Interactions on record — worth a quick check against your medications. Based on 6 of 16 ingredients. Check your meds →
Dietary supplement

Digest Extra Ingredients & Drug Interactions

by The Vitamin Shoppe

Digest Extra label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Digest Extra against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Digest Extra is a dietary supplement by The Vitamin Shoppe with 16 active ingredients. Its ingredients are commonly taken for digestive support, bloating and gas, fat digestion.Based on those ingredients, 333 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Legume and Grain Digesting Enzymes, Bromelain, Papain. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Digest Extra by The Vitamin Shoppe

Ask about any prescription or over-the-counter medication and we check it for interactions with Digest Extra by The Vitamin Shoppe — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Digest Extra by The Vitamin Shoppe

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 23, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 17 active ingredients.
  • “Fat Digesting Enzymes” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.
  • “Protein and Gluten Digesting Enzymes” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.
  • “DPP IV Peptidase Blend” is a proprietary blend — the label doesn't break down how much of each component you get.

Digest Extra is a 17-ingredient digestive enzyme blend designed to support the breakdown of different foods. The active ingredients include bromelain (from pineapple), papain (from papaya), and a range of other enzymes: proteases for protein digestion, amylase and diastase for starch breakdown, lactase for lactose, lipase for fats, cellulase for fiber, and several others that target complex carbohydrates, legumes, and grains.

The product also contains inactive ingredients—vegetable cellulose, maltodextrin, microcrystalline cellulose, and medium chain triglycerides—which serve as capsule material and fillers.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: Digestive enzyme formula for gluten and dairy support.
  • We looked for evidence on: Celiac disease, Lactose intolerance, Dyspepsia, Enzyme deficiency, Malabsorption.
  • The strongest evidence on file: Lactase is rated "Effective" for Lactose intolerance (Natural Medicines).
  • Also on file: Lipase is rated "Insufficient Reliable Evidence To Rate" for Dyspepsia, Celiac disease.

The evidence we hold doesn't establish that Digest Extra works for any single condition. Bromelain, one of its main enzymes, shows insufficient reliable evidence for hay fever, burns, cancer, chemotherapy side effects, and other uses.

Papain and most of the other digestive enzymes in the blend have the same limitation—insufficient evidence to say whether they're effective. Lactase, used for lactose intolerance, is rated effective for that specific use.

Beyond that, the data doesn't support claims about this product's digestion-support benefits.

The evidence, ingredient by ingredient Lipase Bromelain Proteolytic Enzymes (proteases) Papain Calabar Bean Lactase

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 5 of the 5 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 5 of 5.
  • General safety write-ups exist for 5 of 5.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

The digestive enzymes in this product are generally well tolerated when used short-term, though some may cause stomach upset, diarrhea, or flatulence—especially bromelain and the proteases. Allergic reactions to enzyme supplements are possible but uncommon; people sensitive to bromelain, papain, or latex should be cautious.

Bromelain should be avoided during pregnancy and breastfeeding due to insufficient safety data. Papain is possibly unsafe in pregnancy—concentrated forms and unripe papaya are a concern—and should be avoided while breastfeeding.

Protease and acid protease are best avoided in pregnancy unless prescribed by your doctor, and safety during breastfeeding hasn't been well studied. Lactase is likely safe during pregnancy but talk with your doctor first; limited data exists for breastfeeding, so check before using.

Lipase carries little pregnancy safety data and warrants a conversation with your healthcare provider before regular use, and the same applies to breastfeeding.

Side effects, ingredient by ingredient Lipase Bromelain Proteolytic Enzymes (proteases) Papain Calabar Bean Lactase

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 5 matched ingredients can interact with medications — Papain, Bromelain.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 141 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Digest Extra, double-check with your doctor or pharmacist if you take warfarin or other blood thinners like dabigatran or apixaban, or antiplatelet drugs such as aspirin, clopidogrel, or ticlopidine. Bromelain may raise your bleeding risk with these.

If you're on tetracycline antibiotics (like doxycycline), bromelain might theoretically increase their levels—another conversation worth having.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product is for people looking to support their digestion with enzymes, though we don't have strong evidence it works. If you take warfarin or any blood thinner or antiplatelet medication, you need to check with your doctor before using it—papain and bromelain carry a real interaction risk.

Pregnant or breastfeeding? Several ingredients lack safety data, so talk with your pharmacist or doctor first.

Use the medication checker below to confirm it's safe with your prescriptions.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 7 of 17 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Sep 22, 2016.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Digest Extra, straight from the product label.

Brand The Vitamin Shoppe
Barcode (UPC) 766536030477
Net contents 216 Veggie Capsule(s)
Market status On market
Date entered into DSLD Sep 22, 2016
DSLD ID 64725
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Digest Extra by The Vitamin Shoppe, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Veggie Capsule(s)
Maximum serving Sizes:
1 Veggie Capsule(s)
UPC/BARCODE
766536030477
IngredientAmount% DV
Invertase0 NP--
Bromelain0 NP--
Fat Digesting Enzymes0 NP--
Protease0 NP--
Amylase I0 NP--
Cellulase0 NP--
Hemicellulase0 NP--
Xylanase0 NP--
Beta-Glucanase0 NP--
Alpha-Galactosidase0 NP--
Lactase0 NP--
Lipase0 NP--
Diastase0 NP--
Protease0 NP--
Peptidase0 NP--
Acid Protease0 NP--
Amylase II0 NP--
Protein and Gluten Digesting Enzymes0 NP--
DPP IV Peptidase Blend0 NP--
Papain0 NP--
Starch Digesting Enzymes0 NP--
Fiber and Complex Carbohydrate Digesting Enzymes0 NP--
Legume and Grain Digesting Enzymes0 NP--
Lactose Digesting Enzyme0 NP--

Other ingredients: Vegetable Cellulose, Maltodextrin, Microcrystalline Cellulose, Medium Chain Triglycerides

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Bonus size 20% more Specialty

Digestive enzyme formula Gluten and dairy support

Actual size

Visit www.vitaminshoppe.com or call 1-800-223-1216 for more information and to reorder.

FDA Statement of Identity

Dietary Supplement

Formulation

Gluten free Dairy free Soy free Nut free

Does not contain: Yeast, Wheat, Gluten, Sugar, Salt, Soy, Dairy, Citrus, Fish, Animal Derivatives, Preservatives, Artificial Colors or Flavors.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement, take one (1) veggie capsule at the beginning of each meal.

Precautions

Warning: Consult your healthcare provider prior to use if you are pregnant, nursing, taking any medication or have any medical conditions.

Keep out of reach of children.

Tamper evident Do not use if outer seal is broken or missing.

Storage

Store in a cool, dry place.

General

Item No. VS-3047 2086494 FQ 52

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Digest Extra by The Vitamin Shoppe label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Digest Extra label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Digest Extra by The Vitamin Shoppe

These are the 16 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Veggie Capsule(s) Dosage formCapsule Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Fat Digesting Enzymes

0 NP per serving

Protein and Gluten Digesting Enzymes

0 NP per serving

Starch Digesting Enzymes

0 NP per serving
  • › Invertase
  • › Amylase I
  • › Diastase
  • › Amylase II

Fiber and Complex Carbohydrate Digesting Enzymes

0 NP per serving
  • › Cellulase
  • › Hemicellulase
  • › Xylanase

Legume and Grain Digesting Enzymes

Interacts with
195 drugs
0 NP per serving

Calabar bean is a highly poisonous West African seed that contains physostigmine, a powerful cholinesterase inhibitor. It is not a safe dietary supple...

Legume and Grain Digesting Enzymes monograph & interactions
  • › Beta-Glucanase
  • › Alpha-Galactosidase

Lactose Digesting Enzyme

0 NP per serving

Other (inactive) ingredients: Vegetable Cellulose, Maltodextrin, Microcrystalline Cellulose, Medium Chain Triglycerides. These complete the product’s ingredient list but are not active constituents.

Interaction report

Digest Extra by The Vitamin Shoppe Drug Interactions

Want to check YOUR meds against Digest Extra?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
333Drugs
122 Moderate 211 Minor

Ingredients driving the most interactions

Legume and Grain Digesting Enzymes 195
Bromelain 141
Papain 2

Individual Drug Interactions

The ingredients in Digest Extra interact with 333 drugs. Click any drug to see the details.

3 of the 16 ingredients in Digest Extra interact with drugs. Each result below shows which ingredient is responsible. Legume and Grain Digesting Enzymes Bromelain Papain

Each ingredient & the kinds of drugs it affects

For each ingredient in Digest Extra with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Legume and Grain Digesting Enzymes1 drug type · 195 drugs

Anticholinergic Drugs

Theoretically, taking calabar bean might reduce the effects of anticholinergic drugs.
Physostigmine, a constituent of calabar bean, reverses the effects of belladonna and other drugs with anticholinergic activity.

Likelihood Unlikely Evidence D
Legume and Grain Digesting Enzymes full monograph & interactions

Bromelain2 drug types · 141 drugs

Anticoagulant/Antiplatelet Drugs

Bromelain may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
There is one case report of a patient experiencing minor bruising while taking bromelain with naproxen. Bromelain is thought to have antiplatelet activity. Whether this interaction is of concern with topical bromelain is unclear. Interference with coagulation of burn wounds has been reported in a patient receiving bromelain-based enzymatic debridement. However, observational research has found that topical bromelain debridement is not associated with increases or decreases in laboratory markers of coagulation when compared with surgical debridement.

Likelihood Possible Evidence D
Tetracycline Antibiotics

Theoretically, bromelain might increase levels of tetracycline antibiotics.
Laboratory research suggests that bromelain might increase the absorption of tetracycline antibiotics. However, a study in healthy adults reported no difference in tetracycline plasma levels when a 500 mg dose was taken with or without bromelain 80 mg.

Likelihood Possible Evidence B
Bromelain full monograph & interactions

Papain1 drug type · 2 drugs

Warfarin (Coumadin)

Theoretically, papain might increase the effects and side effects of warfarin.
In one case report, a patient previously stable on warfarin was found to have an international normalization ratio (INR) of 7.4, which was attributed to ingestion of a supplement containing papain from papaya extract.

Likelihood Possible Evidence D
Papain full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Digest Extra, from the product label.

The Vitamin Shoppe

See all The Vitamin Shoppe products
Name
Vitamin Shoppe, Inc.
City
Secaucus
State
NJ
ZipCode
07094
Phone Number
1-800-223-1216
Web Address
www.vitaminshoppe.com
Pharmacist Counseling Corner

Digest Extra by The Vitamin Shoppe: Common Questions

Does Digest Extra by The Vitamin Shoppe interact with any medications?
Yes. Based on its ingredients, Digest Extra has a known interaction with 333 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Digest Extra contains 16 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does this product really help with digestion?
The data we hold doesn't establish that it works. Bromelain and papain—the main digestive enzymes here—show insufficient evidence for their effectiveness. Lactase does work for lactose intolerance specifically, but the overall blend's digestive benefits aren't proven in our records.
Can I take this if I'm on warfarin?
Not without checking with your doctor first. Papain in this product may increase warfarin's effects and raise your bleeding risk. A case report documented a patient stable on warfarin whose levels spiked after taking a papain-containing supplement. This needs medical review.
What side effects might I get from Digest Extra?
Most commonly, diarrhea, flatulence, stomach upset, and headache—especially from bromelain. Allergic reactions like hives or itching are possible in people sensitive to papain, bromelain, or other enzymes in the blend, though they're uncommon. Stop and contact your doctor if you have difficulty swallowing or severe stomach pain.
Is this safe to take while pregnant?
Not reliably. Bromelain should be avoided during pregnancy; papain is possibly unsafe, especially concentrated forms or unripe papaya products. Protease and acid protease safety hasn't been established either. Talk with your doctor or pharmacist about whether this product is right for you during pregnancy.
Can I take this while breastfeeding?
Safety data is very limited. Bromelain and papain should be avoided while breastfeeding. Protease, acid protease, and lipase haven't been well studied in this context. Check with your healthcare provider first—there's not enough information to say it's okay without medical guidance.
What's the difference between all these enzymes in the blend?
They target different foods: bromelain and papain break down protein; amylase breaks down starches; lipase breaks down fats; cellulase breaks down fiber; lactase breaks down milk sugar. Together they're designed to help your body digest a variety of foods, though we don't have proof the combination works.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Digest Extra is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Digest Extra label
Go deeper

The Full Monographs Behind Digest Extra’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lipase

Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy for people who cannot make enough of their...

Read the full Lipase monograph → Herb & supplement monograph

Bromelain

Interacts with 141 drugs

Bromelain is a group of protein-digesting enzymes from pineapple that people take mainly for inflammation, swelling, and sinus problems. Some early studies are promising, but the overall evi...

Read the full Bromelain monograph → Herb & supplement monograph

Proteolytic Enzymes (proteases)

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...

Read the full Proteolytic Enzymes (proteases) monograph → Herb & supplement monograph

Papain

Interacts with 2 drugs

Papain is a protein-digesting enzyme from the papaya plant that is used in digestive supplements and some topical products. While it has clear food and laboratory uses, strong human evidence...

Read the full Papain monograph → Herb & supplement monograph

Calabar Bean

Interacts with 195 drugs

Calabar bean is a highly poisonous West African seed that contains physostigmine, a powerful cholinesterase inhibitor. It is not a safe dietary supplement, and eating the bean can cause seri...

Read the full Calabar Bean monograph → Herb & supplement monograph

Lactase

Lactase is a digestive enzyme supplement that helps people who lack enough natural lactase break down lactose, the sugar in milk and dairy. It can reduce gas, bloating, cramping, and diarrhe...

Read the full Lactase monograph →
Sources

Sources & How We Checked

Digest Extra's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 37 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Bromelain 19 references
  1. Nettis E, Napoli G, Ferrannini A, Tursi A. IgE-mediated allergy to bromelain. Allergy 2001;56:257-8. PubMed
  2. Taussig SJ, Batkin S. Bromelain, the enzyme complex of pineapple (Ananas comosus) and its clinical application. An update. J Ethnopharmacol 1988;22:191-203.. PubMed
  3. Bradbrook ID, Morrison PJ, Rogers HJ. The effect of bromelain on the absorption of orally administered tetracycline. Br J Clin Pharmacol 1978;6:552-4. PubMed
  4. Bush TM, Rayburn KS, Holloway SW, et al. Adverse interactions between herbal and dietary substances and prescription medications: a clinical survey. Altern Ther Health Med 2007;13:30-5.
  5. Brien S, Lewith G, Walker AF, et al. Bromelain as an adjunctive treatment for moderate-to-severe osteoarthritis of the knee: a randomized placebo-controlled pilot study. QJM 2006;99:841-50. PubMed
  6. Mori S, Ojima Y, Hirose T, et al. The clinical effect of proteolytic enzyme containing bromelain and trypsin on urinary tract infection evaluated by double blind method. Acta Obstet Gynaecol Jpn 1972;19:147-53.
  7. Glaser D, Hilberg T. The influence of bromelain on platelet count and platelet activity in vitro. Platelets 2006;17:37-41. PubMed
  8. Heinicke R M, van der Wal L, Yokoyama M. Effect of bromelain (Ananase) on human platelet aggregation. Experientia 1972;28:844-5. PubMed
  9. Gailhofer, G., Wilders-Truschnig, M., Smolle, J., and Ludvan, M. Asthma caused by bromelain: an occupational allergy. Clin Allergy 1988;18(5):445-450. PubMed
  10. Mattei, O., Fabri, G., and Farina, G. [Occupational health experience regarding four cases of asthma due to bromelain (author's transl)]. Medicina del Lavoro 1979;70(5):404-409.
  11. Galleguillos, F. and Rodriguez, J. C. Asthma caused by bromelin inhalation. Clin Allergy 1978;8(1):21-24. PubMed
  12. Perez-Camo I, Quirce S, Duran MA, and et al. Latex allergy: evidence of cross-reactivity with papain and bromelain [abstract]. Allergy 1996;51(suppl 31):48.
  13. Martin GJ, Ehrenreich J, and Asbell N. Bromelain: pineapple proteases with anti-edema activity. Exp Med Surg 1962;20:227-247.
  14. Kasemsuk T, Saengpetch N, Sibmooh N, Unchern S. Improved WOMAC score following 16-week treatment with bromelain for knee osteoarthritis. Clin Rheumatol. 2016 Oct;35(10):2531-40. PubMed
  15. Kutlu Ö, DemirbaS A, Elmas ÖF, Güvenç U, Metin A. Fixed drug eruption: a new side effect of bromelain. Contact Dermatitis 2020. Online ahead of print. PubMed
  16. Shoham Y, Shapira E, Haik J, et al. Bromelain-based enzymatic debridement of chronic wounds: Results of a multicentre randomized controlled trial. Wound Repair Regen 2021;29(6):899-907. PubMed
  17. Pfister P, Garcia Wendel PD, Kim BS, et al. Coagulation side effects of enzymatic debridement in burned patients. Burns 2022. PubMed
  18. Hasham S, Riyat H, Fletcher A, O'Boyle CP, Alexander S. To bleed or not to bleed? Case series and discussion of haemorrhage risk with enzymatic debridement in burn injuries. Scars Burn Heal 2023;9:20595131231168333. PubMed
  19. Leelakanok N, Petchsomrit A, Janurai T, Saechan C, Sunsandee N. Efficacy and safety of bromelain: A systematic review and meta-analysis. Nutr Health 2023. PubMed

See these in context on the Bromelain monograph →

Proteolytic Enzymes (proteases) 3 references
  1. Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
  2. Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
  3. Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed

See these in context on the Proteolytic Enzymes (proteases) monograph →

Lactase 1 reference
  1. Laukkanen A, Ruoppi P, Remes S, Koistinen T, Mäkinen-Kiljunen S. Lactase-induced occupational protein contact dermatitis and allergic rhinoconjunctivitis. Contact Dermatitis. 2007;57(2):89-93. PubMed

See these in context on the Lactase monograph →

Lipase 1 reference
  1. Casper C, Hascoet JM, Ertl T, et al. Recombinant bile salt-stimulated lipase in preterm infant feeding: A randomized phase 3 study. PLoS One. 2016;11(5):e0156071. PubMed

See these in context on the Lipase monograph →

Papain 11 references
  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Shaw D, Leon C, Kolev S, Murray V. Traditional remedies and food supplements: a 5-year toxicological study (1991-1995). Drug Saf 1997;17:342-56.
  3. Shuttleworth D, Hill S, Marks R, Connelly DM. Relief of experimentally induced pruritus with a novel eutectic mixture of local anaesthetic agents. Br J Dermatol 1988;119:535-40.
  4. Mansfield LE, Ting S, Haverly RW, Yoo TJ. The incidence and clinical implications of hypersensitivity to papain in an allergic population, confirmed by blinded oral challenge. Ann Allergy 1985;55:541-3.
  5. Martin, T., Uhder, K., Kurek, R., Roeddiger, S., Schneider, L., Vogt, H. G., Heyd, R., and Zamboglou, N. Does prophylactic treatment with proteolytic enzymes reduce acute toxicity of adjuvant pelvic irradiation? Results of a double-blind randomized trial PubMed
  6. Walker-Renard, P. Update on the medicinal management of phytobezoars. Am J Gastroenterol. 1993;88(10):1663-1666.
  7. Tymoszuk D, Wiszniewska M, Walusiak-Skorupa J. Papain-induced occupational rhinoconjunctivitis and asthma - A case report. Med Pr 2016;67(1):109-12. PubMed
  8. Soto-Mera MT, López-Rico MR, Filgueira JF, et al. Occupational allergy to papain. Allergy 2000;55(10):983-4. PubMed
  9. Tarlo SM, Shaikh W, Bell B, et al. Papain-induced allergic reactions. Clin Allergy 1978;8(3):207-15. PubMed
  10. Baur X, König G, Bencze K, Fruhmann G. Clinical symptoms and results of skin test, RAST and bronchial provocation test in thirty-three papain workers: Evidence for strong immunogenic potency and clinically relevant proteolytic e?ects of airborne papain. C
  11. Novey HS, Keenan WJ, Fairshter RD, Wells ID, Wilson AF, Culver BD. Pulmonary disease in workers exposed to papain: clinico-physiological and immunological studies. Clin Allergy 1980;10(6):721-31. PubMed

See these in context on the Papain monograph →

Calabar Bean 2 references
  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.

See these in context on the Calabar Bean monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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