What Supplements Interact with Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine?
Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine brand name: Theracaps. Every interaction below applies to the brands too.
Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy
What is this page for?
One answer, for one medication: what supplements and herbal products interact with Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.
This page covers supplement interactions only — to check Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy
What is this?
The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.Of everything on this page, ephedra worries me most for anyone using Theracaps (acetaminophen, dextromethorphan, phenylpropanolamine, and pyrilamine), because the decongestant in this cold formula is itself a stimulant. Adding ephedra or any of the 44 stimulant entries can push blood pressure and heart rate to unsafe levels. Fourteen of the 282 interactions on file are rated major, and I would read those major entries closely before adding any supplement to this medicine.
Alcohol matters too, since beer and wine add to the liver strain acetaminophen already carries. Herbs with drying, anticholinergic effects stack on the antihistamine, and serotonergic supplements combine poorly with dextromethorphan. Most of the remaining 223 moderate and 45 minor entries trace back to how your body breaks down one of the four ingredients, and grapefruit, the everyday example, can raise drug levels by blocking a key liver enzyme.
This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓
Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine: Top Interactions at a Glance
The Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.
Showing the 12 highest-ranked of 282 interacting ingredients — plus 1,170 more checked with no known interaction. See the complete ranked list.
The Most-Checked Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine Combinations Today
The Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.
Bitter orange might increase levels of drugs metabolized by CYP3A4.
Read the full interaction Moderate Likelihood Possible Acetyl-l-carnitine + Acetaminophen, Dextromethorphan, Phenylpropanolamine, PyrilamineiTheoretically, acetyl-L-carnitine might increase the risk of serotonergic side effects, including serotonin syndrome and cerebral vasoconstrictive disorders, wh...
Read the full interaction Moderate Likelihood Possible Phosphatidylserine + Acetaminophen, Dextromethorphan, Phenylpropanolamine, PyrilamineiTheoretically, phosphatidylserine might decrease the effectiveness anticholinergic drugs.
Read the full interaction Moderate Likelihood Possible Thyme + Acetaminophen, Dextromethorphan, Phenylpropanolamine, PyrilamineiTheoretically, concurrent use of anticholinergic drugs and thyme essential oil might reduce the effects of anticholinergic drugs.
Read the full interaction Moderate Likelihood Possible Same + Acetaminophen, Dextromethorphan, Phenylpropanolamine, PyrilamineiTaking SAMe with serotonergic drugs might increase the risk of serotonin syndrome and other serotonergic side effects.
Read the full interaction Moderate Likelihood Possible Butcher's Broom + Acetaminophen, Dextromethorphan, Phenylpropanolamine, PyrilamineiTheoretically, butcher's broom might increase the effects and adverse effects of alpha-adrenergic agonists.
Read the full interactionEvery Supplement Checked Against Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine
All 1,452 ingredients in our database, ranked by severity — 282 with a Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interaction on file and 1,170 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.
Looking for an interaction with a specific supplement product? Search products instead ↓
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GrapefruitCitrus Paradisi Likely
What it is: Grapefruit is a nutritious citrus fruit rich in vitamin C and other nutrients, and it is generally safe to eat.
Grapefruit juice can increase levels of drugs metabolized by CYP3A4.
Read the full Grapefruit + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionSiberian Cocklebur Likely
What it is: Siberian cocklebur is a fruit used in traditional Chinese and other Asian herbal medicine, mainly for nasal congestion, sinus issues, and al...
Siberian cocklebur can adversely affect the kidney.
Read the full Siberian Cocklebur + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionActivated CharcoalActivated Carbon, animal Charcoal, carbo Vegetabilis, +13 more Probable
What it is: Activated charcoal is a highly porous form of carbon that can bind certain substances in the gut, and it is used in hospitals to treat some...
Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the route of administration.
Read the full Activated Charcoal + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionBeer Probable
What it is: Beer is an alcoholic beverage that contains some minerals, B vitamins, and plant compounds from hops and grain, but it is not a health suppl...
Concomitant use of alcohol with hepatotoxic drugs may increase the risk of hepatotoxicity.
Read the full Beer + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionEphedraEphedra Distachya, belcho, cao Mahuang, +13 more Probable
What it is: Ephedra (ma huang) contains powerful stimulants like ephedrine that affect the heart and nervous system.
Theoretically, concomitant use might increase the risk for serious adverse effects.
Read the full Ephedra + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionHenbaneHyoscyamus Niger, beleño, devil's Eye, +11 more Probable
What it is: Henbane is a highly poisonous plant containing potent alkaloids like hyoscyamine and scopolamine, and even small amounts can cause serious o...
Concomitant use of henbane can have additive anticholinergic effects and adverse effects with amantadine, antihistamines, atropine, belladonna alkaloids, hyoscyamine, phenothiazines, procainamide, scopolamine, and tricyclic antidepressants.
Read the full Henbane + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionLithiumCarbonate De Lithium, citrate De Lithium, lithium Aspartate, +8 more Probable
What it is: Lithium is a naturally occurring metal that, in prescription form (lithium carbonate or citrate), is an FDA-approved, well-proven treatment...
Theoretically, taking lithium supplements with serotonergic drugs might both mask and increase the risk of serotonin syndrome.
Read the full Lithium + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionPeyote Probable
What it is: Peyote is a small spineless cactus that contains mescaline, a powerful hallucinogen.
Concomitant use of peyote with stimulant drugs may increase the risk of adverse CNS effects.
Read the full Peyote + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionRauvolfia Vomitoria Probable
What it is: Rauvolfia vomitoria is an African shrub whose root contains powerful alkaloids, including reserpine, that have historically been used for hi...
Theoretically, concomitant use might cause additive effects.
Read the full Rauvolfia Vomitoria + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionScopoliaScopolia Carniolica, belladonna Scopola, escopolia, +6 more Probable
What it is: Scopolia is a poisonous plant in the nightshade family that contains powerful anticholinergic alkaloids like atropine, hyoscyamine, and scop...
The alkaloid constituents of scopolia, including hyoscyamine, scopolamine, and atropine, could potentiate the effects and adverse effects of anticholinergic drugs.
Read the full Scopolia + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionSida CordifoliaAbutilon En Épi, bala, bariar, +15 more Probable
What it is: Sida cordifolia (bala or country mallow) is a traditional Ayurvedic plant that naturally contains ephedrine, a powerful stimulant.
Theoretically, Sida cordifolia might increase the risk of adverse cardiovascular effects when taken with stimulant drugs.
Read the full Sida Cordifolia + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionSt. John's WortHypericum Perforatum, amber Touch-and-heal, barbe De Saint-jean, +13 more Probable
Wine Probable
What it is: Wine is an alcoholic beverage made from fermented grapes and is not a true dietary supplement or medicine.
Concomitant use of alcohol with hepatotoxic drugs may increase the risk of hepatotoxicity.
Read the full Wine + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionAsarabaccaAsarum Europaeum, asara, asari Herba, +12 more Possible
What it is: Asarabacca is a European woodland plant traditionally used to clear the nose, cause sweating, or trigger vomiting, but it is rarely used tod...
Asarabacca, a herbaceous plant, is often contaminated with aristolochic acid, a compound known for its nephrotoxic effects.
Read the full Asarabacca + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionAyahuascaAppane, ayahoasca, caapi, +19 more Probable
What it is: Ayahuasca is a powerful psychoactive brew that combines a DMT-containing plant with a vine that allows the DMT to take effect, causing inten...
Theoretically, ayahuasca might increase plasma concentrations of CYP2D6 substrates.
Read the full Ayahuasca + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionBelladonna Probable
What it is: Belladonna is a highly toxic plant whose alkaloids (like atropine and scopolamine) are powerful medicines used only in carefully controlled,...
Belladonna may increase the risk of adverse effects when used concomitantly with anticholinergic drugs.
Read the full Belladonna + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionBetel Nut Probable
What it is: Betel nut is the seed of the areca palm and is chewed by millions of people across Asia and the Pacific as a stimulant.
In vitro and animal research suggests that betel nut extract can inhibit acetylcholinesterase activity.
Read the full Betel Nut + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionBlack Tea Probable
What it is: Black tea is a popular caffeinated drink made from the fully oxidized leaves of the Camellia sinensis plant, and it contains caffeine and an...
Theoretically, concomitant use might increase stimulant adverse effects.
Read the full Black Tea + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionBrussels Sprout Probable
What it is: Brussels sprouts are a nutritious cruciferous vegetable rich in fiber, vitamin C, vitamin K, and plant compounds called glucosinolates.
A cabbage and Brussels sprout-containing diet seems to boost elimination through glucuronide conjugation.
Read the full Brussels Sprout + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionCabbageBrassica Oleracea, cabbage Leaf, chou, +13 more Probable
What it is: Cabbage is a nutritious, low-calorie vegetable that is safe to eat as food and is sometimes applied to the skin as a leaf wrap for breast en...
Theoretically, cabbage might increase clearance and decrease the effects of drugs metabolized through glucuronide conjugation.
Read the full Cabbage + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionCaffeine Probable
What it is: Caffeine is a natural stimulant found in coffee, tea, and many other plants and products.
Theoretically, concomitant use might increase stimulant adverse effects.
Read the full Caffeine + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionCannabidiol (cbd) Probable
What it is: CBD is a compound from the cannabis (hemp) plant that does not cause a 'high.' It has strong evidence only for certain rare seizure disorder...
Cannabidiol may increase levels of drugs metabolized by CYP1A2.
Read the full Cannabidiol (cbd) + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionCocoaTheobroma Cacao, chocolat, chocolat Noir, +14 more Probable
What it is: Cocoa is rich in plant compounds called flavanols that may modestly support blood vessel function and blood pressure, but most chocolate pro...
Theoretically, concomitant use might increase stimulant adverse effects.
Read the full Cocoa + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionCoffee Probable
What it is: Coffee is a widely consumed beverage made from roasted coffee beans, valued mainly for its caffeine, which boosts alertness and energy.
Theoretically, concomitant use might increase stimulant adverse effects.
Read the full Coffee + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionCoffee CharcoalCafé Arabica, café Carbonisé, café Robusta, +5 more Probable
What it is: Coffee charcoal is made by roasting green coffee beans until they turn black, creating a charcoal-like material used traditionally for diarr...
Coffee charcoal can reduce the absorption of orally administered drugs and should be separated from oral drug administration by at least two hours.
Read the full Coffee Charcoal + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionCola NutCola Acuminata, bissey Nut, bissy Nut, +10 more Probable
What it is: Cola nut is a caffeine-containing seed from West Africa used mainly as a natural stimulant for energy and alertness.
Theoretically, concomitant use might increase stimulant adverse effects.
Read the full Cola Nut + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionDatura Wrightii Probable
What it is: Datura wrightii (sacred datura or jimsonweed relative) is a highly poisonous desert plant that has been used in some traditional and ceremon...
Datura wrightii contains atropine and scopolamine, as well as other tropane alkaloids with anticholinergic activity.
Read the full Datura Wrightii + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionEuropean MandrakeMandragora Officinarum, alraunwurzel, mandragora, +7 more Probable
What it is: European mandrake is a highly toxic plant from the nightshade family that was used in ancient and medieval times as a sedative and pain reli...
Theoretically, concurrent use might increase absorption of some drugs because of inhibited gastrointestinal (GI) motility caused by European mandrake.
Read the full European Mandrake + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionEvodia Probable
What it is: Evodia is a fruit used in traditional Chinese medicine, most often for digestive complaints, headaches, and menstrual pain.
Evodia might reduce the levels and clinical effects of CYP1A2 substrates through induction of CYP1A2.
Read the full Evodia + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionFever BarkAlstonia Constricta, alstonia Bark, australian Febrifuge, +10 more Probable
What it is: Fever bark is the bark of the Australian tree Alstonia constricta, used in traditional medicine for fever, diarrhea, and infections.
Theoretically, fever bark might increase or decrease the effects of stimulant drugs.
Read the full Fever Bark + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionGarlicAllium Sativum, aged Black Garlic Extract, aged Garlic Extract, +16 more Probable
What it is: Garlic is a common food and supplement that may modestly help with blood pressure and cholesterol, though the evidence is mixed and effects...
Garlic might increase levels of drugs metabolized by CYP2E1.
Read the full Garlic + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionGlucomannanGlucomanano, glucomannane, konjac, +1 more Probable
What it is: Glucomannan is a soluble fiber from the konjac root that swells into a gel in your stomach, which may help with mild weight loss, constipati...
Theoretically, glucomannan may decrease absorption of drugs taken orally.
Read the full Glucomannan + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionGoldensealHydrastis Canadensis, chinese Goldenseal, eye Balm, +14 more Probable
What it is: Goldenseal is a popular North American herb that contains berberine, a compound studied for antimicrobial effects.
Goldenseal might increase serum levels of drugs metabolized by CYP2D6.
Read the full Goldenseal + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionGreen CoffeeCoffea Arabica, coffea Canephora, coffea Bukobensis, +2 more Probable
What it is: Green coffee is the unroasted bean of the coffee plant, prized for its high chlorogenic acid content.
Theoretically, concomitant use might increase stimulant adverse effects.
Read the full Green Coffee + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionGreen TeaCamellia Sinensis, green Sencha Tea, green Tea Extract, +17 more Probable
What it is: Green tea is a popular beverage rich in antioxidants called catechins, and drinking it in normal amounts is considered safe for most people.
Theoretically, concomitant use might increase stimulant adverse effects.
Read the full Green Tea + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionGuaranaPaullinia Cupana, brazilian Cocoa, cacao Brésilien, +3 more Probable
What it is: Guarana is an Amazonian seed that is naturally high in caffeine, which explains most of its stimulant and energy effects.
Theoretically, phenylpropanolamine might increase the risk of hypertension, as well as the levels and adverse effects of caffeine.
Read the full Guarana + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionGuggulCommiphora Wightii, devadhupa, gomme Guggul, +17 more Probable
What it is: Guggul is a gum resin from the Commiphora wightii tree, long used in Ayurvedic medicine for cholesterol, joint, and skin problems.
Theoretically, guggul might reduce the effects of CYP3A4 substrates.
Read the full Guggul + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionIlex Guayusa Probable
What it is: Ilex guayusa is a caffeine-containing holly leaf from the Amazon, traditionally brewed as a tea for energy and alertness, much like yerba ma...
Theoretically, concomitant use might increase stimulant adverse effects.
Read the full Ilex Guayusa + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionKavaPiper Methysticum, ava Pepper, ava Root, +20 more Probable
What it is: Kava is a Pacific Island plant traditionally used to promote relaxation and ease anxiety, and some studies suggest it may help mild anxiety.
Kava might increase levels of CYP2E1 substrates.
Read the full Kava + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionMelatoninN-acetyl-5-methoxytryptamine Probable
What it is: Melatonin is a hormone your body makes naturally to help control your sleep-wake cycle, and the supplement form is widely used to help with...
Theoretically, melatonin might increase levels of drugs metabolized by CYP1A2.
Read the full Melatonin + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionOolong Tea Probable
What it is: Oolong tea is a traditional partially oxidized tea made from the same plant as green and black tea, and it provides caffeine and plant antio...
Theoretically, concomitant use might increase stimulant adverse effects.
Read the full Oolong Tea + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionPsilocybin Probable
What it is: Psilocybin is a powerful psychedelic compound found in certain mushrooms and is being studied for hard-to-treat depression, anxiety, and add...
Theoretically, concomitant use of psilocybin with stimulant drugs might increase stimulant adverse effects.
Read the full Psilocybin + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionPu-erh Tea Probable
What it is: Pu-erh tea is a fermented, aged form of tea made from the same plant as green and black tea.
Theoretically, concomitant use might increase stimulant adverse effects.
Read the full Pu-erh Tea + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionResveratrolExtrait De Vin, extrait De Vin Rouge, kojo-kon, +16 more Probable
What it is: Resveratrol is a plant compound found in red grapes, berries, and peanuts that is popular for heart health, anti-aging, and antioxidant supp...
Resveratrol might increase levels of drugs metabolized by CYP2E1.
Read the full Resveratrol + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionSchisandraSchisandra Chinensis, bac Ngu Vi Tu, baie De Schisandra, +10 more Probable
What it is: Schisandra is a traditional Chinese medicine berry used as an adaptogen for stress, fatigue, and liver support.
Schisandra can increase the levels and clinical effects of drugs metabolized by CYP3A4.
Read the full Schisandra + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionSyrian Rue Probable
What it is: Syrian Rue (Peganum harmala) is a traditional plant whose seeds contain potent compounds called harmala alkaloids, including MAO-inhibiting...
Theoretically, Syrian rue might increase the levels and clinical effects of drugs metabolized by CYP2D6.
Read the full Syrian Rue + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionTree Turmeric Probable
What it is: Tree turmeric (Berberis aristata) is a shrub used in traditional Indian (Ayurvedic) medicine, valued mainly for its berberine content.
Theoretically, tree turmeric might increase the levels and clinical effects of drugs that are substrates of CYP3A4.
Read the full Tree Turmeric + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionYerba MateIlex Paraguariensis, chimarrao, green Mate, +14 more Probable
What it is: Yerba mate is a caffeine-containing herbal beverage from South America that is widely enjoyed for its stimulating, coffee-like effects.
Theoretically, concomitant use of stimulant drugs and yerba mate might increase stimulant adverse effects.
Read the full Yerba Mate + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interaction1,3-dmaaDmaa, dimethylamylamine Possible
What it is: DMAA (1,3-dimethylamylamine) is a synthetic stimulant that was sold in pre-workout and weight-loss supplements but has been linked to seriou...
1,3-DMAA strongly inhibits cytochrome P450 2D6 (CYP2D6) enzymes in vitro.
Read the full 1,3-dmaa + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interaction1,3-dmba Possible
What it is: 1,3-DMBA is a synthetic stimulant chemically similar to the banned stimulant DMAA, and it is not a proven or safe dietary ingredient.
Theoretically, combining 1,3-DMBA with other stimulant drugs might increase the risk of cardiovascular toxicity.
Read the full 1,3-dmba + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interaction1,4-dmaa Possible
What it is: 1,4-DMAA is a synthetic stimulant that the U.S.
1,4-DMAA is thought to have stimulant and vasoconstrictive effects, which have been demonstrated in animal studies.
Read the full 1,4-dmaa + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interaction5-htp5 Hydroxy-tryptophan, 5 Hydroxy-tryptophane, 5-hydroxytryptophan, +9 more Possible
What it is: 5-HTP is a compound your body uses to make serotonin, and people take it as a supplement hoping to improve mood, sleep, and headaches.
Combining serotonergic drugs with 5-HTP might cause additive serotonergic effects.
Read the full 5-htp + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionAcacia RigidulaVachellia Rigidula, acacia Rigidula, acaciopsis Rigidula, +3 more Possible
What it is: Acacia rigidula is a shrub from Texas and Mexico that is marketed in weight-loss and energy supplements.
Theoretically, Acacia rigidula products that are adulterated with beta-methylphenylethylamine (BMPEA) might increase the levels of CYP2D6 substrates.
Read the full Acacia Rigidula + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionAcetyl-l-carnitineAcetil-l-carnitina, acetyl Carnitine, acétyl Carnitine, +6 more Possible
What it is: Acetyl-L-carnitine is a form of the amino acid carnitine that the body uses to help produce energy in cells.
Theoretically, acetyl-L-carnitine might increase the risk of serotonergic side effects, including serotonin syndrome and cerebral vasoconstrictive disorders, when taken with serotonergic drugs.
Read the full Acetyl-l-carnitine + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionAconiteAconitum Napellus, aconitum, aconitum Angustifolium, +20 more Possible
What it is: Aconite is a highly poisonous plant, and even small amounts of the raw or improperly processed root can cause severe, life-threatening react...
Theoretically, combining aconite with other stimulant drugs might alter the effects of the stimulant drug or increase the risk of cardiovascular toxicity.
Read the full Aconite + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionActive Hexose Correlated Compound (ahcc) Possible
What it is: AHCC is a proprietary mushroom-derived supplement promoted mainly for immune support and to help people tolerate cancer treatment.
Theoretically, AHCC might increase levels of drugs metabolized by CYP2D6.
Read the full Active Hexose Correlated Compound (ahcc) + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionAdrafinilAdrafinilum, benzhydryl Sulfinyl Acetyl Hydroxamic Acid, crl-40028, +1 more Possible
What it is: Adrafinil is a synthetic compound that the body converts into modafinil, a prescription wakefulness-promoting drug.
Theoretically, adrafinil might reduce the levels and clinical effects of CYP1A2 substrates.
Read the full Adrafinil + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionAfrican Wild Potato Possible
What it is: African Wild Potato (Hypoxis hemerocallidea) is a southern African plant traditionally used as a tonic and for immune, prostate, and inflamm...
In vitro research shows that African wild potato extract inhibits cytochrome P450 1A2 (CYP1A2).
Read the full African Wild Potato + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionAmerican ElderSambucus Canadensis, american Elderberry, common Elderberry, +9 more Possible
What it is: American elder is a North American plant whose cooked, ripe berries and flowers are used mainly for colds, flu, and general immune support.
Theoretically, taking American elder might increase levels of CYP3A4 substrates.
Read the full American Elder + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionAngel's TrumpetBrugmansia Species, devil's Trumpet, floripondio, +5 more Possible
What it is: Angel's Trumpet is a highly poisonous ornamental plant that contains powerful toxins like scopolamine and atropine.
Concomitant use may increase anticholinergic effects and adverse effects.
Read the full Angel's Trumpet + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionAristolochiaAristolochia Auricularia, birthwort, guan Mu Tong, +15 more Possible
What it is: Aristolochia contains aristolochic acid, a potent toxin linked to severe kidney damage and cancer, and it is not safe to take.
Aristolochia is nephrotoxic.
Read the full Aristolochia + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionAshitabaAngelica Keiskei, angelica, ashitaba Du Japon, +6 more Possible
What it is: Ashitaba is a leafy plant from Japan that is eaten as a vegetable and taken as a supplement for general health, antioxidant, and heart benef...
In vitro research shows that ashitaba extract inhibits cytochrome P450 (CYP) 1A2.
Read the full Ashitaba + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionAshwagandhaWithania Somnifera, ajagandha, amangura, +17 more Possible
What it is: Ashwagandha is an Ayurvedic herb most often taken to help with stress, anxiety, and sleep, and some small studies suggest it may help, thoug...
Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.
Read the full Ashwagandha + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionAstaxanthinAstaxanthine, astaxantina, dihydroxy-3, +6 more Possible
What it is: Astaxanthin is a reddish carotenoid pigment with strong antioxidant activity in the lab, and it is widely promoted for skin, eye, heart, and...
Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
Read the full Astaxanthin + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionBacopaBacopa Monnieri, andri, brahmi, +11 more Possible
What it is: Bacopa is an Ayurvedic herb most often used for memory and thinking.
Theoretically, bacopa might increase the levels and adverse effects of CYP1A2 substrates.
Read the full Bacopa + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionBaikal SkullcapScutellaria Baicalensis, baikal Scullcap, baikal Skullcap Root, +16 more Possible
What it is: Baikal skullcap is a traditional Chinese herb (Huang Qin) used for inflammation, allergies, and infections, with active compounds like baica...
Theoretically, Baikal skullcap may increase levels of drugs metabolized by CYP1A2 enzymes.
Read the full Baikal Skullcap + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionBeetBeta Vulgaris, beet Greens, beet Juice, +19 more Possible
What it is: Beet, especially beetroot juice, is a nitrate-rich food that may modestly lower blood pressure and slightly improve exercise performance in...
Theoretically, beet might increase the levels of CYP3A4 substrates.
Read the full Beet + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionBerberineAlcaloïde De Berbérine, berberina, berbérine, +5 more Possible
What it is: Berberine is a yellow plant compound that has shown promise for lowering blood sugar and cholesterol in some studies, but the quality of res...
Theoretically, berberine might increase serum levels of drugs metabolized by CYP2D6.
Read the full Berberine + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionBeta-methylphenethylamine (bmpea) Possible
What it is: Beta-methylphenethylamine (BMPEA) is a synthetic stimulant chemically similar to amphetamine that has been found in some weight-loss and spo...
Theoretically, BMPEA might increase the levels and clinical effects of CYP2D6 substrates.
Read the full Beta-methylphenethylamine (bmpea) + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionBilberryVaccinium Myrtillus, airelle, arándano, +16 more Possible
What it is: Bilberry is a blueberry-like fruit rich in antioxidant plant compounds called anthocyanins, and it has a long history of traditional use for...
Theoretically, bilberry fruit extract might decrease levels of drugs metabolized by CYP2E1.
Read the full Bilberry + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionBishop's WeedAmmi Majus, Élevé, ammi Inodore, +12 more Possible
What it is: Bishop's Weed (Ammi majus) is a flowering plant whose seeds contain natural light-sensitizing compounds called psoralens, which have been st...
Bergapten, a constituent of bishop's weed, has been shown to inhibit cytochrome P450 3A4 (CYP3A4) in vitro.
Read the full Bishop's Weed + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionBitter OrangeCitrus Aurantium, aurantii Fructus, aurantium, +17 more Possible
What it is: Bitter orange is a citrus fruit whose extracts contain synephrine, a mild stimulant often added to weight-loss and energy supplements.
Bitter orange might increase levels of drugs metabolized by CYP3A4.
Read the full Bitter Orange + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionBlack CohoshActaea Racemosa, baie D'actée, baneberry, +10 more Possible
What it is: Black cohosh is a North American plant most often used to ease menopause symptoms like hot flashes, but the research is mixed and far from s...
Some research suggests that black cohosh might inhibit CYP2D6, but there is conflicting evidence.
Read the full Black Cohosh + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionBlack Hoof MushroomPhellinus Linteus, black Hoof Fungus, mesima, +5 more Possible
What it is: Black Hoof Mushroom (Phellinus linteus) is a medicinal mushroom long used in East Asian traditional medicine, mainly for immune support.
Theoretically, black hoof mushroom might increase the levels and clinical effects of CYP1A2 substrates.
Read the full Black Hoof Mushroom + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionBlack PepperPiper Nigrum, black Peppercorn, extrait De Poivre, +23 more Possible
What it is: Black pepper is a common kitchen spice that is generally safe in the amounts used in food.
Theoretically, black pepper might increase levels of drugs metabolized by CYP2D6.
Read the full Black Pepper + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionBlack SeedNigella Sativa, black Caraway, black Cumin, +18 more Possible
What it is: Black seed (Nigella sativa) is a traditional spice and remedy that has been studied for asthma, blood sugar, cholesterol, and blood pressure...
Theoretically, combining serotonergic drugs with black seed might increase the risk of serotonergic side effects, including serotonin syndrome and cerebral vasoconstrictive disorders.
Read the full Black Seed + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionBog Labrador TeaRhododendron Groenlandicum, bog Tea, continental Tea, +12 more Possible
What it is: Bog Labrador tea is a wetland shrub whose leaves have long been brewed as a traditional beverage and folk remedy, especially among Indigenou...
In vitro research shows that aqueous and ethanolic extracts of Bog Labrador tea leaves can increase the concentration of cytochrome P450 3A4 (CYP3A4) enzymes.
Read the full Bog Labrador Tea + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionBoldoPeumus Boldus, boldine, boldo Folium, +4 more Possible
What it is: Boldo is a South American shrub whose leaves are traditionally used for digestive and gallbladder complaints, but good human evidence is ver...
Theoretically, taking boldo with hepatotoxic drugs might increase the risk of hepatic injury and disease.
Read the full Boldo + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionBoswellia SerrataBoswellia Serrata, arbre à Oliban Indien, boswella, +10 more Possible
What it is: Boswellia serrata is a tree resin used in traditional medicine, mainly for joint pain and inflammation.
Theoretically, Boswellia serrata might increase the levels of CYP2D6 substrates.
Read the full Boswellia Serrata + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionBoxwoodBuxus Sempervirens, bois D'artois, bois Béni, +15 more Possible
What it is: Boxwood is an evergreen shrub whose leaves have been used in folk medicine, most notably in some early studies looking at HIV.
Evidence from in vitro research suggests that boxwood extract can inhibit acetylcholinesterase activity.
Read the full Boxwood + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionBreadfruit Possible
What it is: Breadfruit is a starchy tropical fruit eaten as a staple food, and its leaves are used in traditional medicine for conditions like high bloo...
Breadfruit might increase the levels of drugs metabolized by uridine diphosphoglucuronosyl transferase (UGT).
Read the full Breadfruit + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionBroccoli Possible
What it is: Broccoli is a nutritious cruciferous vegetable rich in fiber, vitamins, and plant compounds like sulforaphane that have drawn scientific int...
Theoretically, broccoli might reduce the levels and effects of drugs metabolized by CYP1A2.
Read the full Broccoli + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionBuchuAgathosma Betulina, anysboegoe, barasmae Folium, +12 more Possible
What it is: Buchu is a fragrant South African shrub whose leaves are traditionally used for urinary and bladder complaints and as a diuretic.
Buchu contains pulegone, a known hepatotoxin.
Read the full Buchu + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionBulbine Natalensis Possible
What it is: Bulbine natalensis is a South African plant marketed mainly as a testosterone-boosting and libido supplement, but the human evidence is esse...
Theoretically, Bulbine natalensis stem might reduce the levels and clinical effects of CYP1A2 substrates.
Read the full Bulbine Natalensis + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionButcher's BroomRuscus Aculeatus, balai Du Boucher, box Holly, +17 more Possible
What it is: Butcher's broom is a plant extract most often used for circulation problems in the legs, such as chronic venous insufficiency, where some ev...
Theoretically, butcher's broom might increase the effects and adverse effects of alpha-adrenergic agonists.
Read the full Butcher's Broom + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionCajeput OilMelaleuca Leucadendra, aceite De Cajeput, cajeputi Aetheroleum, +10 more Possible
What it is: Cajeput oil is an aromatic essential oil traditionally used for aches, congestion, and minor skin complaints, but solid human evidence for t...
Evidence from in vitro research suggests that cajeput leaf extract can inhibit cytochrome P450 2D6 (CYP2D6) by approximately 30%.
Read the full Cajeput Oil + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionCalamusAcorus Calamus, acore Calame, acore Odorant, +20 more Possible
What it is: Calamus is a swamp plant with a long history in Ayurvedic and traditional Chinese medicine, mostly for digestive and nervous-system complain...
Theoretically, taking calamus with drugs metabolized by CYP2D6 might increase drug levels and potentially increase the risk of adverse effects.
Read the full Calamus + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionCalcium D-glucarate Possible
What it is: Calcium D-glucarate is a supplement form of a natural compound found in fruits and vegetables that is promoted for 'detoxification' and help...
Theoretically, calcium D-glucarate might increase the clearance of drugs that undergo glucuronidation.
Read the full Calcium D-glucarate + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionCamphor Possible
What it is: Camphor is a strong-smelling compound from the camphor tree (or made synthetically) that is used in many topical rub-on products for muscle...
Theoretically, concomitant use of camphor with other hepatotoxic drugs might increase the risk of liver damage.
Read the full Camphor + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionCannabinol (cbn) Possible
What it is: Cannabinol (CBN) is a minor cannabinoid found in the cannabis plant, often marketed as a 'sleep' aid, but solid human research is very limit...
Theoretically, cannabinol might increase the levels and clinical effects of CYP2E1 substrates.
Read the full Cannabinol (cbn) + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionCannabisCannabis Sativa, anashca, banji, +25 more Possible
What it is: Cannabis contains many active compounds, mainly THC (which causes a 'high') and CBD (which does not).
Theoretically, cannabis may increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cannabis + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionCassia CinnamonCinnamomum Aromaticum, bastard Cinnamon, chinese Cinnamon, +1 more Possible
What it is: Cassia cinnamon is the common, inexpensive cinnamon used in cooking, and it is also taken as a supplement, most often for blood sugar suppor...
Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
Read the full Cassia Cinnamon + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionCat's ClawGriffe Du Chat, hawk's Claw, liane Du Pérou, +4 more Possible
What it is: Cat's claw is a South American vine traditionally used for inflammation, joint pain, and immune support.
Theoretically, cat's claw might increase or decrease the levels and effects of drugs metabolized by CYP3A4.
Read the full Cat's Claw + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionCatechuBlack Catechu, acacia Catechu: Acacia à Cachou, acacia Catechu Heartwood Extract, +17 more Possible
What it is: Catechu is an astringent extract made from the heartwood of the Acacia (Senegalia) catechu tree, used traditionally for mouth sores, sore th...
Theoretically, black catechu may increase the levels and clinical effects of CYP1A2 substrates.
Read the full Catechu + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionCauliflower Possible
What it is: Cauliflower is a nutritious cruciferous vegetable that provides vitamin C, fiber, and plant compounds called glucosinolates.
Preliminary clinical evidence suggests that eating cruciferous vegetables, including broccoli, cauliflower, daikon radish sprouts, and cabbage, can increase cytochrome P450 1A2 (CYP1A2) activity by 14% to 27%.
Read the full Cauliflower + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionCeleryApium Graveolens, ache Des Marais, ajamoda, +13 more Possible
What it is: Celery is a common vegetable that is also taken as a seed extract or oil supplement, mainly for blood pressure, fluid retention, and joint d...
Theoretically, celery might increase levels of drugs metabolized by CYP1A2.
Read the full Celery + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionCeylon Leadwort Possible
What it is: Ceylon Leadwort (Plumbago zeylanica) is a plant long used in Ayurvedic and other traditional medicine systems, mainly for digestion, skin pr...
Plumbagin, a constituent of Ceylon leadwort, has been shown to inhibit cytochrome P450 2D6 (CYP2D6) in vitro.
Read the full Ceylon Leadwort + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionChanca PiedraPhyllanthus Niruri, amli, arranca-pedras, +16 more Possible
What it is: Chanca piedra is a tropical herb traditionally used as a 'stone breaker' for kidney and gallstones, and for liver and urinary health.
Theoretically, chanca piedra might reduce the levels and clinical effects of CYP1A2 substrates.
Read the full Chanca Piedra + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionChaparralLarrea Divaricata, creosote Bush, créosotier, +4 more Possible
What it is: Chaparral is a desert shrub long used in traditional medicine, but there is no reliable proof it treats any condition.
Theoretically, chaparral might have additive adverse effects on the liver when used with hepatotoxic drugs.
Read the full Chaparral + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionChokeberryAronia Arbutifolia, aronia Melanocarpa, aronia Nigra, +1 more Possible
What it is: Chokeberry (aronia) is a dark berry rich in antioxidants called polyphenols, and it's widely eaten as juice, jam, and supplements.
Theoretically, chokeberry might increase levels of drugs metabolized by CYP3A4.
Read the full Chokeberry + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionCinchonaCinchona Calisaya, arbol De La Quina, bois Aux Fièvres, +14 more Possible
What it is: Cinchona bark is the natural source of quinine and has been used for centuries to treat malaria and fever, but the bark itself is not standa...
Theoretically, taking cinchona might inhibit cytochrome P450 2D6 (CYP2D6) and increase levels of drugs metabolized by this enzyme.
Read the full Cinchona + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionCloveSyzygium Aromaticum, bourgeon Floral De Clou De Girofle, bouton Floral De Clou De Girofle, +12 more Possible
What it is: Clove is a common cooking spice that is also used in traditional medicine, especially as a topical numbing agent for tooth pain thanks to it...
Theoretically, concomitant use of clove may increase levels of drugs metabolized by CYP2D6.
Read the full Clove + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionClubmossLycopodium Clavatum, club Moss, common Clubmoss, +12 more Possible
What it is: Clubmoss (Lycopodium clavatum) is a primitive plant with a long history in folk medicine and homeopathy, but there is very little reliable h...
Evidence from in vitro research suggests that clubmoss extract can inhibit acetylcholinesterase activity.
Read the full Clubmoss + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionColeus6beta, 17beta-acetoxy-8, 13-epoxy-1alpha, +15 more Possible
What it is: Coleus is a plant from the mint family whose root contains a compound called forskolin, often marketed for weight loss, asthma, and heart he...
Theoretically, taking coleus might decrease serum levels of drugs metabolized by CYP3A4.
Read the full Coleus + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionComfreySymphytum Officinale, ass Ear, beinwellwurzel, +15 more Possible
What it is: Comfrey is a traditional herb used mainly on the skin for bruises, sprains, and joint pain, and some topical products show modest benefit fo...
Theoretically, comfrey might have additive adverse effects on the liver when used with hepatotoxic drugs.
Read the full Comfrey + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionCorkwood Tree Possible
What it is: Corkwood Tree (Duboisia myoporoides) is an Australian plant best known as a commercial source of powerful tropane alkaloids like scopolamine...
Theoretically, corkwood tree might increase the risk of adverse anticholinergic effects when taken with anticholinergic drugs.
Read the full Corkwood Tree + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionCorydalis Yanhusuo Possible
What it is: Corydalis yanhusuo is a traditional Chinese herb used mainly for pain.
Theoretically, Corydalis yanhusuo might increase serum levels of drugs metabolized by CYP2D6.
Read the full Corydalis Yanhusuo + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionCranberryVaccinium Macrocarpon, agrio, american Cranberry, +16 more Possible
What it is: Cranberry is best known for helping to prevent repeated urinary tract infections (UTIs) in some people, and the evidence here is moderate bu...
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionCubebsPiper Cubeba, cubeb, cubeb Berries, +14 more Possible
What it is: Cubebs are spicy, peppery berries from a vine in the pepper family that have long been used in traditional medicine for coughs, digestion, a...
Several compounds isolated from cubebs can inhibit cytochrome P450 3A4 (CYP3A4) in vitro.
Read the full Cubebs + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionDandelionTaraxacum Officinale, blowball, cankerwort, +17 more Possible
What it is: Dandelion is a common plant used in food and traditional medicine, often promoted as a natural 'water pill' and digestive aid.
Theoretically, dandelion might increase levels of drugs metabolized by CYP1A2.
Read the full Dandelion + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionDanshenSalvia Bowleyana, ch'ih Shen, chinese Red Sage, +15 more Possible
What it is: Danshen is a root used in traditional Chinese medicine, mainly for heart and circulation problems.
Theoretically, danshen may increase the levels and clinical effects of drugs metabolized by CYP1A2.
Read the full Danshen + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionDelta-9-tetrahydrocannabinol (thc)Bho, black Glass, budder, +9 more Possible
What it is: THC is the main mind-altering compound in cannabis and is best known for causing a 'high.' A prescription form (dronabinol) is approved for...
Theoretically, THC might decrease the levels and clinical effects of CYP2E1 substrates.
Read the full Delta-9-tetrahydrocannabinol (thc) + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionDevil's ClawHarpagophytum Procumbens, devils Claw, devil's Claw Root, +9 more Possible
What it is: Devil's claw is a southern African plant used mainly for arthritis and back pain, and some studies suggest it may help ease these types of d...
Theoretically, devil's claw might increase levels of drugs metabolized by CYP3A4.
Read the full Devil's Claw + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionDhea3b-hydroxy-androst-5-ene-17-one, 3betahydroxy-androst-5-ene-17-one, androstenolone, +4 more Possible
What it is: DHEA is a natural hormone that the body makes and that declines with age, and it is sold as a supplement claiming many benefits.
Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.
Read the full Dhea + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionDimethylhexylamine (dmha) Possible
What it is: DMHA (dimethylhexylamine, also called octodrine) is a synthetic stimulant added to some pre-workout and weight-loss supplements, often false...
Theoretically, combining DMHA with stimulant drugs might increase the risk of adverse cardiovascular effects.
Read the full Dimethylhexylamine (dmha) + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionDiosmin Possible
What it is: Diosmin is a citrus-derived flavonoid most often used for vein-related problems such as chronic venous insufficiency and hemorrhoids, and it...
Theoretically, diosmin might inhibit the metabolism of CYP3A4 substrates.
Read the full Diosmin + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionEchinaceaAmerican Cone Flower, black Sampson, black Susans, +7 more Possible
What it is: Echinacea is a popular herb taken to help prevent or shorten the common cold, but study results are mixed and the overall benefit appears sm...
Echinacea might inhibit the metabolism of CYP1A2 and increase plasma levels of some drugs.
Read the full Echinacea + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionEleutheroEleutherococcus Senticosus, acanthopanax Obovatus, ciwujia Root, +13 more Possible
What it is: Eleuthero is an herb traditionally used as an 'adaptogen' to fight fatigue, boost energy, and help the body handle stress.
Theoretically, eleuthero might increase levels of drugs metabolized by CYP1A2.
Read the full Eleuthero + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionEnglish IvyHedera Helix, common Ivy, gum Ivy, +9 more Possible
What it is: English ivy leaf extract is most commonly used in cough and cold syrups to help loosen mucus and ease coughing, and it is a popular ingredie...
Theoretically, English ivy might increase the levels of drugs metabolized by CYP2D6.
Read the full English Ivy + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionEpistane Possible
What it is: Epistane is a synthetic anabolic steroid (a methylated 'designer steroid'), not a true dietary supplement or herb, even though it has been s...
Theoretically, concomitant use might have additive adverse hepatotoxic effects.
Read the full Epistane + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionErgotClaviceps Purpurea, cockspur Rye, cornezuelo, +7 more Possible
What it is: Ergot is a toxic fungus that grows on rye and contains powerful chemicals (ergot alkaloids) that strongly narrow blood vessels and squeeze t...
Certain ergot alkaloids, such as dihydroergotamine, act as serotonin agonists.
Read the full Ergot + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionEucalyptusEucalyptus Globulus, blue Gum, blue Mallee, +13 more Possible
What it is: Eucalyptus is best known for its strong-smelling oil used in vapor rubs, inhalants, and lozenges to ease coughs and congestion.
Theoretically, eucalyptus might increase the levels of CYP1A2 substrates.
Read the full Eucalyptus + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionEuropean BarberryBerberis Vulgaris, agracejo, barberry, +15 more Possible
What it is: European barberry is a shrub whose root, bark, and berries contain berberine, a bitter plant alkaloid that has been studied mostly in isolat...
Theoretically, European barberry might increase the levels and clinical effects of CYP3A4 substrates.
Read the full European Barberry + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionFalse UnicornChamaelirium Luteum, alétris, blazing Star, +9 more Possible
What it is: False Unicorn is a North American plant whose root has long been used in traditional medicine for women's reproductive and menstrual concern...
In vitro, false unicorn extract inhibits cytochrome P450 2D6 (CYP2D6) activity.
Read the full False Unicorn + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionFennelFoeniculum Vulgare, adas, almindelig Fennikel, +20 more Possible
What it is: Fennel is a Mediterranean herb widely used as a food and spice, and traditionally taken for digestive complaints, colic, and menstrual cramp...
Theoretically, fennel might increase levels of drugs metabolized by CYP3A4.
Read the full Fennel + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionFermented Wheat Germ Extract Possible
What it is: Fermented wheat germ extract is a supplement made by fermenting wheat germ with yeast, and it is most often marketed for people going throug...
Theoretically, concomitant use of fermented wheat germ extract with serotonergic medications may increase the risk of serotonergic adverse effects.
Read the full Fermented Wheat Germ Extract + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionFeverfewTanacetum Parthenium, altamisa, bachelor's Buttons, +13 more Possible
What it is: Feverfew is a daisy-family herb best known for migraine prevention, where some studies suggest it may modestly lower how often migraines occ...
Theoretically, feverfew might increase levels of drugs metabolized by CYP2D6.
Read the full Feverfew + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionFo-ti Possible
What it is: Fo-ti (He Shou Wu) is a root used in traditional Chinese medicine, often promoted for healthy aging and hair.
Theoretically, fo-ti may increase the levels and clinical effects of drugs metabolized by CYP2D6.
Read the full Fo-ti + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionGarciniaGarcinia Gummi-gutta, acide Hydroxycitrique, ahc, +11 more Possible
What it is: Garcinia is a tropical fruit whose rind contains hydroxycitric acid (HCA), widely marketed for weight loss and appetite control.
Theoretically, combining garcinia with other serotonergic drugs might increase the risk of serotonergic side effects, including serotonin syndrome.
Read the full Garcinia + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionGerman ChamomileMatricaria Recutita, blue Chamomile, camomèle, +12 more Possible
What it is: German chamomile is a widely used herbal remedy taken mainly as a tea for calming, sleep, and digestive complaints.
Theoretically, German chamomile might inhibit CYP2D6 and increase levels of drugs metabolized by these enzymes.
Read the full German Chamomile + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionGingerZingiber Officinale, african Ginger, ardraka, +21 more Possible
What it is: Ginger is a widely used culinary spice with a long history in traditional medicine, and it has the strongest evidence for helping with nause...
Ginger might increase or decrease the levels of CYP3A4 substrates.
Read the full Ginger + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionGinkgoGinkgo Biloba, abricot Argenté Japonais, adiantifolia, +13 more Possible
What it is: Ginkgo is one of the world's most popular herbal supplements, mostly taken to support memory and circulation.
Theoretically, ginkgo might increase levels of drugs metabolized by CYP1A2.
Read the full Ginkgo + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionGojiLycium Chinense, lycium Barbarum, barberry Matrimony Vine, +15 more Possible
What it is: Goji berries are a nutritious fruit rich in antioxidants, vitamins, and plant polysaccharides, and they are safe for most people as a food.
Theoretically, goji berry might inhibit CYP2D6 and reduce metabolism of CYP2D6 substrates.
Read the full Goji + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionGoldthreadCoptis Chinensis, cankerroot, chinese Coptis, +13 more Possible
What it is: Goldthread is a traditional Chinese and East Asian herb whose root is rich in berberine, a compound being studied for blood sugar, cholester...
There's very preliminary evidence that berberine, a constituent of goldthread, might inhibit cytochrome P450 3A4 (CYP3A4) enzyme.
Read the full Goldthread + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionGotu KolaCentella Asiatica, asiatic Pennywort, brahma-buti, +12 more Possible
What it is: Gotu kola is a traditional Ayurvedic and Asian herb that people use for wound healing, circulation, skin problems, and as a calming or memor...
Theoretically, taking gotu kola with hepatotoxic drugs might have additive adverse effects.
Read the full Gotu Kola + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionGrapeVitis Vinifera, activin, black Grape Raisins, +10 more Possible
What it is: Grapes and grape products like grape seed extract contain antioxidant compounds such as resveratrol and proanthocyanidins that may support h...
Theoretically, grape seed extract may increase the levels of CYP2D6 substrates.
Read the full Grape + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionGreater CelandineChelidonium Majus, bai Qu Cai, celandine, +9 more Possible
What it is: Greater celandine is a traditional herb most often promoted for digestive and gallbladder complaints, but solid human evidence for any use i...
Research in vitro shows that chelidonine, a constituent of greater celandine, inhibits cytochrome P450 2D6 (CYP2D6) enzyme activity.
Read the full Greater Celandine + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionGriffonia SimplicifoliaBandeiraea Simplicifolia Possible
What it is: Griffonia simplicifolia is a West African shrub whose seeds are a natural source of 5-HTP, a building block of the brain chemical serotonin.
Theoretically, taking Griffonia simplicifolia seed extract with dextromethorphan might increase the risk of serotonergic adverse effects, such as serotonin syndrome and cerebral vasoconstrictive disorders such as Call-Fleming syndrome.
Read the full Griffonia Simplicifolia + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionGuar GumDietary Fiber, farine De Guar, fibre Alimentaire, +10 more Possible
What it is: Guar gum is a soluble, gel-forming fiber from the guar bean that may modestly help with cholesterol, blood sugar, and bowel regularity.
Guar gum might reduce the absorption of some oral drugs, potentially decreasing their effectiveness.
Read the full Guar Gum + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionGum ArabicAcacia, acacia Gum, arabic Gum, +16 more Possible
What it is: Gum arabic is a soluble dietary fiber from the acacia tree that is widely used as a safe food additive and is sometimes taken as a supplemen...
Theoretically, gum arabic can alter the absorption of oral drugs due to its fiber content.
Read the full Gum Arabic + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionGymnemaGymnema Sylvestre, gimnema, gur-mar, +14 more Possible
What it is: Gymnema is an Ayurvedic herb best known for possibly helping lower blood sugar and reducing the taste of sweetness on the tongue.
Theoretically, gymnema might increase levels of drugs metabolized by CYP1A2.
Read the full Gymnema + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionHawaiian Baby WoodroseArgyreia Nervosa, baby Hawaiian Woodrose, baby Woodrose, +11 more Possible
What it is: Hawaiian Baby Woodrose seeds contain LSD-like compounds and are most often used recreationally to cause hallucinations, not as a safe or pro...
Theoretically, concomitant use may increase the risk for serotonergic adverse effects.
Read the full Hawaiian Baby Woodrose + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionHemp AgrimonyEupatorium Cannabinum, alpenkraut, cañamazo, +15 more Possible
What it is: Hemp agrimony is a traditional European herb that has been used for digestion, colds, and as a general tonic, but there is very little relia...
Hemp agrimony contains hepatotoxic pyrrolizidine alkaloids (PA).
Read the full Hemp Agrimony + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionHigenamine Possible
What it is: Higenamine is a plant-based stimulant compound added to many weight-loss and pre-workout supplements, but there is very little human evidenc...
Theoretically, higenamine might increase the levels and clinical effects of drugs metabolized by CYP2D6.
Read the full Higenamine + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionHordenineAnhalinine Possible
What it is: Hordenine is a natural alkaloid found in barley and some cacti that is marketed as a stimulant for energy, focus, and fat loss, but solid hu...
Hordenine is structurally similar to N-methyltyramine and synephrine, constituents in bitter orange known to have stimulant properties.
Read the full Hordenine + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionHorny Goat WeedEpimedium Grandiflorum, barrenwort, Épimède, +10 more Possible
What it is: Horny goat weed (Epimedium) is a traditional Chinese herb most often marketed for low libido and erectile problems, but solid human evidence...
Theoretically, horny goat weed might increase the effects and side effects of CYP1A2 substrates.
Read the full Horny Goat Weed + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionHu Zhang Possible
What it is: Hu Zhang (Japanese knotweed root) is a traditional Chinese herb that is one of the richest natural sources of resveratrol and emodin.
Theoretically, hu zhang might increase levels of drugs metabolized by CYP1A2.
Read the full Hu Zhang + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionHuperzine AHupa, huperzina A, huperzine, +3 more Possible
What it is: Huperzine A is a purified compound from a Chinese clubmoss that acts like a mild cholinesterase inhibitor, similar in mechanism to some pres...
Theoretically, huperzine A might decrease the effects of anticholinergic drugs.
Read the full Huperzine A + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionIbogaTabernanthe Iboga, bois Sacré, eboka Possible
What it is: Iboga is a Central African shrub whose root bark contains ibogaine, a powerful hallucinogenic compound studied mainly for addiction.
Theoretically, taking iboga with serotonergic drugs might increase levels of serotonin, resulting in additive effects with serotonergic drugs.
Read the full Iboga + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionIndian Long PepperPiper Longum, bi Ba, bi Bo, +17 more Possible
What it is: Indian long pepper (pippali) is a spice long used in Ayurvedic medicine and is best known for its piperine content, which may increase how w...
Theoretically, Indian long pepper might increase the effects and adverse effects of CYP3A4 substrates.
Read the full Indian Long Pepper + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionIndian SnakerootRauvolfia Serpentina, ajmaline, alseroxylon, +16 more Possible
What it is: Indian snakeroot is a traditional Ayurvedic plant that contains reserpine, a compound with real blood-pressure-lowering and sedative effects...
Theoretically, Indian snakeroot might inhibit CYP2D6 enzymes and reduce the metabolism of CYP2D6 substrates.
Read the full Indian Snakeroot + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionIndole-3-carbinol Possible
What it is: Indole-3-carbinol (I3C) is a compound formed when you eat cruciferous vegetables like broccoli and cabbage, and it is sold as a supplement m...
Theoretically, indole-3-carbinol might increase the metabolism of CYP1A2 substrates and lower serum concentrations.
Read the full Indole-3-carbinol + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionIpriflavone7-isopropoxyisoflavone, ipriflavona Possible
What it is: Ipriflavone is a synthetic isoflavone studied mainly for bone health and osteoporosis, but high-quality research has not shown that it relia...
Ipriflavone is thought to competitively inhibit cytochrome P450 1A2 (CYP1A2).
Read the full Ipriflavone + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionIsopropylnorsynephrine Possible
What it is: Isopropylnorsynephrine is a synthetic stimulant chemically related to synephrine, marketed mainly in weight-loss and pre-workout supplements...
Theoretically, taking isopropylnorsynephrine with stimulant drugs might have additive effects and increase the risk of adverse cardiovascular effects.
Read the full Isopropylnorsynephrine + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionJimson Weed Possible
What it is: Jimson Weed is a highly poisonous plant that contains powerful nerve-affecting compounds, and even small amounts can cause severe poisoning,...
Theoretically, jimson weed may increase anticholinergic effects and adverse effects.
Read the full Jimson Weed + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionJob's Tears Possible
What it is: Job's Tears is a grain-like seed long used as a food and in traditional medicine, especially in East Asia.
Animal research suggests that Job's tears might enhance absorption of dextromethorphan in the small intestine.
Read the full Job's Tears + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionKhatCatha Edulis, abessinischer Tea, abyssinian Tea, +23 more Possible
What it is: Khat is a plant chewed for its amphetamine-like stimulant effects, but it carries serious risks including high blood pressure, heart problem...
Cathinone, a constituent of khat, appears to have sympathomimetic effects and can increase blood pressure and heart rate.
Read the full Khat + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionKhellaAmmi Visnaga, ammi Daucoides, daucus Visnaga, +13 more Possible
What it is: Khella is a Mediterranean herb whose seeds contain compounds like khellin that may relax smooth muscle in the airways and blood vessels.
Theoretically, khella might have additive adverse effects on the liver when used with hepatotoxic drugs.
Read the full Khella + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionKratomMitragyna Speciosa, biak-biak, cratom, +16 more Possible
What it is: Kratom is a Southeast Asian plant whose leaves act on the brain's opioid receptors and can produce both stimulant-like and opioid-like effec...
Theoretically, taking kratom in combination with serotonergic drugs may increase levels of serotonin, increasing the risk of serotonin syndrome.
Read the full Kratom + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionKudzuPueraria Montana, bidarikand, bilaikanda, +18 more Possible
What it is: Kudzu is a fast-growing vine whose root has long been used in traditional Chinese medicine and is now studied mostly for reducing alcohol in...
Theoretically, concomitant use might have additive hepatotoxic effects.
Read the full Kudzu + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionL-tryptophanL-triptofano, l-trypt, l-tryptophane, +1 more Possible
What it is: L-tryptophan is an essential amino acid the body uses to make serotonin and melatonin, and people take it to support sleep and mood.
Theoretically, combining L-tryptophan with serotonergic drugs might cause additive serotonergic effects.
Read the full L-tryptophan + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionLemongrassCymbopogon Citratus, abafado, cana Santa, +17 more Possible
What it is: Lemongrass is a fragrant tropical grass widely used as a cooking herb, a tea, and an aromatherapy oil.
Theoretically, lemongrass might decrease the metabolism of CYP3A4 substrates.
Read the full Lemongrass + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionLentinanBeta-glucan Lentinan, lentinane, lentinus Edodes Polysaccharide, +4 more Possible
What it is: Lentinan is a beta-glucan polysaccharide from shiitake mushrooms that is studied mainly as an immune-modulating add-on to cancer chemotherap...
Laboratory research suggests that lentinan might increase the activity of cytochrome P450 2D6 (CYP2D6).
Read the full Lentinan + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionLicoriceGlycyrrhiza Echinate, alcacuz, bois Doux, +17 more Possible
What it is: Licorice root is a traditional remedy used for sore throats, coughs, and digestive complaints, but solid human evidence is limited for most...
Theoretically, licorice might increase or decrease levels of drugs metabolized by CYP3A4.
Read the full Licorice + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionLigandrol Possible
What it is: Ligandrol (LGD-4033) is a synthetic selective androgen receptor modulator (SARM), not a natural herb or approved dietary supplement.
Theoretically, concomitant use might have additive hepatotoxic effects.
Read the full Ligandrol + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionLimeCitrus Aurantifolia, adam's Apple, bara Nimbu, +11 more Possible
What it is: Lime is a common citrus fruit and a good natural source of vitamin C and plant antioxidants.
Animal research shows that phenolics in lime juice inhibit cytochrome P450 3A4.
Read the full Lime + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionMace Possible
What it is: Mace is the lacy red covering of the nutmeg seed and comes from the same tree as nutmeg.
Animal research suggests that intraperitoneal injections of myristicin, a constituent of mace, can induce cytochrome P450 1A2 (CYP1A2) enzyme system.
Read the full Mace + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionManchurian Thorn Possible
What it is: Manchurian Thorn (Aralia elata) is a thorny shrub or small tree used in traditional East Asian medicine, mainly for blood sugar, joint pain,...
Animal research suggests that high doses of Manchurian thorn can induce liver damage.
Read the full Manchurian Thorn + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionMarjoramOriganum Majorana, essence De Marjolaine, garden Marjoram, +12 more Possible
What it is: Marjoram is a Mediterranean kitchen herb related to oregano that is widely used in food and traditional medicine for digestive, sleep, and r...
In vitro research suggests that marjoram extract can inhibit acetylcholinesterase activity.
Read the full Marjoram + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionMethoxylated Flavones Possible
What it is: Methoxylated flavones (often called polymethoxyflavones) are a group of plant compounds, found mainly in citrus peel, that include substance...
Some in vitro evidence suggests that methoxylated flavones might induce CYP1A2, possibly by increasing gene transcription.
Read the full Methoxylated Flavones + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionMethylene Blue3, 7-bis (dimethylamino)-phenazathionium Chloride, Azul De Metileno, +8 more Possible
What it is: Methylene blue is a synthetic dye that is an FDA-approved prescription medicine for a rare blood disorder called methemoglobinemia, and it i...
Combining serotonergic drugs with methylene blue can cause additive serotonergic effects, including serotonin syndrome.
Read the full Methylene Blue + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionMethylsynephrine Possible
What it is: Methylsynephrine (also called oxilofrine) is a synthetic stimulant sometimes added to weight-loss and pre-workout products, but it is not a...
Methylsynephrine has cardiac stimulant effects.
Read the full Methylsynephrine + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionMilk ThistleSilybum Marianum, artichaut Sauvage, blessed Milk Thistle, +12 more Possible
What it is: Milk thistle is a popular herbal supplement most often used for liver health, and its main active component is a group of compounds called s...
Theoretically, milk thistle might affect the clearance of drugs that undergo glucuronidation.
Read the full Milk Thistle + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionMoringaMoringa Oleifera Possible
What it is: Moringa is a nutrient-rich plant whose leaves are widely used as a food and supplement, especially in parts of the world where malnutrition...
Theoretically, moringa might increase or decrease levels of CYP3A4 substrates.
Read the full Moringa + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionMountain AshSorbus Aucuparia, arbre Aux Grives, corbier D'europe, +12 more Possible
What it is: Mountain ash (rowan) is a northern-hemisphere tree whose bright red berries are traditionally cooked into jams, syrups, and teas.
Taking large amounts of fresh mountain ash berries may cause kidney damage due to its parasorbic acid constituent.
Read the full Mountain Ash + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionN,n-dmpea Possible
What it is: N,N-DMPEA (N,N-dimethylphenethylamine) is a synthetic relative of phenethylamine sometimes marketed in stimulant or pre-workout supplements.
In vitro research shows that N,N-DMPEA strongly inhibits cytochrome P450 2D6 (CYP2D6).
Read the full N,n-dmpea + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionNeemAzadirachta Indica, arishta, arishtha, +18 more Possible
What it is: Neem is a tree from India used for centuries in traditional medicine, especially for skin, dental, and antimicrobial purposes.
Theoretically, neem leaf extract might increase the levels and clinical effects of CYP1A2 substrates.
Read the full Neem + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionNiacin3-pyridinecarboxylic Acid, vitamin B3 Possible
What it is: Niacin (vitamin B3) is an essential nutrient your body needs for energy and metabolism, and deficiency is uncommon in most developed countri...
Theoretically, concomitant use of niacin and hepatotoxic drugs might increase the risk of hepatotoxicity.
Read the full Niacin + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionNoniMorinda Citrifolia, ba Ji Tian, bois Douleur, +17 more Possible
What it is: Noni is a tropical fruit used widely in folk medicine and sold mostly as a juice or supplement, but solid human evidence for its many claime...
Theoretically, taking noni with hepatotoxic drugs might increase the risk of liver damage.
Read the full Noni + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionNutmegMyristica Fragrans, buah Pala, jaatipatree, +14 more Possible
What it is: Nutmeg is a popular cooking spice that has long been used in traditional medicine for digestion and other complaints, but there is little so...
Theoretically, nutmeg might decrease levels of drugs metabolized by CYP1A2.
Read the full Nutmeg + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionOnionAllium Cepa, allii Cepae Bulbus, cebolla, +9 more Possible
What it is: Onion is a common food with a long history in traditional medicine, and it contains antioxidants like quercetin and sulfur compounds.
Theoretically, taking onion might increase the levels and clinical effects of drugs metabolized by CYP2E1.
Read the full Onion + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionOregon GrapeMahonia Aquifolium, barberry, berberis, +13 more Possible
What it is: Oregon grape is a shrub whose root contains berberine and related compounds.
Theoretically, Oregon grape might increase serum levels of drugs metabolized by CYP2D6.
Read the full Oregon Grape + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionOstarine Possible
What it is: Ostarine (also called MK-2866 or enobosarm) is an experimental, unapproved drug known as a SARM (selective androgen receptor modulator), not...
Theoretically, concomitant use with hepatotoxic drugs might increase the risk of adverse hepatotoxic effects.
Read the full Ostarine + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionPadang Cassia Possible
What it is: Padang Cassia is a type of cinnamon (Indonesian or Korintje cinnamon) grown mainly in Indonesia and used widely as a kitchen spice.
There is some concern that ingesting large amounts of Padang cassia might cause hepatotoxicity in some people.
Read the full Padang Cassia + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionPanax GinsengAsian Ginseng, asiatic Ginseng, chinese Ginseng, +12 more Possible
What it is: Panax ginseng is a popular traditional herb used to boost energy, ease stress, and support overall wellness, though scientific evidence is m...
Theoretically, Panax ginseng might increase levels of drugs metabolized by CYP2D6.
Read the full Panax Ginseng + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionPanax NotoginsengPanax Notoginseng, field Seven, noto-gin, +15 more Possible
What it is: Panax notoginseng (sanqi or tienchi ginseng) is a traditional Chinese herb most often used to help with bleeding, bruising, and circulation.
Theoretically, taking Panax notoginseng might reduce the levels and clinical effects of CYP1A2 substrates.
Read the full Panax Notoginseng + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionParsleyPetroselinum Crispum, common Parsley, garden Parsley, +16 more Possible
What it is: Parsley is a popular culinary herb that is safe to eat in normal food amounts and is a good source of vitamins K and C.
Theoretically, parsley might increase serum levels of CYP1A2 substrates.
Read the full Parsley + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionPennyroyal Possible
What it is: Pennyroyal is a mint-family plant whose essential oil is highly toxic and has caused serious poisonings and deaths, especially when used to...
Concomitant use of pennyroyal essential oil and acetaminophen might increase the risk of acetaminophen-induced hepatotoxicity.
Read the full Pennyroyal + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionPeonyPaeonia Lactiflora, bai Shao, chi Shao, +17 more Possible
What it is: Peony root is a traditional Chinese medicine herb often used for menstrual problems, cramps, and inflammation, frequently as part of combina...
Theoretically, use of peony may increase the levels and clinical effects of drugs metabolized by CYP1A2.
Read the full Peony + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionPeppermintMentha X Piperita, black Peppermint, brandy Mint, +12 more Possible
What it is: Peppermint is a popular herb with the best evidence supporting enteric-coated peppermint oil for easing IBS symptoms.
Theoretically, peppermint might increase the levels of CYP3A4 substrates.
Read the full Peppermint + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionPhellodendronPhellodendron Amurense, amur Cork Bark, amur Cork Tree, +7 more Possible
What it is: Phellodendron is a traditional Chinese medicine bark (Huang Bai) that contains berberine and other plant compounds with antimicrobial and an...
Theoretically, phellodendron might increase serum levels of drugs metabolized by CYP2D6.
Read the full Phellodendron + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionPhenethylamine (pea)2-phenylethanamine, methylphenylethylamine, pea Possible
What it is: Phenethylamine (PEA) is a natural compound made in the body and found in foods like chocolate; supplements are marketed for mood, focus, and...
Theoretically, combining serotonergic drugs with phenethylamine might increase the risk of serotonergic adverse effects.
Read the full Phenethylamine (pea) + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionPhenpromethamine Possible
What it is: Phenpromethamine is a synthetic stimulant drug, not a herb or legitimate dietary supplement.
Theoretically, taking phenpromethamine with stimulant drugs might have additive effects and increase the risk of adverse cardiovascular effects.
Read the full Phenpromethamine + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionPhosphatidylserine Possible
What it is: Phosphatidylserine is a natural fat-like compound found in cell membranes, especially in the brain, and it is sold mainly to support memory...
Theoretically, phosphatidylserine might decrease the effectiveness anticholinergic drugs.
Read the full Phosphatidylserine + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionPomegranatePunica Granatum, anardana, dadim, +14 more Possible
What it is: Pomegranate is a nutrient-rich fruit that is high in antioxidants and is widely enjoyed as food and juice.
Theoretically, pomegranate might increase levels of drugs metabolized by CYP2D6.
Read the full Pomegranate + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionPoria Mushroom Possible
What it is: Poria mushroom (Fu Ling) is a fungus long used in Traditional Chinese Medicine, mainly as a mild diuretic and digestive and calming aid.
Theoretically, poria mushroom might decrease the clinical effects of anticholinergic drugs.
Read the full Poria Mushroom + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionPropolisAcide De Cire D'abeille, baume De Propolis, bee Glue, +12 more Possible
What it is: Propolis is a natural, resin-like substance made by bees that has antimicrobial and anti-inflammatory properties in lab studies.
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP2D6.
Read the full Propolis + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionPurple Nut Sedge Possible
What it is: Purple nut sedge (Cyperus rotundus) is a common weed whose tubers have a long history in Ayurvedic, Chinese, and other traditional medicine...
In vitro, purple nut sedge dose-dependently inhibits acetylcholinesterase (AChE).
Read the full Purple Nut Sedge + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionQuercetin7-pentahydroxyflavone, bioflavonoid, bioflavonoid Complex, +9 more Possible
What it is: Quercetin is a plant flavonoid with antioxidant and anti-inflammatory properties found in many common foods and sold as a supplement.
Theoretically, concomitant use might increase the levels and adverse effects of CYP2D6 substrates.
Read the full Quercetin + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionRabdosia RubescensRabdosia Rubescens, bing Ling Cao, blushred Rabdosia, +5 more Possible
What it is: Rabdosia rubescens is a Chinese herb traditionally used for sore throats, inflammation, and infections, and its compound oridonin has drawn...
In vitro research shows that oridonin, a constituent of Rabdosia rubescens, induces cytochrome P450 3A4 (CYP3A4) enzyme.
Read the full Rabdosia Rubescens + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionRaspberry Ketone Possible
What it is: Raspberry ketone is a natural aroma compound found in red raspberries that is heavily marketed for weight loss, but there is no good human e...
Theoretically, raspberry ketone might increase the risk of adverse cardiovascular effects with stimulant drugs.
Read the full Raspberry Ketone + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionRauwolscine Possible
What it is: Rauwolscine (alpha-yohimbine) is a stimulant alkaloid closely related to yohimbine that is marketed mainly in fat-burning and pre-workout su...
Theoretically, rauwolscine might increase levels of drugs metabolized by CYP2D6.
Read the full Rauwolscine + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionRed Yeast RiceMonascus Purpureus, cholestin, hong Qu, +19 more Possible
What it is: Red yeast rice contains monacolin K, which is chemically identical to the prescription statin lovastatin, and it can lower LDL ('bad') chole...
Theoretically, concomitant use might increase the risk of liver damage.
Read the full Red Yeast Rice + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionRhubarbRheum Officinale, chinese Rhubarb, da Huang, +13 more Possible
What it is: Rhubarb root has a long history of use as a laxative and in traditional Chinese medicine, and its edible stalks are a common food.
Theoretically, long-term use of anthraquinones from rhubarb might increase the risk of nephrotoxicity when used with nephrotoxic drugs.
Read the full Rhubarb + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionRooibosAspalathus Linearis, green Red Bush, infusion Rooibos, +9 more Possible
What it is: Rooibos is a caffeine-free herbal tea from South Africa that is rich in antioxidants and generally considered safe as a beverage.
Theoretically, taking rooibos with CYP2D6 substrates may increase the effects of CYP2D6 substrates.
Read the full Rooibos + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionSageSalvia Officinalis, broadleaf Sage, common Sage, +14 more Possible
What it is: Sage is a common kitchen herb that is generally safe in food amounts and is traditionally used for sore throats, digestion, sweating, and me...
Theoretically, sage might increase the levels and clinical effects of drugs metabolized by CYP2D6.
Read the full Sage + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionSaigon Cinnamon Possible
What it is: Saigon cinnamon is a flavorful spice from a Cinnamomum tree grown mainly in Vietnam, and it is a type of 'cassia' cinnamon.
Theoretically, Saigon cinnamon might cause additive effects when used with hepatotoxic drugs.
Read the full Saigon Cinnamon + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionSameS-adenosyl-l-methionine, ademetionine, adomet, +8 more Possible
What it is: SAM-e is a compound your body makes naturally that is sold as a supplement, most often for depression and osteoarthritis.
Taking SAMe with serotonergic drugs might increase the risk of serotonin syndrome and other serotonergic side effects.
Read the full Same + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionSchizonepeta Possible
What it is: Schizonepeta is a mint-family herb long used in traditional Chinese medicine, usually as part of combination formulas for colds, fevers, and...
Animal research suggests that schizonepetin, a monoterpene constituent of schizonepeta, inhibits cytochrome P450 (CYP) 2D6.
Read the full Schizonepeta + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionSecurinega Suffruticosa Possible
What it is: Securinega suffruticosa is a shrub used in traditional East Asian medicine, best known for an alkaloid called securinine that strongly stimu...
Theoretically, taking Securinega suffruticosa with stimulant drugs might increase the risk of serious adverse effects.
Read the full Securinega Suffruticosa + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionShiitake Mushroom Possible
What it is: Shiitake is a popular edible mushroom that is nutritious and safe to eat as food for most people.
Theoretically, shiitake mushroom might decrease levels of drugs metabolized by CYP2D6.
Read the full Shiitake Mushroom + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionSlippery ElmIndian Elm, moose Elm, olmo Americano, +7 more Possible
What it is: Slippery elm is a traditional herbal remedy made from the inner bark of a North American elm tree, used mainly to soothe sore throats and ir...
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionSpearmintMentha Spicata, curled Mint, fish Mint, +16 more Possible
What it is: Spearmint is a common culinary mint that is generally safe in food and tea amounts.
Theoretically, high doses of spearmint might increase the risk of liver damage when taken with hepatotoxic drugs.
Read the full Spearmint + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionSulforaphane Possible
What it is: Sulforaphane is a natural compound found in broccoli and other cruciferous vegetables that has shown promising antioxidant and anti-inflamma...
Theoretically, sulforaphane might alter the levels and clinical effects of CYP1A2 substrates.
Read the full Sulforaphane + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionSweet AnnieArtemisia Annua, absinthe Sauvage, ajenjo Silvestre, +11 more Possible
What it is: Sweet Annie (Artemisia annua) is the source of artemisinin, a compound used in prescription antimalarial drugs.
Theoretically, concomitant use might have additive adverse hepatotoxic effects.
Read the full Sweet Annie + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionSweet CloverMelilotus Officinalis, angipars, casse Lunettes, +14 more Possible
What it is: Sweet clover is a traditional European herb most often promoted for vein problems and leg swelling, but high-quality human evidence is limit...
Theoretically, concomitant use of sweet clover with hepatoxic drugs might increase the risk of hepatotoxicity.
Read the full Sweet Clover + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionTeazleDipsacus Fullonum, baignoire De Vénus, barber's Brush, +11 more Possible
What it is: Teazle (Dipsacus fullonum) is a spiky plant used in traditional and folk medicine, most notably as a tincture marketed for Lyme disease and...
In vitro research suggests that teazle extract can inhibit acetylcholinesterase activity.
Read the full Teazle + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionTerminaliaTerminalia Arjuna, abhaya, amandier Indien, +19 more Possible
What it is: Terminalia is a group of traditional Ayurvedic tree species (most notably Terminalia arjuna) used for heart, digestive, and general wellness...
Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP2D6 substrates.
Read the full Terminalia + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionTestolone Possible
What it is: Testolone (RAD-140) is a synthetic experimental drug called a selective androgen receptor modulator (SARM), not a dietary supplement or herb...
Theoretically, concomitant use might have additive hepatotoxic effects.
Read the full Testolone + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionThunder God VineTripterygium Wilfordii, huang-t'eng Ken, lei Gong Teng, +8 more Possible
What it is: Thunder God Vine is a Chinese herb studied mainly for rheumatoid arthritis and other autoimmune conditions, with some promising but limited...
Theoretically, thunder god vine might increase the levels and clinical effects of CYP1A2 substrates.
Read the full Thunder God Vine + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionThymeThymus Vulgaris, farigoule, farigoulette, +14 more Possible
What it is: Thyme is a common kitchen herb that has long been used for coughs, sore throats, and digestive complaints.
Theoretically, concurrent use of anticholinergic drugs and thyme essential oil might reduce the effects of anticholinergic drugs.
Read the full Thyme + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionTinospora Cordifolia Possible
What it is: Tinospora cordifolia, known as Guduchi or Giloy in Ayurvedic medicine, is a climbing plant traditionally used to support immunity and treat...
Theoretically, Tinospora cordifolia might increase levels of drugs metabolized by CYP2D6.
Read the full Tinospora Cordifolia + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionToothed ClubmossHuperzia Serrata, chinese Club Moss, huperazon, +4 more Possible
What it is: Toothed Clubmoss is a moss-like plant best known as the natural source of huperzine A, a compound studied mainly for memory and Alzheimer's...
In animal models, toothed clubmoss and huperzine A, an active constituent of toothed clubmoss, reversed cognitive deficits induced by scopolamine.
Read the full Toothed Clubmoss + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionTragacanthAdragante, astragale Adragant, astragale De Marseille, +14 more Possible
What it is: Tragacanth is a plant gum used mainly as a thickener and emulsifier in foods, cosmetics, and medicines, and traditionally to soothe the thro...
Theoretically, tragacanth might alter absorption of oral drugs.
Read the full Tragacanth + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionTurmericCurcuma Longa, curcuma, curcumae Longa, +17 more Possible
What it is: Turmeric is a popular spice whose main active compounds, curcuminoids, are studied mostly for inflammation and joint pain.
Theoretically, turmeric might increase the risk of liver damage when taken with hepatotoxic drugs.
Read the full Turmeric + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionUva UrsiArctostaphylos Uva-ursi, arberry, arbousier, +16 more Possible
What it is: Uva ursi is a traditional herb used mainly for urinary tract infections, and its leaves contain a compound called arbutin that may have anti...
Theoretically, uva ursi may decrease the metabolism of CYP3A4 substrates.
Read the full Uva Ursi + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionValerianValeriana Officinalis, all-heal, amantilla, +10 more Possible
What it is: Valerian is an herb whose root is widely used as a natural sleep aid and for calming nerves.
Valerian might weakly inhibit glucuronidation and increase concentrations of drugs metabolized by UGT1A1 and UGT2B7.
Read the full Valerian + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionVitamin A Possible
What it is: Vitamin A is an essential nutrient important for vision, skin, immune function, and growth.
Theoretically, taking high doses of vitamin A in combination with other potentially hepatotoxic drugs might increase the risk of liver disease.
Read the full Vitamin A + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionVitamin EAlpha-tocopherol, beta-tocopherol, delta-tocopherol, +1 more Possible
What it is: Vitamin E is an essential fat-soluble vitamin and antioxidant that most people get in adequate amounts from a normal diet.
Theoretically, vitamin E might induce metabolism of CYP3A4, possibly reducing the levels CYP3A4 substrates.
Read the full Vitamin E + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionWheatgrassTriticum Aestivum, agropyre, blé En Herbe, +7 more Possible
What it is: Wheatgrass is the young grass of the wheat plant, taken as a juice or powder, and is mainly used as a concentrated source of vitamins and pl...
Theoretically, wheatgrass might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Wheatgrass + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionWhite Pepper Possible
What it is: White pepper comes from the same plant as black pepper and is mostly used as a kitchen spice.
In vitro evidence suggests that some constituents of white pepper inhibit cytochrome P450 2D6 (CYP2D6).
Read the full White Pepper + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionWild CherryPrunus Serotine, american Black Cherry, bird Cherry, +12 more Possible
What it is: Wild cherry bark is a traditional cough remedy found in many old-fashioned cough syrups and lozenges, but there is little modern scientific...
In vitro research suggests that wild cherry can inhibit cytochrome P450 3A4 (CYP3A4) enzymes.
Read the full Wild Cherry + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionWild LettuceLactuca Virosa, acrid Lettuce, allubbyne, +13 more Possible
What it is: Wild lettuce is a traditional herb used mainly for sleep, anxiety, and pain, but solid human research supporting these uses is very limited.
Studies report varying evidence on whether or not wild lettuce contains hyoscyamine, an anticholinergic drug.
Read the full Wild Lettuce + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionWinter Cherry Possible
What it is: Winter Cherry is another name for ashwagandha (Withania somnifera), an herb long used in Ayurvedic medicine, most often for stress, sleep, a...
In vitro, winter cherry extract inhibited levels of cytochrome P450 2E1 (CYP2E1).
Read the full Winter Cherry + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionYohimbePausinystalia Yohimbe, 11-hydroxy Yohimbine, coryanthe Yohimbe, +7 more Possible
What it is: Yohimbe is a West African tree bark that contains yohimbine, a compound mainly promoted for erectile dysfunction and as an aphrodisiac.
Theoretically, yohimbe might increase the levels and adverse effects of CYP2D6 substrates.
Read the full Yohimbe + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionZedoary Possible
What it is: Zedoary is a ginger-family root used in traditional Asian and Indian medicine, mostly for digestion and as a spice.
Theoretically, zedoary might increase levels of drugs metabolized by CYP3A4.
Read the full Zedoary + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionZizyphusZiziphus Jujuba, anèbe, annab, +20 more Possible
What it is: Zizyphus (jujube) is an edible fruit and traditional remedy used mainly for sleep, anxiety, and digestion.
Theoretically, zizyphus might decrease the levels and clinical effects of drugs metabolized by CYP1A2.
Read the full Zizyphus + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionThyroid Extract Likely
What it is: Thyroid extract supplements are made from dried animal thyroid gland and may contain real thyroid hormones (T3 and T4), but the amounts in o...
Food and medications can interfere with thyroid hormone absorption.
Read the full Thyroid Extract + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionHibiscus SabdariffaHibiscus Sabdariffa, agua De Jamaica, ambashthaki, +16 more Probable
What it is: Hibiscus sabdariffa is a tart, cranberry-flavored plant most often consumed as a tea, and its best-studied use is for mildly lowering blood...
Theoretically, taking Hibiscus sabdariffa with acetaminophen might decrease the clinical effects of acetaminophen.
Read the full Hibiscus Sabdariffa + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionVitamin C Probable
What it is: Vitamin C (ascorbic acid) is an essential nutrient your body needs but cannot make, so you must get it from food or supplements.
High-dose vitamin C might slightly prolong the clearance of acetaminophen.
Read the full Vitamin C + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionAegeline Possible
What it is: Aegeline is a compound originally identified in the bael tree (Aegle marmelos) that gained attention because it was added to some weight-los...
Aegeline inhibits cytochrome P450 3A4 (CYP3A4) activity in vitro.
Read the full Aegeline + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionAgarAgar-agar, agarose, agarose Gel, +17 more Possible
What it is: Agar is a plant-based gel made from red seaweed that is widely used as a vegetarian alternative to gelatin and as a source of dietary fiber.
Agar forms a thick gel, which may disrupt the absorption of nutrients and medications.
Read the full Agar + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionAlginAlginate, alginate De Calcium, alginate De Magnésium, +12 more Possible
What it is: Algin (alginate) is a fiber-like substance from brown seaweed that is widely used as a thickener, gel, and binder in foods and medicines.
Theoretically, algin can alter the absorption of oral drugs.
Read the full Algin + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionAloeAloe Vera, aloe Capensis, aloe Gel, +18 more Possible
What it is: Aloe vera gel is widely used on the skin for minor burns and irritation, and some research suggests it may help.
Theoretically, aloe might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Aloe + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionAnisePimpinella Anisum, anis, anís, +14 more Possible
What it is: Anise is a fragrant, licorice-flavored seed used for centuries to ease digestion and soothe coughs.
Theoretically, anise oil might decrease the levels and clinical effects of acetaminophen.
Read the full Anise + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionAtractylodesAtractylodes Lancea, amk, atr, +9 more Possible
What it is: Atractylodes is a root used for centuries in traditional Chinese, Japanese, and Thai medicine, mostly for digestive complaints and fatigue,...
Theoretically, atractylodes might decrease the levels of CYP1A2 substrates.
Read the full Atractylodes + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionBaelAegle Marmelos, arbre De Bael, bael Tree, +16 more Possible
What it is: Bael is a fruit-bearing tree long used in traditional Indian (Ayurvedic) medicine, mostly for digestive problems like diarrhea and indigesti...
Bael extract and its constituent marmesinin inhibited cytochrome P450 1A2 (CYP1A2) activity in vitro.
Read the full Bael + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionBlack PsylliumAfrican Plantain, brown Psyllium, dietary Fiber, +16 more Possible
What it is: Black psyllium is a soluble-fiber supplement made from the seeds of a Plantago plant, used mostly to ease constipation and support digestive...
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Black Psyllium + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionBlond PsylliumPlantago Ovata, balle De Psyllium, blond Plantago, +14 more Possible
What it is: Blond psyllium is a soluble fiber from the seed husks of Plantago ovata, and it is one of the better-studied fiber supplements.
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Blond Psyllium + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionBroccoli Sprout Possible
What it is: Broccoli sprouts are young broccoli seedlings rich in a compound called sulforaphane, which is being studied for antioxidant, anti-inflammat...
Theoretically, broccoli sprout might reduce levels and effects of drugs metabolized by CYP1A2.
Read the full Broccoli Sprout + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionCarobCeratonia Siliqua, algarrobo, carob Flour, +16 more Possible
What it is: Carob is a Mediterranean tree whose pods are widely used as a caffeine-free, naturally sweet cocoa alternative and as a thickener (carob gum...
Theoretically, carob might also impair the absorption of oral drugs.
Read the full Carob + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionCascara SagradaFrangula Purshiana, rhamnus Purshiana, bitter Bark, +13 more Possible
What it is: Cascara sagrada is a stimulant laxative made from the aged bark of a Pacific Northwest tree, used mainly for short-term relief of constipati...
Theoretically, cascara sagrada might decrease the effects of CYP3A4 substrates.
Read the full Cascara Sagrada + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionEurycoma LongifoliaAkar Pasak Bumi, ali's Umbrella, ali's Walking Stick, +17 more Possible
What it is: Eurycoma longifolia (tongkat ali) is a Southeast Asian herb most popular for supporting testosterone, libido, and male fertility, with some...
Theoretically, Eurycoma longifolia might increase levels CYP1A2 substrates.
Read the full Eurycoma Longifolia + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionFucus VesiculosusBlack Tang, bladder Fucus, bladder Wrack, +14 more Possible
What it is: Fucus vesiculosus (bladderwrack) is a brown seaweed rich in iodine that has been used traditionally for thyroid concerns, weight, and skin.
Theoretically, concomitant use of Fucus vesiculosus with CYP2D6 substrates might alter the effects of these substrates.
Read the full Fucus Vesiculosus + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionGlucosamine Possible
What it is: Glucosamine is a natural compound found in cartilage and joint fluid, and it is one of the most popular supplements for osteoarthritis, espe...
Acetaminophen might interfere with the activity of glucosamine sulfate by interacting with the sulfate portion.
Read the full Glucosamine + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionHempCannabis Sativa, cheungsam, fiber Hemp, +14 more Possible
What it is: Hemp seeds and hemp seed oil are nutritious foods rich in protein, fiber, and healthy omega-3 and omega-6 fatty acids, and they are generall...
Theoretically, hemp might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Hemp + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionHoneyBeri Honey, blossom Honey, buckwheat Honey, +13 more Possible
What it is: Honey is a natural food with some real, modest evidence for easing coughs and helping certain wounds, especially when special medical-grade...
Theoretically, honey might decrease levels of drugs metabolized by CYP3A4, but research is conflicting.
Read the full Honey + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionHopsHumulus Lupulus, asperge Sauvage, common Hops, +13 more Possible
What it is: Hops are most often used for sleep and mild anxiety, frequently combined with valerian, but the human evidence is limited and not very stron...
Theoretically, hops extract might alter metabolism of CYP3A4 substrates; however, this effect may not be clinically significant.
Read the full Hops + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionKaraya GumBassora Tragacanth, goma Karaya, gomme Karaya, +14 more Possible
What it is: Karaya gum is a natural plant gum from the Sterculia tree that is mostly used as a bulk-forming laxative and as a thickener or adhesive in f...
Co-administration of oral drugs with bulk forming laxatives such as karaya gum may decrease, increase, or have no effect on the absorption of drugs.
Read the full Karaya Gum + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionMarshmallowAlthaea Officinalis, altea, alteia, +16 more Possible
What it is: Marshmallow root is a traditional herb rich in soothing, gel-like fibers called mucilage, which is why it has long been used for coughs, sor...
Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Read the full Marshmallow + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionN-methyltyramine Possible
What it is: N-methyltyramine is a natural compound related to tyramine that is found in bitter orange, barley, and other plants, and it is often added t...
N-methyltyramine is thought to have stimulant effects.
Read the full N-methyltyramine + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionOctopamine Possible
What it is: Octopamine is a stimulant-like compound found in small amounts in some plants (such as bitter orange) and made naturally in the body.
Octopamine is thought to have stimulant effects.
Read the full Octopamine + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionPassion FlowerPassiflora Incarnata, apricot Vine, burucuya, +18 more Possible
What it is: Passion flower is a traditional calming herb that many people use for anxiety and sleep.
Theoretically, passion flower might decrease the effects of CYP3A4 substrates.
Read the full Passion Flower + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionPuravive Possible
What it is: Puravive is a branded, multi-ingredient capsule marketed mainly for weight loss by claiming to boost brown fat activity, but there is no pub...
Puravive contains Panax ginseng.
Read the full Puravive + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionRhodiolaRhodiola Rosea, arctic Root, golden Root, +12 more Possible
What it is: Rhodiola is an herb traditionally used to fight fatigue and help the body cope with stress.
Theoretically, rhodiola might increase levels of drugs metabolized by CYP1A2.
Read the full Rhodiola + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionTyramine Possible
What it is: Tyramine is a natural compound formed when certain proteins break down, and it is found in aged cheeses, cured meats, fermented foods, and s...
Theoretically, taking tyramine with stimulant drugs might increase the risk of adverse cardiovascular effects.
Read the full Tyramine + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionVitamin DErgocalciferol, cholecalciferol Possible
What it is: Vitamin D is a fat-soluble vitamin that helps your body absorb calcium and is important for healthy bones, muscles, and immune function.
Vitamin D might induce CYP3A4 enzymes and reduce the bioavailability of CYP3A4 substrates.
Read the full Vitamin D + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionXanthan GumBacterial Polysaccharide, corn Sugar Gum, goma Xantana, +7 more Possible
What it is: Xanthan gum is a fermentation-made fiber widely used to thicken and stabilize foods and to thicken liquids for people with swallowing diffic...
Theoretically, xanthan gum can alter the absorption of oral drugs due to its fiber qualities.
Read the full Xanthan Gum + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionAsian Water PlantainAlisma Plantago-aquatica, dong Fang Ze Xie, jilgyeongitaegsa, +6 more Unlikely
What it is: Asian water plantain (Ze Xie) is a rhizome long used in traditional Chinese medicine, mainly as a diuretic and for fluid retention.
Studies on animals have shown that Asian water plantain extract, which contains triterpenoids, is generally safe at doses up to 1440 mg/kg orally daily and does not cause harm to the body.
Read the full Asian Water Plantain + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionCalabar BeanPhysostigma Venenosum, chop Nut, esere Nut, +7 more Unlikely
What it is: Calabar bean is a highly poisonous West African seed that contains physostigmine, a powerful cholinesterase inhibitor.
Theoretically, taking calabar bean might reduce the effects of anticholinergic drugs.
Read the full Calabar Bean + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionChrysin Unlikely
What it is: Chrysin is a plant flavonoid sold mainly as a bodybuilding supplement claimed to raise testosterone or block estrogen, but human studies hav...
Theoretically, chrysin might increase levels of drugs metabolized by CYP1A2.
Read the full Chrysin + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionDeanol2-dimethyl Aminoethanol, cyclohexylpropionate De Déanol, deaner, +9 more Unlikely
What it is: Deanol (DMAE) is a compound related to choline that is marketed for memory, focus, and mood, but solid human evidence for most of these uses...
Theoretically, deanol might decrease the effectiveness of anticholinergic drugs.
Read the full Deanol + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionDiindolylmethaneDim Unlikely
What it is: Diindolylmethane (DIM) is a compound made when your body digests cruciferous vegetables, and it is sold as a supplement mainly for hormone b...
Theoretically, diindolylmethane might lower serum levels of CYP1A2 substrates.
Read the full Diindolylmethane + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionHumann Superbeets Heart Chews Unlikely
What it is: SuperBeets Heart Chews are a beetroot- and grape-seed-based supplement marketed to support healthy blood flow, blood pressure, and nitric ox...
Each serving of HumanN SuperBeets includes 150mg of grape seed extract (2 chews).
Read the full Humann Superbeets Heart Chews + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionJequirityAbrus Precatorius, bead Vine, black-eyed Susan, +19 more Unlikely
What it is: Jequirity (Abrus precatorius) is a tropical plant whose bright red, black-tipped seeds contain abrin, one of the most toxic plant proteins k...
In vitro research shows that jequirity extract inhibits CYP3A4 enzymes.
Read the full Jequirity + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionMommy's Bliss Gripe Water Unlikely
What it is: Mommy's Bliss Gripe Water is a sugar-free, alcohol-free liquid made with fennel and ginger that parents use to soothe gassy, colicky, or fus...
Mommy's Bliss Gripe Water contains fennel seed.
Read the full Mommy's Bliss Gripe Water + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionPolypodium Leucotomos Unlikely
What it is: Polypodium leucotomos is a fern extract taken by mouth, mostly studied as an add-on to (not a replacement for) sunscreen and for certain lig...
Theoretically, Polypodium leucotomos might increase levels of drugs metabolized by CYP3A4.
Read the full Polypodium Leucotomos + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionRed CloverTrifolium Pratense, beebread, clovone, +17 more Unlikely
What it is: Red clover is a plant rich in isoflavones (plant compounds with weak estrogen-like activity) that is most often used for menopause symptoms...
Theoretically, red clover might increase levels of drugs metabolized by CYP1A2; however, a small clinical study found no effect.
Read the full Red Clover + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionRosemaryRosmarinus Officinalis, alecrim, compass Plant, +14 more Unlikely
What it is: Rosemary is a fragrant Mediterranean herb that is safe and flavorful in normal food amounts.
Theoretically, rosemary might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Rosemary + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionTangerine Unlikely
What it is: Tangerine is a sweet citrus fruit that is a good source of vitamin C and other nutrients, and is widely enjoyed as food.
In vitro, tangeretin, a constituent of tangerine, induces a 52% increase in the metabolism of midazolam by cytochrome P450 3A4 (CYP3A4).
Read the full Tangerine + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionTheanine Unlikely
What it is: Theanine (usually L-theanine) is an amino acid found naturally in tea leaves that many people take to feel calmer and less stressed without...
Clinical studies regarding the effects of L-theanine on serotonin levels are conflicting.
Read the full Theanine + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionTurpentine OilPinus Palustris, aceite De Trementina, essence De Térébenthine, +9 more Unlikely
What it is: Turpentine oil is a strong-smelling pine resin product used mostly in tiny amounts in topical rubs for muscle aches and congestion.
There is some concern that turpentine oil can inhibit CYP1A2 enzyme activity by up to 90% via induction of inflammation and subsequent downregulation of CYP activity.
Read the full Turpentine Oil + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionCan You Take It With Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine?
One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.
Can you take Bitter Orange with Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine?
Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Bitter orange might increase levels of drugs metabolized by CYP3A4.
Full Bitter Orange + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine answerCan you take Acetyl-l-carnitine with Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine?
Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, acetyl-L-carnitine might increase the risk of serotonergic side effects, including serotonin syndrome and cerebral vasoconstr...
Full Acetyl-l-carnitine + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine answerCan you take Phosphatidylserine with Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine?
Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, phosphatidylserine might decrease the effectiveness anticholinergic drugs.
Full Phosphatidylserine + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine answerCan you take Thyme with Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine?
Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concurrent use of anticholinergic drugs and thyme essential oil might reduce the effects of anticholinergic drugs.
Full Thyme + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine answerCan you take Same with Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine?
Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Taking SAMe with serotonergic drugs might increase the risk of serotonin syndrome and other serotonergic side effects.
Full Same + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine answerCan you take Chokeberry with Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine?
Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, chokeberry might increase levels of drugs metabolized by CYP3A4.
Full Chokeberry + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine answerCan you take Cinchona with Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine?
Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking cinchona might inhibit cytochrome P450 2D6 (CYP2D6) and increase levels of drugs metabolized by this enzyme.
Full Cinchona + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine answerCan you take Clove with Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine?
Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of clove may increase levels of drugs metabolized by CYP2D6.
Full Clove + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine answerCan you take Clubmoss with Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine?
Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Evidence from in vitro research suggests that clubmoss extract can inhibit acetylcholinesterase activity.
Full Clubmoss + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine answerCan you take Coleus with Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine?
Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking coleus might decrease serum levels of drugs metabolized by CYP3A4.
Full Coleus + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine answerCan you take Comfrey with Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine?
Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, comfrey might have additive adverse effects on the liver when used with hepatotoxic drugs.
Full Comfrey + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine answerCan you take Corkwood Tree with Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine?
Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, corkwood tree might increase the risk of adverse anticholinergic effects when taken with anticholinergic drugs.
Full Corkwood Tree + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine answerCan you take Corydalis Yanhusuo with Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine?
Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Corydalis yanhusuo might increase serum levels of drugs metabolized by CYP2D6.
Full Corydalis Yanhusuo + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine answerCan you take Cranberry with Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine?
Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Full Cranberry + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine answerCan you take Cubebs with Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine?
Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Several compounds isolated from cubebs can inhibit cytochrome P450 3A4 (CYP3A4) in vitro.
Full Cubebs + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine answerCan you take Dandelion with Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine?
Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, dandelion might increase levels of drugs metabolized by CYP1A2.
Full Dandelion + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine answerCan you take Danshen with Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine?
Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, danshen may increase the levels and clinical effects of drugs metabolized by CYP1A2.
Full Danshen + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine answerCan you take Delta-9-tetrahydrocannabinol (thc) with Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine?
Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, THC might decrease the levels and clinical effects of CYP2E1 substrates.
Full Delta-9-tetrahydrocannabinol (thc) + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine answerCan you take Devil's Claw with Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine?
Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, devil's claw might increase levels of drugs metabolized by CYP3A4.
Full Devil's Claw + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine answerCan you take Dhea with Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine?
Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.
Full Dhea + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine answerWhat Severity, Likelihood & Evidence Mean
Severity — How Serious It Can Be
- Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
- Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
- Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
- No known interaction. Checked against our sources with nothing documented — not the same as proven safety.
Likelihood — How Well It’s Documented
- Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
- Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
- Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
- Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Where This Data Comes From
- Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
- Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
- Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
How Does Our Interaction Checker Work?
Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).
So the check works in three steps: (1) Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.
Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine sits in 17 interaction categories. Open any one to see what the group means:
Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients
A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.
121 of the supplement ingredients on this page reach Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine through this category.
Cytochrome P450 1A2 (Cyp1A2) Substrates 79 ingredients
A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.
79 of the supplement ingredients on this page reach Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine through this category.
Cytochrome P450 2D6 (Cyp2D6) Substrates 60 ingredients
A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.
60 of the supplement ingredients on this page reach Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine through this category.
Stimulant Drugs 44 ingredients
A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.
44 of the supplement ingredients on this page reach Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine through this category.
Hepatotoxic Drugs 38 ingredients
Medications with known liver considerations. Supplements that can stress the liver add to the load.
38 of the supplement ingredients on this page reach Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine through this category.
Anticholinergic Drugs 30 ingredients
A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.
30 of the supplement ingredients on this page reach Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine through this category.
Cytochrome P450 2E1 (Cyp2E1) Substrates 24 ingredients
A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.
24 of the supplement ingredients on this page reach Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine through this category.
Serotonergic Drugs 20 ingredients
Medications that raise serotonin activity. Combining them with serotonin-active supplements can, in rare cases, push serotonin too high.
20 of the supplement ingredients on this page reach Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine through this category.
Oral Drugs 17 ingredients
A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.
17 of the supplement ingredients on this page reach Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine through this category.
Glucuronidated Drugs 12 ingredients
A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.
12 of the supplement ingredients on this page reach Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine through this category.
Phenylpropanolamine 12 ingredients
A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.
12 of the supplement ingredients on this page reach Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine through this category.
Dextromethorphan (Robitussin Dm, Others) 9 ingredients
A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.
9 of the supplement ingredients on this page reach Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine through this category.
Acetaminophen (Tylenol, Others) 8 ingredients
A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.
8 of the supplement ingredients on this page reach Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine through this category.
Nephrotoxic Drugs 6 ingredients
A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.
6 of the supplement ingredients on this page reach Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine through this category.
Alpha-Adrenergic Agonists 1 ingredient
A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.
1 of the supplement ingredient on this page reaches Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine through this category.
Cytochrome P450 1A2 (Cyp1A2) Substrates 1 ingredient
A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.
1 of the supplement ingredient on this page reaches Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine through this category.
Serotonergic Drugs 1 ingredient
Medications that raise serotonin activity. Combining them with serotonin-active supplements can, in rare cases, push serotonin too high.
1 of the supplement ingredient on this page reaches Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine through this category.
Related: does Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine deplete any nutrients?
Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine has 1 reported nutrient association in the research literature — see the Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine nutrient depletion report.
Take a Supplement Product? Check the Whole Bottle Against Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine
Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine.
Search a supplement product
Type a product name, brand, or UPC — smart search across our full catalog.
Grounded search over our product catalog — every verdict comes from our interaction database, never AI guesswork. How we use AI
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Products that contain Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine-interacting ingredients
Real supplements from the NIH label database that contain the top interacting ingredients on this page — each one is worth a full label check before combining with Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine.
Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine & Supplements: Common Questions
What supplements interact with Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine?
Which Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine supplement interactions are the most serious?
Can I take vitamins or supplements while on Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine?
Do brands like Theracaps have the same supplement interactions as Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine?
Where do these interaction ratings come from?
Does Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine deplete any vitamins or nutrients?
What about Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine and my other medications?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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Where This Data Comes From — and Why You Can Trust It
🧪 Licensed clinical database
Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.
🧑⚕️ Pharmacist review
This page is curated and coded by Dr. Brian Staiger, PharmD, BCPS, Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.
🔄 Kept current
Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 23, 2026.
🔍 Full transparency
How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.
Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.