Digestin Ingredients & Drug Interactions
by Progressive Professional from Progressive Laboratories
What is this page for?
First and foremost: checking Digestin against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Digestin is a dietary supplement by Progressive Professional from Progressive Laboratories with 10 active ingredients. Its ingredients are commonly taken for low stomach acid (hypochlorhydria), bloating and gas, indigestion.Based on those ingredients, 38 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Betaine Hydrochloride, Papain. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Digestin by Progressive Professional from Progressive Laboratories
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AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Digestin by Progressive Professional from Progressive Laboratories
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Partial disclosure
Digestin is a digestive enzyme blend with 10 active ingredients designed to support your digestive system. It contains proteolytic enzymes (protease and pepsin) to help break down proteins, lipase to work on fats, amylase for carbohydrates, and cellulase for plant fiber.
It also includes betaine hydrochloride to increase stomach acid, plus papain from papaya, and includes tissue extracts from the stomach, pancreas, duodenum, and bile to mimic the body's own digestive secretions. The capsule itself is gelatin, with stearic acid, microcrystalline cellulose, and magnesium stearate as inactive ingredients.
Does it work?
Not established
The evidence for betaine hydrochloride supporting indigestion, low thyroid function, diarrhea, rheumatoid arthritis, food allergies, and hay fever is insufficient — we don't have reliable data backing its use for these. The same goes for papain across cancer, tooth decay, radiation burn recovery, exercise soreness, shingles, and parasite infection.
For lipase, protease, and pepsin, we hold no effectiveness ratings in our data.
How safe is it?
Well-documented data
Betaine hydrochloride is not safe for people with ulcers, gastritis, or true acid reflux, as it increases stomach acid and could worsen these conditions or trigger heartburn. Papain is generally tolerated as a food but may cause digestive tract irritation and allergic reactions in supplement form; in sensitive people, allergic reactions can include itchy eyes, runny nose, sneezing, and diarrhea.
Protease and pepsin are generally well tolerated but may cause digestive upset or allergic reactions in some people. Regarding pregnancy, betaine hydrochloride should be avoided — there isn't enough safety data.
Papain from concentrated sources or unripe papaya should also be avoided in pregnancy. Lipase, protease, and pepsin have limited pregnancy data; talk with your doctor before using if you're pregnant.
For breastfeeding, betaine hydrochloride should be avoided, papain use is not recommended without medical advice, and the same caution applies to lipase, protease, and pepsin.
Meds to double-check
Moderate interaction found
If you take warfarin (a blood thinner), check with your doctor before using this product — papain may increase its effects in unpredictable ways. Similarly, if you're on H2-blockers like famotidine, antacids, or proton pump inhibitors like omeprazole, let your pharmacist know, because betaine hydrochloride could reduce their effectiveness.
The bottom line
Scorecard at a glancePartially disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.
Digestin is a multi-enzyme digestive aid that's generally well tolerated, but if you're on warfarin, an H2-blocker, an antacid, or a PPI, or if you have ulcers or gastritis, you need to check with your pharmacist before starting. Pregnant or breastfeeding people should talk with their doctor first.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 5 of 10 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 16, 2022.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Digestin, straight from the product label.
| Brand | Progressive Professional from Progressive Laboratories |
|---|---|
| Barcode (UPC) | 351821098722 |
| Net contents | 250 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Jun 16, 2022 |
| DSLD ID | 261609 |
| Product type | Other Combinations |
| Supplement form | Capsule |
| Dietary claims / uses | All Other |
| Intended target group(s) | Adult (18 - 50 Years) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Digestin by Progressive Professional from Progressive Laboratories, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Betaine Hydrochloride | 155 mg | -- |
| Papain | 100 mg | -- |
| Lipase | 0 NP | -- |
| Protease | 0 NP | -- |
| Cellulase | 2 mg | -- |
| Amylase | 0 NP | -- |
| Pepsin | 30 mg | -- |
| Stomach Substance | 5 mg | -- |
| Pancrelipase | 100 mg | -- |
| Bile, Powder | 50 mg | -- |
| Duodenal Substance | 5 mg | -- |
Other ingredients: Gelatin Capsule, Stearic Acid, Microcrystalline Cellulose, Magnesium Stearate
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Directions: One capsule with each meal, or more, as directed by a health care professional.
General Statements
Sold only for dispensing by a licensed health care professional.
Precautions
Pregnant and/or lactating women should consult their physician prior to use.
Tamper evident band around cap and seal on bottle. Do not use if either seal is broken or missing.
Keep out of reach of children.
Brand IP Statement(s)
Progressive Professional from Progressive Laboratories
FDA Statement of Identity
Enzyme Supplement
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Digestin by Progressive Professional from Progressive Laboratories label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Digestin by Progressive Professional from Progressive Laboratories
These are the 10 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container250 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Betaine Hydrochloride
Interacts with36 drugs
Betaine hydrochloride is a supplement used to temporarily increase stomach acid in people who may have low acid levels. Evidence for its benefits is l...
Betaine Hydrochloride monograph & interactionsPapain
Interacts with2 drugs
Papain is a protein-digesting enzyme from the papaya plant that is used in digestive supplements and some topical products. While it has clear food an...
Papain monograph & interactionsCellulase
Pepsin
No knowninteractions
Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), tr...
Pepsin monograph & interactionsStomach Substance
Bile, Powder
Duodenal Substance
Other (inactive) ingredients: Gelatin Capsule, Stearic Acid, Microcrystalline Cellulose, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.
Digestin by Progressive Professional from Progressive Laboratories Drug Interactions
HelloPharmacist Interaction Report
Digestin by Progressive Professional from Progressive Laboratories contains two ingredients with documented interactions.
Papain carries a Moderate interaction with warfarin (Coumadin), a blood thinner. A case report describes a patient stable on warfarin whose blood-thinning levels spiked dangerously after taking a papain-containing supplement; the mechanism isn't fully understood, but it's a real concern worth discussing with your doctor if you're on this medication.
Read the full breakdown — every affected drug type, severity by severity
Betaine hydrochloride has Minor interactions with three classes of stomach medications: H2-blockers (like famotidine), antacids, and proton pump inhibitors (PPIs, like omeprazole). Betaine increases stomach acid, which could blunt the effects of these acid-reducing drugs.
If you take any of them and want to try this product, your doctor or pharmacist should weigh whether that trade-off makes sense.
We could not check interactions for cellulase, amylase, stomach substance, bile powder, and duodenal substance — we hold no data for them. Altogether, these interactions span 38 individual medications.
Use the medication checker below with your exact prescriptions before starting.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Digestin?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Digestin interact with 38 drugs. Click any drug to see the details.
2 of the 10 ingredients in Digestin interact with drugs. Each result below shows which ingredient is responsible. Betaine Hydrochloride Papain
WarfarinWarfarin
How Warfarin interacts with Digestin — through 1 ingredient. Tap an ingredient for the detail:
PapainWarfarin (coumadin) Moderate
Interaction Summary
Theoretically, papain might increase the effects and side effects of warfarin.
Read the full Papain + Warfarin interactionWarfarin SodiumCoumadin, Panwarfin, Sofarin
How Warfarin Sodium interacts with Digestin — through 1 ingredient. Tap an ingredient for the detail:
PapainWarfarin (coumadin) Moderate
Interaction Summary
Theoretically, papain might increase the effects and side effects of warfarin.
Read the full Papain + Warfarin Sodium interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Digestin with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Betaine Hydrochloride
Antacids
Betaine hydrochloride increases stomach acidity and could decrease the effects of antacids.
In human research, betaine hydrochloride increases stomach acidity. Antacids are taken to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with antacids might decrease the effects of the antacids.
H2-Blockers
Betaine hydrochloride increases stomach acidity and could decrease the effects of H2-blockers.
In human research, betaine hydrochloride increases stomach acidity. H2-blockers are used to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with H2-blockers might decrease the effects of H2-blockers.
Proton Pump Inhibitors (Ppis)
Betaine hydrochloride increases stomach acidity and could decrease the effects of PPIs.
In human research, betaine hydrochloride increases stomach acidity. PPIs are used to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with PPIs might decrease the effects of PPIs
Papain
Warfarin (Coumadin)
Theoretically, papain might increase the effects and side effects of warfarin.
In one case report, a patient previously stable on warfarin was found to have an international normalization ratio (INR) of 7.4, which was attributed to ingestion of a supplement containing papain from papaya extract.
Brand information
Manufacturer and brand details for Digestin, from the product label.
Progressive Professional from Progressive Laboratories
See all Progressive Professional from Progressive Laboratories products- Name
- Progressive Laboratories, Inc.
- City
- Irving
- State
- Texas
- ZipCode
- 75038
- Phone Number
- 1-800-527-9512
Digestin by Progressive Professional from Progressive Laboratories: Common Questions
Does Digestin by Progressive Professional from Progressive Laboratories interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Will this help with my indigestion?
Can I take this if I have an ulcer or acid reflux?
Is it safe to use while pregnant?
What does papain actually do in this supplement?
Could this interfere with my stomach acid medication?
Are there any fillers in this?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Digestin is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Digestin’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Betaine Hydrochloride
Interacts with 36 drugsBetaine hydrochloride is a supplement used to temporarily increase stomach acid in people who may have low acid levels. Evidence for its benefits is limited and mostly based on tradition rat...
Read the full Betaine Hydrochloride monograph → Herb & supplement monographPapain
Interacts with 2 drugsPapain is a protein-digesting enzyme from the papaya plant that is used in digestive supplements and some topical products. While it has clear food and laboratory uses, strong human evidence...
Read the full Papain monograph → Herb & supplement monographProteolytic Enzymes (proteases)
Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...
Read the full Proteolytic Enzymes (proteases) monograph → Herb & supplement monographLipase
Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy for people who cannot make enough of their...
Read the full Lipase monograph →Sources & How We Checked
Digestin's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 17 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Betaine Hydrochloride 2 references
- Yago MR, Frymoyer A, Benet LZ, Smelick GS, Frassetto LA, Ding X, Dean B, Salphati L, Budha N, Jin JY, Dresser MJ, Ware JA. The use of betaine HCl to enhance dasatinib absorption in healthy volunteers with rabeprazole-induced hypochlorhydria. AAPS J. 2014 PubMed
- Yago MR, Frymoyer AR, Smelick GS, Frassetto LA, Budha NR, Dresser MJ, Ware JA, Benet LZ. Gastric reacidification with betaine HCl in healthy volunteers with rabeprazole-induced hypochlorhydria. Mol Pharm. 2013 Nov 4;10(11):4032-7. PubMed
See these in context on the Betaine Hydrochloride monograph →
Papain 11 references
- The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
- Shaw D, Leon C, Kolev S, Murray V. Traditional remedies and food supplements: a 5-year toxicological study (1991-1995). Drug Saf 1997;17:342-56.
- Shuttleworth D, Hill S, Marks R, Connelly DM. Relief of experimentally induced pruritus with a novel eutectic mixture of local anaesthetic agents. Br J Dermatol 1988;119:535-40.
- Mansfield LE, Ting S, Haverly RW, Yoo TJ. The incidence and clinical implications of hypersensitivity to papain in an allergic population, confirmed by blinded oral challenge. Ann Allergy 1985;55:541-3.
- Martin, T., Uhder, K., Kurek, R., Roeddiger, S., Schneider, L., Vogt, H. G., Heyd, R., and Zamboglou, N. Does prophylactic treatment with proteolytic enzymes reduce acute toxicity of adjuvant pelvic irradiation? Results of a double-blind randomized trial PubMed
- Walker-Renard, P. Update on the medicinal management of phytobezoars. Am J Gastroenterol. 1993;88(10):1663-1666.
- Tymoszuk D, Wiszniewska M, Walusiak-Skorupa J. Papain-induced occupational rhinoconjunctivitis and asthma - A case report. Med Pr 2016;67(1):109-12. PubMed
- Soto-Mera MT, López-Rico MR, Filgueira JF, et al. Occupational allergy to papain. Allergy 2000;55(10):983-4. PubMed
- Tarlo SM, Shaikh W, Bell B, et al. Papain-induced allergic reactions. Clin Allergy 1978;8(3):207-15. PubMed
- Baur X, König G, Bencze K, Fruhmann G. Clinical symptoms and results of skin test, RAST and bronchial provocation test in thirty-three papain workers: Evidence for strong immunogenic potency and clinically relevant proteolytic e?ects of airborne papain. C
- Novey HS, Keenan WJ, Fairshter RD, Wells ID, Wilson AF, Culver BD. Pulmonary disease in workers exposed to papain: clinico-physiological and immunological studies. Clin Allergy 1980;10(6):721-31. PubMed
Lipase 1 reference
- Casper C, Hascoet JM, Ertl T, et al. Recombinant bile salt-stimulated lipase in preterm infant feeding: A randomized phase 3 study. PLoS One. 2016;11(5):e0156071. PubMed
Proteolytic Enzymes (proteases) 3 references
- Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
- Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
- Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed
See these in context on the Proteolytic Enzymes (proteases) monograph →
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC