Interactions on record — worth a quick check against your medications. Based on 7 of 17 ingredients. Check your meds →
Dietary supplement

Digestive Enzymes Ingredients & Drug Interactions

by Sports Research

Digestive Enzymes label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Digestive Enzymes against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Digestive Enzymes is a dietary supplement by Sports Research with 17 active ingredients. Its ingredients are commonly taken for inflammation and swelling, sinus and nasal congestion, digestion support.Based on those ingredients, 1,153 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Ginger Rhizome Extract, B. subtilis DE111, Bromelain. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Digestive Enzymes by Sports Research

Ask about any prescription or over-the-counter medication and we check it for interactions with Digestive Enzymes by Sports Research — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Digestive Enzymes by Sports Research

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 1 of its 17 active ingredients.
  • “Ginger Rhizome Extract” is listed as a grouped ingredient — the label gives one combined amount (33 mg) without saying how much of each component you get.
  • “Protein & Fat Digestive Blend” is a proprietary blend — the label gives one combined amount (113 mg) without saying how much of each component you get.
  • “Immune Digestive Blend” is a proprietary blend — the label gives one combined amount (38 mg) without saying how much of each component you get.

This product contains 17 active ingredients designed to break down different components of food. The key digestive enzymes are bromelain (from pineapple), protease (breaks down proteins), lipase (breaks down fats), lactase (breaks down milk sugar), and phytase (breaks down plant compounds).

You'll also get cellulase, amylase, and other carbohydrate-digesting enzymes, plus B. subtilis DE111, a probiotic strain. The formula includes ginger rhizome extract and several proprietary enzyme blends — a "Protein & Fat Digestive Blend," "Immune Digestive Blend," "Carbs & Sugar Digestive Blend," and "Fruit & Vegetable Fiber Digestive Blend" — which combine the individual enzymes listed above.

The capsule itself is made from microcrystalline cellulose, hypromellose, purified water, and medium chain triglyceride (inactive ingredients that hold the formula together).

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: digestive support and enzyme function.
  • We looked for evidence on: Dyspepsia, Flatulence, Lactose intolerance, Diarrhea, Irritable bowel syndrome (IBS), Exercise-induced muscle soreness — and 4 related terms.
  • The strongest evidence on file: Lactase is rated "Effective" for Lactose intolerance (Natural Medicines).
  • Also on file: Bacillus Subtilis is rated "Possibly Effective" for Antibiotic-associated diarrhea.
  • Also on file: Lipase is rated "Insufficient Reliable Evidence To Rate" for Dyspepsia.

The evidence on these enzymes is mixed and often limited. Lactase is effective for lactose intolerance — that one's solid.

B. subtilis DE111 is possibly effective for antibiotic-associated diarrhea. For the others, the data we hold shows insufficient reliable evidence: bromelain hasn't been established for hay fever, burns, cancer, or diabetes; protease, lipase, and phytase similarly lack established evidence for their respective uses.

If you're taking this for a specific condition, talk to your pharmacist about what the science actually supports.

The evidence, ingredient by ingredient Bromelain Proteolytic Enzymes (proteases) Lipase Ginger Bacillus Subtilis Phytase Lactase

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 6 of the 6 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 6 of 6.
  • General safety write-ups exist for 6 of 6.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Most of these enzymes are generally well tolerated when taken by mouth. The most common side effects are digestive ones — diarrhea, gas, stomach upset, and headache, especially with bromelain.

Rarely, people may have allergic reactions; occupational exposure to airborne enzyme powders has caused asthma and other allergic symptoms in workers, but oral use is much lower-risk. B. subtilis is generally well tolerated in healthy adults, though very rarely diarrhea has been reported.

There's one case of Bacillus bacteremia in an elderly, immunocompromised person with frequent consumption of fermented soy. Protease, lipase, phytase, and lactase carry little long-term safety data in supplement form, especially for pregnancy and breastfeeding.

Bromelain is best avoided in pregnancy due to insufficient safety data; safety while breastfeeding is also unknown. For B. subtilis, phytase, lipase, and protease, there isn't enough data in pregnancy or lactation — check with your doctor before regular use if you're pregnant or nursing.

Side effects, ingredient by ingredient Bromelain Proteolytic Enzymes (proteases) Lipase Ginger Bacillus Subtilis Phytase Lactase

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 6 matched ingredients can interact with medications — Bromelain, Bacillus Subtilis.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 306 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you're on blood thinners or antiplatelet drugs (like warfarin, clopidogrel, or daily aspirin), check with your pharmacist before starting this — bromelain may increase bleeding risk. If you take antibiotics, separate them from this product; taking them together might reduce the probiotic's benefit.

Also double-check if you're on tetracycline antibiotics, since bromelain may theoretically affect how your body absorbs them.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This is a multi-enzyme formula aimed at helping digestion. If you take blood thinners, antiplatelet drugs, or antibiotics, run this by your pharmacist first — those are the main interactions to watch.

If you're pregnant or breastfeeding, talk to your doctor; data on long-term safety in these situations is limited. For most other people in good digestive health, it's generally well tolerated, though some may experience gas, diarrhea, or mild stomach upset.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 6 of 17 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 23, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Digestive Enzymes, straight from the product label.

Brand Sports Research
Barcode (UPC) 023249090205
Net contents 90 Veggie Capsule(s)
Market status On market
Date entered into DSLD Jan 23, 2025
DSLD ID 326253
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Digestive Enzymes by Sports Research, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Veggie Capsule(s)
Maximum serving Sizes:
1 Veggie Capsule(s)
Servings per container
90
UPC/BARCODE
023249090205
IngredientAmount% DV
Bromelain0 NP--
Protease0 NP--
Lipase0 NP--
Lactase0 NP--
ProHydrolase0 NP--
Cellulase0 NP--
Invertase0 NP--
Glucoamylase0 NP--
Pectinase0 NP--
Phytase0 NP--
Hemicellulase0 NP--
Alpha-Galactosidase0 NP--
Ginger Rhizome Extract33 mg--
Amylase, Fungal0 NP--
Diastase0 NP--
Protein & Fat Digestive Blend113 mg--
Immune Digestive Blend38 mg--
Carbs & Sugar Digestive Blend23 mg--
Fruit & Vegetable Fiber Digestive Blend23 mg--
Beta-Glucanase0 NP--
Gingerols1.65 mg--
B. subtilis DE1110 NP--
Dairy Digestive Enzymes3 mg--

Other ingredients: Microcrystalline Cellulose, Hypromellose, Water, Purified, Medium Chain Triglyceride

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested use: Adults take 1 veggie capsule daily before a meal, or as recommended by a qualified healthcare professional.

General Statements

Quality Matters:

HDPE Non BPA Please recycle Scan for more

@sportsresearch

Seals/Symbols

Non GMO Project Verified nongmoproject.org Gluten-Free

Formulation

Non-GMO verified Gluten-Free

Third party tested cGMP compliant

Plant-based Helps ease digestion

Vegan

Gluten-Free Non-GMO

Proudly manufactured in the USA with carefully selected ingredients of domestic and international origins.

Precautions

Caution: Keep out of reach of children and pets.

Consult with a qualified healthcare professional prior to using this product, especially if you are pregnant, nursing, have a diagnosed, medical condition, or are taking a prescription medication.

Do not exceed recommended daily intake. Do not use if safety seal is damaged or missing.

Storage

Store at room temperature, in a dry place. Protect product from excessive heat, freezing, humidity and light.

Brand IP Statement(s)

ProHydrolase & De111 are registered trademarks of Deerland Probiotics & Enzymes, Inc.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Formula

15 enzymes Probiotic & ginger

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Digestive Enzymes by Sports Research label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Digestive Enzymes label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Digestive Enzymes by Sports Research

These are the 17 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Veggie Capsule(s) Dosage formCapsule Servings per container90 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Protein & Fat Digestive Blend

113 mg per serving

Immune Digestive Blend

38 mg per serving

Carbs & Sugar Digestive Blend

23 mg per serving
  • › Invertase
  • › Glucoamylase
  • › Amylase, Fungal
  • › Diastase

Fruit & Vegetable Fiber Digestive Blend

23 mg per serving
  • › Cellulase
  • › Pectinase
  • › Phytase
  • › Hemicellulase
  • › Alpha-Galactosidase
  • › Beta-Glucanase

Dairy Digestive Enzymes

3 mg per serving

Other (inactive) ingredients: Microcrystalline Cellulose, Hypromellose, Water, Purified, Medium Chain Triglyceride. These complete the product’s ingredient list but are not active constituents.

Interaction report

Digestive Enzymes by Sports Research Drug Interactions

Want to check YOUR meds against Digestive Enzymes?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,153Drugs
1,024 Moderate 129 Minor

Ingredients driving the most interactions

Ginger Rhizome Extract 1,007
B. subtilis DE111 182
Bromelain 141

Individual Drug Interactions

The ingredients in Digestive Enzymes interact with 1,153 drugs. Click any drug to see the details.

3 of the 17 ingredients in Digestive Enzymes interact with drugs. Each result below shows which ingredient is responsible. Ginger Rhizome Extract B. subtilis DE111 Bromelain

Each ingredient & the kinds of drugs it affects

For each ingredient in Digestive Enzymes with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Ginger Rhizome Extract14 drug types · 1,007 drugs

Anticoagulant/Antiplatelet Drugs

Ginger may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs. However, research is conflicting.
Laboratory research suggests that ginger inhibits thromboxane synthetase and decreases platelet aggregation. However, this has not been demonstrated unequivocally in humans, with mixed results from clinical trials. Theoretically, excessive amounts of ginger might increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.

Likelihood Possible Evidence B
Antidiabetes Drugs

Theoretically, taking ginger with antidiabetes drugs might increase the risk of hypoglycemia.
Animal and human research suggests that ginger might increase insulin levels and/or decrease blood glucose levels.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Ginger might increase or decrease the levels of CYP3A4 substrates.
In vitro research and some case reports suggest that ginger inhibits CYP3A4 activity. Three case reports from the World Health Organization (WHO) adverse drug reaction database describe increased toxicity in patients taking ginger and cancer medications that are CYP3A4 substrates (imatinib, dabrafenib, and crizotinib). However, the causality of this interaction is unclear due to the presence of multiple interacting drugs and routes of administration.
Conversely, other in vitro research suggests that ginger induces CYP3A4 activity, leading to reduced levels of CYP3A4 substrates. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Losartan (Cozaar)

Theoretically, ginger might increase levels of losartan and the risk of hypotension.
In animal research, ginger increased the levels and hypotensive effects of a single dose of losartan. It is not clear if ginger alters the concentration or effects of losartan when taken continuously. Additionally, this interaction has not been shown in humans.

Likelihood Possible Evidence D
Nifedipine (Procardia)

Ginger may have antiplatelet effects and increase the risk of bleeding if used with nifedipine.
Clinical research shows that combined treatment with ginger 1 gram plus nifedipine 10 mg significantly inhibits platelet aggregation when compared to nifedipine or ginger alone.

Likelihood Possible Evidence B
P-Glycoprotein Substrates

Ginger might increase the absorption and blood levels of P-glycoprotein (P-gp) substrates.
In vitro research and case reports suggest that ginger inhibits drug efflux by P-gp, potentially increasing absorption and serum levels of P-gp substrates. Two case reports from the World Health Organization (WHO) adverse drug reaction database describe increased toxicity in patients taking ginger and cancer medications that are P-gp substrates (trametinib, crizotinib). However, the causality of this interaction is unclear due to the presence of multiple interacting drugs and routes of administration.

Likelihood Possible Evidence D
Phenprocoumon (Marcoumar, Others)

Ginger might increase the risk of bleeding with phenprocoumon.
Phenprocoumon, a warfarin-related anticoagulant, might increase the international normalized ratio (INR) when taken with ginger. There is one case report of a 76-year-old woman with a stable INR on phenprocoumon that increased to greater than 10 when she began consuming dried ginger and ginger tea.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Ginger might increase the risk of bleeding with warfarin.
Laboratory research suggests that ginger might inhibit thromboxane synthetase and decrease platelet aggregation. In one case report, ginger increased the INR when taken with phenprocoumon, which has similar pharmacological effects as warfarin. In another case report, ginger increased the INR when taken with a combination of warfarin, hydrochlorothiazide, and acetaminophen. A longitudinal analysis suggests that taking ginger increases the risk of bleeding in patients taking warfarin for at least 4 months. However, research in healthy people suggests that ginger has no effect on INR, or the pharmacokinetics or pharmacodynamics of warfarin. Until more is known, monitor INRs closely in patients taking large amounts of ginger.

Likelihood Possible Evidence B
Calcium Channel Blockers

Theoretically, taking ginger with calcium channel blockers might increase the risk of hypotension.
Some animal and in vitro research suggests that ginger has hypotensive and calcium channel-blocking effects. Another animal study shows that concomitant administration of ginger and the calcium channel blocker amlodipine leads to greater reductions in blood pressure when compared with amlodipine alone.

Likelihood Unlikely Evidence D
Cyclosporine (Neoral, Sandimmune)

Theoretically, when taken prior to cyclosporine, ginger might decrease cyclosporine levels.
In an animal model, ginger juice taken 2 hours prior to cyclosporine administration reduced the maximum concentration and area under the curve of cyclosporine by 51% and 40%, respectively. This effect was not observed when ginger juice and cyclosporine were administered at the same time.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, ginger might increase the levels of CYP1A2 substrates.
In vitro research shows that ginger inhibits CYP1A2 activity. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2B6 (Cyp2B6) Substrates

Theoretically, ginger might increase the levels of CYP2B6 substrates.
In vitro research shows that ginger inhibits CYP2B6 activity. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, ginger might increase the levels of CYP2C9 substrates.
In vitro research shows that ginger inhibits CYP2C9 activity. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Metronidazole (Flagyl)

Theoretically, ginger might increase levels of metronidazole.
In an animal model, ginger increased the absorption and plasma half-life of metronidazole. In addition, the elimination rate and clearance of metronidazole was significantly reduced.

Likelihood Possible Evidence D
Ginger Rhizome Extract full monograph & interactions

B. subtilis DE1111 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Bacillus subtilis with antibiotic drugs might decrease the effectiveness of B. subtilis.
Since B. subtilis preparations usually contain live and active organisms, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. subtilis preparations by at least 2 hours.

Likelihood Probable Evidence D
B. subtilis DE111 full monograph & interactions

Bromelain2 drug types · 141 drugs

Anticoagulant/Antiplatelet Drugs

Bromelain may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
There is one case report of a patient experiencing minor bruising while taking bromelain with naproxen. Bromelain is thought to have antiplatelet activity. Whether this interaction is of concern with topical bromelain is unclear. Interference with coagulation of burn wounds has been reported in a patient receiving bromelain-based enzymatic debridement. However, observational research has found that topical bromelain debridement is not associated with increases or decreases in laboratory markers of coagulation when compared with surgical debridement.

Likelihood Possible Evidence D
Tetracycline Antibiotics

Theoretically, bromelain might increase levels of tetracycline antibiotics.
Laboratory research suggests that bromelain might increase the absorption of tetracycline antibiotics. However, a study in healthy adults reported no difference in tetracycline plasma levels when a 500 mg dose was taken with or without bromelain 80 mg.

Likelihood Possible Evidence B
Bromelain full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Digestive Enzymes, from the product label.

Sports Research

See all Sports Research products
Name
Sports Research
Street Address
784 Channel St.
City
San Pedro
State
CA
ZipCode
90731
Phone Number
310.519.1484
Web Address
sportsresearch.com
Pharmacist Counseling Corner

Digestive Enzymes by Sports Research: Common Questions

Does Digestive Enzymes by Sports Research interact with any medications?
Yes. Based on its ingredients, Digestive Enzymes has a known interaction with 1,153 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Digestive Enzymes contains 17 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this help my digestion?
Digestive enzyme supplements like this are designed to help break down foods, but the evidence for most of these enzymes isn't well established in our data. Lactase is proven to help with lactose intolerance. For other uses, the science is limited. Talk to your pharmacist about whether this fits your specific situation.
Can I take it if I'm pregnant or breastfeeding?
Bromelain is best avoided in pregnancy due to limited safety data, and its safety while breastfeeding is unknown. For the other enzymes — B. subtilis, protease, lipase, and phytase — there isn't enough reliable information, so check with your doctor before regular use. Lactase is likely safe in pregnancy, but ask your doctor before you start.
What side effects should I watch for?
The most common are digestive: diarrhea, gas, stomach upset, and headache. Rarely, allergic reactions can occur. If you notice any of these, especially if they're severe or persistent, stop and talk to your pharmacist.
Can I take it with my antibiotics?
You shouldn't take them at the same time. The antibiotic may kill the beneficial bacteria (B. subtilis) in this product. Ask your pharmacist how to space them out — usually several hours apart works.
Is there ginger in this?
Yes, ginger rhizome extract is one of the active ingredients, likely included for its digestive and anti-inflammatory properties.
What are all these enzyme blends?
The product includes blends named for what they target — "Protein & Fat Digestive Blend," "Carbs & Sugar Digestive Blend," "Fruit & Vegetable Fiber Digestive Blend," and "Immune Digestive Blend." Each blends several individual enzymes (like amylase and cellulase) to help break down different food types.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Digestive Enzymes is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Digestive Enzymes label
Go deeper

The Full Monographs Behind Digestive Enzymes’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Bromelain

Interacts with 141 drugs

Bromelain is a group of protein-digesting enzymes from pineapple that people take mainly for inflammation, swelling, and sinus problems. Some early studies are promising, but the overall evi...

Read the full Bromelain monograph → Herb & supplement monograph

Proteolytic Enzymes (proteases)

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...

Read the full Proteolytic Enzymes (proteases) monograph → Herb & supplement monograph

Lipase

Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy for people who cannot make enough of their...

Read the full Lipase monograph → Herb & supplement monograph

Ginger

Interacts with 1,007 drugs

Ginger is a widely used culinary spice with a long history in traditional medicine, and it has the strongest evidence for helping with nausea and vomiting, including from motion sickness, pr...

Read the full Ginger monograph → Herb & supplement monograph

Bacillus Subtilis

Interacts with 182 drugs

Bacillus subtilis is a spore-forming probiotic bacterium found in soil and some fermented foods, and it is used mainly to support gut health and digestion. Early research is promising for ce...

Read the full Bacillus Subtilis monograph → Herb & supplement monograph

Phytase

Phytase is an enzyme that breaks down phytic acid (phytate) found in grains, beans, nuts, and seeds, which can free up minerals like iron, zinc, and calcium for absorption. It is widely used...

Read the full Phytase monograph → Herb & supplement monograph

Lactase

Lactase is a digestive enzyme supplement that helps people who lack enough natural lactase break down lactose, the sugar in milk and dairy. It can reduce gas, bloating, cramping, and diarrhe...

Read the full Lactase monograph →
Sources

Sources & How We Checked

Digestive Enzymes's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 105 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Bromelain 19 references
  1. Nettis E, Napoli G, Ferrannini A, Tursi A. IgE-mediated allergy to bromelain. Allergy 2001;56:257-8. PubMed
  2. Taussig SJ, Batkin S. Bromelain, the enzyme complex of pineapple (Ananas comosus) and its clinical application. An update. J Ethnopharmacol 1988;22:191-203.. PubMed
  3. Bradbrook ID, Morrison PJ, Rogers HJ. The effect of bromelain on the absorption of orally administered tetracycline. Br J Clin Pharmacol 1978;6:552-4. PubMed
  4. Bush TM, Rayburn KS, Holloway SW, et al. Adverse interactions between herbal and dietary substances and prescription medications: a clinical survey. Altern Ther Health Med 2007;13:30-5.
  5. Brien S, Lewith G, Walker AF, et al. Bromelain as an adjunctive treatment for moderate-to-severe osteoarthritis of the knee: a randomized placebo-controlled pilot study. QJM 2006;99:841-50. PubMed
  6. Mori S, Ojima Y, Hirose T, et al. The clinical effect of proteolytic enzyme containing bromelain and trypsin on urinary tract infection evaluated by double blind method. Acta Obstet Gynaecol Jpn 1972;19:147-53.
  7. Glaser D, Hilberg T. The influence of bromelain on platelet count and platelet activity in vitro. Platelets 2006;17:37-41. PubMed
  8. Heinicke R M, van der Wal L, Yokoyama M. Effect of bromelain (Ananase) on human platelet aggregation. Experientia 1972;28:844-5. PubMed
  9. Gailhofer, G., Wilders-Truschnig, M., Smolle, J., and Ludvan, M. Asthma caused by bromelain: an occupational allergy. Clin Allergy 1988;18(5):445-450. PubMed
  10. Mattei, O., Fabri, G., and Farina, G. [Occupational health experience regarding four cases of asthma due to bromelain (author's transl)]. Medicina del Lavoro 1979;70(5):404-409.
  11. Galleguillos, F. and Rodriguez, J. C. Asthma caused by bromelin inhalation. Clin Allergy 1978;8(1):21-24. PubMed
  12. Perez-Camo I, Quirce S, Duran MA, and et al. Latex allergy: evidence of cross-reactivity with papain and bromelain [abstract]. Allergy 1996;51(suppl 31):48.
  13. Martin GJ, Ehrenreich J, and Asbell N. Bromelain: pineapple proteases with anti-edema activity. Exp Med Surg 1962;20:227-247.
  14. Kasemsuk T, Saengpetch N, Sibmooh N, Unchern S. Improved WOMAC score following 16-week treatment with bromelain for knee osteoarthritis. Clin Rheumatol. 2016 Oct;35(10):2531-40. PubMed
  15. Kutlu Ö, DemirbaS A, Elmas ÖF, Güvenç U, Metin A. Fixed drug eruption: a new side effect of bromelain. Contact Dermatitis 2020. Online ahead of print. PubMed
  16. Shoham Y, Shapira E, Haik J, et al. Bromelain-based enzymatic debridement of chronic wounds: Results of a multicentre randomized controlled trial. Wound Repair Regen 2021;29(6):899-907. PubMed
  17. Pfister P, Garcia Wendel PD, Kim BS, et al. Coagulation side effects of enzymatic debridement in burned patients. Burns 2022. PubMed
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Proteolytic Enzymes (proteases) 3 references
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Lipase 1 reference
  1. Casper C, Hascoet JM, Ertl T, et al. Recombinant bile salt-stimulated lipase in preterm infant feeding: A randomized phase 3 study. PLoS One. 2016;11(5):e0156071. PubMed

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Lactase 1 reference
  1. Laukkanen A, Ruoppi P, Remes S, Koistinen T, Mäkinen-Kiljunen S. Lactase-induced occupational protein contact dermatitis and allergic rhinoconjunctivitis. Contact Dermatitis. 2007;57(2):89-93. PubMed

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Phytase 7 references
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Ginger 64 references
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See these in context on the Ginger monograph →

Bacillus Subtilis 10 references
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See these in context on the Bacillus Subtilis monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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