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Dietary supplement

DIM 100 mg + Broccoli Sprouts Ingredients & Drug Interactions

by Natural Grocers by Vitamin Cottage

DIM 100 mg + Broccoli Sprouts label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking DIM 100 mg + Broccoli Sprouts against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

DIM 100 mg + Broccoli Sprouts is a dietary supplement by Natural Grocers by Vitamin Cottage with 2 active ingredients. Its ingredients are commonly taken for estrogen/hormone balance, acne and hormonal skin issues, prostate health support.Based on those ingredients, 270 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are DIM, Broccoli. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against DIM 100 mg + Broccoli Sprouts by Natural Grocers by Vitamin Cottage

Ask about any prescription or over-the-counter medication and we check it for interactions with DIM 100 mg + Broccoli Sprouts by Natural Grocers by Vitamin Cottage — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of DIM 100 mg + Broccoli Sprouts by Natural Grocers by Vitamin Cottage

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 23, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains two active ingredients: 100 mg of DIM (diindolylmethane), a compound found naturally in cruciferous vegetables, and broccoli sprout extract. DIM is believed to support hormone metabolism, and broccoli is rich in glucosinolates, compounds thought to have potential health effects.

The remaining ingredients—microcrystalline cellulose, silica, and rice bran—are inactive fillers and capsule materials that help hold the product together.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: Women's health and hormone balance.
  • We looked for evidence on: Mastalgia, Premenstrual syndrome (PMS), Menopause symptoms, Hormonal acne.
  • The closest evidence on file: Diindolylmethane is rated "Insufficient Reliable Evidence To Rate" for Mastalgia (Natural Medicines).
  • Also on file: Diindolylmethane is rated "Insufficient Reliable Evidence To Rate" for Premenstrual syndrome (PMS).

The evidence supporting DIM for any condition—including benign prostatic hyperplasia, breast cancer, colorectal cancer, cervical dysplasia, and breast pain—is insufficient, meaning we don't have reliable data to say whether it works. Broccoli shows possibly effective evidence for colorectal cancer prevention when eaten as food, but data on concentrated broccoli sprout extracts like the one in this product is less clear.

For breast cancer, bladder cancer, fibromyalgia, and gastric cancer, the evidence on broccoli is also insufficient. Talk with your doctor or pharmacist about whether this product is likely to help your specific health goal.

The evidence, ingredient by ingredient Diindolylmethane Broccoli

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

DIM is generally well tolerated in short-term use, but long-term safety isn't well established. The most common side effects are digestive—diarrhea, gas, nausea, and headache—plus rash and vomiting in some people.

A rare serious side effect called DRESS (drug rash with eosinophilia and systemic symptoms) has been reported. One case of stroke was reported in a person taking DIM, though many other factors were at play and a direct link is unclear.

Broccoli as a food is safe in normal amounts, but concentrated broccoli supplements are less studied; loose stools, diarrhea, and abdominal cramping have been reported, especially at high doses. Both ingredients are rated likely safe in pregnancy and lactation based on available data.

Side effects, ingredient by ingredient Diindolylmethane Broccoli

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Diindolylmethane, Broccoli.
  • The most serious interaction on file is rated Moderate.
  • For scale: 270 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your doctor or pharmacist if you take birth control pills, hormone replacement therapy, water pills (especially sodium-depleting diuretics), or any medications metabolized by CYP1A2 or CYP2A6 liver enzymes. Both ingredients can speed up how quickly your body clears these drugs, which may reduce their effectiveness.

The risk is Moderate for estrogens, diuretics, and the CYP enzyme substrates, and the medication count is high.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

This product may appeal to someone interested in supporting hormone metabolism with a natural approach, but the evidence that it works for any specific condition is weak. The bigger practical concern is that both ingredients speed up how your liver processes certain medications, potentially making them less effective—especially birth control, hormone therapy, and drugs metabolized by specific liver enzymes.

If you take prescription medications or hormonal contraceptives, talk with your doctor or pharmacist before starting this product to make sure it won't interfere.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 22, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about DIM 100 mg + Broccoli Sprouts, straight from the product label.

Brand Natural Grocers by Vitamin Cottage
Barcode (UPC) 849327002959
Net contents 90 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Oct 22, 2021
DSLD ID 256728
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegetarian, Adult Female (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for DIM 100 mg + Broccoli Sprouts by Natural Grocers by Vitamin Cottage, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Vegetarian Capsule(s)
Maximum serving Sizes:
1 Vegetarian Capsule(s)
Servings per container
90
UPC/BARCODE
849327002959
IngredientAmount% DV
DIM100 mg--
Broccoli50 mg--

Other ingredients: Microcrystalline Cellulose, Capsule, Silica, Rice Bran

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested use: As a dietary supplement, adults take one (1) vegetarian capsule daily, or as directed by a health care professional.

Storage

Store in a cool, dry place and away from direct light.

Formulation

We only put our name on formulas that meet our unrivaled quality standards, and we continue raising the bar on these standards without raising the bar on your budget. Our supplements are GMP (Good Manufacturing Practices) certified, ingredient verified, screened for heavy metals, and formulated without questionable fillers, artificial colors, sweeteners, flavors, and other problematic ingredients. We scrutinize every detail, so you don't have to, because we are, and always have been, your Original good4u Grocers. To your health, - The Isely Family

Our supplements are GMP (Good Manufacturing Practices) certified, ingredient verified, screened for heavy metals, and formulated without questionable fillers, artificial colors, sweeteners, flavors, and other problematic ingredients.

Gluten free

Vegetarian

Made in USA

BPA Free

Contains no: Sugar, salt, dairy, yeast, wheat, gluten, corn, soy, preservatives, magnesium stearate, artificial colors or flavors.

Seals/Symbols

GMP Good Manufacturing Practice

Formula

Women's health

FDA Statement of Identity

Dietary Supplement

Precautions

Caution: As with any supplement, consult your healthcare practitioner before using this product, especially if you are pregnant, nursing, or are under medical supervision for any reason.

Keep out of reach of children.

For serious adverse event reporting call (877) 455-2826.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

DIM 100 mg + Broccoli Sprouts by Natural Grocers by Vitamin Cottage label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

DIM 100 mg + Broccoli Sprouts label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in DIM 100 mg + Broccoli Sprouts by Natural Grocers by Vitamin Cottage

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Vegetarian Capsule(s) Dosage formCapsule Servings per container90 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

DIM

Interacts with
269 drugs
100 mg per serving

Diindolylmethane (DIM) is a compound made when your body digests cruciferous vegetables, and it is sold as a supplement mainly for hormone balance and...

DIM monograph & interactions

Broccoli

Interacts with
187 drugs
50 mg per serving

Broccoli is a nutritious cruciferous vegetable rich in fiber, vitamins, and plant compounds like sulforaphane that have drawn scientific interest for...

Broccoli monograph & interactions

Other (inactive) ingredients: Microcrystalline Cellulose, Capsule, Silica, Rice Bran. These complete the product’s ingredient list but are not active constituents.

Interaction report

DIM 100 mg + Broccoli Sprouts by Natural Grocers by Vitamin Cottage Drug Interactions

Want to check YOUR meds against DIM 100 mg + Broccoli Sprouts?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
270Drugs
270 Moderate

Ingredients driving the most interactions

DIM 269
Broccoli 187

Individual Drug Interactions

The ingredients in DIM 100 mg + Broccoli Sprouts interact with 270 drugs. Click any drug to see the details.

2 of the 2 ingredients in DIM 100 mg + Broccoli Sprouts interact with drugs. Each result below shows which ingredient is responsible. DIM Broccoli

Each ingredient & the kinds of drugs it affects

For each ingredient in DIM 100 mg + Broccoli Sprouts with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

DIM3 drug types · 269 drugs

Diuretic Drugs

Theoretically, diindolylmethane might increase the risk of hyponatremia if used with sodium-depleting diuretics.
Large doses of diindolylmethane (600 mg daily) have been associated with two cases of asymptomatic hyponatremia in clinical research.

Likelihood Possible Evidence B
Estrogens

Theoretically, diindolylmethane might increase or decrease the effects of estrogens.
Diindolylmethane might have mild estrogenic or antiestrogenic effects. Theoretically, large amounts of diindolylmethane might interfere with hormone replacement therapy.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, diindolylmethane might lower serum levels of CYP1A2 substrates.
In vitro evidence suggests that diindolylmethane can induce CYP1A2. Theoretically, it might increase metabolism of CYP1A2 substrates and lower serum concentrations. This interaction has not been reported in humans.

Likelihood Unlikely Evidence D
DIM full monograph & interactions

Broccoli2 drug types · 187 drugs

Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, broccoli might reduce the levels and effects of drugs metabolized by CYP1A2.
Pharmacokinetic research in humans shows that eating 500 grams of fresh broccoli daily for 6-12 days can increase CYP1A2 activity by 10% to 200%. Induction of CYP1A2 activity by broccoli is attributed to its glucosinolate constituents.

Likelihood Possible Evidence B
Cytochrome P450 2A6 (Cyp2A6) Substrates

Theoretically, broccoli might reduce the levels and effects of drugs metabolized by CYP2A6.
Pharmacokinetic research in humans shows that eating 500 grams of broccoli daily for 6 days increases CYP2A6 activity by 135% to 550%. Induction of CYP2A6 activity is attributed to its glucosinolate constituents.

Likelihood Possible Evidence B
Broccoli full monograph & interactions
The maker

Brand information

Manufacturer and brand details for DIM 100 mg + Broccoli Sprouts, from the product label.

Natural Grocers by Vitamin Cottage

See all Natural Grocers by Vitamin Cottage products
Name
Vitamin Cottage Natural Food Markets, Inc.
City
Lakewood
State
CO
ZipCode
80228
Phone Number
877-455-2826
Web Address
www.naturalgrocers.com
Pharmacist Counseling Corner

DIM 100 mg + Broccoli Sprouts by Natural Grocers by Vitamin Cottage: Common Questions

Does DIM 100 mg + Broccoli Sprouts by Natural Grocers by Vitamin Cottage interact with any medications?
Yes. Based on its ingredients, DIM 100 mg + Broccoli Sprouts has a known interaction with 270 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
DIM 100 mg + Broccoli Sprouts contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm on birth control or hormone therapy?
DIM theoretically may increase or decrease the effects of estrogens, which includes birth control and hormone replacement therapy. Large amounts might even interfere with hormone therapy. You need to check with your doctor or pharmacist before taking this product alongside any hormone-based medication to make sure it won't reduce its effectiveness.
What are the most common side effects?
The most common side effects are digestive issues: diarrhea, gas, nausea, and headache. Some people also report rash or vomiting. These tend to happen when taking DIM; broccoli in food amounts is usually tolerated well.
Is this safe to take long term?
DIM is generally well tolerated in short-term studies, but long-term safety hasn't been well established, so we don't have good data on how safe it is to use for months or years. The safety of concentrated broccoli sprout extracts is also not well studied. Talk with your doctor about your specific situation.
Will this actually help with cancer prevention or hormone balance?
For DIM, the evidence isn't strong enough yet to say whether it works for breast cancer, prostate health, colorectal cancer, or any other condition. Broccoli as food shows possibly effective evidence for colorectal cancer, but we don't know if the concentrated extract in this product works the same way. The evidence isn't there to make a strong claim either way.
Is it safe during pregnancy or breastfeeding?
Both DIM and broccoli are rated likely safe during pregnancy and lactation based on current data. That said, if you're pregnant or nursing, it's best to talk with your doctor before adding any new supplement.
What's the difference between DIM and broccoli in this product?
DIM (diindolylmethane) is a single compound extracted from cruciferous vegetables that may support hormone metabolism. Broccoli sprout extract is a more complex ingredient containing many compounds called glucosinolates. Both are included in this product, and both can speed up your liver's metabolism of certain drugs.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if DIM 100 mg + Broccoli Sprouts is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

DIM 100 mg + Broccoli Sprouts label
Go deeper

The Full Monographs Behind DIM 100 mg + Broccoli Sprouts’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Diindolylmethane

Interacts with 269 drugs

Diindolylmethane (DIM) is a compound made when your body digests cruciferous vegetables, and it is sold as a supplement mainly for hormone balance and cancer prevention. Although early lab s...

Read the full Diindolylmethane monograph → Herb & supplement monograph

Broccoli

Interacts with 187 drugs

Broccoli is a nutritious cruciferous vegetable rich in fiber, vitamins, and plant compounds like sulforaphane that have drawn scientific interest for health benefits. Eating broccoli as food...

Read the full Broccoli monograph →
Sources

Sources & How We Checked

DIM 100 mg + Broccoli Sprouts's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 19 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Diindolylmethane 14 references
  1. Natl Inst Health, Natl Inst Environmental Health Sci. Indole-3-carbinol. Available at: http://ntp-server.niehs.nih.gov.
  2. Balk JL. Indole-3-carbinol for cancer prevention. Altern Med Alert 2000; 3:105-7.
  3. Riby JE, Chang GHF, Firestone GL, Bjeldanes LF. Ligand-independent activation of estrogen receptor function by 3,3'-diindolylmethane in human breast cancer cells. Biochem Pharmacol 2000;60:167-77. PubMed
  4. Lake BG, Tredger JM, Renwick AB, et al. 3'3-diindolylmethane induces CYP1A2 in cultured precision-cut human liver slices. Xenobiotica 1998;28:803-11. PubMed
  5. Dalessandri, K. M., Firestone, G. L., Fitch, M. D., Bradlow, H. L., and Bjeldanes, L. F. Pilot study: effect of 3,3'-diindolylmethane supplements on urinary hormone metabolites in postmenopausal women with a history of early-stage breast cancer. Nutr Canc PubMed
  6. Reed, G. A., Arneson, D. W., Putnam, W. C., Smith, H. J., Gray, J. C., Sullivan, D. K., Mayo, M. S., Crowell, J. A., and Hurwitz, A. Single-dose and multiple-dose administration of indole-3-carbinol to women: pharmacokinetics based on 3,3'-diindolylmetha
  7. Reed, G. A., Sunega, J. M., Sullivan, D. K., Gray, J. C., Mayo, M. S., Crowell, J. A., and Hurwitz, A. Single-dose pharmacokinetics and tolerability of absorption-enhanced 3,3'-diindolylmethane in healthy subjects. Cancer Epidemiol.Biomarkers Prev. 2008; PubMed
  8. Del Priore G., Gudipudi, D. K., Montemarano, N., Restivo, A. M., Malanowska-Stega, J., and Arslan, A. A. Oral diindolylmethane (DIM): pilot evaluation of a nonsurgical treatment for cervical dysplasia. Gynecol.Oncol. 2010;116(3):464-467. PubMed
  9. Heath, E. I., Heilbrun, L. K., Li, J., Vaishampayan, U., Harper, F., Pemberton, P., and Sarkar, F. H. A phase I dose-escalation study of oral BR-DIM (BioResponse 3,3'- Diindolylmethane) in castrate-resistant, non-metastatic prostate cancer. Am.J.Transl.R
  10. Jellinck, P. H., Forkert, P. G., Riddick, D. S., Okey, A. B., Michnovicz, J. J., and Bradlow, H. L. Ah receptor binding properties of indole carbinols and induction of hepatic estradiol hydroxylation. Biochem.Pharmacol. 3-9-1993;45(5):1129-1136. PubMed
  11. Bui PV, Moualla M, Upson DJ. A Possible Association of Diindolylmethane with Pulmonary Embolism and Deep Venous Thrombosis. Case Rep Med. 2016;2016:7527098. PubMed
  12. Castañon A, Tristram A, Mesher D, Powell N, Beer H, Ashman S, Rieck G, Fielder H, Fiander A, Sasieni P. Effect of diindolylmethane supplementation on low-grade cervical cytological abnormalities: double-blind, randomised, controlled trial. Br J Cancer. 20 PubMed
  13. Le TM, Sanders CJ, van de Corput L, van Erpecum KJ, Röckmann H. Drug rash with eosinophilia and systemic symptoms caused by the dietary supplement diindolylmethane. J Allergy Clin Immunol Pract. 2016 Jan-Feb;4(1):175-6. PubMed
  14. Pence ST, Mehta K, Crum-Bailey J. The Serious Side of Supplements: An Ischemic Stroke in a Healthy 38-year-old Female. Mil Med 2022. PubMed

See these in context on the Diindolylmethane monograph →

Broccoli 5 references
  1. Kristal AR, Lampe JW. Brassica vegetables and prostate cancer risk: a review of the epidemiological evidence. Nutr Cancer 2002;42:1-9. PubMed
  2. Chakrabarti A, Prais L, Foulds IS. Allergic contact dermatitis to broccoli. Br J Dermatol 2003;148:172-3. PubMed
  3. Hakooz, N. and Hamdan, I. Effects of dietary broccoli on human in vivo caffeine metabolism: a pilot study on a group of Jordanian volunteers. Curr Drug Metab 2007;8(1):9-15. PubMed
  4. Kall MA, Vang O, Clausen J. Effects of dietary broccoli on human drug metabolising activity. Cancer Lett. 1997;114(1-2):169-70. PubMed
  5. Bauman JE, Hsu CH, Centuori S, et al. Randomized Crossover Trial Evaluating Detoxification of Tobacco Carcinogens by Broccoli Seed and Sprout Extract in Current Smokers. Cancers (Basel). 2022;14(9):2129. Published 2022 Apr 24. PubMed

See these in context on the Broccoli monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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