DNA Protection Formula Ingredients & Drug Interactions
What is this page for?
First and foremost: checking DNA Protection Formula against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
DNA Protection Formula is a dietary supplement by Life Extension with 6 active ingredients. Its ingredients are commonly taken for zinc deficiency, immune support, cold symptoms.Based on those ingredients, 1,296 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are BCM-95 Bio-Curcumin Turmeric 25:1 extract, Chlorophyllin, Broccoli extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against DNA Protection Formula by Life Extension
Ask about any prescription or over-the-counter medication and we check it for interactions with DNA Protection Formula by Life Extension — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of DNA Protection Formula by Life Extension
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
DNA Protection Formula contains six active ingredients, each chosen for cellular support. Zinc is an essential mineral that helps your immune system and wound healing.
Chlorophyllin is a semi-synthetic form of chlorophyll, the green pigment in plants. Wasabi powder comes from the root of the Japanese horseradish plant.
Watercress extract is derived from a leafy green vegetable. Broccoli extract concentrates compounds from the cruciferous vegetable.
The formula also includes BCM-95 Bio-Curcumin, a turmeric extract standardized to deliver curcumin, its active compound, with enhanced absorption. The product also contains inactive ingredients—vegetable cellulose (capsule material), microcrystalline cellulose and silica (for texture), vegetable stearate (a flow agent), and maltodextrin (a thickener).
Does it work?
Couldn't assess
The evidence for this formula's ingredients varies widely. Zinc is effective for zinc deficiency and likely effective for Wilson disease; it's possibly effective for acne, age-related macular degeneration, and diabetes.
Broccoli extract is possibly effective for colorectal cancer prevention. Turmeric is possibly effective for depression, high cholesterol, hay fever symptoms, and indigestion.
For chlorophyllin, watercress extract in medicinal doses, and wasabi powder at supplement strength, the data we hold shows insufficient or no reliable evidence of effectiveness for most of their marketed uses. Chlorophyllin appears possibly ineffective for urinary odor.
None of these ingredients has been established in our data as effective for general DNA protection as a category.
How safe is it?
Well-documented data
Zinc is generally well tolerated in doses below 40 mg daily, though higher amounts carry risk of copper deficiency if used long-term. Common side effects at higher doses include nausea, vomiting, metallic taste, diarrhea, and abdominal cramps.
Turmeric and broccoli are generally well tolerated as foods; concentrated supplements may cause digestive upset (constipation, diarrhea, nausea, cramping) or, rarely, liver problems with turmeric. Watercress and wasabi as food amounts are considered safe, but concentrated supplements lack robust safety data.
Chlorophyllin is generally well tolerated short-term but has limited long-term safety information; topical chlorophyll cream has caused dermatitis, and oral chlorophyll has been associated with photosensitization and rare blistering (pseudoporphyria). Raw wild watercress can carry parasitic flukes that cause liver disease if contaminated.
Pregnancy and breastfeeding safety is mixed. Zinc is likely safe in pregnancy and breastfeeding.
Turmeric is likely safe in pregnancy and breastfeeding. Broccoli is likely safe during pregnancy and lactation.
Watercress is rated likely unsafe in pregnancy—the safety data advises against it. Chlorophyllin and wasabi powder lack sufficient data for pregnancy and breastfeeding; there isn't enough information to know either way, so discuss personalized guidance with your doctor or pharmacist if you're pregnant or nursing.
Meds to double-check
Moderate interaction found
Before taking this product, check with your doctor or pharmacist if you're on any of the following: antibiotics (especially quinolones, tetracyclines, or cephalexin), HIV medications (ritonavir, integrase inhibitors, or biktegravir-based combinations), immunosuppressants like tacrolimus, blood thinners like warfarin or antiplatelet drugs, chemotherapy or cancer drugs (especially tamoxifen, methotrexate, topoisomerase inhibitors, or antitumor antibiotics), sulfasalazine, chlorzoxazone (a muscle relaxer), tramadol (a painkiller), lithium, or drugs that are broken down by your liver (particularly those metabolized by the CYP1A2 or CYP2A6 pathways), or photosensitizing drugs. These represent the Moderate-severity interactions documented for the formula's ingredients.
The bottom line
Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
This formula combines nutrients and plant extracts with some evidence for immune and cellular support, but it carries documented interactions with a wide range of medications—from antibiotics and antivirals to blood thinners, immunosuppressants, and cancer drugs. If you take any prescription medication, run it through the interaction checker on this page before you start.
Talk it over with your doctor or pharmacist to make sure it's a fit for your health situation and medications.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 6 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 24, 2016.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about DNA Protection Formula, straight from the product label.
| Brand | Life Extension |
|---|---|
| Barcode (UPC) | 737870157069 |
| Net contents | 60 Vegetarian Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Jun 24, 2016 |
| DSLD ID | 60682 |
| Product type | Other Combinations |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for DNA Protection Formula by Life Extension, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Zinc | 8 mg | 53% |
| Chlorophyllin | 20 mg | -- |
| Wasabi powder | 50 mg | -- |
| Watercress extract | 100 mg | -- |
| Broccoli extract | 225 mg | -- |
| BCM-95 Bio-Curcumin Turmeric 25:1 extract | 240 mg | -- |
Other ingredients: Vegetable Cellulose, Microcrystalline Cellulose, Silica, Vegetable Stearate, Maltodextrin
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Storage
Store tightly closed in a cool, dry place.
Precautions
~ DO NOT EXCEED RECOMMENDED DOSE. ~ Do not purchase if outer seal is broken or damaged.
~ When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.
CAUTION: Do not take if you have gallbladder problems or gallstones.
If you are taking anti-coagulant or anti-platelet medications, or have a bleeding disorder, consult your healthcare provider before taking this product.
WARNINGS: ~ KEEP OUT OF REACH OF CHILDREN.
FDA Disclaimer Statement
* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
General Statements
Promotes Healthy DNA*
To report a serious adverse event or obtain product information, contact 1-866-280-2852.
Scan for product info
It is a natural characteristic of this product to have yellow speckles due to the granular nature of the turmeric.
FDA Statement of Identity
Dietary Supplement
Brand IP Statement(s)
Bio-Curcumin and BCM-95 are registered trademarks of Dolcas-Biotech, LLC. U.S. Patent Nos. 7,883,728, 7,736,679 and 7,879,373.
Formulation
Non-GMO
Suggested/Recommended/Usage/Directions
Read the entire label and follow the directions carefully prior to use. DIRECTIONS: Take one (1) capsule twice daily with food, or as recommended by a healthcare practitioner.
General
QE01570D
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
DNA Protection Formula by Life Extension label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in DNA Protection Formula by Life Extension
These are the 6 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Vegetarian Capsule(s) Dosage formCapsule Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Zinc
Interacts with67 drugs
Zinc is an essential mineral that your body needs for immune function, wound healing, taste, and smell. Most people get enough from food, but suppleme...
Zinc monograph & interactionsChlorophyllin
Interacts with335 drugs
Chlorophyllin is a water-soluble, semi-synthetic form of chlorophyll most often used to help control body and fecal odor and to support wound healing....
Chlorophyllin monograph & interactionsWasabi powder
Interacts with122 drugs
Wasabi is best known as the pungent green condiment served with sushi, made from a Japanese plant in the cabbage family. Its natural compounds (isothi...
Wasabi powder monograph & interactionsWatercress extract
Interacts with6 drugs
Watercress is a nutrient-rich leafy green that provides vitamins A, C, and K plus minerals and antioxidant plant compounds. Eaten as a food it is gene...
Watercress extract monograph & interactionsBroccoli extract
Interacts with187 drugs
Broccoli is a nutritious cruciferous vegetable rich in fiber, vitamins, and plant compounds like sulforaphane that have drawn scientific interest for...
Broccoli extract monograph & interactionsBCM-95 Bio-Curcumin Turmeric 25:1 extract
Interacts with1,133 drugs
Turmeric is a popular spice whose main active compounds, curcuminoids, are studied mostly for inflammation and joint pain. Some research is promising,...
BCM-95 Bio-Curcumin Turmeric 25:1 extract monograph & interactionsOther (inactive) ingredients: Vegetable Cellulose, Microcrystalline Cellulose, Silica, Vegetable Stearate, Maltodextrin. These complete the product’s ingredient list but are not active constituents.
DNA Protection Formula by Life Extension Drug Interactions
HelloPharmacist Interaction Report
Life Extension's DNA Protection Formula contains six active ingredients, and several of them interact with medications.
Through its zinc, chlorophyllin, wasabi powder, watercress extract, broccoli extract, and turmeric content, this product affects a broad range of drugs. The most serious documented interaction is a Moderate-severity effect: zinc may reduce ritonavir (an HIV protease inhibitor) levels, which could weaken its ability to control viral replication.
Read the full breakdown — every affected drug type, severity by severity
Zinc is the ingredient with the widest interaction profile. It moderately decreases the absorption and effects of quinolone and tetracycline antibiotics, cephalexin, and penicillamine; it may reduce ritonavir and theoretically interfere with integrase inhibitors and bictegravir/emtricitabine/tenofovir alafenamide (Biktarvy).
Timing matters—you'll need to separate zinc and these antibiotics or antivirals by hours to avoid reduced drug levels. Turmeric contains curcumin, which moderately interacts with chemotherapy drugs (topoisomerase I inhibitors and antitumor antibiotics), tacrolimus (an immunosuppressant), tamoxifen, sulfasalazine, methotrexate, tramadol, and theoretically OATP transporter substrates, sometimes by raising drug levels and sometimes by lowering them.
Watercress extract moderately affects lithium (may raise levels), chlorzoxazone (may raise levels and side effects), and warfarin (may reduce its blood-thinning effect) through diuretic properties or vitamin K content. Broccoli extract theoretically moderately induces two liver enzymes that clear many drugs—CYP1A2 and CYP2A6 substrates—which could reduce their effectiveness.
Wasabi powder and chlorophyllin carry Moderate interactions as well: wasabi with blood thinners and antiplatelet drugs, and chlorophyllin theoretically with photosensitizing medications.
Each of these medication types—antibiotics, antivirals, immunosuppressants, anticoagulants, cancer drugs, and others—depends on careful dosing. Altogether, these interactions span 1,297 individual medications.
Before starting this product, check your exact medications with the tool on this page and discuss the results with your doctor or pharmacist.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against DNA Protection Formula?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in DNA Protection Formula interact with 1,296 drugs. Click any drug to see the details.
6 of the 6 ingredients in DNA Protection Formula interact with drugs. Each result below shows which ingredient is responsible. BCM-95 Bio-Curcumin Turmeric 25:1 extract Chlorophyllin Broccoli extract Wasabi powder Zinc Watercress extract
6-mercaptopurinePurinethol
How 6-mercaptopurine interacts with DNA Protection Formula — through 1 ingredient. Tap an ingredient for the detail:
Bcm-95 Bio-curcumin Turmeric 25:1 ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, turmeric might increase the risk of liver damage when taken with hepatotoxic drugs.
Read the full Bcm-95 Bio-curcumin Turmeric 25:1 Extract + 6-mercaptopurine interactionAdo-trastuzumab EmtansineKadcyla
How Ado-trastuzumab Emtansine interacts with DNA Protection Formula — through 1 ingredient. Tap an ingredient for the detail:
Bcm-95 Bio-curcumin Turmeric 25:1 ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Turmeric might increase or decrease levels of drugs metabolized by CYP3A4.
Read the full Bcm-95 Bio-curcumin Turmeric 25:1 Extract + Ado-trastuzumab Emtansine interactionAbacavir Sulfate, Dolutegravir, LamivudineTriumeq
How Abacavir Sulfate, Dolutegravir, Lamivudine interacts with DNA Protection Formula — through 1 ingredient. Tap an ingredient for the detail:
Bcm-95 Bio-curcumin Turmeric 25:1 ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, turmeric might increase the risk of liver damage when taken with hepatotoxic drugs.
Read the full Bcm-95 Bio-curcumin Turmeric 25:1 Extract + Abacavir Sulfate, Dolutegravir, Lamivudine interactionAbacavir, LamivudineEpzicom
How Abacavir, Lamivudine interacts with DNA Protection Formula — through 1 ingredient. Tap an ingredient for the detail:
Bcm-95 Bio-curcumin Turmeric 25:1 ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, turmeric might increase the risk of liver damage when taken with hepatotoxic drugs.
Read the full Bcm-95 Bio-curcumin Turmeric 25:1 Extract + Abacavir, Lamivudine interactionAbciximabReoPro
How Abciximab interacts with DNA Protection Formula — through 2 ingredients. Tap an ingredient for the detail:
Bcm-95 Bio-curcumin Turmeric 25:1 ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Turmeric may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Bcm-95 Bio-curcumin Turmeric 25:1 Extract + Abciximab interactionWasabi PowderAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, wasabi might increase the risk of bleeding with anticoagulant or antiplatelet drugs.
Read the full Wasabi Powder + Abciximab interactionAbemaciclibVerzenio
How Abemaciclib interacts with DNA Protection Formula — through 1 ingredient. Tap an ingredient for the detail:
Bcm-95 Bio-curcumin Turmeric 25:1 ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Turmeric might increase or decrease levels of drugs metabolized by CYP3A4.
Read the full Bcm-95 Bio-curcumin Turmeric 25:1 Extract + Abemaciclib interactionAbiraterone
How Abiraterone interacts with DNA Protection Formula — through 1 ingredient. Tap an ingredient for the detail:
Bcm-95 Bio-curcumin Turmeric 25:1 ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Hepatotoxic Drugs Moderate
Interaction Summary
Turmeric might increase or decrease levels of drugs metabolized by CYP3A4.
Read the full Bcm-95 Bio-curcumin Turmeric 25:1 Extract + Abiraterone interactionAbiraterone AcetateYonsa, Zytiga
How Abiraterone Acetate interacts with DNA Protection Formula — through 1 ingredient. Tap an ingredient for the detail:
Bcm-95 Bio-curcumin Turmeric 25:1 ExtractHepatotoxic Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, turmeric might increase the risk of liver damage when taken with hepatotoxic drugs.
Read the full Bcm-95 Bio-curcumin Turmeric 25:1 Extract + Abiraterone Acetate interactionAbrocitinibCibinqo
How Abrocitinib interacts with DNA Protection Formula — through 2 ingredients. Tap an ingredient for the detail:
Bcm-95 Bio-curcumin Turmeric 25:1 ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Turmeric may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Bcm-95 Bio-curcumin Turmeric 25:1 Extract + Abrocitinib interactionWasabi PowderAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, wasabi might increase the risk of bleeding with anticoagulant or antiplatelet drugs.
Read the full Wasabi Powder + Abrocitinib interactionAcalabrutinibCalquence
How Acalabrutinib interacts with DNA Protection Formula — through 1 ingredient. Tap an ingredient for the detail:
Bcm-95 Bio-curcumin Turmeric 25:1 ExtractCytochrome P450 3a4 (cyp3a4) Substrates, P-glycoprotein Substrates Moderate
Interaction Summary
Turmeric might increase or decrease levels of drugs metabolized by CYP3A4.
Read the full Bcm-95 Bio-curcumin Turmeric 25:1 Extract + Acalabrutinib interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with DNA Protection Formula — through 1 ingredient. Tap an ingredient for the detail:
Bcm-95 Bio-curcumin Turmeric 25:1 ExtractHepatotoxic Drugs, Antidiabetes Drugs Moderate
Interaction Summary
Theoretically, turmeric might increase the risk of liver damage when taken with hepatotoxic drugs.
Read the full Bcm-95 Bio-curcumin Turmeric 25:1 Extract + Acarbose interactionAcebutololRhotral, Sectral
How Acebutolol interacts with DNA Protection Formula — through 1 ingredient. Tap an ingredient for the detail:
Bcm-95 Bio-curcumin Turmeric 25:1 ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, turmeric might increase the risk of liver damage when taken with hepatotoxic drugs.
Read the full Bcm-95 Bio-curcumin Turmeric 25:1 Extract + Acebutolol interactionAcenocoumarolSintrom
How Acenocoumarol interacts with DNA Protection Formula — through 2 ingredients. Tap an ingredient for the detail:
Bcm-95 Bio-curcumin Turmeric 25:1 ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Turmeric may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Bcm-95 Bio-curcumin Turmeric 25:1 Extract + Acenocoumarol interactionWasabi PowderAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, wasabi might increase the risk of bleeding with anticoagulant or antiplatelet drugs.
Read the full Wasabi Powder + Acenocoumarol interactionAcepromazineAtravet
How Acepromazine interacts with DNA Protection Formula — through 1 ingredient. Tap an ingredient for the detail:
ChlorophyllinPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, concomitant use of chlorophyllin with photosensitizing drugs may have additive effects.
Read the full Chlorophyllin + Acepromazine interactionAcetaminophenChildren's Tylenol, Children's Tylenol Meltaways, Tylenol, Tylenol Ex Strength
How Acetaminophen interacts with DNA Protection Formula — through 2 ingredients. Tap an ingredient for the detail:
Bcm-95 Bio-curcumin Turmeric 25:1 ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Hepatotoxic Drugs Moderate
Interaction Summary
Theoretically, turmeric might increase levels of drugs metabolized by CYP1A2.
Read the full Bcm-95 Bio-curcumin Turmeric 25:1 Extract + Acetaminophen interactionBroccoli ExtractCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, broccoli might reduce the levels and effects of drugs metabolized by CYP1A2.
Read the full Broccoli Extract + Acetaminophen interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with DNA Protection Formula — through 3 ingredients. Tap an ingredient for the detail:
Bcm-95 Bio-curcumin Turmeric 25:1 ExtractHepatotoxic Drugs, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, turmeric might increase the risk of liver damage when taken with hepatotoxic drugs.
Read the full Bcm-95 Bio-curcumin Turmeric 25:1 Extract + Acetaminophen, Aspirin interactionBroccoli ExtractCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, broccoli might reduce the levels and effects of drugs metabolized by CYP1A2.
Read the full Broccoli Extract + Acetaminophen, Aspirin interactionWasabi PowderAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, wasabi might increase the risk of bleeding with anticoagulant or antiplatelet drugs.
Read the full Wasabi Powder + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with DNA Protection Formula — through 3 ingredients. Tap an ingredient for the detail:
Bcm-95 Bio-curcumin Turmeric 25:1 ExtractHepatotoxic Drugs, Anticoagulant/antiplatelet Drugs +2 Moderate
Interaction Summary
Theoretically, turmeric might increase the risk of liver damage when taken with hepatotoxic drugs.
Read the full Bcm-95 Bio-curcumin Turmeric 25:1 Extract + Acetaminophen, Aspirin, Caffeine interactionWasabi PowderAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, wasabi might increase the risk of bleeding with anticoagulant or antiplatelet drugs.
Read the full Wasabi Powder + Acetaminophen, Aspirin, Caffeine interactionBroccoli ExtractCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, broccoli might reduce the levels and effects of drugs metabolized by CYP1A2.
Read the full Broccoli Extract + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, Brompheniramine, PhenylpropanolamineDimetapp Cold and Flu
How Acetaminophen, Brompheniramine, Phenylpropanolamine interacts with DNA Protection Formula — through 3 ingredients. Tap an ingredient for the detail:
Broccoli ExtractCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, broccoli might reduce the levels and effects of drugs metabolized by CYP1A2.
Read the full Broccoli Extract + Acetaminophen, Brompheniramine, Phenylpropanolamine interactionBcm-95 Bio-curcumin Turmeric 25:1 ExtractHepatotoxic Drugs, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, turmeric might increase the risk of liver damage when taken with hepatotoxic drugs.
Read the full Bcm-95 Bio-curcumin Turmeric 25:1 Extract + Acetaminophen, Brompheniramine, Phenylpropanolamine interactionChlorophyllinPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, concomitant use of chlorophyllin with photosensitizing drugs may have additive effects.
Read the full Chlorophyllin + Acetaminophen, Brompheniramine, Phenylpropanolamine interactionAcetaminophen, ButalbitalAxocet, Bancap, Bucet, Butex Forte, Esgic CF, Orbivan CF +5 more
How Acetaminophen, Butalbital interacts with DNA Protection Formula — through 2 ingredients. Tap an ingredient for the detail:
Bcm-95 Bio-curcumin Turmeric 25:1 ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Hepatotoxic Drugs Moderate
Interaction Summary
Theoretically, turmeric might increase levels of drugs metabolized by CYP1A2.
Read the full Bcm-95 Bio-curcumin Turmeric 25:1 Extract + Acetaminophen, Butalbital interactionBroccoli ExtractCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, broccoli might reduce the levels and effects of drugs metabolized by CYP1A2.
Read the full Broccoli Extract + Acetaminophen, Butalbital interactionAcetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more
How Acetaminophen, Butalbital, Caffeine interacts with DNA Protection Formula — through 2 ingredients. Tap an ingredient for the detail:
Broccoli ExtractCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, broccoli might reduce the levels and effects of drugs metabolized by CYP1A2.
Read the full Broccoli Extract + Acetaminophen, Butalbital, Caffeine interactionBcm-95 Bio-curcumin Turmeric 25:1 ExtractHepatotoxic Drugs, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, turmeric might increase the risk of liver damage when taken with hepatotoxic drugs.
Read the full Bcm-95 Bio-curcumin Turmeric 25:1 Extract + Acetaminophen, Butalbital, Caffeine interactionAcetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
How Acetaminophen, Butalbital, Caffeine, Codeine interacts with DNA Protection Formula — through 2 ingredients. Tap an ingredient for the detail:
Bcm-95 Bio-curcumin Turmeric 25:1 ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Hepatotoxic Drugs +1 Moderate
Interaction Summary
Turmeric might increase or decrease levels of drugs metabolized by CYP3A4.
Read the full Bcm-95 Bio-curcumin Turmeric 25:1 Extract + Acetaminophen, Butalbital, Caffeine, Codeine interactionBroccoli ExtractCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, broccoli might reduce the levels and effects of drugs metabolized by CYP1A2.
Read the full Broccoli Extract + Acetaminophen, Butalbital, Caffeine, Codeine interactionAcetaminophen, Butalbital, CodeineBancap w/ Codeine
How Acetaminophen, Butalbital, Codeine interacts with DNA Protection Formula — through 2 ingredients. Tap an ingredient for the detail:
Bcm-95 Bio-curcumin Turmeric 25:1 ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Hepatotoxic Drugs Moderate
Interaction Summary
Theoretically, turmeric might increase levels of drugs metabolized by CYP1A2.
Read the full Bcm-95 Bio-curcumin Turmeric 25:1 Extract + Acetaminophen, Butalbital, Codeine interactionBroccoli ExtractCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, broccoli might reduce the levels and effects of drugs metabolized by CYP1A2.
Read the full Broccoli Extract + Acetaminophen, Butalbital, Codeine interactionAcetaminophen, Butalbital, Codeine PhosphatePhrenilin #3
How Acetaminophen, Butalbital, Codeine Phosphate interacts with DNA Protection Formula — through 2 ingredients. Tap an ingredient for the detail:
Broccoli ExtractCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, broccoli might reduce the levels and effects of drugs metabolized by CYP1A2.
Read the full Broccoli Extract + Acetaminophen, Butalbital, Codeine Phosphate interactionBcm-95 Bio-curcumin Turmeric 25:1 ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Hepatotoxic Drugs Moderate
Interaction Summary
Theoretically, turmeric might increase levels of drugs metabolized by CYP1A2.
Read the full Bcm-95 Bio-curcumin Turmeric 25:1 Extract + Acetaminophen, Butalbital, Codeine Phosphate interactionAcetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with DNA Protection Formula — through 3 ingredients. Tap an ingredient for the detail:
Bcm-95 Bio-curcumin Turmeric 25:1 ExtractHepatotoxic Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, turmeric might increase the risk of liver damage when taken with hepatotoxic drugs.
Read the full Bcm-95 Bio-curcumin Turmeric 25:1 Extract + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionBroccoli ExtractCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, broccoli might reduce the levels and effects of drugs metabolized by CYP1A2.
Read the full Broccoli Extract + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionChlorophyllinPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, concomitant use of chlorophyllin with photosensitizing drugs may have additive effects.
Read the full Chlorophyllin + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAcetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
How Acetaminophen, Caffeine, Codeine interacts with DNA Protection Formula — through 2 ingredients. Tap an ingredient for the detail:
Broccoli ExtractCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, broccoli might reduce the levels and effects of drugs metabolized by CYP1A2.
Read the full Broccoli Extract + Acetaminophen, Caffeine, Codeine interactionBcm-95 Bio-curcumin Turmeric 25:1 ExtractHepatotoxic Drugs, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, turmeric might increase the risk of liver damage when taken with hepatotoxic drugs.
Read the full Bcm-95 Bio-curcumin Turmeric 25:1 Extract + Acetaminophen, Caffeine, Codeine interactionAcetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
How Acetaminophen, Caffeine, Codeine, Salicylamide interacts with DNA Protection Formula — through 2 ingredients. Tap an ingredient for the detail:
Bcm-95 Bio-curcumin Turmeric 25:1 ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Turmeric might increase or decrease levels of drugs metabolized by CYP3A4.
Read the full Bcm-95 Bio-curcumin Turmeric 25:1 Extract + Acetaminophen, Caffeine, Codeine, Salicylamide interactionBroccoli ExtractCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, broccoli might reduce the levels and effects of drugs metabolized by CYP1A2.
Read the full Broccoli Extract + Acetaminophen, Caffeine, Codeine, Salicylamide interactionAcetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
How Acetaminophen, Caffeine, Dihydrocodeine interacts with DNA Protection Formula — through 2 ingredients. Tap an ingredient for the detail:
Broccoli ExtractCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, broccoli might reduce the levels and effects of drugs metabolized by CYP1A2.
Read the full Broccoli Extract + Acetaminophen, Caffeine, Dihydrocodeine interactionBcm-95 Bio-curcumin Turmeric 25:1 ExtractHepatotoxic Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, turmeric might increase the risk of liver damage when taken with hepatotoxic drugs.
Read the full Bcm-95 Bio-curcumin Turmeric 25:1 Extract + Acetaminophen, Caffeine, Dihydrocodeine interactionAcetaminophen, Caffeine, IsomethepteneMigralam
How Acetaminophen, Caffeine, Isometheptene interacts with DNA Protection Formula — through 2 ingredients. Tap an ingredient for the detail:
Bcm-95 Bio-curcumin Turmeric 25:1 ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, turmeric might increase levels of drugs metabolized by CYP1A2.
Read the full Bcm-95 Bio-curcumin Turmeric 25:1 Extract + Acetaminophen, Caffeine, Isometheptene interactionBroccoli ExtractCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, broccoli might reduce the levels and effects of drugs metabolized by CYP1A2.
Read the full Broccoli Extract + Acetaminophen, Caffeine, Isometheptene interactionAcetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
How Acetaminophen, Caffeine, Pyrilamine interacts with DNA Protection Formula — through 2 ingredients. Tap an ingredient for the detail:
Bcm-95 Bio-curcumin Turmeric 25:1 ExtractHepatotoxic Drugs, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, turmeric might increase the risk of liver damage when taken with hepatotoxic drugs.
Read the full Bcm-95 Bio-curcumin Turmeric 25:1 Extract + Acetaminophen, Caffeine, Pyrilamine interactionBroccoli ExtractCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, broccoli might reduce the levels and effects of drugs metabolized by CYP1A2.
Read the full Broccoli Extract + Acetaminophen, Caffeine, Pyrilamine interactionAcetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
How Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interacts with DNA Protection Formula — through 3 ingredients. Tap an ingredient for the detail:
Broccoli ExtractCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, broccoli might reduce the levels and effects of drugs metabolized by CYP1A2.
Read the full Broccoli Extract + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionBcm-95 Bio-curcumin Turmeric 25:1 ExtractHepatotoxic Drugs, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, turmeric might increase the risk of liver damage when taken with hepatotoxic drugs.
Read the full Bcm-95 Bio-curcumin Turmeric 25:1 Extract + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionChlorophyllinPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, concomitant use of chlorophyllin with photosensitizing drugs may have additive effects.
Read the full Chlorophyllin + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionEach ingredient & the kinds of drugs it affects
For each ingredient in DNA Protection Formula with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
BCM-95 Bio-Curcumin Turmeric 25:1 extract
Alkylating Agents
Turmeric has antioxidant effects. Theoretically, this may reduce the activity of chemotherapy drugs that generate free radicals. However, research is conflicting.
In vitro research suggests that curcumin, a constituent of turmeric, inhibits mechlorethamine-induced apoptosis of breast cancer cells by up to 70%. Also, animal research shows that curcumin inhibits cyclophosphamide-induced tumor regression. However, some in vitro research shows that curcumin does not affect the apoptosis capacity of etoposide. Also, other laboratory research suggests that curcumin might augment the cytotoxic effects of alkylating agents. Reasons for the discrepancies may relate to the dose of curcumin and the specific chemotherapeutic agent. Lower doses of curcumin might have antioxidant effects while higher doses might have pro-oxidant effects. More evidence is needed to determine what effect, if any, turmeric might have on alkylating agents.
Amlodipine (Norvasc)
Taking turmeric with amlodipine may increase levels of amlodipine.
Animal research shows that giving amlodipine 1 mg/kg as a single dose following the use of turmeric extract 200 mg/kg daily for 2 weeks increases the maximum concentration and area under the curve by 53% and 56%, respectively, when compared with amlodipine alone. Additional animal research shows that taking amlodipine 1 mg/kg with a curcumin 2 mg/kg pretreatment for 10 days increases the maximum concentration and area under the curve by about 2-fold when compared with amlodipine alone.
Anticoagulant/Antiplatelet Drugs
Turmeric may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs. However, research is conflicting.
Curcumin, a constituent of turmeric, has demonstrated antiplatelet effects in vitro. Furthermore, two case reports have found that taking turmeric along with warfarin or fluindione was associated with an increased international normalized ratio (INR). However, one clinical study in healthy volunteers shows that taking curcumin 500 mg daily for 3 weeks, alone or with aspirin 100 mg, does not increase antiplatelet effects or bleeding risk. It is possible that the dose of turmeric used in this study was too low to produce a notable effect.
Antidiabetes Drugs
Theoretically, taking turmeric with antidiabetes drugs might increase the risk of hypoglycemia.
Animal research and case reports suggest that curcumin, a turmeric constituent, can reduce blood glucose levels in patients with diabetes. Furthermore, clinical research in adults with type 2 diabetes shows that taking curcumin 475 mg daily for 10 days prior to taking glyburide 5 mg decreased postprandial glucose levels for up to 24 hours when compared with glyburide alone, despite the lack of a significant pharmacokinetic interaction. Other clinical studies in patients with diabetes show that taking curcumin daily can reduce blood glucose levels when compared with placebo.
Antitumor Antibiotics
Turmeric has antioxidant effects. Theoretically, this may reduce the activity of chemotherapy drugs that generate free radicals. However, research is conflicting.
In vitro and animal research shows that curcumin, a constituent of turmeric, inhibits doxorubicin-induced apoptosis of breast cancer cells by up to 65%. However, curcumin does not seem to affect the apoptosis capacity of daunorubicin. In fact, some research shows that curcumin might augment the cytotoxic effects of antitumor antibiotics, increasing their effectiveness. Reasons for the discrepancies may relate to the dose of curcumin and the chemotherapeutic agent. Lower doses of curcumin might have antioxidant effects while higher doses might have pro-oxidant effects. More evidence is needed to determine what effects, if any, antioxidants such as turmeric have on antitumor antibiotics.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Turmeric might increase or decrease levels of drugs metabolized by CYP3A4.
In vitro and animal research show that turmeric and its constituents curcumin and curcuminoids inhibit CYP3A4. Also, 8 case reports from the World Health Organization (WHO) adverse drug reaction database describe increased toxicity in patients taking turmeric and cancer medications that are CYP3A4 substrates, including everolimus, ruxolitinib, ibrutinib, and palbociclib, and bortezomib. In another case report, a transplant patient presented with acute nephrotoxicity and elevated tacrolimus levels after consuming turmeric powder at a dose of 15 or more spoonfuls daily for ten days prior. It was thought that turmeric increased levels of tacrolimus due to CYP3A4 inhibition.
Conversely, other in vitro research suggests that turmeric induces CYP3A4 activity, leading to reduced levels of CYP3A4 substrates. An animal model suggests that induction of CYP3A4 occurs after daily curcumin use for 1 week. However, the induction of CYP3A4 by turmeric has not been reported in humans.
Hepatotoxic Drugs
Theoretically, turmeric might increase the risk of liver damage when taken with hepatotoxic drugs.
There is concern that turmeric might cause hepatotoxicity, especially when highly bioavailable formulations are used in high doses.
Methotrexate (Trexall, Others)
Theoretically, turmeric might have additive effects when used with hepatotoxic drugs such as methotrexate.
In one case report, a 39-year-old female taking methotrexate, turmeric, and linseed oil developed hepatotoxicity.
Organic Anion-Transporting Polypeptide Substrates (Oatp)
Theoretically, turmeric might increase blood levels of OATP4C1 substrates.
In vitro research shows that the turmeric constituent curcumin competitively inhibits OATP4C1 transport. This transporter is expressed in the kidney and facilitates the renal excretion of certain drugs. Theoretically, taking turmeric might decrease renal excretion of OATP substrates.
Sulfasalazine (Azulfidine)
Turmeric might increase the effects and adverse effects of sulfasalazine.
Clinical research shows that taking the turmeric constituent, curcumin, can increase blood levels of sulfasalazine by 3.2-fold.
Tacrolimus (Prograf)
Turmeric might increase the effects and adverse effects of tacrolimus.
In one case report, a transplant patient presented with acute nephrotoxicity and elevated tacrolimus levels of 29 ng/mL. The patient previously had tacrolimus levels within the therapeutic range at 9.7 ng/mL. Ten days prior to presenting at the emergency room the patient started consumption of turmeric powder at a dose of 15 or more spoonfuls daily. It was thought that turmeric increased levels of tacrolimus due to cytochrome P450 3A4 (CYP3A4) inhibition. In vitro and animal research show that turmeric and its constituent curcumin inhibit CYP3A4.
Talinolol
Turmeric may reduce the absorption of talinolol in some situations.
Clinical research shows that taking curcumin for 6 days decreases the bioavailability of talinolol when taken together on the seventh day. The clinical significance of this effect is unclear.
Tamoxifen (Nolvadex)
Theoretically, turmeric might reduce the levels and clinical effects of tamoxifen.
In a small clinical trial in patients with breast cancer taking tamoxifen 20-30 mg daily, adding curcumin 1200 mg plus piperine 10 mg three times daily reduces the 24-hour area under the curve of tamoxifen and the active metabolite endoxifen by 12.8% and 12.4%, respectively, as well as the maximum concentrations of tamoxifen, when compared with tamoxifen alone. However, in the absence of piperine, the area under the curve for endoxifen and the maximum concentration of tamoxifen were not significantly reduced. Effects were most pronounced in patients who were extensive cytochrome P450 (CYP) 2D6 metabolizers.
Topoisomerase I Inhibitors
Turmeric has antioxidant effects. There is some concern that this may reduce the activity of chemotherapy drugs that generate free radicals. However, research is conflicting.
In vitro research shows that curcumin, a constituent of turmeric, inhibits camptothecin-induced apoptosis of breast cancer cells by up to 71%. However, other in vitro research shows that curcumin augments the cytotoxic effects of camptothecin. Reasons for the discrepancies may relate to the dose of curcumin and the chemotherapeutic agents. Lower doses of curcumin might have antioxidant effects while higher doses might have pro-oxidant effects. More evidence is needed to determine what effect, if any, turmeric might have.
Tramadol (Ultram)
Theoretically, turmeric might increase or decrease levels of tramadol.
Animal research suggests that a single dose of curcumin, a constituent of turmeric, may increase tramadol's maximum concentration (Cmax) by inhibiting metabolism, while continued daily use for 7 days may reduce the area under the curve (AUC) due to the induction of drug-metabolizing enzymes such as cytochrome P450 3A4 (CYP3A4). However, this interaction has not been reported in humans.
Warfarin (Coumadin)
Turmeric might increase the risk of bleeding with warfarin.
One case of increased international normalized ratio (INR) has been reported for a patient taking warfarin who began taking turmeric. Prior to taking turmeric, the patient had stable INR measurements. Within a few weeks of starting turmeric supplementation, the patient's INR increased to 10. Additionally, curcumin, the active constituent in turmeric, has demonstrated antiplatelet effects in vitro, which may produce additive effects when taken with warfarin.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, turmeric might increase levels of drugs metabolized by CYP1A2. However, research is conflicting.
In vitro and animal research show that the turmeric constituent, curcumin, inhibits CYP1A2. However, other in vitro research suggests that curcumin does not significantly affect CYP1A2.
Docetaxel (Taxotere)
Theoretically, turmeric might increase blood levels of oral docetaxel.
Animal research suggests that the turmeric constituent, curcumin, enhances the oral bioavailability of docetaxel. However, the significance of this interaction is unclear, as this drug is typically administered intravenously in clinical settings.
Estrogens
Theoretically, large amounts of turmeric might interfere with hormone replacement therapy through competition for estrogen receptors.
In vitro research shows that curcumin, a constituent of turmeric, displaces the binding of estrogen to its receptors.
Glyburide (Diabeta, Others)
Theoretically, taking turmeric and glyburide in combination might increase the risk of hypoglycemia.
Clinical research shows that taking curcumin 475 mg daily for 10 days prior to taking glyburide 5 mg increases blood levels of glyburide by 12% at 2 hours after the dose in patients with type 2 diabetes. While maximal blood concentrations of glyburide were not affected, turmeric modestly decreased postprandial glucose levels for up to 24 hours when compared to glyburide alone, possibly due to the hypoglycemic effect of turmeric demonstrated in animal research.
Losartan (Cozaar)
Theoretically, turmeric might increase the effects of losartan.
Research in hypertensive rats shows that taking turmeric can increase the hypotensive effects of losartan.
Norfloxacin (Noroxin)
Theoretically, turmeric might increase the effects and adverse effects of norfloxacin.
Animal research shows that taking curcumin, a turmeric constituent, can increase blood levels of orally administered norfloxacin.
P-Glycoprotein Substrates
Theoretically, turmeric might increase the absorption of P-glycoprotein substrates.
In vitro and animal research shows that curcuminoids and other constituents found in turmeric can inhibit P-glycoprotein expression and activity.
Paclitaxel (Abraxane, Onxol)
Theoretically, turmeric might alter blood levels of paclitaxel, although any effect may not be clinically relevant.
Clinical research in adults with breast cancer receiving intravenous paclitaxel suggests that taking turmeric may modestly alter paclitaxel pharmacokinetics. Patients received paclitaxel on day 1, followed by either no treatment or turmeric 2 grams daily from days 2-22. Pharmacokinetic modeling suggests that turmeric reduces the maximum concentration and area under the curve of paclitaxel by 12.1% and 7.7%, respectively. However, these changes are not likely to be considered clinically relevant. Conversely, animal research suggests that curcumin, a constituent of turmeric, enhances the oral bioavailability of paclitaxel. However, the significance of this interaction is unclear, as this drug is typically administered intravenously in clinical settings.
Chlorophyllin
Photosensitizing Drugs
Theoretically, concomitant use of chlorophyllin with photosensitizing drugs may have additive effects.
Chlorophyllin is a semi-synthetic derivative of chlorophyll. Chlorophyll has been reported to cause photosensitization. Orally, chlorophyll has also been associated with the development of pseudoporphyria in multiple case reports.
Broccoli extract
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, broccoli might reduce the levels and effects of drugs metabolized by CYP1A2.
Pharmacokinetic research in humans shows that eating 500 grams of fresh broccoli daily for 6-12 days can increase CYP1A2 activity by 10% to 200%. Induction of CYP1A2 activity by broccoli is attributed to its glucosinolate constituents.
Cytochrome P450 2A6 (Cyp2A6) Substrates
Theoretically, broccoli might reduce the levels and effects of drugs metabolized by CYP2A6.
Pharmacokinetic research in humans shows that eating 500 grams of broccoli daily for 6 days increases CYP2A6 activity by 135% to 550%. Induction of CYP2A6 activity is attributed to its glucosinolate constituents.
Wasabi powder
Anticoagulant/Antiplatelet Drugs
Theoretically, wasabi might increase the risk of bleeding with anticoagulant or antiplatelet drugs.
In vitro research shows that 6-(methylsulfinyl) hexyl isothiocyanate, a constituent of wasabi, inhibits platelet aggregation.
Zinc
Bictegravir/Emtricitabine/Tenofovir Alafenamide (Biktarvy)
Theoretically, zinc might decrease levels of bictegravir/emtricitabine/tenofovir alafenamide by reducing its absorption.
Advise patients that bictegravir/emtricitabine/tenofovir alafenamide should be taken at least 2 hours before or 6 hours after zinc containing products.
Cephalexin (Keflex)
Zinc might decrease cephalexin levels by chelating with cephalexin in the gut and preventing its absorption.
A pharmacokinetic study shows that zinc sulfate 250 mg taken concomitantly with cephalexin 500 mg decreases peak levels of cephalexin by 31% and reduces the exposure to cephalexin by 27%. Also, taking zinc sulfate 3 hours before cephalexin decreases peak levels of cephalexin by 11% and reduces the exposure to cephalexin by 18%. By decreasing cephalexin levels, zinc might increase the risk of treatment failure. This effect does not occur when zinc is taken 3 hours after the cephalexin dose. To avoid an interaction, advise patients take zinc sulfate 3 hours after taking cephalexin.
Cisplatin (Platinol-Aq)
Theoretically, zinc might interfere with the therapeutic effects of cisplatin.
Animal research suggests that zinc stimulates tumor cell production of the protein metallothionein, which binds and inactivates cisplatin. It is not known whether zinc supplements or high dietary zinc intake can cause clinically significant interference with cisplatin therapy. Cisplatin might also increase zinc excretion.
Integrase Inhibitors
Theoretically, taking zinc along with integrase inhibitors might decrease the levels and clinical effects of these drugs.
Zinc is a divalent cation. Pharmacokinetic studies have shown that other divalent cations such as calcium and iron can decrease blood levels of the integrase inhibitor dolutegravir through chelation.
Penicillamine (Cuprimine, Depen)
Zinc might reduce the levels and clinical effects of penicillamine.
By forming an insoluble complex with penicillamine, zinc interferes with penicillamine absorption and activity. Zinc supplements reduce the efficacy of low-dose penicillamine (0.5-1 gram/day), but do not seem to affect higher doses (1-2.75 gram/day), provided dosing times are separated. Advise patients to take zinc and penicillamine at least 2 hours apart.
Quinolone Antibiotics
Zinc can decrease the levels and clinical effects of quinolones antibiotics.
Quinolones form complexes with zinc in the gastrointestinal tract, reducing absorption of both the quinolone and zinc if taken at the same time. Advise patients to take these drugs at least 2 hours before, or 4-6 hours after, zinc supplements.
Ritonavir (Norvir)
Zinc modestly reduces levels of ritonavir.
Clinical research shows that zinc might reduce serum ritonavir levels by chelating with ritonavir in the gut and preventing its absorption. In patients with HIV, ritonavir is taken with atazanavir to prevent the metabolism and increase the effects of atazanavir. A pharmacokinetic study shows that, in patients being treated with atazanavir/ritonavir, co-administration of zinc sulfate (Solvazinc tablets) 125 mg as a single dose or as multiple daily doses for 2 weeks reduces plasma levels of ritonavir by about 16%. However, atazanavir levels still remains high enough to prevent HIV virus replication. Therefore, the decrease in ritonavir levels is not likely to be clinically significant.
Tetracycline Antibiotics
Zinc might reduce levels of tetracycline antibiotics.
Tetracyclines form complexes with zinc in the gastrointestinal tract, which can reduce absorption of both the tetracycline and zinc when taken at the same time. Taking zinc sulfate 200 mg with tetracycline reduces absorption of the antibiotic by 30% to 40%. Demeclocycline and minocycline cause a similar interaction. However, doxycycline does not seem to interact significantly with zinc. Advise patients to take tetracyclines at least 2 hours before, or 4-6 hours after, zinc supplements to avoid any interactions.
Amiloride (Midamor)
Amiloride can modestly reduce zinc excretion and increase zinc levels.
Clinical research shows that amiloride can reduce urinary zinc excretion, especially at doses of 10 mg per day or more. This zinc-sparing effect can help to counteract zinc losses caused by thiazide diuretics, but it is unlikely to cause zinc toxicity at usual amiloride doses. The other potassium-sparing diuretics, spironolactone (Aldactone) and triamterene (Dyrenium), do not seem to have a zinc-sparing effect.
Atazanavir (Reyataz)
Zinc modestly reduces levels of atazanavir, although this effect does not seem to be clinically significant.
Clinical research shows that zinc might decrease serum atazanavir levels by chelating with atazanavir in the gut and preventing its absorption. Although a single dose of zinc sulfate (Solvazinc tablets) 125 mg orally does not affect atazanavir concentrations in patients being treated with atazanavir/ritonavir, co-administration of zinc sulfate 125 mg daily for 2 weeks reduces plasma levels of atazanavir by about 22% in these patients. However, despite this decrease, atazanavir levels still remain at high enough concentrations for the prevention of HIV virus replication.
Watercress extract
Chlorzoxazone (Parafon Forte, Paraflex)
Watercress might reduce the metabolism of chlorzoxazone and increase its effects and side effects. Clinical research in healthy volunteers shows that a single ingestion of watercress 50 grams increases the chlorzoxazone plasma concentration-time curve by about 56% and increases its half-life by about 53%.
Lithium
Watercress is thought to have diuretic properties. Theoretically, due to these potential diuretic effects, watercress might reduce excretion and increase levels of lithium.
Warfarin (Coumadin)
Watercress contains vitamin K. Consuming large amounts of watercress might antagonize the anticoagulant effects of warfarin.
Brand information
Manufacturer and brand details for DNA Protection Formula, from the product label.
Life Extension
See all Life Extension products- Name
- Quality Supplements and Vitamins, Inc.
- City
- Ft. Lauderdale
- State
- FL
- ZipCode
- 33309
- Phone Number
- 1-866-280-2852
- Web Address
- LifeExtension.com
DNA Protection Formula by Life Extension: Common Questions
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Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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The Full Monographs Behind DNA Protection Formula’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Zinc
Interacts with 67 drugsZinc is an essential mineral that your body needs for immune function, wound healing, taste, and smell. Most people get enough from food, but supplements can help correct or prevent a defici...
Read the full Zinc monograph → Herb & supplement monographChlorophyllin
Interacts with 335 drugsChlorophyllin is a water-soluble, semi-synthetic form of chlorophyll most often used to help control body and fecal odor and to support wound healing. The best evidence is for its use as a d...
Read the full Chlorophyllin monograph → Herb & supplement monographWasabi
Interacts with 122 drugsWasabi is best known as the pungent green condiment served with sushi, made from a Japanese plant in the cabbage family. Its natural compounds (isothiocyanates) show antimicrobial and antiox...
Read the full Wasabi monograph → Herb & supplement monographWatercress
Interacts with 6 drugsWatercress is a nutrient-rich leafy green that provides vitamins A, C, and K plus minerals and antioxidant plant compounds. Eaten as a food it is generally safe and healthy for most people,...
Read the full Watercress monograph → Herb & supplement monographBroccoli
Interacts with 187 drugsBroccoli is a nutritious cruciferous vegetable rich in fiber, vitamins, and plant compounds like sulforaphane that have drawn scientific interest for health benefits. Eating broccoli as food...
Read the full Broccoli monograph → Herb & supplement monographTurmeric
Interacts with 1,133 drugsTurmeric is a popular spice whose main active compounds, curcuminoids, are studied mostly for inflammation and joint pain. Some research is promising, but quality is mixed and curcumin is po...
Read the full Turmeric monograph →Sources & How We Checked
DNA Protection Formula's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 237 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Zinc 88 references
- Barceloux DG. Zinc. J Toxicol Clin Toxicol 1999;37:279-92.
- Eby GA, Davis DR, Halcomb WW. Reduction in duration of common colds by zinc gluconate lozenges in a double-blind study. Antimicrob Agents Chemother 1984;25:20-4. DOI
- Smith DS, Helzner EC, Nuttall CE Jr, et al. Failure of zinc gluconate in treatment of acute upper respiratory tract infections. Antimicrob Agents Chemother 1989;33:646-8. PubMed
- Blondeau JM. Expanded activity and utility of the new fluoroquinolones: a review. Clin Ther 1999;21:3-40. PubMed
- Reyes AJ, Olhaberry JV, Leary WP, et al. Urinary zinc excretion, diuretics, zinc deficiency and some side-effects of diuretics. S Afr Med J 1983;64:936-41.
- Kugelmas M. Preliminary observation: oral zinc sulfate replacement is effective in treating muscle cramps in cirrhotic patients. J Am Coll Nutr 2000;19:13-5. PubMed
- Hebel SK, ed. Drug Facts and Comparisons. 52nd ed. St. Louis: Facts and Comparisons, 1998.
- Chan S, Gerson B, Subramaniam S. The role of copper, molybdenum, selenium, and zinc in nutrition and health. Clin Lab Med 1998;18:673-85. DOI
- Brewer GJ, Yuzbasiyan-Gurkan V, Johnson V, et al. Treatment of Wilson's disease with zinc: XI. Interaction with other anticopper agents. J Am Coll Nutr 1993;12:26-30. PubMed
- Fosmire GJ. Zinc toxicity. Am J Clin Nutr 1990;51:225-7.
- Lomaestro BM, Bailie GR. Absorption interactions with fluoroquinolones. 1995 update. Drug Saf 1995;12:314-33. PubMed
- Hansten PD, Horn JR. Drug Interactions Analysis and Management. Vancouver, WA: Applied Therapeutics Inc., 1997 and updates.
- Seelig MS. Auto-immune complications of D-penicillamine - A possible result of zinc and magnesium depletion and of pyridoxine inactivation. J Am Coll Nutr 1982;1:207-14. PubMed
- Neuvonen PJ. Interactions with the absorption of tetracyclines. Drugs 1976;11:45-54.. PubMed
- Hirt M, Nobel S, Barron E. Zinc nasal gel for the treatment of common cold symptoms: A double-blind, placebo-controlled trial. Ear Nose Throat J 2000;79:778-82.. DOI
- Simkin PA. Oral zinc sulphate in rheumatoid arthritis. Lancet 1976;2:539-42. PubMed
- Wray D. A double-blind trial of systemic zinc sulfate in recurrent aphthous stomatitis. Oral Surg Oral Med Oral Pathol 1982;53:469-72. PubMed
- Douglas RM, Miles HB, Moore BW, et al. Failure of effervescent zinc acetate lozenges to alter the course of upper respiratory tract infections in Australian adults. Antimicrob Agents Chemother 1987;31:1263-5. PubMed
- Lagiou P, Wuu J, Trichopoulou A, et al. Diet and benign prostatic hyperplasia: a study in Greece. Urology 1999;54:284-90. PubMed
- Ewing CI, Gibbs AC, Ashcroft C, David TJ. Failure of oral zinc supplementation in atopic eczema. Eur J Clin Nutr 1991;45:507-10.
- Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
- Age-Related Eye Disease Study Research Group. A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss. AREDS report no. 8. Arch Oph
- Greenberg JE, Lynn M, Kirsner RS, et al. Mucocutaneous pigmented macule as a result of zinc deposition. J Cutan Pathol 2002;29:613-5. PubMed
- Godfrey HR, Godfrey NJ, Godfrey JC, Riley D. A randomized clinical trial on the treatment of oral herpes with topical zinc oxide/glycine. Altern Ther Health Med 2001;7:49-56.
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
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