No known drug interactions for the matched ingredients — not a guarantee none exist. Based on 3 of 14 ingredients. Check your meds →
Dietary supplement

Digestive Enzymes Ingredients & Drug Interactions

by Healthy Origins

Capsule Category: Non-nutrient/non-botanical
No known interaction
The interaction bottom line No known interaction

Digestive Enzymes is a dietary supplement by Healthy Origins with 14 active ingredients. Its ingredients are commonly taken for lactose intolerance, gas and bloating after dairy, diarrhea from dairy foods.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.

HelloPharmacist Scorecard of Digestive Enzymes by Healthy Origins

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 14 active ingredients.
  • “Enzyme Blend” is a proprietary blend — the label gives one combined amount (400 mg) without saying how much of each component you get.

This formula contains 14 active digestive enzymes — each one breaks down a different part of food so your body can absorb nutrients better. Lactase breaks down milk sugar, lipase handles fats, and protease enzymes work on proteins.

The rest — amylase, glucoamylase, cellulase, hemicellulase, beta-glucanase, alpha-galactosidase, invertase, peptidase, pectinase, and diastase — target carbohydrates, fiber, and other plant compounds. The capsule itself is vegetarian, filled with microcrystalline cellulose (a flow agent) and calcium laurate (a binder).

There are no other added ingredients.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: aid digestion and assimilation of nutrients.
  • We looked for evidence on: Dyspepsia, Lactose intolerance, indigestion, bloating, malabsorption, pancreatic insufficiency.
  • The strongest evidence on file: Lactase is rated "Effective" for Lactose intolerance (Natural Medicines).
  • Also on file: Lipase is rated "Insufficient Reliable Evidence To Rate" for Dyspepsia.

Lactase is effective for lactose intolerance — if you can't digest milk sugar well, this enzyme can help. For the other uses we have data on — colic, prematurity, inflammatory bowel disease, and indigestion — the evidence isn't strong enough to say whether these enzymes work.

We don't have effectiveness information on file for the protease enzymes or the other enzyme components in this blend.

The evidence, ingredient by ingredient Lactase Lipase Proteolytic Enzymes (proteases)

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lactase and lipase are generally well tolerated when used as directed. The protease enzymes are also generally well tolerated for most adults, though they may cause digestive upset or allergic reactions in some people.

Rare cases of allergic reactions to protease enzymes — including allergic rhinoconjunctivitis and asthma from occupational exposure — have been reported, mostly in workers exposed to airborne forms in detergents. During pregnancy, lipase and the protease enzymes lack enough safety data; the facts advise against protease use in pregnancy unless prescribed, and suggest checking with your doctor before using lipase.

For lactase, pregnancy safety is likely okay but warrants a conversation with your doctor. Breastfeeding safety data is limited for lipase and the protease enzymes — ask your healthcare provider first.

We have no safety data on file for the other enzyme ingredients.

Side effects, ingredient by ingredient Lactase Lipase Proteolytic Enzymes (proteases)

Meds to double-check

No known interactions
Known Interaction Concern · database check
No known interactions

No medication interactions are currently documented for the matched ingredients — that isn't a guarantee none exist.

Why this rating?
  • None of the 3 matched ingredients has a documented medication interaction on file.

No interactions are documented for the ingredients we could check in this product. However, we have no data for nearly half the enzymes in the formula, so use the medication checker below with your full list before you start.

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with clinical evidence supporting its stated purpose. No medication interactions are currently documented, and safety information is well characterized.

This product is a broad-spectrum enzyme blend aimed at people who struggle to digest certain foods — especially dairy if lactase is your main concern. If you have serious digestive conditions, are pregnant or breastfeeding, or take any medications, check with your pharmacist or doctor before starting.

Run your medications through our tool to make sure nothing in this formula interferes with what you're taking.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 14 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 21, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Digestive Enzymes, straight from the product label.

Brand Healthy Origins
Barcode (UPC) 603573857349
Net contents 90 Veggie Cap(s)
Market status On market
Date entered into DSLD Jul 21, 2022
DSLD ID 269304
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Digestive Enzymes by Healthy Origins, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Vegetarian Capsule(s)
Maximum serving Sizes:
1 Vegetarian Capsule(s)
Servings per container
90
UPC/BARCODE
603573857349
IngredientAmount% DV
Lactase0 NP--
Lipase0 NP--
Beta-Glucanase0 NP--
Cellulase0 NP--
Hemicellulase0 NP--
Enzyme Blend400 mg--
Amylase0 NP--
Glucoamylase0 NP--
Alpha-Galactosidase0 NP--
Invertase0 NP--
Peptidase0 NP--
Pectinase0 NP--
Diastase0 NP--
Protease 4.50 NP--
Protease 6.00 NP--

Other ingredients: Vegetarian Capsule, Microcrystalline Cellulose, Calcium Laurate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement for adults, take one (1) vegetarian capsule with every meal, or as directed by a physician.

Formula

Heathy Origins Natural Digestive Enzymes include 14 different enzymes to aid in the digestion and assimilation of sugars, grains, fats, carbohydrates, and proteins.

Formulation

Not manufactured with milk, egg, fish, shellfish, peanut, or tree nut derived ingredients. Gluten-free product. Non GMO

Natural Broad spectrum formula Supports digestive health

Suitable for vegans

Manufactured in a cGMP facility.

Precautions

Caution: Consult a physician before use if you are pregnant, nursing, taking medication or have a medical condition.

Keep out of reach of children

Storage

Store in a cool, dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Brand IP Statement(s)

Healthy Origins Since 1996

General Statements

New look

Seals/Symbols

3rd Party Tested

FDA Statement of Identity

Dietary Supplement

See for yourself

Digestive Enzymes by Healthy Origins label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Digestive Enzymes by Healthy Origins

These are the 14 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Vegetarian Capsule(s) Dosage formCapsule Servings per container90 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Enzyme Blend

400 mg per serving
  • Lactase
  • Lipase
  • › Beta-Glucanase
  • › Cellulase
  • › Hemicellulase
  • › Amylase
  • › Glucoamylase
  • › Alpha-Galactosidase
  • › Invertase
  • › Peptidase
  • › Pectinase
  • › Diastase
  • Protease 4.5
  • Protease 6.0

Other (inactive) ingredients: Vegetarian Capsule, Microcrystalline Cellulose, Calcium Laurate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Digestive Enzymes by Healthy Origins Drug Interactions

We don’t currently list any known drug interactions for the mapped ingredients in Digestive Enzymes. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.

The maker

Brand information

Manufacturer and brand details for Digestive Enzymes, from the product label.

Healthy Origins

See all Healthy Origins products
Name
Healthy Origins
City
Pittsburgh
State
PA
ZipCode
15241
Phone Number
1-888-228-6650
Pharmacist Counseling Corner

Digestive Enzymes by Healthy Origins: Common Questions

Does Digestive Enzymes by Healthy Origins interact with any medications?
We do not currently list a known interaction for the mapped ingredients in Digestive Enzymes. This does not guarantee none exist, so confirm with your pharmacist.
How can one product interact with so many drugs?
Digestive Enzymes contains 14 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this help me digest dairy if I'm lactose intolerant?
Yes — lactase is effective for lactose intolerance. This enzyme breaks down lactose (milk sugar) so your body can absorb it instead of experiencing bloating, gas, or cramping. The stronger your lactose intolerance, the more helpful it may be.
Can I take this if I'm pregnant?
Lactase is likely safe in pregnancy, but lipase and the protease enzymes have limited pregnancy safety data. The facts recommend avoiding the protease enzymes unless your doctor prescribes them, and checking with your doctor before using lipase. Talk with your healthcare provider about what's right for you.
What if I'm allergic to enzymes or have sensitive digestion?
Allergic reactions to enzymes are rare but can happen — case reports show allergic rhinoconjunctivitis and asthma from occupational exposure to protease enzymes. If you have a known enzyme allergy or sensitive digestion, mention this product to your pharmacist before starting. Most people tolerate it well, but it's worth a conversation if you're unsure.
Is this better than taking one single-enzyme supplement?
This blend targets multiple food types — proteins, fats, carbs, and fiber — in one dose, so it may help if you struggle with several types of food. A single-enzyme supplement like lactase alone works better if your problem is just one nutrient, like dairy. Your digestive issues will guide which one makes sense for you.
Can I take this while breastfeeding?
Lactase safety during breastfeeding isn't well studied, and lipase and protease enzymes have limited breastfeeding safety data. Ask your healthcare provider or pharmacist before starting — we don't have enough information to say yes or no on our own.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Digestive Enzymes is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Digestive Enzymes label
Sources

Sources & How We Checked

Digestive Enzymes's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 5 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lactase 1 reference
  1. Laukkanen A, Ruoppi P, Remes S, Koistinen T, Mäkinen-Kiljunen S. Lactase-induced occupational protein contact dermatitis and allergic rhinoconjunctivitis. Contact Dermatitis. 2007;57(2):89-93. PubMed

See these in context on the Lactase monograph →

Lipase 1 reference
  1. Casper C, Hascoet JM, Ertl T, et al. Recombinant bile salt-stimulated lipase in preterm infant feeding: A randomized phase 3 study. PLoS One. 2016;11(5):e0156071. PubMed

See these in context on the Lipase monograph →

Proteolytic Enzymes (proteases) 3 references
  1. Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
  2. Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
  3. Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed

See these in context on the Proteolytic Enzymes (proteases) monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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