Digest Ingredients & Drug Interactions
by Enzymedica
What is this page for?
First and foremost: checking Digest against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Digest is a dietary supplement by Enzymedica with 12 active ingredients. Its ingredients are commonly taken for digestion and bloating, muscle soreness and exercise recovery, inflammation and swelling.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.
HelloPharmacist Scorecard of Digest by Enzymedica
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
Enzymedica Digest is a 12-ingredient enzyme blend designed to help break down food. It includes protease (for protein), lipase (for fat), lactase (for lactose in milk products), and nine other enzymes—amylase, cellulase, pectinase, invertase, glucoamylase, alpha-galactosidase, xylanase, maltase, and hemicellulase—that target different carbohydrates and fiber.
The only inactive ingredients are cellulose and water.
Does it work?
Strong evidence
Lactase in this product is rated effective for lactose intolerance—that's the main enzyme with solid evidence. The other enzymes don't have enough reliable evidence in our data to establish how well they work for digestive complaints like indigestion (dyspepsia) or inflammatory bowel disease.
Your results may depend on your individual digestion and the types of foods you eat.
How safe is it?
Well-documented data
Protease, lipase, and lactase are generally well tolerated in most adults, though some people report mild digestive upset. Rarely, people with airborne or skin exposure to proteolytic enzymes have developed allergic reactions like allergic rhinoconjunctivitis or asthma; direct ingestion in supplement form carries lower risk.
For pregnancy, safety data is limited: protease should be avoided unless prescribed, lipase should only be used on doctor's advice, and lactase is rated likely safe but check first. During breastfeeding, protease and lipase are not recommended without medical guidance; lactase acts only in the gut but still warrants a conversation with your doctor or pharmacist first.
Meds to double-check
No known interactions
No interactions are documented in our data for the three enzymes we could check. The remaining nine ingredients could not be checked because we hold no monograph data for them.
If you take medications, run them through the checker below to be sure.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with clinical evidence supporting its stated purpose. No medication interactions are currently documented, and safety information is well characterized.
This product makes sense if you're looking for enzyme support with digestion, especially if you have trouble with lactose. If you're pregnant or breastfeeding, take it up with your doctor or pharmacist first—the safety data varies by ingredient.
If you take any prescription medications, check them with the tool on this page before you start.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 3 of 12 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated May 21, 2025.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Digest, straight from the product label.
| Brand | Enzymedica |
|---|---|
| Barcode (UPC) | 670480981108 |
| Net contents | 180 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | May 21, 2025 |
| DSLD ID | 328877 |
| Product type | Non-nutrient/non-botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Vegan, Vegetarian, Adult (18 - 50 Years), Kosher, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Digest by Enzymedica, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Amylase | 0 NP | -- |
| Protease | 0 NP | -- |
| Lipase | 0 NP | -- |
| Lactase | 0 NP | -- |
| Cellulase | 0 NP | -- |
| Pectinase | 0 NP | -- |
| Invertase | 0 NP | -- |
| Glucoamylase | 0 NP | -- |
| Alpha-Galactosidase | 0 NP | -- |
| Xylanase | 0 NP | -- |
| Maltase | 0 NP | -- |
| Hemicellulase | 0 NP | -- |
Other ingredients: Cellulose, Water
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation
Enzyme deficiencies may result from a combination of age, diet and lifestyle. These deficiencies can lead to a variety of digestive discomforts, including occasional gas, bloating, indigestion and irregularity.
Digest is an enhanced formula that breaks down carbohydrates, fats, fiber and protein. The enzymes included in Digest support optimal digestion by helping the body absorb nutrients and convert food into energy. Digestive well-being improves concentration and increases vitality.
Thera-blend enzymes are comprised of multiple variants which are blended to work synergistically throughout the broad pH range of the human body.
No fillers added
Made in USA with global ingredients
Non GMO
Digestive
Complete enzyme formula Enhanced digestive support
Vegan & Kosher
Contains No: Gluten, milk, casein, soy, egg, artificial colors or flavors
Do no use if safety seal is broken or missing.
Suggested/Recommended/Usage/Directions
Recommended use: 1 capsule with each meal. More may be taken as needed. For higher enzyme potency, Enzymedica's Digest Gold may be helpful.
General Statements
#1 selling enzyme brand
Twice the enzyme power of digest basic
Toll-free: 1-888-918-1118 | enzymedica.com
Enzymedica Supports Autism Hope Alliance Vitamin Angels Proud Supporter Green Mountain Energy
FDA Statement of Identity
Dietary Supplement
Formula
Vegan & Kosher
K Parve (Kosher) #K1840
Storage
Keep closed in dry place; avoid excessive heat.
Precautions
Please keep out of reach of children.
Seals/Symbols
K Parve (Kosher) #K1840
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Digest by Enzymedica label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Digest by Enzymedica
These are the 12 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container180 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Amylase
Protease
No knowninteractions
Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), tr...
Protease monograph & interactionsLipase
No knowninteractions
Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy fo...
Lipase monograph & interactionsLactase
No knowninteractions
Lactase is a digestive enzyme supplement that helps people who lack enough natural lactase break down lactose, the sugar in milk and dairy. It can red...
Lactase monograph & interactionsCellulase
Pectinase
Invertase
Glucoamylase
Alpha-Galactosidase
Xylanase
Maltase
Hemicellulase
Other (inactive) ingredients: Cellulose, Water. These complete the product’s ingredient list but are not active constituents.
Digest by Enzymedica Drug Interactions
We don’t currently list any known drug interactions for the mapped ingredients in Digest. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.
Brand information
Manufacturer and brand details for Digest, from the product label.
Enzymedica
See all Enzymedica products- Name
- Enzymedica, Inc.
- Street Address
- 771 Commerce Drive
- City
- Venice
- State
- FL
- ZipCode
- 34292
- Phone Number
- 1-888-918-1118
- Web Address
- enzymedica.com
Digest by Enzymedica: Common Questions
Does Digest by Enzymedica interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Will this help if I'm lactose intolerant?
Can I take this if I'm pregnant?
Is it safe to breastfeed while taking this?
What are these enzymes supposed to do?
Are there any known side effects?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Digest is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Digest’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Proteolytic Enzymes (proteases)
Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...
Read the full Proteolytic Enzymes (proteases) monograph → Herb & supplement monographLipase
Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy for people who cannot make enough of their...
Read the full Lipase monograph → Herb & supplement monographLactase
Lactase is a digestive enzyme supplement that helps people who lack enough natural lactase break down lactose, the sugar in milk and dairy. It can reduce gas, bloating, cramping, and diarrhe...
Read the full Lactase monograph →Sources & How We Checked
Digest's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 5 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Proteolytic Enzymes (proteases) 3 references
- Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
- Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
- Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed
See these in context on the Proteolytic Enzymes (proteases) monograph →
Lipase 1 reference
- Casper C, Hascoet JM, Ertl T, et al. Recombinant bile salt-stimulated lipase in preterm infant feeding: A randomized phase 3 study. PLoS One. 2016;11(5):e0156071. PubMed
Lactase 1 reference
- Laukkanen A, Ruoppi P, Remes S, Koistinen T, Mäkinen-Kiljunen S. Lactase-induced occupational protein contact dermatitis and allergic rhinoconjunctivitis. Contact Dermatitis. 2007;57(2):89-93. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC