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Dietary supplement

Beta-Pepsin Ingredients & Drug Interactions

by Solgar

Beta-Pepsin label
See full label image
Tablet Or Pill Category: Non-nutrient/non-botanical
Most serious interaction: Minor
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Beta-Pepsin against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Minor

Beta-Pepsin is a dietary supplement by Solgar with 2 active ingredients. Its ingredients are commonly taken for digestion and bloating, muscle soreness and exercise recovery, inflammation and swelling.Based on those ingredients, 36 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are Betaine Hydrochloride. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Beta-Pepsin by Solgar

Ask about any prescription or over-the-counter medication and we check it for interactions with Beta-Pepsin by Solgar — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Beta-Pepsin by Solgar

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Beta-Pepsin contains two active ingredients: pepsin, a proteolytic enzyme (a protein-digesting enzyme), and betaine hydrochloride, which increases stomach acid. The product also includes several inactive ingredients—microcrystalline cellulose, stearic acid, silica, vegetable cellulose, and natural peppermint flavor—that serve as binders and fillers in the tablet.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: aids digestion by providing favorable digestive environment.
  • We looked for evidence on: Dyspepsia, indigestion, heartburn, bloating.
  • The closest evidence on file: Betaine Hydrochloride is rated "Insufficient Reliable Evidence To Rate" for Dyspepsia (Natural Medicines).

The evidence for both ingredients in this product is limited. For betaine hydrochloride, we hold insufficient reliable evidence to rate its effectiveness for dyspepsia (indigestion), hypothyroidism, diarrhea, rheumatoid arthritis, food allergies, or allergic rhinitis (hay fever).

For pepsin, effectiveness ratings are not established in our data. If you're considering this product for a specific condition, your doctor or pharmacist can help you weigh whether the research supports its use for your situation.

The evidence, ingredient by ingredient Proteolytic Enzymes (proteases) Betaine Hydrochloride

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Pepsin is generally well tolerated for most adults, but it may cause digestive upset or allergic reactions in some people. In rare cases, occupational airborne exposure to pepsin has triggered allergic rhinitis or asthma; this is unlikely with oral supplement use but worth noting if you have a history of enzyme sensitivities.

Betaine hydrochloride can irritate the stomach and is not safe if you have ulcers, gastritis, or true acid reflux—it may worsen heartburn or prevent ulcer healing. During pregnancy, the safety data for both ingredients advises against use.

During breastfeeding, there isn't enough data to know either way for pepsin, and betaine hydrochloride is best avoided; talk with your doctor or pharmacist for personalized advice.

Side effects, ingredient by ingredient Proteolytic Enzymes (proteases) Betaine Hydrochloride

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Betaine Hydrochloride.
  • The most serious interaction on file is rated Minor.
  • For scale: 36 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take H2-blockers, antacids, or proton pump inhibitors (PPIs)—medications that reduce stomach acid—betaine hydrochloride in this product may decrease how well they work. Double-check your exact drugs with your doctor or pharmacist before taking this supplement.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Only minor medication interactions are documented, and safety information is well characterized.

Beta-Pepsin is a two-ingredient digestive enzyme and acid supplement. It's generally well tolerated by most adults, but it's not right for you if you have ulcers, gastritis, or acid reflux, and it will counteract stomach acid–reducing medications.

If you take H2-blockers, antacids, or PPIs, or if you're pregnant or breastfeeding, check with your doctor or pharmacist before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Apr 24, 2015.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Beta-Pepsin, straight from the product label.

Brand Solgar
Barcode (UPC) 033984002401
Net contents 100 Tablet(s)
Market status On market
Date entered into DSLD Apr 24, 2015
DSLD ID 44288
Product type Non-nutrient/non-botanical
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Beta-Pepsin by Solgar, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
UPC/BARCODE
033984002401
IngredientAmount% DV
Pepsin59 mg--
Betaine Hydrochloride325 mg--

Other ingredients: Microcrystalline Cellulose, Stearic Acid, Silica, Vegetable Cellulose, natural Peppermint flavor

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Provides a dietarily insignificant amount of sugar.

Solgar’s Beta-Pepsin Tablets supply betaine hydrochloride, which further aids digestion by providing a favorable digestive environment.*

BETAINE HYDROCHLORIDE WITH PEPSIN

Contains milk.

FDA Statement of Identity

*This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

DIETARY SUPPLEMENT

Formulation

Solgar’s Beta-Pepsin Tablets are free of yeast, wheat, soy and gluten and are formulated without the use of artificial preservatives, flavors or colors.

SUGAR, SALT AND STARCH FREE

Storage

To assure freshness and potency, store at room temperature 59(0)-86(0)F (15(0)-30(0)C). Store away from heat, light and moisture.

Precautions

DO NOT USE IF OUTER BOTTLE SEAL IS MISSING, TORN OR DAMAGED IN ANY WAY.

If you are pregnant, nursing, taking any medication or have a medical condition, please consult your healthcare practitioner before taking any dietary supplement.

Keep out of reach of children.

CAUTION: Do not take in cases of stomach or duodenal pain or history of ulcers.

Contains milk.

General

00240US06PD

General Statements

Since 1947

Suggested/Recommended/Usage/Directions

SUGGESTED USE: As a dietary supplement for adults, take one (1) tablet up to three times daily, preferably after each meal, or as directed by a healthcare practitioner.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Beta-Pepsin by Solgar label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Beta-Pepsin label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Beta-Pepsin by Solgar

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Pepsin

No known
interactions
59 mg per serving

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), tr...

Pepsin monograph & interactions

Betaine Hydrochloride

Interacts with
36 drugs
325 mg per serving Form: Beets

Betaine hydrochloride is a supplement used to temporarily increase stomach acid in people who may have low acid levels. Evidence for its benefits is l...

Betaine Hydrochloride monograph & interactions

Other (inactive) ingredients: Microcrystalline Cellulose, Stearic Acid, Silica, Vegetable Cellulose, Natural Peppermint flavor. These complete the product’s ingredient list but are not active constituents.

Interaction report

Beta-Pepsin by Solgar Drug Interactions

Want to check YOUR meds against Beta-Pepsin?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
36Drugs
36 Minor

Ingredients driving the most interactions

Betaine Hydrochloride 36

Individual Drug Interactions

The ingredients in Beta-Pepsin interact with 36 drugs. Click any drug to see the details.

1 of the 2 ingredients in Beta-Pepsin interact with drugs. Each result below shows which ingredient is responsible. Betaine Hydrochloride

Each ingredient & the kinds of drugs it affects

For each ingredient in Beta-Pepsin with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Betaine Hydrochloride3 drug types · 36 drugs

Antacids

Betaine hydrochloride increases stomach acidity and could decrease the effects of antacids.
In human research, betaine hydrochloride increases stomach acidity. Antacids are taken to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with antacids might decrease the effects of the antacids.

Likelihood Possible Evidence D
H2-Blockers

Betaine hydrochloride increases stomach acidity and could decrease the effects of H2-blockers.
In human research, betaine hydrochloride increases stomach acidity. H2-blockers are used to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with H2-blockers might decrease the effects of H2-blockers.

Likelihood Possible Evidence D
Proton Pump Inhibitors (Ppis)

Betaine hydrochloride increases stomach acidity and could decrease the effects of PPIs.
In human research, betaine hydrochloride increases stomach acidity. PPIs are used to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with PPIs might decrease the effects of PPIs

Likelihood Possible Evidence D
Betaine Hydrochloride full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Beta-Pepsin, from the product label.

Solgar

See all Solgar products
Phone Number
1-877-765-4274
Web Address
www.solgar.com
Pharmacist Counseling Corner

Beta-Pepsin by Solgar: Common Questions

Does Beta-Pepsin by Solgar interact with any medications?
Yes. Based on its ingredients, Beta-Pepsin has a known interaction with 36 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Beta-Pepsin contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I have acid reflux or heartburn?
No. Betaine hydrochloride increases stomach acid and can irritate the stomach or worsen heartburn. If you have acid reflux, gastritis, or ulcers, this product is not for you—talk with your pharmacist about alternatives.
Is it safe during pregnancy?
The safety data advises against both pepsin and betaine hydrochloride during pregnancy. If you're pregnant and considering this supplement, talk with your doctor or pharmacist for personalized advice.
Can I take it while breastfeeding?
There isn't enough safety data on pepsin during breastfeeding, and betaine hydrochloride is best avoided. You'll want to discuss this with your doctor or pharmacist to see what's right for you.
What does pepsin do?
Pepsin is a protein-digesting enzyme meant to help break down proteins in food. It's added to digestive enzyme supplements for that purpose.
What is betaine hydrochloride?
Betaine hydrochloride is a compound that increases stomach acid. It's included in digestive supplements to support stomach function, though the evidence for its effectiveness is limited.
Are there any allergen concerns with the enzyme?
Pepsin is generally well tolerated, but in rare cases people with enzyme sensitivities have had allergic reactions. If you've had problems with enzyme-containing products before, mention that to your pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Beta-Pepsin is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Beta-Pepsin label
Go deeper

The Full Monographs Behind Beta-Pepsin’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Proteolytic Enzymes (proteases)

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...

Read the full Proteolytic Enzymes (proteases) monograph → Herb & supplement monograph

Betaine Hydrochloride

Interacts with 36 drugs

Betaine hydrochloride is a supplement used to temporarily increase stomach acid in people who may have low acid levels. Evidence for its benefits is limited and mostly based on tradition rat...

Read the full Betaine Hydrochloride monograph →
Sources

Sources & How We Checked

Beta-Pepsin's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 5 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Proteolytic Enzymes (proteases) 3 references
  1. Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
  2. Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
  3. Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed

See these in context on the Proteolytic Enzymes (proteases) monograph →

Betaine Hydrochloride 2 references
  1. Yago MR, Frymoyer A, Benet LZ, Smelick GS, Frassetto LA, Ding X, Dean B, Salphati L, Budha N, Jin JY, Dresser MJ, Ware JA. The use of betaine HCl to enhance dasatinib absorption in healthy volunteers with rabeprazole-induced hypochlorhydria. AAPS J. 2014 PubMed
  2. Yago MR, Frymoyer AR, Smelick GS, Frassetto LA, Budha NR, Dresser MJ, Ware JA, Benet LZ. Gastric reacidification with betaine HCl in healthy volunteers with rabeprazole-induced hypochlorhydria. Mol Pharm. 2013 Nov 4;10(11):4032-7. PubMed

See these in context on the Betaine Hydrochloride monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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