Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Double Strength Pantethine 600 mg Ingredients & Drug Interactions

by NOW

Double Strength Pantethine 600 mg label
See full label image
Softgel Capsule Category: Vitamin
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Double Strength Pantethine 600 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Double Strength Pantethine 600 mg is a dietary supplement by NOW with 1 active ingredient. Its ingredients are commonly taken for high cholesterol, high triglycerides, heart health support.Based on those ingredients, 122 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Pantethine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Double Strength Pantethine 600 mg by NOW

Ask about any prescription or over-the-counter medication and we check it for interactions with Double Strength Pantethine 600 mg by NOW — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Double Strength Pantethine 600 mg by NOW

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 23, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This softgel contains one active ingredient: 600 mg of pantethine, a form of pantothenic acid (vitamin B5). The inactive ingredients are rice bran oil, sunflower lecithin, and beeswax — all part of the softgel capsule itself.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Pantethine for lipid metabolism and heart health.
  • We looked for evidence on: Hyperlipidemia, Hyperlipoproteinemia, triglyceride metabolism, cardiovascular support.
  • The strongest evidence on file: Pantethine is rated "Possibly Effective" for Hyperlipoproteinemia (Natural Medicines).
  • Also on file: Pantethine is rated "Insufficient Reliable Evidence To Rate" for Hyperlipidemia.

Pantethine is possibly effective for high cholesterol (hyperlipoproteinemia). For athletic performance and other forms of high cholesterol (hyperlipidemia), the evidence isn't established well enough to rate it.

There's also insufficient evidence to know whether it helps with pantothenate kinase-associated neurodegeneration (PKAN), a rare genetic condition.

The evidence, ingredient by ingredient Pantethine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Pantethine is generally well tolerated in studies, but long-term safety data are limited. The most common side effects are mild stomach complaints — nausea, vomiting, diarrhea, bloating, flatulence, and discomfort in the upper abdomen.

Mild itching has been reported but is uncommon. There isn't enough reliable safety data in pregnancy, so it's best to avoid it unless your doctor advises otherwise.

Safety during breastfeeding hasn't been well studied, so caution is advised — talk it over with your doctor or pharmacist before taking it if you're nursing.

Side effects, ingredient by ingredient Pantethine

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Pantethine.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 122 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take blood thinners (anticoagulants like warfarin) or antiplatelet drugs (such as aspirin or clopidogrel), check your exact medications with your doctor or pharmacist before adding this product — pantethine may increase your bleeding risk.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Pantethine may help with high cholesterol, though the evidence isn't strong across the board. The main caution is if you're on blood thinners or antiplatelet drugs — you'll want to check with your doctor or pharmacist first, since pantethine might raise your bleeding risk.

If you're pregnant or breastfeeding, talk it through with your healthcare provider before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Feb 25, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Double Strength Pantethine 600 mg, straight from the product label.

Brand NOW
Barcode (UPC) 733739004895
Net contents 60 Softgel(s)
Market status On market
Date entered into DSLD Feb 25, 2021
DSLD ID 244393
Product type Vitamin
Supplement form Softgel Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Kosher, Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Double Strength Pantethine 600 mg by NOW, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
1 Softgel(s)
UPC/BARCODE
733739004895
IngredientAmount% DV
Pantethine600 mg--

Other ingredients: Softgel Capsule, Rice Bran Oil, Sunflower Lecithin, Beeswax

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Take 1 softgel daily with a meal.

Formula

Pantethine is a highly absorbable and biologically active form of pantothenic acid (vitamin B-5). Pantethine is a precursor in the formation of coenzyme A (CoA), an essential cofactor for lipid, carbohydrate, and protein metabolism. Pantethine also helps to support proper cholesterol production and fat storage in the liver, which can help to promote healthy body fat distribution. It has been shown in clinical studies to assist in the maintenance of already healthy serum lipid levels for the support of a healthy cardiovascular system when used in conjunction with a healthy diet.

Double strength Pantethine 600 mg

Triangle K (Kosher)

Vitamins

This double strength product has twice the Pantethine (600 mg) as in our regular strength product (300 mg).

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Precautions

Caution: For adults only. May cause minor gastrointestinal discomfort.

Consult physician if pregnant/nursing, taking medication, or have a medical condition.

Keep out of reach of children.

Contains Gelatin

Not manufactured with yeast, wheat, gluten, milk, egg, fish or shellfish ingredients. Produced in a GMP facility that processes other ingredients containing these allergens.

Seals/Symbols

GMP Quality Assured

Triangle K (Kosher)

Formulation

Cardiovascular health Supports healthy serum lipids already within the normal range

Non-GMO

Not manufactured with yeast, wheat, gluten, milk, egg, fish or shellfish ingredients.

Natural color variation may occur in this product.

FDA Statement of Identity

A Dietary Supplement

General Statements

Family owned since 1968.

Storage

Store in a cool, dry place after opening

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Double Strength Pantethine 600 mg by NOW label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Double Strength Pantethine 600 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Double Strength Pantethine 600 mg by NOW

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Amounts shown are per serving.

Pantethine

Interacts with
122 drugs
600 mg per serving

Pantethine is a derivative of vitamin B5 (pantothenic acid) that some studies suggest may modestly lower cholesterol and triglycerides. The evidence i...

Pantethine monograph & interactions

Other (inactive) ingredients: Softgel Capsule, Rice Bran Oil, Sunflower Lecithin, Beeswax. These complete the product’s ingredient list but are not active constituents.

Interaction report

Double Strength Pantethine 600 mg by NOW Drug Interactions

Want to check YOUR meds against Double Strength Pantethine 600 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
122Drugs
122 Moderate

Ingredients driving the most interactions

Pantethine 122

Individual Drug Interactions

The ingredients in Double Strength Pantethine 600 mg interact with 122 drugs. Click any drug to see the details.

1 of the 1 ingredient in Double Strength Pantethine 600 mg interact with drugs. Each result below shows which ingredient is responsible. Pantethine

Each ingredient & the kinds of drugs it affects

For each ingredient in Double Strength Pantethine 600 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Pantethine1 drug type · 122 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, pantethine might increase the risk of bleeding with anticoagulant or antiplatelet drugs.
Some evidence suggests that pantethine reduces platelet aggregation.

Likelihood Possible Evidence B
Pantethine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Double Strength Pantethine 600 mg, from the product label.

NOW

See all NOW products
Name
NOW Foods
Street Address
395 S. Glen Ellyn Rd.
City
Bloomingdale
State
IL
ZipCode
60108
Web Address
nowfoods.com
Pharmacist Counseling Corner

Double Strength Pantethine 600 mg by NOW: Common Questions

Does Double Strength Pantethine 600 mg by NOW interact with any medications?
Yes. Based on its ingredients, Double Strength Pantethine 600 mg has a known interaction with 122 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Double Strength Pantethine 600 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What's pantethine, and why is it in this product?
Pantethine is a form of pantothenic acid, a B vitamin. It's included here because evidence suggests it may help with high cholesterol, particularly a condition called hyperlipoproteinemia.
What side effects might I notice?
Most common are mild stomach issues — nausea, diarrhea, bloating, gas, or discomfort in the upper abdomen. Mild itching is rare. These tend to be mild and go away.
Can I take this if I'm pregnant?
There isn't enough reliable safety data in pregnancy, so it's best to avoid it unless your doctor advises otherwise. Talk it over with your healthcare provider before taking it.
Is pantethine safe to use long-term?
It's generally well tolerated in studies, but long-term safety data are limited — we don't have strong evidence about what happens after months or years of use. If you're planning to take it regularly, check in with your doctor or pharmacist.
Will this work for athletic performance?
There isn't enough reliable evidence to say whether pantethine helps with athletic performance. The data we have isn't strong enough to rate it for that purpose.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Double Strength Pantethine 600 mg is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Double Strength Pantethine 600 mg label
Go deeper

The Full Monographs Behind Double Strength Pantethine 600 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Pantethine

Interacts with 122 drugs

Pantethine is a derivative of vitamin B5 (pantothenic acid) that some studies suggest may modestly lower cholesterol and triglycerides. The evidence is limited and not strong enough to repla...

Read the full Pantethine monograph →
Sources

Sources & How We Checked

Double Strength Pantethine 600 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 9 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Pantethine 9 references
  1. Da Col PG, Cattin L, Fonda M, et al. Pantethine in the treatment of hypercholesterolemia: a randomized double-blind trial versus tiadenol. Curr Ther Res 1984;36:314-22.
  2. Rubba P, Postaiglione B, De Simone F, et al. Comparative evaluation of the lipid-lowering effects of fenofibrate and pantethine in type II hyperlipoproteinemia. Curr Ther Res 1985;38:719-27.
  3. Coronel F, Tornero F, Torrente J, et al. Treatment of hyperlipemia in diabetic patients on dialysis with a physiological substance. Am J Nephrol 1991;11:32-6.. PubMed
  4. Agrati AM, Ambrosi G, Ferraro G, Palmieri. Gemfibrozil efficacy vs pantethine in dyslipoproteinemic patients: a controlled study. Curr Ther Res 1989;45:650-63.
  5. Rumberger, J. A., Napolitano, J., Azumano, I., Kamiya, T., and Evans, M. Pantethine, a derivative of vitamin B(5) used as a nutritional supplement, favorably alters low-density lipoprotein cholesterol metabolism in low- to moderate-cardiovascular risk No
  6. Hiramatsu, K., Nozaki, H., and Arimori, S. Influence of pantethine on platelet volume, microviscosity, lipid composition and functions in diabetes mellitus with hyperlipidemia. Tokai J.Exp.Clin.Med. 1981;6(1):49-57.
  7. McRae MP. Treatment of hyperlipoproteinemia with pantethine: A review and analysis of efficacy and tolerability. Nutrition Res 2005;25:319-333. DOI
  8. Cattin, L., Da Col, P. G., Fonda, M., Mameli, M. G., and Fergulio, G. A. Treatment of hypercholesterolemia with pantethine and fenofibrate; open randomized study on 43 subjects. Current Therapeutic Research 1985;38(Sep):386-395.
  9. Evans M, Rumberger JA, Azumano I, Napolitano JJ, Citrolo D, Kamiya T. Pantethine, a derivative of vitamin B5, favorably alters total, LDL and non-HDL cholesterol in low to moderate cardiovascular risk subjects eligible for statin therapy: a triple-blinded

See these in context on the Pantethine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team