American Ginseng Root Ingredients & Drug Interactions
by Solgar
What is this page for?
First and foremost: checking American Ginseng Root against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
American Ginseng Root is a dietary supplement by Solgar with 2 active ingredients. Its ingredients are commonly taken for iron-deficiency anemia, low iron stores during pregnancy, fatigue from iron deficiency.Based on those ingredients, 295 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are American Ginseng extract, Iron. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against American Ginseng Root by Solgar
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HelloPharmacist Scorecard of American Ginseng Root by Solgar
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains 2 active ingredients: iron and American ginseng extract. Iron is a mineral your body needs to make healthy red blood cells and carry oxygen; it's used when you don't have enough of it in your system.
American ginseng is a plant extract traditionally used to support immune function and possibly help with cold and flu symptoms. The capsule itself is made from vegetable cellulose, with vegetable magnesium stearate as a flow agent.
Does it work?
Moderate evidence
Iron is effective for treating iron deficiency anemia and anemia of chronic disease, and is also effective for pregnancy-related iron deficiency. It may be helpful for heart failure, though the evidence is less strong.
American ginseng has possibly effective evidence for upper respiratory tract infections (common colds and similar illnesses). For other uses listed on the label—like American ginseng for anemia of chronic disease or breast cancer—the evidence isn't established in our data.
How safe is it?
Well-documented data
Iron is generally well tolerated at recommended doses, but excess iron can be toxic, so it should only be used when there's a real need. The most common side effects from oral iron are stomach upset: abdominal pain, constipation, diarrhea, nausea, and vomiting.
Rare serious concerns include stomach ulcers and, with long-term overuse without monitoring, acquired hemochromatosis (iron overload). American ginseng is generally well tolerated in the short term in healthy adults, but long-term safety hasn't been well studied and quality varies between products.
For pregnancy, iron is often recommended but your prenatal care provider should guide the dose; American ginseng safety data is insufficient in pregnancy, so it's best avoided. During breastfeeding, iron at appropriate doses is generally considered acceptable, but American ginseng has too little safety data, so avoidance is the safer choice.
Talk with your doctor or pharmacist about what's right for you.
Meds to double-check
Major interaction found
Before you take this product, double-check if you're on warfarin (a blood thinner)—American ginseng can reduce its effectiveness. Also check for iron-sensitive medications: levodopa, quinolone or tetracycline antibiotics, bisphosphonates, methyldopa, levothyroxine, mycophenolate mofetil, and penicillamine.
If you take diabetes drugs, antidepressants called MAOIs, or immunosuppressants, run those by your pharmacist too. Separating doses by a few hours can help with many of these.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Major medication interactions have been identified, and safety information is well characterized.
This product combines iron—useful if you're genuinely low on this mineral—with American ginseng for immune and cold support. If you take warfarin or any thyroid, antibiotic, bone, diabetes, or blood pressure medication, check your specific drugs with the interaction tool before starting.
Always talk with your pharmacist about whether iron supplementation is right for you and whether this product fits your health plan.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 26, 2020.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about American Ginseng Root, straight from the product label.
| Brand | Solgar |
|---|---|
| Barcode (UPC) | 033984012868 |
| Net contents | 100 Vegetable Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Feb 26, 2020 |
| DSLD ID | 214060 |
| Product type | Botanical |
| Supplement form | Capsule |
| Dietary claims / uses | Nutrient, All Other |
| Intended target group(s) | Vegetarian, Adult (18 - 50 Years), Kosher, Gluten Free, Dairy Free, Sugar Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for American Ginseng Root by Solgar, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Iron | 1.6 mg | 9% |
| American Ginseng extract | 260 mg | -- |
Other ingredients: Vegetable Cellulose, Vegetable Magnesium Stearate
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation
This product is free of sugar, salt, yeast, wheat, soy, gluten and dairy products and is formulated without the use of artificial preservatives, flavors or colors.
Suitable for vegetarians
Storage
To assure freshness and potency, store at room temperature 59 degrees-86 degrees F (15 degrees-30 degrees C). Store away from heat, light and moisture.
Formula
Solgar's KOF-K certification #K-1250
Full potency herbs (Panax quinquefolius)
Precautions
Do not use if outer bottle seal is missing, torn or damaged in any way.
If you are pregnant, nursing, taking any medication or have a medical condition, please consult your healthcare practitioner before taking any dietary supplement.
Keep out of reach of children. Warning: Accidental overdose of iron-containing products is a leading cause of fatal poisoning in children under 6. In case of accidental overdose, call a doctor or poison control center immediately.
General Statements
Solgar since 1947
FDA Statement of Identity
Dietary Supplement
Seals/Symbols
K Parve (Kosher)
Suggested/Recommended/Usage/Directions
Suggested Use: As a dietary supplement for adults, take one (1) to two (2) vegetable capsules daily, preferably at mealtimes, or as directed by a healthcare practitioner.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
American Ginseng Root by Solgar label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in American Ginseng Root by Solgar
These are the 2 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Vegetable Capsule(s) Dosage formCapsule Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Iron
Interacts with80 drugs
Iron is an essential mineral your body needs to make hemoglobin and carry oxygen in the blood. Supplements are mainly useful for treating or preventin...
Iron monograph & interactionsAmerican Ginseng extract
Interacts with217 drugs
American ginseng is an herbal root used as an 'adaptogen' to support energy, stress, immune function, and blood sugar. Some uses—such as reducing the...
American Ginseng extract monograph & interactionsOther (inactive) ingredients: Vegetable Cellulose, Vegetable Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.
American Ginseng Root by Solgar Drug Interactions
HelloPharmacist Interaction Report
Solgar's American Ginseng Root contains iron and American ginseng extract, and both have documented interactions with medications.
The most serious is American ginseng's effect on warfarin (a blood thinner used to prevent clots): it can reduce warfarin's effectiveness and lower your INR (a measure of how well the drug is working), which could raise your clot risk.
Read the full breakdown — every affected drug type, severity by severity
Iron reduces how well your body absorbs several medications. These include levodopa (used for Parkinson's), quinolone and tetracycline antibiotics, bisphosphonates (for bone health), methyldopa (a blood pressure drug), levothyroxine (thyroid hormone), mycophenolate mofetil (an immunosuppressant), and penicillamine (for Wilson's disease).
All of these interactions are Moderate in severity, and spacing doses by 2–6 hours apart can help reduce the problem.
American ginseng may also lower blood sugar more than expected if you take diabetes drugs, theoretically raising hypoglycemia risk. It can interfere with immunosuppressants and, in rare case reports, caused problems when paired with MAOIs (an older class of antidepressant).
Altogether, these interactions span 289 individual medications.
Check your exact medications with the search tool on this page before you start.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against American Ginseng Root?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in American Ginseng Root interact with 295 drugs. Click any drug to see the details.
2 of the 2 ingredients in American Ginseng Root interact with drugs. Each result below shows which ingredient is responsible. American Ginseng extract Iron
WarfarinWarfarin
How Warfarin interacts with American Ginseng Root — through 1 ingredient. Tap an ingredient for the detail:
American Ginseng ExtractWarfarin (coumadin) Major
Interaction Summary
American ginseng seems to decrease the effectiveness of warfarin therapy.
Read the full American Ginseng Extract + Warfarin interactionWarfarin SodiumCoumadin, Panwarfin, Sofarin
How Warfarin Sodium interacts with American Ginseng Root — through 1 ingredient. Tap an ingredient for the detail:
American Ginseng ExtractWarfarin (coumadin) Major
Interaction Summary
American ginseng seems to decrease the effectiveness of warfarin therapy.
Read the full American Ginseng Extract + Warfarin Sodium interaction6-mercaptopurinePurinethol
How 6-mercaptopurine interacts with American Ginseng Root — through 1 ingredient. Tap an ingredient for the detail:
American Ginseng ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, American ginseng use might interfere with immunosuppressive therapy.
Read the full American Ginseng Extract + 6-mercaptopurine interactionAbrocitinibCibinqo
How Abrocitinib interacts with American Ginseng Root — through 1 ingredient. Tap an ingredient for the detail:
American Ginseng ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, American ginseng use might interfere with immunosuppressive therapy.
Read the full American Ginseng Extract + Abrocitinib interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with American Ginseng Root — through 1 ingredient. Tap an ingredient for the detail:
American Ginseng ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking American ginseng with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full American Ginseng Extract + Acarbose interactionAcetohexamideDymelor
How Acetohexamide interacts with American Ginseng Root — through 1 ingredient. Tap an ingredient for the detail:
American Ginseng ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking American ginseng with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full American Ginseng Extract + Acetohexamide interactionAdalimumabHumira
How Adalimumab interacts with American Ginseng Root — through 1 ingredient. Tap an ingredient for the detail:
American Ginseng ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, American ginseng use might interfere with immunosuppressive therapy.
Read the full American Ginseng Extract + Adalimumab interactionAdalimumab-adazHyrimoz
How Adalimumab-adaz interacts with American Ginseng Root — through 1 ingredient. Tap an ingredient for the detail:
American Ginseng ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, American ginseng use might interfere with immunosuppressive therapy.
Read the full American Ginseng Extract + Adalimumab-adaz interactionAdalimumab-adbmCyltezo
How Adalimumab-adbm interacts with American Ginseng Root — through 1 ingredient. Tap an ingredient for the detail:
American Ginseng ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, American ginseng use might interfere with immunosuppressive therapy.
Read the full American Ginseng Extract + Adalimumab-adbm interactionAdalimumab-afzbAbrilada
How Adalimumab-afzb interacts with American Ginseng Root — through 1 ingredient. Tap an ingredient for the detail:
American Ginseng ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, American ginseng use might interfere with immunosuppressive therapy.
Read the full American Ginseng Extract + Adalimumab-afzb interactionAdalimumab-attoAmjevita
How Adalimumab-atto interacts with American Ginseng Root — through 1 ingredient. Tap an ingredient for the detail:
American Ginseng ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, American ginseng use might interfere with immunosuppressive therapy.
Read the full American Ginseng Extract + Adalimumab-atto interactionAdalimumab-bwwdHadlima
How Adalimumab-bwwd interacts with American Ginseng Root — through 1 ingredient. Tap an ingredient for the detail:
American Ginseng ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, American ginseng use might interfere with immunosuppressive therapy.
Read the full American Ginseng Extract + Adalimumab-bwwd interactionAdalimumab-fkjpHulio
How Adalimumab-fkjp interacts with American Ginseng Root — through 1 ingredient. Tap an ingredient for the detail:
American Ginseng ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, American ginseng use might interfere with immunosuppressive therapy.
Read the full American Ginseng Extract + Adalimumab-fkjp interactionAlbiglutideTanzeum
How Albiglutide interacts with American Ginseng Root — through 1 ingredient. Tap an ingredient for the detail:
American Ginseng ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking American ginseng with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full American Ginseng Extract + Albiglutide interactionAlefaceptAmevive
How Alefacept interacts with American Ginseng Root — through 1 ingredient. Tap an ingredient for the detail:
American Ginseng ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, American ginseng use might interfere with immunosuppressive therapy.
Read the full American Ginseng Extract + Alefacept interactionAlemtuzumabCampath
How Alemtuzumab interacts with American Ginseng Root — through 1 ingredient. Tap an ingredient for the detail:
American Ginseng ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, American ginseng use might interfere with immunosuppressive therapy.
Read the full American Ginseng Extract + Alemtuzumab interactionAlendronateBinosto, Fosamax
How Alendronate interacts with American Ginseng Root — through 1 ingredient. Tap an ingredient for the detail:
IronBisphosphonates Moderate
Interaction Summary
Iron reduces the absorption of bisphosphonates.
Read the full Iron + Alendronate interactionAlendronate Sodium
How Alendronate Sodium interacts with American Ginseng Root — through 1 ingredient. Tap an ingredient for the detail:
IronBisphosphonates Moderate
Interaction Summary
Iron reduces the absorption of bisphosphonates.
Read the full Iron + Alendronate Sodium interactionAlendronate Sodium, CholecalciferolFosamax Plus D
How Alendronate Sodium, Cholecalciferol interacts with American Ginseng Root — through 1 ingredient. Tap an ingredient for the detail:
IronBisphosphonates Moderate
Interaction Summary
Iron reduces the absorption of bisphosphonates.
Read the full Iron + Alendronate Sodium, Cholecalciferol interactionAlogliptinNesina
How Alogliptin interacts with American Ginseng Root — through 1 ingredient. Tap an ingredient for the detail:
American Ginseng ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking American ginseng with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full American Ginseng Extract + Alogliptin interactionAlogliptin, MetforminKazano
How Alogliptin, Metformin interacts with American Ginseng Root — through 1 ingredient. Tap an ingredient for the detail:
American Ginseng ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking American ginseng with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full American Ginseng Extract + Alogliptin, Metformin interactionAlogliptin, PioglitazoneOseni
How Alogliptin, Pioglitazone interacts with American Ginseng Root — through 1 ingredient. Tap an ingredient for the detail:
American Ginseng ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking American ginseng with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full American Ginseng Extract + Alogliptin, Pioglitazone interactionAmphetamineAdensys XR-ODT, Adzenys ER, Dyanavel XR, Mydayis
How Amphetamine interacts with American Ginseng Root — through 1 ingredient. Tap an ingredient for the detail:
American Ginseng ExtractMonoamine Oxidase Inhibitors (maois) Moderate
Interaction Summary
Theoretically, American ginseng can interfere with MAOI therapy.
Read the full American Ginseng Extract + Amphetamine interactionAmphotericin, TetracyclineMysteclin-F
How Amphotericin, Tetracycline interacts with American Ginseng Root — through 1 ingredient. Tap an ingredient for the detail:
IronTetracycline Antibiotics Moderate
Interaction Summary
Iron might decrease levels of tetracycline antibiotics by reducing their absorption.
Read the full Iron + Amphotericin, Tetracycline interactionAnifrolumab-fniaSaphnelo
How Anifrolumab-fnia interacts with American Ginseng Root — through 1 ingredient. Tap an ingredient for the detail:
American Ginseng ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, American ginseng use might interfere with immunosuppressive therapy.
Read the full American Ginseng Extract + Anifrolumab-fnia interactionAntidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) InhibitorGlyxambi
How Antidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) Inhibitor interacts with American Ginseng Root — through 1 ingredient. Tap an ingredient for the detail:
American Ginseng ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking American ginseng with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full American Ginseng Extract + Antidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) Inhibitor interactionAntithymocyte GlobulinThymoglobulin
How Antithymocyte Globulin interacts with American Ginseng Root — through 1 ingredient. Tap an ingredient for the detail:
American Ginseng ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, American ginseng use might interfere with immunosuppressive therapy.
Read the full American Ginseng Extract + Antithymocyte Globulin interactionAtezolizumabTecentriq
How Atezolizumab interacts with American Ginseng Root — through 1 ingredient. Tap an ingredient for the detail:
American Ginseng ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, American ginseng use might interfere with immunosuppressive therapy.
Read the full American Ginseng Extract + Atezolizumab interactionAzamuneImmunoprin
How Azamune interacts with American Ginseng Root — through 1 ingredient. Tap an ingredient for the detail:
American Ginseng ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, American ginseng use might interfere with immunosuppressive therapy.
Read the full American Ginseng Extract + Azamune interactionAzathioprineAzamune, Imuran
How Azathioprine interacts with American Ginseng Root — through 1 ingredient. Tap an ingredient for the detail:
American Ginseng ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, American ginseng use might interfere with immunosuppressive therapy.
Read the full American Ginseng Extract + Azathioprine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in American Ginseng Root with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
American Ginseng extract
Warfarin (Coumadin)
American ginseng seems to decrease the effectiveness of warfarin therapy.
Healthy patients receiving warfarin 5 mg daily, who also take American ginseng 1 gram twice daily, seem to have a significantly reduced international normalized ratio (INR).
Antidiabetes Drugs
Theoretically, taking American ginseng with antidiabetes drugs might increase the risk of hypoglycemia.
American ginseng seems to lower postprandial blood glucose. Theoretically, concomitant use with antidiabetes drugs might enhance blood glucose lowering effects and possibly cause hypoglycemia.
Immunosuppressants
Theoretically, American ginseng use might interfere with immunosuppressive therapy.
American ginseng seems to stimulate immune function. Theoretically, American ginseng might decrease the effectiveness of immunosuppressant drugs.
Monoamine Oxidase Inhibitors (Maois)
Theoretically, American ginseng can interfere with MAOI therapy.
There is one case report of insomnia, headache, and tremors when an unspecified ginseng product was used with phenelzine (Nardil), an MAOI. There is also one case report of hypomania when an unspecified ginseng product was used with phenelzine. Theoretically, American ginseng may interfere with MAOI therapy.
Iron
Bictegravir/Emtricitabine/Tenofovir Alafenamide (Biktarvy)
Iron might decrease levels of bictegravir/emtricitabine/tenofovir alafenamide by reducing its absorption when taken in a fasting state.
Advise patients that bictegravir/emtricitabine/tenofovir alafenamide and iron can be taken together if taken with food. However, if taken on an empty stomach, bictegravir/emtricitabine/tenofovir alafenamide should not be taken with, or 2 hours after, iron containing products.
Bisphosphonates
Iron reduces the absorption of bisphosphonates.
Advise patients that doses of bisphosphonates should be separated by at least two hours from doses of all other medications, including supplements such as iron. Divalent cations, including iron, can decrease absorption of bisphosphonates by forming insoluble complexes in the gastrointestinal tract.
Denosumab (Prolia, Others)
Administration of intravenous iron within one month of denosumab administration might increase the risk of severe hypophosphatemia and hypocalcemia.
A case of severe hypocalcemia (albumin corrected calcium 6.88 mg/dL, ionized calcium 3.68 mg/dL) and hypophosphatemia (<0.5 mg/dL) with respiratory acidosis, QT interval prolongation, and nonsustained ventricular tachycardia was reported in a 76-year-old male who had received an iron polymaltose infusion within 2 weeks of a subcutaneous injection of denosumab. Serum parathyroid hormone was also elevated (348 pg/mL). Subsequent iron infusions with iron polymaltose and ferric carboxymaltose were followed by transient hypophosphatemia, but without hypocalcemia. Additionally, a literature review describes 6 additional cases of hypophosphatemia and hypocalcemia in patients 52-92 years of age who had been administered intravenous iron as either ferric carboxymaltose or iron polymaltose and subcutaneous denosumab within 1-4 weeks of each other.
Dolutegravir (Tivicay)
Iron might decrease dolutegravir levels by reducing its absorption.
Advise patients to take dolutegravir at least 2 hours before or 6 hours after taking iron. Pharmacokinetic research shows that iron can decrease the absorption of dolutegravir from the gastrointestinal tract through chelation. When taken under fasting conditions, a single dose of ferrous fumarate 324 mg orally along with dolutegravir 50 mg reduces overall exposure to dolutegravir by 54%.
Integrase Inhibitors
Theoretically, taking iron along with integrase inhibitors might decrease the levels and clinical effects of these drugs.
Iron is a divalent cation. There is concern that iron may decrease the absorption of integrase inhibitors from the gastrointestinal tract through chelation. One pharmacokinetic study shows that iron can decrease blood levels of the specific integrase inhibitor dolutegravir through chelation. Also, other pharmacokinetic research shows that other divalent cations such as calcium can decrease the absorption and levels of some integrase inhibitors through chelation.
Levodopa
Iron might decrease levodopa levels by reducing its absorption.
Advise patients to separate doses of levodopa and iron as much as possible. There is some evidence in healthy people that iron forms chelates with levodopa, reducing the amount of levodopa absorbed by around 50%. The clinical significance of this hasn't been determined.
Levothyroxine (Synthroid, Others)
Iron might decrease levothyroxine levels by reducing its absorption.
Advise patients to separate levothyroxine and iron doses by at least 2 hours. Iron can decrease the absorption and efficacy of levothyroxine by forming insoluble complexes in the gastrointestinal tract.
Methyldopa (Aldomet)
Iron might decrease methyldopa levels by reducing its absorption.
Advise patients to separate methyldopa and iron doses by at least 2 hours. Iron can decrease the absorption of methyldopa from the gastrointestinal tract through chelation, resulting in increases in blood pressure.
Mycophenolate Mofetil (Cellcept)
Theoretically, iron might decrease mycophenolate mofetil levels by reducing its absorption.
Advise patients to take iron 4-6 hours before, or 2 hours after, mycophenolate mofetil. It has been suggested that a decrease of absorption is possible, probably by forming nonabsorbable chelates. However, mycophenolate pharmacokinetics are not affected by iron supplementation in available clinical research.
Penicillamine (Cuprimine, Depen)
Iron might decrease penicillamine levels by reducing its absorption.
Advise patients to separate penicillamine and iron doses by at least 2 hours. Oral iron supplements can reduce absorption of penicillamine by 30% to 70%, probably due to chelate formation. In people with Wilson's disease, this interaction has led to reduced efficacy of penicillamine.
Quinolone Antibiotics
Iron might decrease levels of quinolone antibiotics by reducing their absorption.
Advise patients to separate quinolone antibiotics and iron doses by at least 2 hours. Iron decreases the absorption of quinolones due to formation of insoluble complexes in the gastrointestinal tract.
Tetracycline Antibiotics
Iron might decrease levels of tetracycline antibiotics by reducing their absorption.
Advise patients to take iron at least 2 hours before or 4 hours after tetracycline antibiotics. Concomitant use can decrease absorption of tetracycline antibiotics from the gastrointestinal tract by 50% to 90%.
Chloramphenicol
Theoretically, taking chloramphenicol with iron might reduce the response to iron therapy in iron deficiency anemia.
Chloramphenicol interferes with erythrocyte maturation. However, since chloramphenicol isn't usually taken for prolonged periods, this isn't likely to be clinically significant.
Brand information
Manufacturer and brand details for American Ginseng Root, from the product label.
Solgar
See all Solgar products- Name
- Solgar Vitamin and Herb
- Street Address
- 500 Willow Tree Road
- City
- Leonia
- State
- N.J.
- ZipCode
- 07605
- Phone Number
- 1-877-765-4234
- Web Address
- www.solgar.com
American Ginseng Root by Solgar: Common Questions
Does American Ginseng Root by Solgar interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
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Can I take this while breastfeeding?
What does the American ginseng in this product actually do?
Are there side effects from the iron?
Is this safe if I don't actually have an iron deficiency?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if American Ginseng Root is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind American Ginseng Root’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Iron
Interacts with 80 drugsIron is an essential mineral your body needs to make hemoglobin and carry oxygen in the blood. Supplements are mainly useful for treating or preventing iron deficiency and iron-deficiency an...
Read the full Iron monograph → Herb & supplement monographAmerican Ginseng
Interacts with 217 drugsAmerican ginseng is an herbal root used as an 'adaptogen' to support energy, stress, immune function, and blood sugar. Some uses—such as reducing the chance or length of colds and modestly l...
Read the full American Ginseng monograph →Sources & How We Checked
American Ginseng Root's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 84 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Iron 72 references
- McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
- Bruner AB, Joffe A, Duggan AK, et al. Randomized study of cognitive effects of iron supplementation in non- anaemic iron-deficient adolescent girls. Lancet 1996;348:992-6.
- Ullen H, Augustsson K, Gustavsson C, Steineck G. Supplementary iron intake and risk of cancer: reversed causality? Cancer Lett 1997;114:215-6.
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