhenylpropanolamineAnatuss
How Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine interacts with Curamin Extra Strength — through 1 ingredient. Tap an ingredient for the detail:
Boswellia (boswellia Serrata) Gum Resin ExtractCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, Boswellia serrata might increase the levels of CYP2D6 substrates.
Read the full Boswellia (boswellia Serrata) Gum Resin Extract + Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine interactionAcetaminophen, Dextromethorphan, Guaifenesin, PseudoephedrineRobitussin Cold, Severe Cold, Suphedrine Cold/Cough
How Acetaminophen, Dextromethorphan, Guaifenesin, Pseudoephedrine interacts with Curamin Extra Strength — through 1 ingredient. Tap an ingredient for the detail:
Boswellia (boswellia Serrata) Gum Resin ExtractCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, Boswellia serrata might increase the levels of CYP2D6 substrates.
Read the full Boswellia (boswellia Serrata) Gum Resin Extract + Acetaminophen, Dextromethorphan, Guaifenesin, Pseudoephedrine interactionAcetaminophen, Dextromethorphan, Phenylpropanolamine, PyrilamineTheracaps
How Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interacts with Curamin Extra Strength — through 1 ingredient. Tap an ingredient for the detail:
Boswellia (boswellia Serrata) Gum Resin ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates +1 Moderate
Interaction Summary
Theoretically, Boswellia serrata might increase the levels of CYP1A2 substrates.
Read the full Boswellia (boswellia Serrata) Gum Resin Extract + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionAcetaminophen, Dextromethorphan, PseudoephedrineAlka-Seltzer PLUS Flu Liquid Gels, Non Aspirin Cold Caps, Tylenol Cold, Tylenol Flu Daytime Ex Strength, Tylenol Flu Ex Strength
How Acetaminophen, Dextromethorphan, Pseudoephedrine interacts with Curamin Extra Strength — through 1 ingredient. Tap an ingredient for the detail:
Boswellia (boswellia Serrata) Gum Resin ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates +1 Moderate
Interaction Summary
Theoretically, Boswellia serrata might increase or decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Boswellia (boswellia Serrata) Gum Resin Extract + Acetaminophen, Dextromethorphan, Pseudoephedrine interactionAcetaminophen, Dichloralantipyrine, IsomethepteneAmidrine, Midchlor, Migquin, Migratine
How Acetaminophen, Dichloralantipyrine, Isometheptene interacts with Curamin Extra Strength — through 1 ingredient. Tap an ingredient for the detail:
Boswellia (boswellia Serrata) Gum Resin ExtractCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, Boswellia serrata might increase the levels of CYP1A2 substrates.
Read the full Boswellia (boswellia Serrata) Gum Resin Extract + Acetaminophen, Dichloralantipyrine, Isometheptene interactionAcetaminophen, Dichloralphenazone, IsomethepteneMidrin
How Acetaminophen, Dichloralphenazone, Isometheptene interacts with Curamin Extra Strength — through 1 ingredient. Tap an ingredient for the detail:
Boswellia (boswellia Serrata) Gum Resin ExtractCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, Boswellia serrata might increase the levels of CYP1A2 substrates.
Read the full Boswellia (boswellia Serrata) Gum Resin Extract + Acetaminophen, Dichloralphenazone, Isometheptene interactionAcetaminophen, Dichlorophenazone, IsometheptaneIsocom
How Acetaminophen, Dichlorophenazone, Isometheptane interacts with Curamin Extra Strength — through 1 ingredient. Tap an ingredient for the detail:
Boswellia (boswellia Serrata) Gum Resin ExtractCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, Boswellia serrata might increase the levels of CYP1A2 substrates.
Read the full Boswellia (boswellia Serrata) Gum Resin Extract + Acetaminophen, Dichlorophenazone, Isometheptane interactionAcetaminophen, DiphenhydramineTylenol PM, Tylenol PM Ex Strength
How Acetaminophen, Diphenhydramine interacts with Curamin Extra Strength — through 1 ingredient. Tap an ingredient for the detail:
Boswellia (boswellia Serrata) Gum Resin ExtractCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, Boswellia serrata might increase the levels of CYP1A2 substrates.
Read the full Boswellia (boswellia Serrata) Gum Resin Extract + Acetaminophen, Diphenhydramine interactionAcetaminophen, Diphenhydramine, PseudoephedrineChildren's Tylenol Allergy, Cold Control, Contac Night Allergy Relief
How Acetaminophen, Diphenhydramine, Pseudoephedrine interacts with Curamin Extra Strength — through 1 ingredient. Tap an ingredient for the detail:
Boswellia (boswellia Serrata) Gum Resin ExtractCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, Boswellia serrata might increase the levels of CYP1A2 substrates.
Read the full Boswellia (boswellia Serrata) Gum Resin Extract + Acetaminophen, Diphenhydramine, Pseudoephedrine interactionAcetaminophen, Doxylamine, PseudoephedrineEx Strength Tylenol Sinus Nighttime
How Acetaminophen, Doxylamine, Pseudoephedrine interacts with Curamin Extra Strength — through 1 ingredient. Tap an ingredient for the detail:
Boswellia (boswellia Serrata) Gum Resin ExtractCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, Boswellia serrata might increase the levels of CYP1A2 substrates.
Read the full Boswellia (boswellia Serrata) Gum Resin Extract + Acetaminophen, Doxylamine, Pseudoephedrine interactionAcetaminophen, HydrocodoneAnexsia, Anodynos DHC, Azdone, Co-Gesic, Doucet, Lorcet +9 more
How Acetaminophen, Hydrocodone interacts with Curamin Extra Strength — through 1 ingredient. Tap an ingredient for the detail:
Boswellia (boswellia Serrata) Gum Resin ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates +1 Moderate
Interaction Summary
Theoretically, Boswellia serrata might increase the levels of CYP1A2 substrates.
Read the full Boswellia (boswellia Serrata) Gum Resin Extract + Acetaminophen, Hydrocodone interactionAcetaminophen, IbuprofenCombogesic
How Acetaminophen, Ibuprofen interacts with Curamin Extra Strength — through 2 ingredients. Tap an ingredient for the detail:
Boswellia (boswellia Serrata) Gum Resin ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 2c9 (cyp2c9) Substrates Moderate
Interaction Summary
Theoretically, Boswellia serrata might increase the levels of CYP1A2 substrates.
Read the full Boswellia (boswellia Serrata) Gum Resin Extract + Acetaminophen, Ibuprofen interactionNattokinaseAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Nattokinase might increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.
Read the full Nattokinase + Acetaminophen, Ibuprofen interactionAcetaminophen, MeperidineDemerol APAP
How Acetaminophen, Meperidine interacts with Curamin Extra Strength — through 1 ingredient. Tap an ingredient for the detail:
Boswellia (boswellia Serrata) Gum Resin ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, Boswellia serrata might increase the levels of CYP1A2 substrates.
Read the full Boswellia (boswellia Serrata) Gum Resin Extract + Acetaminophen, Meperidine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Curamin Extra Strength with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Boswellia (Boswellia serrata) gum resin extract
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, Boswellia serrata might increase the levels of CYP1A2 substrates.
In vitro research shows that Boswellia serrata gum resin inhibits CYP1A2 enzymes.
Cytochrome P450 2C19 (Cyp2C19) Substrates
Theoretically, Boswellia serrata might increase the levels of CYP2C19 substrates.
In vitro research shows that Boswellia serrata gum resin inhibits CYP2C19 enzymes.
Cytochrome P450 2C9 (Cyp2C9) Substrates
Theoretically, Boswellia serrata might increase the levels of CYP2C9 substrates.
In vitro research shows that Boswellia serrata gum resin inhibits CYP2C9 enzymes.
Cytochrome P450 2D6 (Cyp2D6) Substrates
Theoretically, Boswellia serrata might increase the levels of CYP2D6 substrates.
In vitro research shows that Boswellia serrata gum resin inhibits CYP2D6 enzymes.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, Boswellia serrata might increase or decrease the levels and clinical effects of CYP3A4 substrates.
In vitro research shows that Boswellia serrata gum resin inhibits CYP3A4 enzymes. Other in vitro research shows that Boswellia serrata extract inhibits CYP3A4 enzymes at most concentrations, although it may modestly induce enzyme activity at low concentrations.
Immunosuppressants
Theoretically, Boswellia serrata might alter the effects of immunosuppressive drugs.
Some in vitro research suggests that Boswellia serrata extracts might inhibit mediators of autoimmune disorders such as leukotrienes and reduce production of antibodies and cell-mediated immunity. However, other in vitro research suggests that, when coupled with calcium ions, boswellic acids containing the keto group have immunostimulant properties within specific cell signaling pathways.
Nattokinase
Anticoagulant/Antiplatelet Drugs
Nattokinase might increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.
Nattokinase has thrombolytic and anticoagulant effects. There is a case report of intracranial hemorrhage in a patient who added nattokinase to aspirin therapy.
Antihypertensive Drugs
Theoretically, nattokinase might increase the risk of hypotension when used with antihypertensive drugs.
Some clinical research suggests that nattokinase may reduce systolic and diastolic blood pressure.
Brand information
Manufacturer and brand details for Curamin Extra Strength, from the product label.
Terry Naturally
See all Terry Naturally products- Name
- EuroPharma, Inc.
- City
- Green Bay
- State
- WI
- ZipCode
- 54311
- Phone Number
- (866) 807-2731
- Web Address
- EuroPharmaUSA.com
Curamin Extra Strength by Terry Naturally: Common Questions
Does Curamin Extra Strength by Terry Naturally interact with any medications?
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What's nattokinase, and why is it in here?
Does Boswellia actually work for joint pain?
Is it safe to take while breastfeeding?
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Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Curamin Extra Strength’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Nattokinase
Interacts with 289 drugsNattokinase is an enzyme from the fermented soybean food natto that may have mild blood-thinning and blood-flow effects. Some small studies hint at benefits for blood pressure and circulatio...
Read the full Nattokinase monograph → Herb & supplement monographBoswellia Serrata
Interacts with 952 drugsBoswellia serrata is a tree resin used in traditional medicine, mainly for joint pain and inflammation. Some studies suggest it may help with osteoarthritis symptoms, but the overall evidenc...
Read the full Boswellia Serrata monograph →Sources & How We Checked
Curamin Extra Strength's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 25 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Nattokinase 9 references
- Suzuki Y, Kondo K, Matsumoto Y, et al. Dietary supplementation of fermented soybean, natto, suppresses intimal thickening and modulates the lysis of mural thrombi after endothelial injury in rat femoral artery. Life Sci 2003;73:1289-98.. PubMed
- Sumi H, Hamada H, Nakanishi K, Hiratani H. Enchancement of fibrinolytic activity in plasma by oral administration of nattokinase. Acta Haematol 1990;84:139-43.
- Chang, Y. Y., Liu, J. S., Lai, S. L., Wu, H. S., and Lan, M. Y. Cerebellar hemorrhage provoked by combined use of nattokinase and aspirin in a patient with cerebral microbleeds. Intern Med 2008;47(5):467-469. PubMed
- Kim, J. Y., Gum, S. N., Paik, J. K., Lim, H. H., Kim, K. C., Ogasawara, K., Inoue, K., Park, S., Jang, Y., and Lee, J. H. Effects of nattokinase on blood pressure: a randomized, controlled trial. Hypertens.Res 2008;31(8):1583-1588. PubMed
- <p>Maruyama M, Sumi H (eds): Effect of natto diet on blood pressure, in Basic and Clinical Aspects of Japanese Traditional Food Natto II. Japan Technology Transfer Association (JTTAS), 1998, pp 1–3.</p>
- Kurosawa Y, Nirengi S, Homma T, et al. A single-dose of oral nattokinase potentiates thrombolysis and anti-coagulation profiles. Sci Rep 2015;5:11601. PubMed
- Ramachandran L, Aqeel A, Jafri A, Sidhu Y, Mohamed Djirdeh T. Nattokinase-associated hemoperitoneum in an elderly woman. Cureus 2021;13(12):e20074. PubMed
- Awatani-Yoshidome K, Hashimoto T, Satoh T. Anaphylaxis from nattokinase in a patient with fermented soybean (natto) allergy. Allergol Int 2022;71(1):153-4. PubMed
- Suzuki K, Nakamura M, Sato N, Futamura K, Matsunaga K, Yagami A. Nattokinase, a subtilisin family serine protease, is a novel allergen contained in the traditional Japanese fermented food natto. Allergol Int 2022.
Boswellia Serrata 16 references
- Gupta I, Gupta V, Parihar A, et al. Effects of Boswellia serrata gum resin in patients with bronchial asthma: results of a double-blind, placebo-controlled, 6-week clinical study. Eur J Med Res 1998;3:511-4.
- Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
- Kimmatkar N, Thawani V, Hingorani L, et al. Efficacy and tolerability of Boswellia serrata extract in treatment of osteoarthritis of knee--a randomized double blind placebo controlled trial. Phytomedicine 2003;10:3-7. PubMed
- Liu JJ, Nilsson A, Oredsson S, et al. Boswellic acids trigger apoptosis via a pathway dependent on caspase-8 activation but independent on Fas/Fas ligand interaction in colon cancer HT-29 cells. Carcinogenesis 2002;23:2087-93. PubMed
- Wildfeuer A, Neu IS, Safayhi H, et al. Effects of boswellic acids extracted from a herbal medicine on the biosynthesis of leukotrienes and the course of experimental autoimmune encephalomyelitis. Arzneimittelforschung 1998;48:668-74.
- Gupta I, Parihar A, Malhotra P, et al. Effects of gum resin of Boswellia serrata in patients with chronic colitis. Planta Med 2001;67:391-5. PubMed
- Sengupta K, Alluri KV, Satish AR, et al. A double blind, randomized, placebo controlled study of the efficacy and safety of 5-Loxin. Arthritis Res Ther 2008;10:R85.
- Sengupta K, Krishnaraju AV, Vishal AA, et al. Comparative efficacy and tolerability of 5-Loxin and Aflapin against osteoarthritis of the knee: a double blind, randomized, placebo controlled clinical study. Int J Med Sci 2010;7:366-77.
- Ernst E. Frankincense: systematic review. BMJ 2008;337:a2813. PubMed
- Kirste S, Treier M, Wehrle SJ, et al. Boswellia serratea extract acts on cerebral edema in patients irradiated for brain tumors: a prospective, randomized, placebo-controlled, double-blind pilot trial. Cancer 2011;117:3788-95.
- Frank A, Unger M. Analysis of frankincense from various Boswellia species with inhibitory activity on human drug metabolising cytochrome P450 enzymes using liquid chromatography mass spectrometry after automated on-line extraction. J Chromatogr A 2006;111 PubMed
- Altmann A, Poeckel D, Fischer L, et al. Coupling of boswellic acid-incuded Ca2+ mobilisation and MAPK activation to lipid metabolism and peroxide formation in human leucocytes. Br J Pharmacol 2004;141:223-32.
- El Fortia, M., Badi, H., Elalem, Kh, Kadiki, O., and Topov, Y. Olibanum bezoar: complication of a traditional popular medicine. East Mediterr.Health J 2006;12(6):927-929.
- Meshkat S, Mahmoodi Baram S, Rajaei S, et al. Boswellia serrata extract shows cognitive benefits in a double-blind, randomized, placebo-controlled pilot clinical trial in individuals who suffered traumatic brain injury. Brain Inj 2022;36(4):553-559. PubMed
- Haron MH, Dale O, Martin K, et al. Evaluation of the Herb-Drug Interaction Potential of Commonly Used Botanicals on the US Market with Regard to PXR- and AhR-Mediated Influences on CYP3A4 and CYP1A2. J Diet Suppl 2022. PubMed
- Valente IVB, Garcia D, Abbott A, et al. The anti-proliferative effects of a frankincense extract in a window of opportunity phase ia clinical trial for patients with breast cancer. Breast Cancer Res Treat 2024;204(3):521-530. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC