Major interaction on record — check this product against your medications before combining. Based on 7 of 10 ingredients. Check your meds →
Dietary supplement

Dust Extreme Pineapple Mango Ingredients & Drug Interactions

by Blackstone Labs

Dust Extreme Pineapple Mango label
See full label image
Powder Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Dust Extreme Pineapple Mango against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Dust Extreme Pineapple Mango is a dietary supplement by Blackstone Labs with 10 active ingredients. Its ingredients are commonly taken for athletic performance and endurance, high-intensity exercise capacity, reducing muscle fatigue.Based on those ingredients, 1,299 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Higenamine, Caffeine Anhydrous, 1,3 DMAA. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Dust Extreme Pineapple Mango by Blackstone Labs

Ask about any prescription or over-the-counter medication and we check it for interactions with Dust Extreme Pineapple Mango by Blackstone Labs — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Dust Extreme Pineapple Mango by Blackstone Labs

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 23, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 10 of its 10 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Dust Extreme Pineapple Mango is a powder formula with 10 active ingredients designed for athletic and cognitive support. The active ingredients are beta-alanine (an amino acid for physical performance), caffeine anhydrous (a stimulant for alertness and endurance), N-acetyl-L-tyrosine (a tyrosine derivative), agmatine sulfate (a signaling compound), Noopept (a nootropic), huperzine A (a plant-derived cognition compound), dimethylaminoethanol (a choline-related compound), higenamine (a plant stimulant), and citrulline malate (an amino acid compound).

The formula also contains inactive ingredients including maltodextrin, citric acid, erythritol, natural and artificial flavors, sucralose, silicon dioxide, and acesulfame-K.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: pre-workout athletic performance and energy.
  • We looked for evidence on: Athletic performance, Physical performance, Exercise-induced muscle breakdown, Exercise-induced muscle soreness, Muscle strength, Endurance — and 3 related terms.
  • The strongest evidence on file: Caffeine is rated "Likely Effective" for Athletic performance (Natural Medicines).
  • Also on file: Beta-alanine is rated "Possibly Effective" for Athletic performance, Physical performance.
  • Also on file: Deanol is rated "Insufficient Reliable Evidence To Rate" for Athletic performance.

The evidence for this product's ingredients is mixed. Beta-alanine is possibly effective for athletic and physical performance.

Caffeine anhydrous is likely effective for mental alertness and athletic performance, and effective for neonatal apnea and postoperative headache (though those aren't the intended use here). Huperzine A is possibly effective for Alzheimer disease.

The other active ingredients — N-acetyl-L-tyrosine, agmatine sulfate, Noopept, dimethylaminoethanol, higenamine, and citrulline malate — either lack established effectiveness ratings in our data or have insufficient evidence. Dimethylaminoethanol is rated likely ineffective for Alzheimer disease and tardive dyskinesia.

Because we hold no data for three of the ten ingredients, we cannot fully assess the formula's combined effect.

The evidence, ingredient by ingredient Beta-alanine Caffeine Agmatine Huperzine A Deanol Higenamine 1,3-dmaa

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 7 of the 7 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 7 of 7.
  • General safety write-ups exist for 7 of 7.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Beta-alanine is generally well tolerated but causes a harmless tingling sensation (paresthesia) and skin flushing in most users, typically starting on the scalp within 20 minutes and lasting about an hour; the strength depends on dose. Caffeine in moderate amounts is generally safe for healthy adults but can cause anxiety, insomnia, restlessness, jitteriness, nausea, headache, and tremors; high doses may cause serious effects rarely including stroke.

Agmatine appears well tolerated short-term but long-term safety in humans isn't well studied; diarrhea, nausea, and indigestion have been reported. Huperzine A is a pharmacologically active compound requiring careful use and medical guidance; it can cause dose-dependent cholinergic side effects (blurred vision, nausea, vomiting, diarrhea, dizziness, dry mouth, insomnia, sweating) and decreased heart rate.

Dimethylaminoethanol may be tolerated but has caused constipation, diarrhea, drowsiness, insomnia, nausea, vomiting, confusion, and mood changes including depression and hypomania at higher doses. Higenamine is a cardiac stimulant with limited safety study; headache is most common orally, but serious effects including rhabdomyolysis and cardiovascular toxicity have been reported.

1,3-DMAA is banned in supplements in many countries due to serious cardiovascular harm; it has caused cardiac arrest, heart attacks, atrial fibrillation, severe high blood pressure, stroke, and lactic acidosis, plus anxiety, paranoia, and suicidal behavior. Pregnancy and breastfeeding data are insufficient or absent for most ingredients; the safety notes advise against beta-alanine, agmatine, huperzine A, higenamine, and 1,3-DMAA during pregnancy and breastfeeding.

Caffeine carries a 'possibly unsafe' rating in pregnancy and a 'possibly safe' rating in lactation at moderate doses. No pregnancy/breastfeeding data is on file for N-acetyl-L-tyrosine, Noopept, dimethylaminoethanol, or citrulline malate.

Side effects, ingredient by ingredient Beta-alanine Caffeine Agmatine Huperzine A Deanol Higenamine 1,3-dmaa

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 6 of the 7 matched ingredients can interact with medications — Deanol, Huperzine A, Caffeine, 1,3-dmaa, Higenamine, among others.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications; lithium.
  • For scale: 1,300 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before starting Dust Extreme, check with your doctor or pharmacist if you take stimulant drugs (including other caffeine products or weight-loss pills), blood-pressure medications, diabetes drugs, seizure medications, heart drugs like dipyridamole or propranolol, antipsychotics like clozapine, blood thinners or antiplatelet drugs, quinolone antibiotics, acid-reflux medication (cimetidine), barbiturates (pentobarbital or phenobarbital), anticholinergic or cholinergic drugs, or any drug that your pharmacist says is metabolized by CYP2D6 or CYP3A4 enzymes. The Major-severity interactions with stimulants and ephedrine, and the banned status of 1,3-DMAA in many countries, make this a high-risk product to combine with other medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

This is a high-stimulant, multi-ingredient sports and cognition powder that carries serious safety and interaction risks—particularly from 1,3-DMAA and caffeine. It's not suitable for anyone taking heart medications, blood-pressure drugs, diabetes medications, seizure drugs, antipsychotics, blood thinners, or other stimulants.

If you're pregnant, breastfeeding, or have any heart or psychiatric condition, avoid it. Even in healthy adults, the cardiac stimulant effects and high stimulant load warrant caution.

Talk with your doctor or pharmacist before taking this product, especially if you take any prescription medications.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 7 of 10 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 25, 2018.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Dust Extreme Pineapple Mango, straight from the product label.

Brand Blackstone Labs
Net contents 12.69 Oz(s); 360 Gram(s)
Market status On market
Date entered into DSLD Oct 25, 2018
DSLD ID 171982
Product type Other Combinations
Supplement form Powder
Dietary claims / uses No Claim
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Dust Extreme Pineapple Mango by Blackstone Labs, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Scoop(s)
Maximum serving Sizes:
1 Scoop(s)
Servings per container
30
IngredientAmount% DV
Beta-Alanine2.5 Gram(s)--
Caffeine Anhydrous350 mg--
N-Acetyl-L-Tyrosine500 mg--
Agmatine Sulfate1 Gram(s)--
Noopept30 mg--
Huperzine A300 mcg--
Dimethylaminoethanol750 mg--
Higenamine75 mg--
Citrulline Malate4 Gram(s)--
1,3 DMAA75 mg--

Other ingredients: Maltodextrin, Citric Acid, Erythritol, Natural & Artificial flavors, Sucralose, Silicon Dioxide, Acesulfame-K

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

The perfect pre-workout

Naturally & artificially flavored

FDA Statement of Identity

Dietary Supplement

Formula

75 mg of 1,3-DMAA per serving

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Dust Extreme Pineapple Mango by Blackstone Labs label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Dust Extreme Pineapple Mango label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Dust Extreme Pineapple Mango by Blackstone Labs

These are the 10 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Scoop(s) Dosage formPowder Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Beta-Alanine

No known
interactions
2.5 Gram(s) per serving

Beta-alanine is an amino acid taken mostly by athletes to raise muscle carnosine, which may help buffer acid and reduce fatigue during short, high-int...

Beta-Alanine monograph & interactions

Caffeine Anhydrous

Interacts with
655 drugs
350 mg per serving

Caffeine is a natural stimulant found in coffee, tea, and many other plants and products. In moderate amounts it can boost alertness and reduce tiredn...

Caffeine Anhydrous monograph & interactions

N-Acetyl-L-Tyrosine

500 mg per serving

Agmatine Sulfate

Interacts with
258 drugs
1 Gram(s) per serving

Agmatine is a compound your body makes from the amino acid arginine, and it is sold mainly as a workout and 'pump' supplement. Human evidence for most...

Agmatine Sulfate monograph & interactions

Noopept

30 mg per serving

Huperzine A

Interacts with
219 drugs
300 mcg per serving Form: Huperzia serrata extract

Huperzine A is a purified compound from a Chinese clubmoss that acts like a mild cholinesterase inhibitor, similar in mechanism to some prescription A...

Huperzine A monograph & interactions

Dimethylaminoethanol

Interacts with
219 drugs
750 mg per serving

Deanol (DMAE) is a compound related to choline that is marketed for memory, focus, and mood, but solid human evidence for most of these uses is limite...

Dimethylaminoethanol monograph & interactions

Higenamine

Interacts with
891 drugs
75 mg per serving

Higenamine is a plant-based stimulant compound added to many weight-loss and pre-workout supplements, but there is very little human evidence that it...

Higenamine monograph & interactions

Citrulline Malate

4 Gram(s) per serving

1,3 DMAA

Interacts with
321 drugs
75 mg per serving

DMAA (1,3-dimethylamylamine) is a synthetic stimulant that was sold in pre-workout and weight-loss supplements but has been linked to serious harm, in...

1,3 DMAA monograph & interactions

Other (inactive) ingredients: Maltodextrin, Citric Acid, Erythritol, Natural & Artificial flavors, Sucralose, Silicon Dioxide, Acesulfame-K. These complete the product’s ingredient list but are not active constituents.

Interaction report

Dust Extreme Pineapple Mango by Blackstone Labs Drug Interactions

Want to check YOUR meds against Dust Extreme Pineapple Mango?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,299Drugs
8 Major 1,270 Moderate 21 Minor

Ingredients driving the most interactions

Higenamine 891
Caffeine Anhydrous 655
1,3 DMAA 321
Agmatine Sulfate 258
Huperzine A 219

Individual Drug Interactions

The ingredients in Dust Extreme Pineapple Mango interact with 1,299 drugs. Click any drug to see the details.

6 of the 10 ingredients in Dust Extreme Pineapple Mango interact with drugs. Each result below shows which ingredient is responsible. Higenamine Caffeine Anhydrous 1,3 DMAA Agmatine Sulfate Huperzine A Dimethylaminoethanol

Each ingredient & the kinds of drugs it affects

For each ingredient in Dust Extreme Pineapple Mango with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Higenamine5 drug types · 891 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, higenamine might increase the risk of bleeding or bruising when taken with anticoagulant/antiplatelet drugs.
Animal research shows that higenamine inhibits platelet aggregation and reduces the size of thrombus formation.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, higenamine might increase the levels and clinical effects of drugs metabolized by CYP2D6.
In vitro research shows that higenamine inhibits CYP2D6 enzymes. However, this effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, higenamine might increase the levels and clinical effects drugs metabolized by CYP3A4.
In vitro research shows that higenamine inhibits CYP3A4 enzymes by 21%. However, this effect has not been reported in humans.

Likelihood Possible Evidence D
Stimulant Drugs

Theoretically, higenamine might increase the risk of cardiovascular toxicity when taken with stimulant drugs.
Higenamine has stimulant effects due to agonist activity at beta2-adrenoreceptors. In cardiac muscle, higenamine appears to have a positive inotropic effect and increase heart rate. However, it does not appear to increase blood pressure.

Likelihood Possible Evidence D
Propranolol (Inderal)

Theoretically, the positive inotropic effects of higenamine might be reduced by propranolol.
Animal research shows that higenamine has a positive inotropic effect on the heart, and administering propranolol appears to block this cardiac effect. In animals, propranolol also appears to inhibit corpus cavernosum relaxation induced by higenamine.

Likelihood Possible Evidence D
Higenamine full monograph & interactions

Caffeine Anhydrous41 drug types · 655 drugs

Ephedrine

Theoretically, concomitant use might increase the risk for stimulant adverse effects.
Use of ephedrine with caffeine can increase the risk of stimulatory adverse effects. There is evidence that using ephedrine with caffeine might increase the risk of serious life-threatening or debilitating adverse effects such as hypertension, myocardial infarction, stroke, seizures, and death.

Likelihood Probable Evidence D
Adenosine (Adenocard)

Theoretically, caffeine might decrease the vasodilatory effects of adenosine and interfere with its use prior to stress testing.
Some evidence shows that caffeine is a competitive inhibitor of adenosine and can reduce the vasodilatory effects of adenosine in humans. However, other research shows that caffeine does not seem to affect supplemental adenosine because high interstitial levels of adenosine overcome the antagonistic effects of caffeine. It is recommended that methylxanthines and methylxanthine-containing products be stopped 24 hours prior to pharmacological stress tests. However, methylxanthines appear more likely to interfere with dipyridamole (Persantine) than adenosine-induced stress testing.

Likelihood Possible Evidence B
Anticoagulant/Antiplatelet Drugs

Theoretically, caffeine may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Caffeine is reported to have antiplatelet activity. Theoretically, it might increase the risk of bleeding when used concomitantly with these agents; however, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Beta-Adrenergic Agonists

Theoretically, large amounts of caffeine might increase the cardiac inotropic effects of beta-agonists.

Likelihood Probable Evidence D
Carbamazepine (Tegretol)

Theoretically, caffeine might reduce the effects of carbamazepine and increase the risk for convulsions.
Animal research suggests that taking caffeine can lower the anticonvulsant effects of carbamazepine and can induce seizures when taken in doses above 400 mg/kg. Human research has shown that taking caffeine 300 mg in three divided doses along with carbamazepine 200 mg reduces the bioavailability of carbamazepine by 32% and prolongs the plasma half-life of carbamazepine 2-fold in healthy individuals.

Likelihood Possible Evidence D
Cimetidine (Tagamet)

Theoretically, cimetidine might increase the levels and adverse effects of caffeine.
Cimetidine decreases the rate of caffeine clearance by 31% to 42%.

Likelihood Likely Evidence B
Clozapine (Clozaril)

Caffeine might increase the levels and adverse effects of clozapine and acutely exacerbate psychotic symptoms.
Caffeine might increase the effects and toxicity of clozapine. Caffeine doses of 400-1000 mg per day inhibit clozapine metabolism. Clozapine is metabolized by cytochrome P450 1A2 (CYP1A2). Although researchers speculate that caffeine might inhibit CYP1A2, there is no reliable evidence that caffeine affects CYP1A2. There is also speculation that genetic factors might make some patients more sensitive to an interaction between clozapine and caffeine. In one case report, severe, life-threatening clozapine toxicity and multiorgan system failure occurred in a patient with schizophrenia stabilized on clozapine who consumed caffeine 600 mg daily.

Likelihood Possible Evidence B
Dipyridamole (Persantine)

Theoretically, caffeine might decrease the vasodilatory effects of dipyridamole and interfere with its use prior to stress testing.
Caffeine inhibits dipyridamole-induced vasodilation. It is recommended that methylxanthines and methylxanthine-containing products be stopped 24 hours prior to pharmacological stress tests. Methylxanthines appear more likely to interfere with dipyridamole (Persantine) than adenosine-induced stress testing.

Likelihood Probable Evidence B
Disulfiram (Antabuse)

Theoretically, disulfiram use might increase the levels and adverse effects of caffeine.
Disulfiram decreases the rate of caffeine clearance.

Likelihood Probable Evidence B
Diuretic Drugs

Theoretically, using caffeine with diuretic drugs might increase the risk of hypokalemia.
Caffeine, especially in excessive amounts, can reduce potassium levels due to stimulation of the sodium-potassium pump. Diuretics can also cause lower potassium levels.

Likelihood Possible Evidence D
Estrogens

Theoretically, estrogens might increase the levels and adverse effects of caffeine.
Estrogen inhibits caffeine metabolism.

Likelihood Probable Evidence B
Ethosuximide (Zarontin)

Theoretically, caffeine might reduce the effects of ethosuximide and increase the risk for convulsions.
Animal research suggests that caffeine 92.4 mg/kg can decrease the anticonvulsant activity of ethosuximide. However, this effect has not been reported in humans.

Likelihood Possible Evidence D
Felbamate (Felbatol)

Theoretically, caffeine might reduce the effects of felbamate and increase the risk for convulsions.
Animal research suggests that a high dose of caffeine 161.7 mg/kg can decreases the anticonvulsant activity of felbamate. However, this effect has not been reported in humans.

Likelihood Possible Evidence D
Flutamide (Eulexin)

Theoretically, caffeine might increase the levels and adverse effects of flutamide.
In vitro evidence suggests that caffeine can inhibit the metabolism of flutamide. However, this effect has not been reported in humans.

Likelihood Probable Evidence D
Fluvoxamine (Luvox)

Theoretically, fluvoxamine might increase the levels and adverse effects of caffeine.
Fluvoxamine reduces caffeine metabolism.

Likelihood Probable Evidence D
Lithium

Abrupt caffeine withdrawal might increase the levels and adverse effects of lithium.
Caffeine has diuretic activity. When abruptly discontinued, caffeine may alter the clearance of lithium. There are two case reports of lithium tremor that worsened upon abrupt coffee withdrawal and 6 case reports of elevated serum lithium levels after reducing or eliminating caffeine intake. In one case, a male with schizoaffective disorder stabilized on lithium had an elevated lithium level after reducing his caffeine intake by 87%. At a later date, he increased his caffeine intake by 6-fold, resulting in a subtherapeutic lithium level and a recurrence of psychiatric symptoms.

Likelihood Probable Evidence D
Monoamine Oxidase Inhibitors (Maois)

Theoretically, concomitant use might increase the risk of a hypertensive crisis.
Caffeine has been shown to inhibit monoamine oxidase (MAO) A and B in laboratory studies. Concomitant intake of large amounts of caffeine with MAOIs might precipitate a hypertensive crisis. In a case report, a patient that consumed 10-12 cups of caffeinated coffee and took the MAOI tranylcypromine presented with severe hypertension. Hypertension was resolved after the patient switched to drinking decaffeinated coffee.

Likelihood Possible Evidence D
Nicotine

Theoretically, concomitant use might increase the risk of hypertension.
Concomitant use of caffeine and nicotine has been shown to have additive cardiovascular effects, including increased heart rate and blood pressure. Blood pressure was increased by 10.8/12.4 mmHg when the agents were used concomitantly.

Likelihood Probable Evidence B
Pentobarbital (Nembutal)

Theoretically, caffeine might decrease the effects of pentobarbital.
Caffeine might negate the hypnotic effects of pentobarbital.

Likelihood Possible Evidence B
Phenobarbital (Luminal)

Theoretically, caffeine might reduce the effects of phenobarbital and increase the risk for convulsions.
Animal research suggests that caffeine can decrease the anticonvulsant activity of phenobarbital. However, the exact mechanism of this interaction is unclear.

Likelihood Possible Evidence D
Phenylpropanolamine

Theoretically, phenylpropanolamine might increase the risk of hypertension, as well as the levels and adverse effects of caffeine.
Concomitant use of phenylpropanolamine and caffeine might cause an additive increase in blood pressure. Phenylpropanolamine also seems to increase caffeine serum levels.

Likelihood Probable Evidence B
Phenytoin (Dilantin)

Theoretically, caffeine might reduce the effects of phenytoin and increase the risk for convulsions.
Animal research suggests that caffeine can decrease the anticonvulsant activity of phenytoin. The effect does not seem to be related to the seizure threshold-lowering effects of caffeine. However, the exact mechanism of this interaction is unclear.

Likelihood Possible Evidence D
Pioglitazone (Actos)

Theoretically, caffeine might increase the levels and clinical effects of pioglitazone.
Animal research suggests that caffeine can modestly increase the maximum concentration, area under the curve, and half-life of pioglitazone, and also reduce its clearance. This increased the antidiabetic effects of pioglitazone. However, the exact mechanism of this interaction is unclear.

Likelihood Possible Evidence D
Quinolone Antibiotics

Theoretically, quinolone antibiotics might increase the levels and adverse effects of caffeine.
Quinolones (also called fluoroquinolones) can decrease caffeine clearance by inhibiting cytochrome P450 1A2 (CYP1A2) enzyme.

Likelihood Probable Evidence B
Riluzole (Rilutek)

Theoretically, concomitant use might increase the levels and adverse effects of both caffeine and riluzole.
Caffeine and riluzole are both metabolized by cytochrome P450 1A2 (CYP1A2), and concomitant use might reduce the metabolism of one or both agents.

Likelihood Possible Evidence D
Caffeine Anhydrous full monograph & all 41 interactions

1,3 DMAA2 drug types · 321 drugs

Cytochrome P450 2D6 (Cyp2D6) Substrates

1,3-DMAA strongly inhibits cytochrome P450 2D6 (CYP2D6) enzymes in vitro. Theoretically, 1,3-DMAA can increase levels of CYP2D6 substrates. Some of drugs that are CYP2D6 substrates include amitriptyline (Elavil), clozapine (Clozaril), codeine, desipramine (Norpramin), donepezil (Aricept), fentanyl (Duragesic), flecainide (Tambocor), fluoxetine (Prozac), meperidine (Demerol), methadone (Dolophine), metoprolol (Lopressor, Toprol XL), olanzapine (Zyprexa), ondansetron (Zofran), tramadol (Ultram), trazodone (Desyrel), and others.

Likelihood Possible Evidence D
Stimulant Drugs

1,3-DMAA is thought to have stimulant effects. There is concern that taking 1,3-DMAA with stimulant drugs might increase the risk of adverse cardiovascular effects. Some preliminary research shows that taking 1,3-DMAA 50 mg daily in combination with caffeine 250 mg daily does not increase respiratory rate, blood pressure, or other cardiovascular outcomes compared to taking caffeine alone in healthy men. However, a number of cardiovascular side effects have been reported for patients taking 1,3-DMAA in combination with other stimulants including caffeine. Theoretically, combining 1,3-DMAA with stimulant drugs might increase the risk of adverse cardiovascular effects. Some stimulant drugs include amphetamine, caffeine, diethylpropion (Tenuate), methylphenidate, phentermine (Ionamin), pseudoephedrine (Sudafed, others), and many others.

Likelihood Possible Evidence D
1,3 DMAA full monograph & interactions

Agmatine Sulfate2 drug types · 258 drugs

Antidiabetes Drugs

Theoretically, agmatine might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Animal and in vitro research suggest that agmatine has mild hypoglycemic effects.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, agmatine might increase the risk of hypotension when taken with antihypertensive drugs.
Animal research suggests that agmatine can modestly decrease heart rate and blood pressure.

Likelihood Possible Evidence D
Agmatine Sulfate full monograph & interactions

Huperzine A2 drug types · 219 drugs

Anticholinergic Drugs

Theoretically, huperzine A might decrease the effects of anticholinergic drugs.
Huperzine A has acetylcholinesterase (AChE) inhibiting effects. In animal models, huperzine A reversed cognitive deficits induced by scopolamine, an anticholinergic drug.

Likelihood Possible Evidence D
Cholinergic Drugs

Theoretically, concurrent use of huperzine A with cholinergic drugs might increase the effects and side effects of these medications.
Huperzine A can inhibit acetylcholinesterase (AChE) and might cause cumulative effects if used with cholinergic drugs.

Likelihood Possible Evidence B
Huperzine A full monograph & interactions

Dimethylaminoethanol2 drug types · 219 drugs

Anticholinergic Drugs

Theoretically, deanol might decrease the effectiveness of anticholinergic drugs.
Deanol is thought to increase acetylcholine levels.

Likelihood Unlikely Evidence D
Cholinergic Drugs

Theoretically, deanol might increase the effects and adverse effects of cholinergic drugs.
Deanol is thought to increase acetylcholine levels.

Likelihood Unlikely Evidence D
Dimethylaminoethanol full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Dust Extreme Pineapple Mango, from the product label.

Blackstone Labs

See all Blackstone Labs products
Name
Blackstone Labs
Pharmacist Counseling Corner

Dust Extreme Pineapple Mango by Blackstone Labs: Common Questions

Does Dust Extreme Pineapple Mango by Blackstone Labs interact with any medications?
Yes. Based on its ingredients, Dust Extreme Pineapple Mango has a known interaction with 1,299 medications, including 8 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Dust Extreme Pineapple Mango contains 10 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What does beta-alanine do in this product?
Beta-alanine is an amino acid that is possibly effective for athletic and physical performance. It's well tolerated but commonly causes a harmless tingling sensation and skin flushing that typically lasts about an hour.
Is caffeine the only stimulant in this powder?
No. The formula also contains higenamine (which acts as a cardiac stimulant on the heart) and 1,3-DMAA (a banned stimulant with serious cardiovascular risks). Combined, these three stimulants create a very high stimulant load, which is why checking with your doctor is essential.
What is huperzine A and does it work?
Huperzine A is a plant-derived compound that is possibly effective for Alzheimer disease. It works by inhibiting an enzyme that breaks down the neurotransmitter acetylcholine. It can cause dose-dependent side effects including nausea, vomiting, diarrhea, blurred vision, and dizziness, and it requires medical guidance because it's pharmacologically active.
Can I take this if I'm pregnant or breastfeeding?
No. Beta-alanine, agmatine, huperzine A, higenamine, and 1,3-DMAA all advise against use during pregnancy and breastfeeding due to insufficient safety data or known risks. Caffeine carries a 'possibly unsafe' rating in pregnancy. There is no pregnancy or breastfeeding data for several other ingredients. Talk with your doctor before taking this if you are pregnant, planning to become pregnant, or breastfeeding.
Why is 1,3-DMAA in this product if it's banned?
1,3-DMAA is banned in dietary supplements in many countries due to serious cardiovascular harm, but it remains in some formulas sold in markets where it is still permitted. It carries a 'avoid' safety rating and has been linked to cardiac arrest, heart attacks, stroke, and psychiatric side effects. This is a significant safety concern.
What is the tingling I might feel when I take this?
The tingling (paresthesia) and skin flushing come from beta-alanine, a common ingredient in pre-workout powders. It's dose-dependent and harmless — it usually starts on the scalp within 20 minutes, spreads to the rest of the body, and lasts about an hour. At lower doses, only a small number of users experience it.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Dust Extreme Pineapple Mango label
Go deeper

The Full Monographs Behind Dust Extreme Pineapple Mango’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Beta-alanine

Beta-alanine is an amino acid taken mostly by athletes to raise muscle carnosine, which may help buffer acid and reduce fatigue during short, high-intensity exercise. The evidence is moderat...

Read the full Beta-alanine monograph → Herb & supplement monograph

Caffeine

Interacts with 655 drugs

Caffeine is a natural stimulant found in coffee, tea, and many other plants and products. In moderate amounts it can boost alertness and reduce tiredness for most healthy adults, but too muc...

Read the full Caffeine monograph → Herb & supplement monograph

Agmatine

Interacts with 258 drugs

Agmatine is a compound your body makes from the amino acid arginine, and it is sold mainly as a workout and 'pump' supplement. Human evidence for most of its claimed benefits is limited and...

Read the full Agmatine monograph → Herb & supplement monograph

Huperzine A

Interacts with 219 drugs

Huperzine A is a purified compound from a Chinese clubmoss that acts like a mild cholinesterase inhibitor, similar in mechanism to some prescription Alzheimer's drugs. Some small studies sug...

Read the full Huperzine A monograph → Herb & supplement monograph

Deanol

Interacts with 219 drugs

Deanol (DMAE) is a compound related to choline that is marketed for memory, focus, and mood, but solid human evidence for most of these uses is limited or mixed. It can cause side effects in...

Read the full Deanol monograph → Herb & supplement monograph

Higenamine

Interacts with 891 drugs

Higenamine is a plant-based stimulant compound added to many weight-loss and pre-workout supplements, but there is very little human evidence that it works and real concerns about heart and...

Read the full Higenamine monograph → Herb & supplement monograph

1,3-dmaa

Interacts with 321 drugs

DMAA (1,3-dimethylamylamine) is a synthetic stimulant that was sold in pre-workout and weight-loss supplements but has been linked to serious harm, including high blood pressure, heart probl...

Read the full 1,3-dmaa monograph →
Sources

Sources & How We Checked

Dust Extreme Pineapple Mango's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 315 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Beta-alanine 13 references
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  2. Hill CA, Harris RC, Kim HJ, et al. Influence of beta-alanine supplementation on skeletal muscle carnosine concentrations and high intensity cycling capacity. Amino Acids 2007;32:225-33.
  3. Bellinger PM, Minahan CL. The effect of ß-alanine supplementation on cycling time trials of different length. Eur J Sport Sci 2016;16(7):829-36.
  4. Chung W, Shaw G, Anderson ME, et al. Effect of 10 week beta-alanine supplementation on competition and training performance in elite swimmers. Nutrients 2012;4(10):1441-53. PubMed
  5. Glenn JM, Gray M, Stewart R, et al. Incremental effects of 28 days of beta-alanine supplementation on high-intensity cycling performance and blood lactate in masters female cyclists. Amino Acids 2015;47(12):2593-600. PubMed
  6. Gross M, Bieri K, Hoppeler H, Norman B, Vogt M. Beta-alanine supplementation improves jumping power and affects severe-intensity performance in professional alpine skiers. Int J Sport Nutr Exerc Metab 2014;24(6):665-73. PubMed
  7. Howe ST, Bellinger PM, Driller MW, Shing CM, Fell JW. The effect of beta-alanine supplementation on isokinetic force and cycling performance in highly trained cyclists. Int J Sport Nutr Exerc Metab 2013;23(6):562-70. PubMed
  8. Sweeney KM, Wright GA, Glenn Brice A, Doberstein ST. The effect of beta-alanine supplementation on power performance during repeated sprint activity. J Strength Cond Res 2010;24(1):79-87.
  9. Décombaz J, Beaumont M, Vuichoud J, Bouisset F, Stellingwerff T. Effect of slow-release ß-alanine tablets on absorption kinetics and paresthesia. Amino Acids 2012;43(1):67-76. Erratum in: Amino Acids 2013;45(4):1015.
  10. Stellingwerff T, Anwander H, Egger A, et al. Effect of two ß-alanine dosing protocols on muscle carnosine synthesis and washout. Amino Acids 2012;42(6):2461-72. PubMed
  11. da Silva RP, de Oliveira LF, Saunders B, et al. Effects of ß-alanine and sodium bicarbonate supplementation on the estimated energy system contribution during high-intensity intermittent exercise. Amino Acids. 2019;51(1):83-96. PubMed
  12. Varanoske AN, Hoffman JR, Church DD, et al. Comparison of sustained-release and rapid-release ß-alanine formulations on changes in skeletal muscle carnosine and histidine content and isometric performance following a muscle-damaging protocol. Amino Acids. PubMed
  13. Perim P, Gobbi N, Duarte B, et al. Beta-alanine did not improve high-intensity performance throughout simulated road cycling. Eur J Sport Sci 2021. PubMed

See these in context on the Beta-alanine monograph →

Caffeine 236 references
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Agmatine 3 references
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Huperzine A 13 references
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Deanol 15 references
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Higenamine 14 references
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1,3-dmaa 21 references
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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