Interactions on record — worth a quick check against your medications. Based on 8 of 14 ingredients. Check your meds →
Dietary supplement

Digestion with Enzymes Ingredients & Drug Interactions

by Nature's Way

Digestion with Enzymes label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Digestion with Enzymes against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Digestion with Enzymes is a dietary supplement by Nature's Way with 14 active ingredients. Its ingredients are commonly taken for water retention (diuretic), digestive upset, liver and gallbladder support.Based on those ingredients, 1,079 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Beet, Fennel, Dandelion. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Digestion with Enzymes by Nature's Way

Ask about any prescription or over-the-counter medication and we check it for interactions with Digestion with Enzymes by Nature's Way — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Digestion with Enzymes by Nature's Way

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 23, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 5 of its 14 active ingredients.
  • “Digestive Enzyme Blend” is a proprietary blend — the label gives one combined amount (100 mg) without saying how much of each component you get.

This product contains 14 ingredients—a mix of digestive enzymes and herbal additions. The enzymes are the main active components: amylase (breaks down starch), lipase (breaks down fats), lactase (breaks down milk sugar), cellulase (breaks down fiber), peptidase (breaks down proteins), invertase (breaks down certain sugars), alpha-galactosidase (breaks down complex sugars), and two protease varieties (also break down proteins).

The herbal actives are dandelion, fennel, cayenne pepper, beet, and gentian. The capsule itself and the inactive ingredients—cellulose, magnesium stearate, and the plant-based capsule material—serve as fillers and binders to hold the formula together.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: digestive support and enzyme supplementation.
  • We looked for evidence on: Dyspepsia, Flatulence, Gastritis, Irritable bowel syndrome (IBS), Lactose intolerance, Nausea and vomiting — and 3 related terms.
  • The strongest evidence on file: Lactase is rated "Effective" for Lactose intolerance (Natural Medicines).
  • Also on file: Capsicum is rated "Possibly Effective" for Postoperative nausea and vomiting (PONV).
  • Also on file: Lipase is rated "Insufficient Reliable Evidence To Rate" for Dyspepsia.

The evidence base is thin here. Lactase is effective for lactose intolerance when you lack the enzyme naturally.

Cayenne pepper is likely effective for two types of nerve pain—postherpetic neuralgia (pain after shingles) and diabetic neuropathy—and possibly effective for cluster headaches, back pain, and nausea after surgery. For the other ingredients in this blend, the evidence isn't established in the data we hold—effectiveness ratings are either insufficient or not available for dandelion, fennel, beet, gentian, the proteases, or most of the other enzymes.

The evidence, ingredient by ingredient Dandelion Fennel Beet Gentian Lipase Lactase Proteolytic Enzymes (proteases) Capsicum

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 8 of the 8 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 8 of 8.
  • General safety write-ups exist for 8 of 8.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lipase is generally well tolerated but should be used only under medical guidance if you have serious digestive conditions; there's little safety data in pregnancy, and breastfeeding safety hasn't been well studied. Lactase is generally well tolerated and likely safe in pregnancy, though check with your doctor before regular use.

A rare allergic reaction to powdered lactase (contact dermatitis and allergic rhinoconjunctivitis) has been reported in occupational exposure. The proteases are generally well tolerated for most adults but may cause digestive upset or allergies; safety hasn't been established in pregnancy, and breastfeeding use isn't recommended without medical advice.

Dandelion is generally well tolerated but can cause diarrhea, heartburn, and stomach discomfort; rare anaphylaxis has occurred in sensitive individuals, particularly those allergic to ragweed or related plants. Fennel is generally safe as a food but should be avoided in medicinal or concentrated amounts during pregnancy due to hormone-like effects; use is also cautioned while breastfeeding.

Beet is widely eaten and generally well tolerated; concentrated supplements lack safety data. Gentian is generally tolerated in small amounts but can cause stomach upset and is best avoided during pregnancy and breastfeeding.

Cayenne pepper is generally safe in food amounts and topical products but commonly causes burning and irritation; food amounts are likely fine during pregnancy and breastfeeding, but concentrated supplements are not well studied.

Side effects, ingredient by ingredient Dandelion Fennel Beet Gentian Lipase Lactase Proteolytic Enzymes (proteases) Capsicum

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 5 of the 8 matched ingredients can interact with medications — Beet, Fennel, Dandelion, Gentian, Capsicum.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications; lithium.
  • For scale: 1,080 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Run this product through your medication list, especially if you take blood thinners or antiplatelet drugs (warfarin, apixaban, aspirin, clopidogrel), potassium-sparing diuretics, diabetes medications, antihypertensive drugs, birth control or hormone replacement therapy, lithium, quinolone antibiotics like ciprofloxacin, theophylline, tamoxifen, or any drug metabolized by your liver's CYP enzymes. These are the drug types with the most serious documented interactions.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product is mainly a multi-enzyme digestive blend with several herbal additions. It may help if you have lactose intolerance or if you take cayenne pepper for nerve pain, but for most of the other ingredients, we don't have strong evidence they work for digestive support.

The real concern is the number of medications it may interact with—especially blood thinners, diabetes drugs, blood pressure drugs, birth control, and antibiotics. Before you start this product, talk it over with your doctor or pharmacist, particularly if you take any prescription medications.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 9 of 14 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 16, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Digestion with Enzymes, straight from the product label.

Brand Nature's Way
Barcode (UPC) 033674792209
Net contents 100 Capsule(s)
Market status On market
Date entered into DSLD Jun 16, 2022
DSLD ID 267829
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Digestion with Enzymes by Nature's Way, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
50
UPC/BARCODE
033674792209
IngredientAmount% DV
Amylase0 NP--
Lipase0 NP--
Lactase0 NP--
Cellulase0 NP--
Peptidase0 NP--
Invertase0 NP--
Alpha-Galactosidase0 NP--
Dandelion315 mg--
Fennel90 mg--
Protease I0 NP--
Protease II0 NP--
Beet100 mg--
Gentian135 mg--
Digestive Enzyme Blend100 mg--
Cayenne Pepper25 mg--

Other ingredients: plant-derived Capsule, Cellulose, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Synergistic support

5-herb blend

Contains no yeast-derived ingredients, or artificial colors, flavors, or preservatives.

Vegetarian

Formula

Nature's Way Digestion formula is a blend of dandelion, beet root, gentian, and other herbs and enzymex specifically designed for synergistic support.

FDA Disclaimer Statement

These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Brand IP Statement(s)

Nature's Way since 1969

2021 Nature's Way Brands, LLC

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Recommendation: Adults take 2 capsules at mealtimes.

Precautions

Warning: Do not use if you have stomach or duodenal ulcers, stomach irritation, or inflammation.

Individuals with allergies to plants of the Asteraceae (Compositae) family, including ragweed, should use this product with caution.

If you are pregnant, nursing, or taking any medications, consult a healthcare professional before use.

Keep out of reach of children.

Safety sealed with inner seal. Do not use if seal is broken or missing.

Storage

Keep tightly closed. Store at room temperature. Avoid excessive heat and direct sunlight.

General Statements

Bottles made from 97% post-consumer recycled plastic

Seals/Symbols

Quality Global Sourcing Bottled & Tested In the USA

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Digestion with Enzymes by Nature's Way label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Digestion with Enzymes label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Digestion with Enzymes by Nature's Way

These are the 14 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container50 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Dandelion

Interacts with
457 drugs
315 mg per serving

Dandelion is a common plant used in food and traditional medicine, often promoted as a natural 'water pill' and digestive aid. Human evidence for thes...

Dandelion monograph & interactions

Fennel

Interacts with
740 drugs
90 mg per serving

Fennel is a Mediterranean herb widely used as a food and spice, and traditionally taken for digestive complaints, colic, and menstrual cramps. Some sm...

Fennel monograph & interactions

Beet

Interacts with
861 drugs
100 mg per serving

Beet, especially beetroot juice, is a nitrate-rich food that may modestly lower blood pressure and slightly improve exercise performance in some peopl...

Beet monograph & interactions

Gentian

Interacts with
172 drugs
135 mg per serving

Gentian is a very bitter root traditionally used to stimulate appetite and ease mild digestive complaints, often as part of "bitters" before meals. Th...

Gentian monograph & interactions

Digestive Enzyme Blend

100 mg per serving

Cayenne Pepper

Interacts with
239 drugs
25 mg per serving

Capsicum (chili pepper) contains capsaicin, which is best known and best studied as a topical treatment for certain types of pain. Topical capsaicin p...

Cayenne Pepper monograph & interactions

Other (inactive) ingredients: Plant-derived Capsule, Cellulose, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Digestion with Enzymes by Nature's Way Drug Interactions

Want to check YOUR meds against Digestion with Enzymes?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,079Drugs
1,079 Moderate

Ingredients driving the most interactions

Beet 861
Fennel 740
Dandelion 457
Cayenne Pepper 239
Gentian 172

Individual Drug Interactions

The ingredients in Digestion with Enzymes interact with 1,079 drugs. Click any drug to see the details.

5 of the 14 ingredients in Digestion with Enzymes interact with drugs. Each result below shows which ingredient is responsible. Beet Fennel Dandelion Cayenne Pepper Gentian

Each ingredient & the kinds of drugs it affects

For each ingredient in Digestion with Enzymes with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Beet3 drug types · 861 drugs

Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, beet might increase the levels of CYP3A4 substrates.
In vitro research suggests that betanin, the major pigment in beet, competitively inhibits CYP3A4 in a dose-dependent manner similarly to strong CYP3A4 inhibitor ketoconazole.

Likelihood Possible Evidence D
Antihypertensive Drugs

Beet and beetroot contain nitrates, which can cause vasodilation, potentially leading to lower blood pressure. However, a study published in the European Journal of Clinical Nutrition using concentrated beetroot juice found no significant impact on blood pressure or heart rate in different age groups. Other small clinical studies suggest that while beet consumption might transiently lower blood pressure due to vessel dilation, there's no consistent evidence of a lasting effect. Overall, the theoretical risk of reduced blood pressure due to beet's nitrate content exists, but studies generally indicate a low and temporary impact rather than a sustained decrease.

Likelihood Possible Evidence A
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, beet might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research suggests that beet induces CYP1A2 enzymes.

Likelihood Possible Evidence D
Beet full monograph & interactions

Fennel6 drug types · 740 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, fennel might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.

Animal research suggests that fennel oil has antithrombotic and antiplatelet effects.

Likelihood Possible Evidence D
Ciprofloxacin (Cipro)

Theoretically, fennel might decrease the levels and clinical effects of ciprofloxacin.

Animal research shows that fennel reduces ciprofloxacin bioavailability by nearly 50%, possibly due to the metal cations such as calcium, iron, and magnesium contained in fennel. This study also found that fennel increased tissue distribution and slowed elimination of ciprofloxacin.

Likelihood Probable Evidence D
Contraceptive Drugs

Theoretically, taking large amounts of fennel might decrease the effects of contraceptive drugs due to competition for estrogen receptors.

Some constituents of fennel have estrogenic activity.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, fennel might increase levels of drugs metabolized by CYP3A4.

In vitro research suggests that fennel inhibits CYP3A4 enzyme activity. This effect has not been reported in humans.

Likelihood Possible Evidence D
Estrogens

Theoretically, taking large amounts of fennel might interfere with hormone replacement therapy due to competition for estrogen receptors.

Some constituents of fennel have estrogenic activity.

Likelihood Possible Evidence D
Tamoxifen (Nolvadex)

Theoretically, taking large amounts of fennel might decrease the antiestrogenic effect of tamoxifen.

Some constituents of fennel have estrogenic activity, which may interfere with the antiestrogenic activity of tamoxifen.

Likelihood Possible Evidence D
Fennel full monograph & interactions

Dandelion7 drug types · 457 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, taking dandelion root along with anticoagulant or antiplatelet drugs might increase the risk of bruising and bleeding.
In vitro research suggests that dandelion root inhibits platelet aggregation.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, dandelion might increase the risk for hypoglycemia when used with antidiabetes drugs.
Laboratory research suggests that dandelion extract may have moderate alpha-glucosidase inhibitor activity and might also increase insulin secretion. Also, in a case report, a 58-year-old woman with type 2 diabetes who was being treated with insulin developed hypoglycemia 2 weeks after beginning to eat salads containing dandelion.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, dandelion might increase levels of drugs metabolized by CYP1A2.
Laboratory research suggests that dandelion might inhibit CYP1A2. So far, this interaction has not been reported in humans. However, until more is known, watch for an increase in the levels of drugs metabolized by CYP1A2 in patients taking dandelion.

Likelihood Possible Evidence D
Glucuronidated Drugs

Theoretically, dandelion might increase the clearance of drugs that are UDP-glucuronosyltransferase substrates.
There is some preliminary evidence that dandelion might induce UDP-glucuronosyltransferase, a phase II enzyme.

Likelihood Possible Evidence D
Lithium

Theoretically, through diuretic effects, dandelion might reduce excretion and increase levels of lithium.
Animal research suggests that dandelion has diuretic properties. As diuretics can increase serum lithium levels, the dose of lithium might need to be decreased when taken with dandelion.

Likelihood Probable Evidence D
Potassium-Sparing Diuretics

Theoretically, dandelion might increase the risk of hyperkalemia when taken with potassium-sparing diuretics.
Dandelion contains significant amounts of potassium.

Likelihood Possible Evidence D
Quinolone Antibiotics

Theoretically, dandelion might lower fluoroquinolone levels.
Animal research shows that dandelion reduces absorption of ciprofloxacin and can lower levels by 73%. However, this effect has not been reported in humans.

Likelihood Possible Evidence D
Dandelion full monograph & interactions

Cayenne Pepper6 drug types · 239 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, capsicum may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
In vitro research shows that capsicum might increase the effects of antiplatelet drugs. Also, population research shows that capsicum is associated with an increased risk of self-reported bleeding in patients taking warfarin. However, clinical research shows that taking a single dose of capsaicin (Asian Herbex Ltd.), the active ingredient in capsicum, 400-800 mcg orally in combination with aspirin 500 mg does not decrease platelet aggregation when compared with taking aspirin 500 mg alone. Also, there was no notable effect on measures of platelet aggregation with capsaicin. It is unclear whether capsaicin must be used in more than a single dose to affect platelet aggregation.

Likelihood Possible Evidence B
Antidiabetes Drugs

Theoretically, taking capsicum with antidiabetes drugs might increase the risk of hypoglycemia.
Preliminary clinical research shows that consuming capsicum 5 grams along with a glucose drink attenuates the rise in plasma glucose after 30 minutes by 21%, decreases the 2-hour postprandial area under the curve of plasma glucose by 11%, and increases the 2-hour postprandial area under the curve of plasma insulin by 58% in healthy individuals when compared with placebo. Other clinical research shows that taking capsicum 5 mg daily for 28 days significantly reduces postprandial blood glucose and insulin levels, but not fasting blood glucose and insulin levels, in patients with gestational diabetes.

Likelihood Possible Evidence B
Aspirin

Theoretically, taking capsicum with aspirin might reduce the bioavailability of aspirin.
Animal research shows that acute or chronic intake of capsicum pepper reduces oral aspirin bioavailability. This has not been shown in humans.

Likelihood Possible Evidence D
Theophylline

Theoretically, taking capsicum with theophylline might increase the levels and adverse effects of theophylline.
In animal research, oral administration of capsicum reduced excretion of theophylline. However, capsicum does not seem to affect the pharmacokinetics of theophylline when administered intravenously.

Likelihood Possible Evidence D
Ace Inhibitors (Aceis)

Theoretically, using topical capsaicin may increase the risk of ACE inhibitor-induced cough.
There is one case report of a topically applied capsaicin cream contributing to the cough reflex in a patient using an ACEI. However, it is unclear if this interaction is clinically significant.

Likelihood Unlikely Evidence D
Ciprofloxacin (Cipro)

Theoretically, taking capsicum with ciprofloxacin might increase levels and adverse effects of ciprofloxacin.
Animal research shows that concomitant use of capsaicin, the active constituent of capsicum, and ciprofloxacin increases the bioavailability of ciprofloxacin by up to 70%.

Likelihood Possible Evidence D
Cayenne Pepper full monograph & interactions

Gentian1 drug type · 172 drugs

Antihypertensive Drugs

Theoretically, taking gentian with antihypertensive drugs might increase the risk of hypotension.
In vitro research shows that gentian can cause vasodilation and lower blood pressure.

Likelihood Possible Evidence D
Gentian full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Digestion with Enzymes, from the product label.

Nature's Way

See all Nature's Way products
Name
Nature's Way Brands, LLC
City
Green Bay
State
WI
ZipCode
54311
Phone Number
1-800-962-8873
Web Address
naturesway.com
Pharmacist Counseling Corner

Digestion with Enzymes by Nature's Way: Common Questions

Does Digestion with Enzymes by Nature's Way interact with any medications?
Yes. Based on its ingredients, Digestion with Enzymes has a known interaction with 1,079 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Digestion with Enzymes contains 14 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this help my digestion?
The evidence is sparse. Lactase definitely works if you can't digest milk sugar; the enzymes amylase, lipase, cellulase, and peptidase are the traditional digestive aids in the formula, but we don't have strong evidence they improve digestion for people who make these enzymes naturally. The herbal ingredients lack solid evidence for digestive support.
Can I take this while pregnant?
There's not enough safety data for most ingredients in pregnancy. Lactase is likely safe, but fennel should be avoided in medicinal amounts. Dandelion, gentian, and the proteases lack enough data—talk with your doctor before using this product while pregnant.
Is it safe to breastfeed while taking this?
Food amounts of beet and cayenne are likely fine, but we don't have enough data on the concentrated or medicinal doses in this supplement. Fennel, dandelion, gentian, lipase, and the proteases all have limited or no safety information while breastfeeding—check with your doctor or pharmacist first.
What is dandelion doing in a digestive enzyme formula?
Dandelion is traditionally used as a bitter to support digestion, but we don't have solid evidence it works for that purpose. It does carry real interaction risks with several medication types, so it's worth being aware of if you take prescription drugs.
Could this cause an allergic reaction?
Yes. Dandelion can trigger anaphylaxis in sensitive individuals, especially those allergic to ragweed or related plants. Fennel, lactase (rarely), and cayenne can also cause allergic reactions. If you have known allergies to these plant families, skip this product or check with your pharmacist first.
Will this interact with my blood pressure medication?
Possibly. Beet and gentian both theoretically lower blood pressure, and fennel's estrogenic effects may interact with certain hormonal blood pressure treatments. Cayenne may also have minor effects. Talk with your doctor or pharmacist before combining this with your blood pressure drug.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Digestion with Enzymes label
Go deeper

The Full Monographs Behind Digestion with Enzymes’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Dandelion

Interacts with 457 drugs

Dandelion is a common plant used in food and traditional medicine, often promoted as a natural 'water pill' and digestive aid. Human evidence for these uses is very limited, so its benefits...

Read the full Dandelion monograph → Herb & supplement monograph

Fennel

Interacts with 740 drugs

Fennel is a Mediterranean herb widely used as a food and spice, and traditionally taken for digestive complaints, colic, and menstrual cramps. Some small studies suggest possible benefit for...

Read the full Fennel monograph → Herb & supplement monograph

Beet

Interacts with 861 drugs

Beet, especially beetroot juice, is a nitrate-rich food that may modestly lower blood pressure and slightly improve exercise performance in some people. It is generally safe as a food, but s...

Read the full Beet monograph → Herb & supplement monograph

Gentian

Interacts with 172 drugs

Gentian is a very bitter root traditionally used to stimulate appetite and ease mild digestive complaints, often as part of "bitters" before meals. The evidence is mostly traditional and pre...

Read the full Gentian monograph → Herb & supplement monograph

Lipase

Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy for people who cannot make enough of their...

Read the full Lipase monograph → Herb & supplement monograph

Lactase

Lactase is a digestive enzyme supplement that helps people who lack enough natural lactase break down lactose, the sugar in milk and dairy. It can reduce gas, bloating, cramping, and diarrhe...

Read the full Lactase monograph → Herb & supplement monograph

Proteolytic Enzymes (proteases)

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...

Read the full Proteolytic Enzymes (proteases) monograph → Herb & supplement monograph

Capsicum

Interacts with 239 drugs

Capsicum (chili pepper) contains capsaicin, which is best known and best studied as a topical treatment for certain types of pain. Topical capsaicin products are supported by reasonable evid...

Read the full Capsicum monograph →
Sources

Sources & How We Checked

Digestion with Enzymes's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 157 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lipase 1 reference
  1. Casper C, Hascoet JM, Ertl T, et al. Recombinant bile salt-stimulated lipase in preterm infant feeding: A randomized phase 3 study. PLoS One. 2016;11(5):e0156071. PubMed

See these in context on the Lipase monograph →

Lactase 1 reference
  1. Laukkanen A, Ruoppi P, Remes S, Koistinen T, Mäkinen-Kiljunen S. Lactase-induced occupational protein contact dermatitis and allergic rhinoconjunctivitis. Contact Dermatitis. 2007;57(2):89-93. PubMed

See these in context on the Lactase monograph →

Dandelion 27 references
  1. Maliakal PP, Wanwimolruk S. Effect of herbal teas on hepatic drug metabolizing enzymes in rats. J Pharm Pharmacol 2001;53:1323-9. PubMed
  2. Williams CA, Goldstone F, Greenham J. Flavonoids, cinnamic acids and coumarins from the different tissues and medicinal preparations of Taraxacum officinale. Phytochemistry 1996;42:121-7. PubMed
  3. Hussain Z, Waheed A, Qureshi RA, et al. The effect of medicinal plants of Islamabad and Murree region of Pakistan on insulin secretion from INS-1 cells. Phytother Res 2004;18:73-7. PubMed
  4. Racz-Kotilla E, Racz G, Solomon A. The action of Taraxacum officinale extracts on the body weight and diuresis of laboratory animals. Planta Med 1974;26:212-7. PubMed
  5. Zhu M, Wong PY, Li RC. Effects of taraxacum mongolicum on the bioavailability and disposition of ciprofloxacin in rats. J Pharm Sci 1999;88:632-4. PubMed
  6. Jovanovic M, Mimica-Dukic N, Poljacki M, Boza P. Erythema multiforme due to contact with weeds: a recurrence after patch testing. Contact Dermatitis 2003;48:17-25. PubMed
  7. Chivato T, Juan F, Montoro A, Laguna R. Anaphylaxis induced by ingestion of a pollen compound. J Investig Allergol Clin Immunol 1996;6:208-9.
  8. Cohen SH, Yunginger JW, Rosenberg N, Fink JN. Acute allergic reaction after composite pollen ingestion. J Allergy Clin Immunol 1979;64:270-4. PubMed
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Beet 14 references
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See these in context on the Capsicum monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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