Higenamine + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine
Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine brand name: Theracaps.
Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine falls into 3 drug categories that Higenamine can interact with; the most serious is rated moderate. Theoretically, higenamine might increase the levels and clinical effects of drugs metabolized by CYP2D6.
Read the full interaction reportHigenamine and Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine
These two interact in 3 distinct ways. Each one is explained separately below.
Why Are There 3 Interactions?
Higenamine interacts with whole categories of medication. Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine falls into 3 of those categories, so it can interact with Higenamine in 3 different ways. We’ve listed each one below — your overall risk is driven by the most serious of them (Moderate).
CYTOCHROME P450 2D6 (CYP2D6) SUBSTRATES
1 of 3Why this applies to Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine
Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine falls under CYTOCHROME P450 2D6 (CYP2D6) SUBSTRATES — the group Higenamine interacts with.
In vitro research shows that higenamine inhibits CYP2D6 enzymes. However, this effect has not been reported in humans.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
This combo product (Theracaps) is a cold and cough medicine, and one ingredient worth focusing on is dextromethorphan, the cough suppressant. Your body clears dextromethorphan using a liver enzyme called CYP2D6. Lab studies suggest higenamine can slow that enzyme down, which in theory could let dextromethorphan build up a bit higher than usual. If that happened, you might notice more dizziness, drowsiness, or feeling off-balance.
I want to be honest about how soft this evidence is. It comes only from test-tube research and has never actually been shown in people, so it's more of a theoretical caution than a proven problem. Still, higenamine itself can rev up your heart and blood pressure, so before pairing it with any cold medicine, please check with your pharmacist or doctor.
- Liu Y, Santillo MF. Cytochrome P450 2D6 and 3A4 enzyme inhibition by amine stimulants in dietary supplements. Drug Test Anal. 2016;8(3-4):307-10. PubMed
CYTOCHROME P450 3A4 (CYP3A4) SUBSTRATES
2 of 3Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine also falls under CYTOCHROME P450 3A4 (CYP3A4) SUBSTRATES.
In vitro research shows that higenamine inhibits CYP3A4 enzymes by 21%. However, this effect has not been reported in humans.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
Here's the bottom line with this combo. In a lab dish, higenamine slowed down a liver enzyme called CYP3A4 by about 21 percent. That same enzyme helps clear parts of this cold and cough product, like dextromethorphan. So in theory, higenamine could let those ingredients build up a bit, which might mean more drowsiness, dizziness, or a foggy, jittery feeling. But honestly, this has only been seen in test tubes, never in real people, so the actual risk looks small.
What worries me more is the overlap in stimulation. Higenamine acts like adrenaline and can raise your heart rate and blood pressure, and phenylpropanolamine is a decongestant that does the same thing. Stacking them could push your heart and pressure higher than you'd want. I'd run this past your pharmacist before mixing them.
- Liu Y, Santillo MF. Cytochrome P450 2D6 and 3A4 enzyme inhibition by amine stimulants in dietary supplements. Drug Test Anal. 2016;8(3-4):307-10. PubMed
STIMULANT DRUGS
3 of 3Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine also falls under STIMULANT DRUGS.
Higenamine has stimulant effects due to agonist activity at beta2-adrenoreceptors. In cardiac muscle, higenamine appears to have a positive inotropic effect and increase heart rate. However, it does not appear to increase blood pressure.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
Here's the piece worth your attention with Theracaps: one of its ingredients, phenylpropanolamine, is a decongestant-type stimulant that can nudge up your heart rate and blood pressure. Higenamine works in a similar stimulant direction by acting on adrenaline-like receptors in the heart. Stack the two and, in theory, you could get more of those overlapping effects, things like a racing or pounding heartbeat, jitteriness, or feeling wired.
I want to be honest about the strength of this: it's a theoretical concern based on how these compounds work, not from strong human studies, so the risk for most people is likely modest. Still, since higenamine products often contain more than the label claims, I'd run this combination by your pharmacist or doctor before pairing them, especially if you have any heart or blood pressure issues.
- Wagner H, Reiter M, Ferstl W. New drugs with cardiotonic activity. Part 1. Chemistry and pharmacology of the cardiotonic active principle of Annona squamosa L. Planta Med 1980;40:77-85.
- Park CW, Chang KC, Lim JK. Effects of higenamine on isolated heart adrenoceptor of rabbit. Arch Int Pharmacodyn Ther 1984;267:279-88.
- Liu WH, Zhou YP, Zeng GY. Effects of dl-demethylcoclaurine on experimental heart failure. Acta Pharm Sinica 1988;23:81-5.
- Zhang Z, Liu X, Tao Z, et al. Effects of higeramine on hemodynamics and its tolerability and safety, an experimental study. Zhonghua Yi Xue Za Zhi 2002;82:352-5.
What These Ratings Mean
Every interaction above is graded three ways — here’s the key to each label.
Clinically significant. Avoid the combination, or use only under close professional supervision.
Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.
Generally not serious. Be aware of it and mention it to your pharmacist.
- LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
- ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
- PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
- UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
- AHigh-quality meta-analysis (quantitative systematic review).
- BCase-control study.
- CConsensus.
- DAnecdotal evidence.
These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.
Higenamine Also Interacts With Other Medications
Higenamine has 890 moderate known drug interactions in our database — the Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine one above is among them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against Higenamine
We haven’t checked that one against Higenamine yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against Higenamine. Pick one to open its full report.
See Every Supplement That Interacts With Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine
This page covers Higenamine only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine page lists 282 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Asarabacca (major), Beer (major), Ephedra (major) and Grapefruit (major).
By severity: 14 major · 223 moderate · 45 minor.
From our pharmacist’s overview on the Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine page
“Of everything on this page, ephedra worries me most for anyone using Theracaps (acetaminophen, dextromethorphan, phenylpropanolamine, and pyrilamine), because the decongestant in this cold formula is itself a stimulant. Adding ephedra or any of the 44 stimulant entries can push blood pressure and heart rate to unsafe levels.”
Reviewed by 2 · Jul 18, 2026
Open the Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interaction page
Taking Higenamine as Part of a Dietary Supplement Product? Check It for Interactions
We hold 154 real supplement products containing Higenamine, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Higenamine. Your product may carry other ingredients that interact with Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine too, on top of Higenamine — and those would not show on this page. Find your product and we’ll check every ingredient on its label:
Where Higenamine and Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#373 of 1,452 supplements looked up here in the last 7 days
#1,738 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
About Higenamine
What is Higenamine?
- Weight loss and fat burning
- Pre-workout energy and performance
- Appetite suppression
- Athletic stimulant
- Traditional medicine remedies
Higenamine is a plant-based stimulant compound added to many weight-loss and pre-workout supplements, but there is very little human evidence that it works and real concerns about heart and blood pressure effects. It is banned in sports by the World Anti-Doping Agency (WADA), and product labels often list inaccurate amounts, so most people should approach it with caution and talk to a pharmacist or doctor first.
Other Drugs & Higenamine
Browse every other medication we’ve checked against Higenamine — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
890 interactions
- Diclofenac Sodium ›
- Diltiazem ›
- Nifedipine ›
- Ibuprofen ›
- Phentermine ›
- Aspirin ›
- Hydrocortisone ›
- Methylphenidate ›
- Naproxen ›
- Erythromycin ›
- Estradiol ›
- Minocycline ›
- Propranolol ›
- Lidocaine ›
- Norethindrone ›
- Testosterone ›
- Verapamil ›
- Levonorgestrel ›
- Phenylpropanolamine ›
- Prednisone ›
- Quinidine ›
- Cyclosporine ›
- Dexamethasone ›
- Triazolam ›
- Zopiclone ›
- Colchicine ›
- Fentanyl ›
- Nicotine ›
- Oxybutynin ›
- Oxycodone ›
- Prednisolone ›
- Tacrolimus ›
- Temazepam ›
- Budesonide ›
- Carbamazepine ›
- Clindamycin ›
- Dextromethorphan ›
- Diclofenac Potassium ›
- Dipyridamole ›
- Doxorubicin ›
- Fluticasone ›
- Formoterol ›
- Miconazole ›
- Morphine Sulfate ›
- Phenylephrine ›
- Pseudoephedrine ›
- Amphetamine ›
- Buprenorphine ›
- Conjugated Estrogens ›
- Diazepam ›
- Diethylpropion ›
- Everolimus ›
- Ivabradine ›
- Ketoprofen ›
- Lofepramine ›
- Medroxyprogesterone ›
- Medroxyprogesterone Acetate ›
- Nortriptyline ›
- Propoxyphene ›
- Rifampin ›
Showing 60 of 890 moderate interactions — see all 890 on the Higenamine page.
No interaction 1,939 drugs checked — show the list
We also checked Higenamine against these medications and found no known interaction in our sources. Open any page to confirm.
- Levothyroxine ›
- Ivermectin ›
- Rosuvastatin ›
- Acetaminophen ›
- Escitalopram ›
- Docusate ›
- Valacyclovir ›
- Hydroxyurea ›
- Tirzepatide ›
- Semaglutide ›
- Sumatriptan ›
- Metformin ›
- Lisinopril ›
- Amoxicillin ›
- Bupropion ›
- Bendamustine ›
- Acyclovir ›
- Methotrexate ›
- Doxycycline ›
- Pregabalin ›
- Lamotrigine ›
- Azithromycin ›
- Gabapentin ›
- Isotretinoin ›
- Methylene Blue ›
- Ciprofloxacin ›
- Levothyroxine, Liothyronine ›
- Candesartan Cilexetil ›
- Cephalexin ›
- Cyclopentolate ›
- Acetaminophen, Dextromethorphan, Doxylamine ›
- Roxithromycin ›
- Mannitol ›
- Levetiracetam ›
- Pegunigalsidase Alfa-iwxj ›
- Ezetimibe ›
- Daptomycin ›
- Levothyroxine Sodium ›
- Mitomycin ›
- Valsartan ›
- Spironolactone ›
- Amoxicillin, Clavulanate Potassium ›
- Hexobarbitone ›
- Phentermine, Topiramate ›
- Thyroid Hormone ›
- Carbidopa, Levodopa ›
- Factor 7a ›
- Levodopa ›
- Minoxidil ›
- Lenvatinib ›
- Cefaclor ›
- Azelaic Acid ›
- Hydroxychloroquine ›
- Dirithromycin ›
- Vancomycin ›
- Pizotifen ›
- Triptorelin ›
- Bentoquatam ›
- Digoxin ›
- Pentobarbitone ›
Showing the 60 most looked-up of 1,939 medications checked with no known interaction — see the full Higenamine list.
Sources & How We Checked
Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference for vitamins, herbs and supplements — the basis for our interaction data.
- MedlinePlus, U.S. National Library of Medicine — NIH consumer drug information, used for the medication overviews.
- NIH Dietary Supplement Label Database (DSLD) — Official supplement product labels.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine Is Linked to Lower Levels of One Nutrient
Natural Medicines records Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine as a medicine that can lower these. This is not an interaction with Higenamine — it is a separate effect of the medicine, and it is a reason some people are advised to supplement rather than to avoid one:
Depletion records come from the licensed Natural Medicines database. Do not start a supplement on the strength of this page — ask your pharmacist or doctor whether it applies to you.
Taking Higenamine and Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine Together: Common Questions
Can you take Higenamine with Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine?
Why are there 3 interactions listed for Higenamine and Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine?
How serious is the Higenamine and Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interaction?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.