D-Mannose 1500 mg Ingredients & Drug Interactions
What is this page for?
First and foremost: checking D-Mannose 1500 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
D-Mannose 1500 mg is a dietary supplement by Mental Refreshment with 2 active ingredients. Its ingredients are commonly taken for preventing urinary tract infections (utis), treating mild utis, urinary tract health.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.
HelloPharmacist Scorecard of D-Mannose 1500 mg by Mental Refreshment
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: D-mannose, a naturally occurring simple sugar. The capsule also holds gelatin and rice powder as inactive ingredients that help hold the formula together.
Does it work?
Leans against
The evidence here is mixed. D-mannose is likely effective for carbohydrate-deficient glycoprotein syndrome type 1b, a rare genetic condition affecting how your body makes certain proteins.
For urinary tract infections (UTIs), though, the data suggests it's possibly ineffective — meaning the evidence doesn't support it as a reliable treatment for that use.
How safe is it?
Well-documented data
D-mannose is generally well tolerated in the short term, but we don't have strong long-term safety data, so talk with your doctor before taking it long-term. The most common side effects are bloating, diarrhea, and nausea.
Diarrhea is more likely if you take a single dose over about 15 grams. There isn't enough reliable safety data in pregnancy, so it's best to avoid it unless your doctor advises otherwise.
Safety while breastfeeding hasn't been well studied, so caution is advised — check with your doctor or pharmacist about whether it's right for you.
Meds to double-check
No known interactions
No interactions are documented in our data for D-mannose. That said, mention this product to your pharmacist when you pick up any new prescriptions — it's always good to double-check.
The bottom line
Scorecard at a glanceFully disclosed formula with graded evidence leaning against its stated purpose. No medication interactions are currently documented, and safety information is well characterized.
D-Mannose 1500 mg may be worth considering if your doctor has prescribed it for carbohydrate-deficient glycoprotein syndrome type 1b. If you're taking it for UTI prevention or treatment, the evidence doesn't support that use.
Anyone pregnant, breastfeeding, or taking regular medications should talk with their doctor or pharmacist before starting.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Apr 22, 2021.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about D-Mannose 1500 mg, straight from the product label.
| Brand | Mental Refreshment |
|---|---|
| Barcode (UPC) | 715854664727 |
| Net contents | 180 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Apr 22, 2021 |
| DSLD ID | 247608 |
| Product type | Fiber And Other Nutrients |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for D-Mannose 1500 mg by Mental Refreshment, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Calories | 6 Calorie(s) | -- |
| Total Carbohydrates | 1.5 Gram(s) | -- |
| Sugar | 1.5 Gram(s) | -- |
| D-Mannose | 1.5 Gram(s) | -- |
Other ingredients: Gelatin, Rice powder
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements
Premium Brand / Optimum Results Maximum Strength
100% Satisfaction Guaranteed
Formulation
Supports Urinary Tract Health Supports Liver Function Supports Intestinal Health
Contains No: Artificial coloring, artificial flavor, preservatives, yeast, corn, milk or milk derivatives, lactose, salt, sodium, soy, sugar, gluten, starch or wheat.
Guaranteed Laboratory Tested Quality
FDA Statement of Identity
Dietary Supplement
Precautions
Keep out of reach of children.
Warning: If you are pregnant, nursing or taking any medications, consult your doctor before use.
Discontinue use and consult your doctor if any adverse reactions occur.
Not intended for use by persons under the age of 18.
Storage
Store in a dry place and avoid excessive heat.
Seals/Symbols
Made in the USA Manufactured in a FDA Registered facility that conforms to GMP standards GMP Good Manufacturing Practice Consistent quality
Suggested/Recommended/Usage/Directions
Directions: For adults, take three (3) capsules daily, preferably with meals. As a reminder discuss supplements and medications you take with your healthcare providers.
FDA Disclaimer Statement
This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
D-Mannose 1500 mg by Mental Refreshment label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in D-Mannose 1500 mg by Mental Refreshment
These are the 2 active ingredients this product is made of. Select any to open its full monograph.
Serving size3 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Sugar
D-Mannose
No knowninteractions
D-mannose is a natural sugar most often used to help prevent urinary tract infections, especially those caused by E. coli. Early research is promising...
D-Mannose monograph & interactionsOther (inactive) ingredients: Gelatin, Rice powder. These complete the product’s ingredient list but are not active constituents.
D-Mannose 1500 mg by Mental Refreshment Drug Interactions
We don’t currently list any known drug interactions for the mapped ingredients in D-Mannose 1500 mg. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.
Brand information
Manufacturer and brand details for D-Mannose 1500 mg, from the product label.
D-Mannose 1500 mg by Mental Refreshment: Common Questions
Does D-Mannose 1500 mg by Mental Refreshment interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Will D-mannose mess with my other medications?
Is D-mannose actually effective for UTIs?
What are the most common side effects?
Can I take this while pregnant or breastfeeding?
What is D-mannose used for?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if D-Mannose 1500 mg is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind D-Mannose 1500 mg’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
D-Mannose 1500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 6 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
D-mannose 6 references
- Westphal V, Kjaergaard S, Davis JA, et al. Genetic and metabolic analysis of the first adult with congenital disorder of glycosylation type Ib: long-term outcome and effects of mannose supplementation. Mol Genet Metab 2001;73:77-85. PubMed
- Kranjcec B, Papes D, Altarac S. D-mannose powder for prophylaxis of recurrent urinary tract infections in women: a randomized clinical trial. World J Urol. 2014 Feb;32(1):79-84.
- de Lonlay P, Seta N. The clinical spectrum of phosphomannose isomerase deficiency, with an evaluation of mannose treatment for CDG-Ib. Biochim Biophys Acta. 2009;1792(9):841-3. PubMed
- Harms HK, Zimmer KP, Kurnik K, Bertele-Harms RM, Weidinger S, Reiter K. Oral mannose therapy persistently corrects the severe clinical symptoms and biochemical abnormalities of phosphomannose isomerase deficiency. Acta Paediatr. 2002;91(10):1065-72. DOI
- . Damen G, de Klerk H, Huijmans J, den Hollander J, Sinaasappel M. Gastrointestinal and other clinical manifestations in 17 children with congenital disorders of glycosylation type Ia, Ib, and Ic. J Pediatr Gastroenterol Nutr. 2004;38(3):282-7. DOI
- Lenger SM, Bradley MS, Thomas DA, Bertolet MH, Lowder JL, Sutcliffe S. D-mannose vs other agents for recurrent urinary tract infection prevention in adult women: a systematic review and meta-analysis. Am J Obstet Gynecol. 2020;223(2):265.e1-265.e13. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC