Cabbage + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine
Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine brand name: Theracaps.
Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine falls into 3 drug categories that Cabbage can interact with; the most serious is rated moderate. Theoretically, cabbage might decrease levels of drugs metabolized by CYP1A2.
Read the full interaction reportCabbage and Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine
These two interact in 3 distinct ways. Each one is explained separately below.
Why Are There 3 Interactions?
Cabbage interacts with whole categories of medication. Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine falls into 3 of those categories, so it can interact with Cabbage in 3 different ways. We’ve listed each one below — your overall risk is driven by the most serious of them (Moderate).
CYTOCHROME P450 1A2 (CYP1A2) SUBSTRATES
1 of 3Why this applies to Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine
Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine falls under CYTOCHROME P450 1A2 (CYP1A2) SUBSTRATES — the group Cabbage interacts with.
Some animal research suggests that cabbage or its constituent indole-3-carbinol might increase drug metabolism and elimination by stimulating CYP1A2 activity.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
This combination cold product (Theracaps) blends acetaminophen for pain and fever, dextromethorphan for cough, phenylpropanolamine as a decongestant, and pyrilamine, an antihistamine. The idea here is that cabbage, especially in concentrated amounts, might gently nudge a liver enzyme called CYP1A2 to work a little faster. If that happens, your body could clear some of these ingredients slightly quicker, which in theory might make them a touch less effective, like a cough or congestion not easing as much as expected.
Honestly, I wouldn't lose sleep over this one. The evidence is only from lab and animal studies, and normal food portions of cabbage are very unlikely to matter. If you're using large supplement doses, just mention it to your pharmacist.
- Balk JL. Indole-3-carbinol for cancer prevention. Altern Med Alert 2000; 3:105-7.
- He YH, Friesen MD, Ruch RJ, Schut HA. Indole-3-carbinol as a chemopreventive agent in 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) carcinogenesis: inhibition of PhIP-DNA adduct formation, acceleration of PhIP metabolism, and induction of cytoch
- Steinkellner, H., Rabot, S., Freywald, C., Nobis, E., Scharf, G., Chabicovsky, M., Knasmuller, S., and Kassie, F. Effects of cruciferous vegetables and their constituents on drug metabolizing enzymes involved in the bioactivation of DNA-reactive dietary c
GLUCURONIDATED DRUGS
2 of 3Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine also falls under GLUCURONIDATED DRUGS.
A small clinical study shows that daily consumption of cabbage and Brussels sprout decreases levels of some drugs metabolized through glucuronide conjugation.
Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports..
This combo product (Theracaps) is a cold and cough mix, and the part that matters here is the acetaminophen (Tylenol) component. Your body clears acetaminophen partly by attaching it to a sugar molecule, a step called glucuronidation. Eating lots of cabbage (and its cousin, Brussels sprouts) may speed up that clearing process, so a bit less drug could stick around. In plain terms, that might make the fever and pain relief feel slightly weaker than expected.
Honestly, this is a modest, mostly theoretical concern based on a small study. Eating cabbage as a normal part of dinner is very unlikely to be a problem. Large daily amounts could matter a little more. If your symptoms aren't easing as expected, check in with your pharmacist or doctor rather than changing anything on your own.
- Pantuck EJ, Pantuck CB, Anderson KE, et al. Effect of brussels sprouts and cabbage on drug conjugation. Clin Pharmacol Ther 1984;35:161-9. PubMed
ACETAMINOPHEN (Tylenol, others)
3 of 3A small clinical study shows that daily consumption of cabbage and Brussels sprout decreases acetaminophen levels by as much as 16%, with some evidence suggesting that this effect is due to increased elimination through glucuronide conjugation.
Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports..
This combination product (Theracaps) is a cold-and-cough mix, and the part that matters here is the acetaminophen in it. Your body clears acetaminophen partly by attaching it to a sugar molecule, a process called glucuronidation. Cabbage and other cruciferous veggies seem to nudge that pathway to work a little faster. In one small human study, eating cabbage and Brussels sprouts daily lowered acetaminophen levels by up to about 16%, meaning slightly less pain or fever relief.
Here is the reassuring part: this is a modest effect, and normal amounts of cabbage in your meals are very unlikely to make a noticeable difference. If you regularly eat large amounts or use concentrated supplements and feel your fever or aches aren't easing, check in with your pharmacist or doctor before changing anything.
- Pantuck EJ, Pantuck CB, Anderson KE, et al. Effect of brussels sprouts and cabbage on drug conjugation. Clin Pharmacol Ther 1984;35:161-9. PubMed
What These Ratings Mean
Every interaction above is graded three ways — here’s the key to each label.
Clinically significant. Avoid the combination, or use only under close professional supervision.
Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.
Generally not serious. Be aware of it and mention it to your pharmacist.
- LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
- ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
- PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
- UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
- AHigh-quality meta-analysis (quantitative systematic review).
- BCase-control study.
- CConsensus.
- DAnecdotal evidence.
These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.
Cabbage Also Interacts With Other Medications
Cabbage has 324 moderate known drug interactions in our database — the Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine one above is among them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against Cabbage
We haven’t checked that one against Cabbage yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against Cabbage. Pick one to open its full report.
See Every Supplement That Interacts With Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine
This page covers Cabbage only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine page lists 282 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Asarabacca (major), Beer (major), Ephedra (major) and Grapefruit (major).
By severity: 14 major · 223 moderate · 45 minor.
From our pharmacist’s overview on the Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine page
“Of everything on this page, ephedra worries me most for anyone using Theracaps (acetaminophen, dextromethorphan, phenylpropanolamine, and pyrilamine), because the decongestant in this cold formula is itself a stimulant. Adding ephedra or any of the 44 stimulant entries can push blood pressure and heart rate to unsafe levels.”
Reviewed by 2 · Jul 18, 2026
Open the Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interaction page
Taking Cabbage as Part of a Dietary Supplement Product? Check It for Interactions
We hold 2,304 real supplement products containing Cabbage, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Cabbage. Your product may carry other ingredients that interact with Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine too, on top of Cabbage — and those would not show on this page. Find your product and we’ll check every ingredient on its label:
Where Cabbage and Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#189 of 1,452 supplements looked up here in the last 7 days
#1,554 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
About Cabbage
What is Cabbage?
- Breast engorgement during breastfeeding
- Joint pain and swelling (topical)
- Digestive and stomach upset
- General nutrition and antioxidant support
- Skin and minor inflammation (topical)
Cabbage is a nutritious, low-calorie vegetable that is safe to eat as food and is sometimes applied to the skin as a leaf wrap for breast engorgement or sore joints. Most medicinal claims are based on tradition or limited research, with the strongest (though still modest) evidence being for cooling cabbage leaves on engorged breasts. Talk to your pharmacist or doctor before using cabbage in large amounts or as a treatment.
Other Drugs & Cabbage
Browse every other medication we’ve checked against Cabbage — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
324 interactions
- Theophylline ›
- Insulin (rdna) ›
- Naproxen ›
- Estradiol ›
- Propranolol ›
- Verapamil ›
- Glyburide ›
- Insulin (pork) ›
- Apomorphine ›
- Doxorubicin ›
- Insulin (human) ›
- Morphine Sulfate ›
- Acetaminophen ›
- Conjugated Estrogens ›
- Diazepam ›
- Lofepramine ›
- Meprobamate ›
- Nortriptyline ›
- Acarbose ›
- Bendamustine ›
- Caffeine (otc Drug) ›
- Cyclobenzaprine ›
- Desipramine ›
- Digoxin ›
- Insulin Glargine ›
- Riluzole ›
- Semaglutide ›
- Warfarin Sodium ›
- Asenapine ›
- Caffeine (prescription Drug) ›
- Chlorpropamide ›
- Clomipramine ›
- Clozapine ›
- Deferasirox ›
- Esterified Estrogens ›
- Exenatide ›
- Flutamide ›
- Glipizide ›
- Glucagon ›
- Imipramine ›
- Insulin Lispro ›
- Irinotecan ›
- Lovastatin ›
- Metformin ›
- Pitavastatin ›
- Propafenone ›
- Repaglinide ›
- Ropinirole ›
- Sitagliptin ›
- Tamoxifen Citrate ›
- Tasimelteon ›
- Tirzepatide ›
- Tizanidine ›
- Zileuton ›
- Acetohexamide ›
- Agomelatine ›
- Albiglutide ›
- Alogliptin ›
- Amitriptyline ›
- Anagrelide ›
Showing 60 of 324 moderate interactions — see all 324 on the Cabbage page.
No interaction 2,505 drugs checked — show the list
We also checked Cabbage against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Sertraline ›
- Testosterone ›
- Losartan Potassium ›
- Metoprolol ›
- Aspirin ›
- Ivermectin ›
- Rivaroxaban ›
- Rosuvastatin ›
- Escitalopram ›
- Tadalafil ›
- Docusate ›
- Valacyclovir ›
- Abemaciclib ›
- Hydroxyurea ›
- Methamphetamine ›
- Ibuprofen ›
- Sumatriptan ›
- Prednisone ›
- Bupropion ›
- Lisdexamfetamine ›
- Amoxicillin ›
- Lisinopril ›
- Acyclovir ›
- Doxycycline ›
- Methotrexate ›
- Fluoxetine ›
- Amphetamine ›
- Gabapentin ›
- Pregabalin ›
- Azithromycin ›
- Dextroamphetamine ›
- Isotretinoin ›
- Clonazepam ›
- Omeprazole ›
- Methylene Blue ›
- Quetiapine ›
- Amlodipine Besylate ›
- Duloxetine ›
- Letrozole ›
- Buspirone ›
- Citalopram ›
- Ciprofloxacin ›
- Bisoprolol ›
- Levothyroxine, Liothyronine ›
- Dapsone ›
- Cyclopentolate ›
- Candesartan Cilexetil ›
- Mannitol ›
- Cephalexin ›
- Roxithromycin ›
- Pegunigalsidase Alfa-iwxj ›
- Daptomycin ›
- Finasteride ›
- Hexobarbitone ›
- Valsartan ›
- Levothyroxine Sodium ›
Showing the 60 most looked-up of 2,505 medications checked with no known interaction — see the full Cabbage list.
Sources & How We Checked
Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference for vitamins, herbs and supplements — the basis for our interaction data.
- MedlinePlus, U.S. National Library of Medicine — NIH consumer drug information, used for the medication overviews.
- NIH Dietary Supplement Label Database (DSLD) — Official supplement product labels.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine Is Linked to Lower Levels of One Nutrient
Natural Medicines records Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine as a medicine that can lower these. This is not an interaction with Cabbage — it is a separate effect of the medicine, and it is a reason some people are advised to supplement rather than to avoid one:
Depletion records come from the licensed Natural Medicines database. Do not start a supplement on the strength of this page — ask your pharmacist or doctor whether it applies to you.
Taking Cabbage and Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine Together: Common Questions
Can you take Cabbage with Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine?
Why are there 3 interactions listed for Cabbage and Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine?
How serious is the Cabbage and Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interaction?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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