DigestMore Ultra Ingredients & Drug Interactions
by Renew Life
What is this page for?
First and foremost: checking DigestMore Ultra against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
DigestMore Ultra is a dietary supplement by Renew Life with 15 active ingredients. Its ingredients are commonly taken for digestive support, bloating and gas, fat digestion.Based on those ingredients, 2 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Papain. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against DigestMore Ultra by Renew Life
Ask about any prescription or over-the-counter medication and we check it for interactions with DigestMore Ultra by Renew Life — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of DigestMore Ultra by Renew Life
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
DigestMore Ultra contains 15 active ingredients, all digestive enzymes designed to break down different foods. The product includes papain (from papaya), protease and lipase (which break down protein and fat), lactase (which breaks down milk sugar), cellulase and hemicellulase (which break down plant fiber), and several others like amylase, invertase, glucoamylase, alpha-galactosidase, xylanase, beta-glucanase, phytase, and pectinase.
These are grouped into three enzyme complexes for fat, protein, and carbohydrate digestion. The capsule itself is made from vegetable material.
Does it work?
Strong evidence
The evidence for most ingredients in this product is not established in our data. Lactase is effective for lactose intolerance.
Papain, protease, lipase, phytase, and several others have insufficient reliable evidence to rate their use for the conditions they're studied in — meaning we don't have enough solid research to say whether they work.
How safe is it?
Well-documented data
Papain is generally tolerated as a food but may irritate the digestive tract and cause allergic reactions in sensitive people. It should be avoided during pregnancy due to safety concerns, and there isn't enough data to recommend it while breastfeeding.
Protease and lipase are generally well tolerated but may cause digestive upset or allergic reactions; they should be avoided in pregnancy unless prescribed, and should not be used while breastfeeding without medical advice. Lactase is generally well tolerated and likely safe in pregnancy.
Phytase has limited human supplement data; there isn't enough safety information for pregnancy, and breastfeeding safety hasn't been well studied. Most serious adverse effects are rare and occur with high doses — papain can cause severe stomach inflammation or even esophageal perforation.
Meds to double-check
Moderate interaction found
Before taking DigestMore Ultra, check with your doctor or pharmacist if you take warfarin (Coumadin) or any other blood thinner — papain in this product may increase its blood-thinning effects. No other interactions are documented for the ingredients we could check.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
This is a multi-enzyme digestive supplement that may help some people with food breakdown, though evidence is limited for most ingredients. If you take warfarin or other blood thinners, do not start this product without checking with your doctor first — papain can interfere with your medication.
Talk with your doctor or pharmacist before using it, especially if you're pregnant, breastfeeding, or have serious digestive conditions.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 5 of 15 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 25, 2018.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about DigestMore Ultra, straight from the product label.
| Brand | Renew Life |
|---|---|
| Barcode (UPC) | 631257534835 |
| Net contents | 45 Vegetable Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Jul 25, 2018 |
| DSLD ID | 178502 |
| Product type | Non-nutrient/non-botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free, Sugar Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for DigestMore Ultra by Renew Life, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Amylase | 0 NP | -- |
| Papain | 0 NP | -- |
| Protease | 0 NP | -- |
| Lipase | 0 NP | -- |
| Lactase | 0 NP | -- |
| Cellulase | 0 NP | -- |
| Invertase | 0 NP | -- |
| Glucoamylase | 0 NP | -- |
| Alpha-Galactosidase | 0 NP | -- |
| Xylanase | 0 NP | -- |
| Beta-Glucanase | 0 NP | -- |
| Phytase | 0 NP | -- |
| Hemicellulase | 0 NP | -- |
| Pectinase, Phytase | 0 NP | -- |
| Plant-based Enzyme Blend | 470 mg | -- |
| Fat Digestive SmartZYME Complex | 0 NP | -- |
| Protein Digestive Complex with SmartZYME: | 0 NP | -- |
| Carbohydrate, Fiber and Sugars Digestive Complex with SmartZYME: | 0 NP | -- |
Other ingredients: Vegetable Capsule
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)
DigestMore Ultra enhances the digestion of proteins, fats, and carbohydrates.
Formula
It is ultra-strength plant-sourced enzyme formula and features the exclusive SmartZYME blend to work more effectively over the pH range of the digestive tract.
With SmartZYME Blend
Soy, dairy, and wheat are used in the fermentation process to make enzymes and may be present in the finished product in very trace amounts.
Formulation
Free of GMOs, yeast, salt, sugar, binders, fillers, and artificial ingredients.
Gluten-free
Storage
Store in a cool, dry place at 77(0)F (25(0)C) or below.
General Statements
Quality, purity, and potency guaranteed through expiration.
Manufactured in USA in a GMP facility.
Ultra-strength plant enzyme formula Relieves occasional gas, bloating & indigestion Enhances digestion & nutrient absorption
Precautions
Keep out of reach of children.
Consult your healthcare professional before using this or any product if you are pregnant, nursing, or under medical supervision.
Tamper Evident: Do not use if safety seal under cap is broken or missing.
Soy, dairy, and wheat are used in the fermentation process to make enzymes and may be present in the finished product in very trace amounts.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
General
#15533 030715 90017B
FDA Statement of Identity
Dietary Supplement
Suggested/Recommended/Usage/Directions
Directions: Take one capsule with meals.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
DigestMore Ultra by Renew Life label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in DigestMore Ultra by Renew Life
These are the 15 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container45 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Plant-based Enzyme Blend
Fat Digestive SmartZYME Complex
- › Lipase
Other (inactive) ingredients: Vegetable Capsule. These complete the product’s ingredient list but are not active constituents.
DigestMore Ultra by Renew Life Drug Interactions
HelloPharmacist Interaction Report
DigestMore Ultra by Renew Life contains papain, an enzyme that interacts with blood thinners (anticoagulants).
Papain may increase the effects and side effects of warfarin (Coumadin), a commonly prescribed blood thinner. In one case report, a patient stable on warfarin developed an unsafe blood-thinning level (international normalization ratio of 7.4) after taking a supplement containing papain.
Read the full breakdown — every affected drug type, severity by severity
We could not check several other ingredients in this product — amylase, cellulase, invertase, glucoamylase, alpha-galactosidase, xylanase, beta-glucanase, hemicellulase, and the enzyme blends — because we hold no interaction data for them. Protease and lipase have been checked and show no documented interactions.
Lactase and phytase have also been checked with no interactions found.
Altogether, these interactions span 2 individual medications.
If you take warfarin or any other blood thinner, check with your doctor or pharmacist before starting this product. You can also search your exact medications in the tool on this page to see if anything else is affected.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against DigestMore Ultra?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in DigestMore Ultra interact with 2 drugs. Click any drug to see the details.
1 of the 15 ingredients in DigestMore Ultra interact with drugs. Each result below shows which ingredient is responsible. Papain
WarfarinWarfarin
How Warfarin interacts with DigestMore Ultra — through 1 ingredient. Tap an ingredient for the detail:
PapainWarfarin (coumadin) Moderate
Interaction Summary
Theoretically, papain might increase the effects and side effects of warfarin.
Read the full Papain + Warfarin interactionWarfarin SodiumCoumadin, Panwarfin, Sofarin
How Warfarin Sodium interacts with DigestMore Ultra — through 1 ingredient. Tap an ingredient for the detail:
PapainWarfarin (coumadin) Moderate
Interaction Summary
Theoretically, papain might increase the effects and side effects of warfarin.
Read the full Papain + Warfarin Sodium interactionEach ingredient & the kinds of drugs it affects
For each ingredient in DigestMore Ultra with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Papain
Warfarin (Coumadin)
Theoretically, papain might increase the effects and side effects of warfarin.
In one case report, a patient previously stable on warfarin was found to have an international normalization ratio (INR) of 7.4, which was attributed to ingestion of a supplement containing papain from papaya extract.
Brand information
Manufacturer and brand details for DigestMore Ultra, from the product label.
Renew Life
- Name
- Renew Life Formulas
- City
- Palm Harbor
- State
- FL
- ZipCode
- 34683
- Phone Number
- 1-800-830-1800
DigestMore Ultra by Renew Life: Common Questions
Does DigestMore Ultra by Renew Life interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take this if I'm pregnant?
Is it safe while breastfeeding?
What's papain and why is it in here?
Does lactase actually work?
Are there any common side effects I should know about?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if DigestMore Ultra is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind DigestMore Ultra’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Lipase
Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy for people who cannot make enough of their...
Read the full Lipase monograph → Herb & supplement monographPapain
Interacts with 2 drugsPapain is a protein-digesting enzyme from the papaya plant that is used in digestive supplements and some topical products. While it has clear food and laboratory uses, strong human evidence...
Read the full Papain monograph → Herb & supplement monographProteolytic Enzymes (proteases)
Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...
Read the full Proteolytic Enzymes (proteases) monograph → Herb & supplement monographLactase
Lactase is a digestive enzyme supplement that helps people who lack enough natural lactase break down lactose, the sugar in milk and dairy. It can reduce gas, bloating, cramping, and diarrhe...
Read the full Lactase monograph → Herb & supplement monographPhytase
Phytase is an enzyme that breaks down phytic acid (phytate) found in grains, beans, nuts, and seeds, which can free up minerals like iron, zinc, and calcium for absorption. It is widely used...
Read the full Phytase monograph →Sources & How We Checked
DigestMore Ultra's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 23 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Papain 11 references
- The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
- Shaw D, Leon C, Kolev S, Murray V. Traditional remedies and food supplements: a 5-year toxicological study (1991-1995). Drug Saf 1997;17:342-56.
- Shuttleworth D, Hill S, Marks R, Connelly DM. Relief of experimentally induced pruritus with a novel eutectic mixture of local anaesthetic agents. Br J Dermatol 1988;119:535-40.
- Mansfield LE, Ting S, Haverly RW, Yoo TJ. The incidence and clinical implications of hypersensitivity to papain in an allergic population, confirmed by blinded oral challenge. Ann Allergy 1985;55:541-3.
- Martin, T., Uhder, K., Kurek, R., Roeddiger, S., Schneider, L., Vogt, H. G., Heyd, R., and Zamboglou, N. Does prophylactic treatment with proteolytic enzymes reduce acute toxicity of adjuvant pelvic irradiation? Results of a double-blind randomized trial PubMed
- Walker-Renard, P. Update on the medicinal management of phytobezoars. Am J Gastroenterol. 1993;88(10):1663-1666.
- Tymoszuk D, Wiszniewska M, Walusiak-Skorupa J. Papain-induced occupational rhinoconjunctivitis and asthma - A case report. Med Pr 2016;67(1):109-12. PubMed
- Soto-Mera MT, López-Rico MR, Filgueira JF, et al. Occupational allergy to papain. Allergy 2000;55(10):983-4. PubMed
- Tarlo SM, Shaikh W, Bell B, et al. Papain-induced allergic reactions. Clin Allergy 1978;8(3):207-15. PubMed
- Baur X, König G, Bencze K, Fruhmann G. Clinical symptoms and results of skin test, RAST and bronchial provocation test in thirty-three papain workers: Evidence for strong immunogenic potency and clinically relevant proteolytic e?ects of airborne papain. C
- Novey HS, Keenan WJ, Fairshter RD, Wells ID, Wilson AF, Culver BD. Pulmonary disease in workers exposed to papain: clinico-physiological and immunological studies. Clin Allergy 1980;10(6):721-31. PubMed
Proteolytic Enzymes (proteases) 3 references
- Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
- Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
- Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed
See these in context on the Proteolytic Enzymes (proteases) monograph →
Lipase 1 reference
- Casper C, Hascoet JM, Ertl T, et al. Recombinant bile salt-stimulated lipase in preterm infant feeding: A randomized phase 3 study. PLoS One. 2016;11(5):e0156071. PubMed
Lactase 1 reference
- Laukkanen A, Ruoppi P, Remes S, Koistinen T, Mäkinen-Kiljunen S. Lactase-induced occupational protein contact dermatitis and allergic rhinoconjunctivitis. Contact Dermatitis. 2007;57(2):89-93. PubMed
Phytase 7 references
- Lei XG, Weaver JD, Mullaney E, Ullah AH, Azain MJ. Phytase, a new life for an "old" enzyme. Annu Rev Anim Biosci. 2013;1:283-309. PubMed
- Smuts CM, Matsungo TM, Malan L, et al. Effect of small-quantity lipid-based nutrient supplements on growth, psychomotor development, iron status, and morbidity among 6- to 12-mo-old infants in South Africa: a randomized controlled trial. Am J Clin Nutr. 2 PubMed
- van Heemst RC, Sander I, Rooyackers J, et al. Hypersensitivity pneumonitis caused by occupational exposure to phytase. Eur Respir J. 2009;33(6):1507-9. PubMed
- Baur X, Melching-Kollmuss S, Koops F, Strassburger K, Zober A. IgE-mediated allergy to phytase -- a new animal feed additive. Allergy. 2002;57(10):943-5. PubMed
- Doekes G, Kamminga N, Helwegen L, Heederik D. Occupational IgE sensitisation to phytase, a phosphatase derived from Aspergillus niger. Occup Environ Med. 1999;56(7):454-9. PubMed
- Brnic M, Hurrell RF, Songré-Ouattara LT, et al. Effect of phytase on zinc absorption from a millet-based porridge fed to young Burkinabe children. Eur J Clin Nutr. 2017;71(1):137-141. PubMed
- Koshy JC, Sharabi SE, Feldman EM, Hollier LH Jr, Patrinely JR, Soparkar CN. Effect of dietary zinc and phytase supplementation on botulinum toxin treatments. J Drugs Dermatol. 2012;11(4):507-12.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC