Eleuthero & Guarana Ingredients & Drug Interactions
by TerraVita
What is this page for?
First and foremost: checking Eleuthero & Guarana against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Eleuthero & Guarana is a dietary supplement by TerraVita with 1 active ingredient. Its ingredients are commonly taken for fatigue and low energy, physical and athletic performance, stress resistance (adaptogen).Based on those ingredients, 1,336 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Eleuthero & Guarana Glycerite Liquid Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Eleuthero & Guarana by TerraVita
Ask about any prescription or over-the-counter medication and we check it for interactions with Eleuthero & Guarana by TerraVita — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Eleuthero & Guarana by TerraVita
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
This product contains 2 active ingredients: eleuthero glycerite liquid extract and guarana glycerite liquid extract, combined in one blend. Eleuthero (also called Siberian ginseng) is an adaptogenic herb traditionally used to support energy and resilience.
Guarana is a South American plant seed that's naturally high in caffeine and has been used as a stimulant and energy booster. The extract is delivered as a liquid in a glycerin base, which helps preserve and dissolve the herbal compounds.
Does it work?
Moderate evidence
For eleuthero, the evidence shows it's possibly effective for genital herpes — the strongest claim we have data for. For other uses like chronic fatigue syndrome, bipolar disorder, familial Mediterranean fever, and osteoporosis, the evidence isn't established enough to rate.
For guarana, we hold no established effectiveness ratings in the data we have. Its traditional use as a caffeine-based stimulant is well known, but the specific conditions and doses studied in clinical trials aren't captured in our evidence summary.
How safe is it?
Well-documented data
Eleuthero is generally well tolerated for short-term use, but long-term safety data is limited. The most common side effects are diarrhea, indigestion, headache, nausea, and hives.
Some people report nervousness (about 7% in one study), anxiety, irritability, or mood changes — these seem more likely with higher doses. There's also a report of increased blood pressure in children and in patients with heart disease, though it's unclear whether eleuthero or a contaminant in some products caused it.
Guarana is usually well tolerated in small amounts, but its high caffeine content can cause stomach burning, nausea, dizziness, insomnia (especially in children), nervousness, restlessness, tremors, headache, and anxiety with larger doses. The safety data for pregnancy advises against eleuthero and recommends caution with guarana — it's rated possibly unsafe to avoid during pregnancy due to caffeine content.
For breastfeeding, eleuthero is not recommended due to lack of safety data, and guarana should be avoided or limited because caffeine passes into breast milk.
Meds to double-check
Major interaction found
Before taking this product, check with your doctor or pharmacist if you take ephedrine or any stimulants (Major concern with guarana); blood thinners or antiplatelet drugs; seizure medications like valproate, felbamate, or carbamazepine; digoxin for the heart; immunosuppressants; diabetes medications; disulfiram; dipyridamole; fluvoxamine or other antidepressants; or clozapine or other antipsychotics. Guarana's caffeine is the main driver of several of these interactions.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence behind its ingredients' uses. Major medication interactions have been identified, and safety information is well characterized.
This product combines an adaptogenic herb (eleuthero) with a caffeinated stimulant (guarana), so it's geared toward people looking for energy support. If you take any prescription medications — especially blood thinners, seizure drugs, heart medications, antidepressants, or stimulants — you'll want to check this product against your exact medications before starting.
Eleuthero has theoretical interactions with many enzyme systems, and guarana's caffeine can interact with several drug classes. Talk with your doctor or pharmacist to see if it's right for you.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 22, 2022.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Eleuthero & Guarana, straight from the product label.
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Eleuthero & Guarana by TerraVita, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Eleuthero & Guarana Glycerite Liquid Extract | 0.13 mL | -- |
| Eleuthero Glycerite Liquid Extract | 0 NP | -- |
| Guarana Glycerite Liquid Extract | 0 NP | -- |
Other ingredients: Glycerin
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)
Copyright 2018 TerraVita - Distributed by ZooScape LLC, All Rights Reserved.
Formula
Glycerite liquid extract (1:5)
Formulation
Alcohol free No flavor
Suggested/Recommended/Usage/Directions
Suggested Use: Take 25-40 drops of extract in a small amount of warm water 3-4 times daily. Shake well before using.
Precautions
Keep away from children.
Do not use if safety seal around cap is broken or missing.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Eleuthero & Guarana by TerraVita label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Eleuthero & Guarana by TerraVita
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size25 Drop(s) Dosage formLiquid Servings per container227 Amounts shown are per serving.
Eleuthero & Guarana Glycerite Liquid Extract
Interacts with1,140 drugs
Eleuthero is an herb traditionally used as an 'adaptogen' to fight fatigue, boost energy, and help the body handle stress. The scientific evidence beh...
Eleuthero & Guarana Glycerite Liquid Extract monograph & interactionsOther (inactive) ingredients: Glycerin. These complete the product’s ingredient list but are not active constituents.
Eleuthero & Guarana by TerraVita Drug Interactions
HelloPharmacist Interaction Report
TerraVita's Eleuthero & Guarana contains two active ingredients with documented interactions.
The most serious concern is guarana's Major-severity interaction with ephedrine — the caffeine in guarana can significantly increase stimulant side effects, including serious or life-threatening reactions. Beyond that, both ingredients interact with multiple drug types.
Read the full breakdown — every affected drug type, severity by severity
Elementhero affects six Moderate-severity drug categories: drugs metabolized by CYP1A2 and CYP2C9 (enzyme interactions that may raise drug levels), P-glycoprotein substrates, blood thinners (anticoagulants and antiplatelet drugs) due to potential bleeding risk, immunosuppressants, and diabetes medications. There's also one documented case of eleuthero raising digoxin levels in a patient on that heart medication.
Guarana's caffeine content interacts with several other Moderate-severity types: seizure medications (valproate, felbamate, and carbamazepine — caffeine may reduce their effectiveness), disulfiram (which slows caffeine clearance), dipyridamole (a blood vessel dilator used in stress tests), fluvoxamine (an antidepressant that raises caffeine levels), and clozapine (an antipsychotic that caffeine can make more toxic).
Elementhero also has one Minor-severity interaction with CYP2D6 substrates, though human research suggests it's unlikely to be clinically important. Altogether, these interactions span 1,337 individual medications.
Use the medication checker on this page to see if any of yours are affected, and confirm with your doctor or pharmacist before starting this product.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Eleuthero & Guarana?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Eleuthero & Guarana interact with 1,336 drugs. Click any drug to see the details.
1 of the 1 ingredient in Eleuthero & Guarana interact with drugs. Each result below shows which ingredient is responsible. Eleuthero & Guarana Glycerite Liquid Extract
Aminophylline, Amobarbital, EphedrineAmesec
How Aminophylline, Amobarbital, Ephedrine interacts with Eleuthero & Guarana — through 1 ingredient. Tap an ingredient for the detail:
Guarana Glycerite Liquid ExtractStimulant Drugs, Ephedrine Major
Interaction Summary
Theoretically, concomitant use might increase stimulant adverse effects.
Read the full Guarana Glycerite Liquid Extract + Aminophylline, Amobarbital, Ephedrine interactionCarbetapentane Tannate, Chlorpheniramine Tannate, Ephedrine Tannate, Phenylephrine TannateQuadratuss, Ry Tuss, Rynatuss, Tri Tannate Plus
How Carbetapentane Tannate, Chlorpheniramine Tannate, Ephedrine Tannate, Phenylephrine Tannate interacts with Eleuthero & Guarana — through 2 ingredients. Tap an ingredient for the detail:
Guarana Glycerite Liquid ExtractEphedrine, Stimulant Drugs Major
Interaction Summary
Theoretically, concomitant use might increase the risk for stimulant adverse effects.
Read the full Guarana Glycerite Liquid Extract + Carbetapentane Tannate, Chlorpheniramine Tannate, Ephedrine Tannate, Phenylephrine Tannate interactionEleuthero Glycerite Liquid ExtractCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, eleuthero might increase levels of drugs metabolized by CYP3A4.
Read the full Eleuthero Glycerite Liquid Extract + Carbetapentane Tannate, Chlorpheniramine Tannate, Ephedrine Tannate, Phenylephrine Tannate interactionDyphylline, Ephedrine, Guaifenesin, PhenobarbitalLufyllin-EPG
How Dyphylline, Ephedrine, Guaifenesin, Phenobarbital interacts with Eleuthero & Guarana — through 1 ingredient. Tap an ingredient for the detail:
Guarana Glycerite Liquid ExtractStimulant Drugs, Phenobarbital (luminal) +1 Major
Interaction Summary
Theoretically, concomitant use might increase stimulant adverse effects.
Read the full Guarana Glycerite Liquid Extract + Dyphylline, Ephedrine, Guaifenesin, Phenobarbital interactionEphedrine, Guaifenesin (otc Drug)Ephedrine Formula 400, Ephedrine Plus Tabs
How Ephedrine, Guaifenesin (otc Drug) interacts with Eleuthero & Guarana — through 1 ingredient. Tap an ingredient for the detail:
Guarana Glycerite Liquid ExtractStimulant Drugs, Ephedrine Major
Interaction Summary
Theoretically, concomitant use might increase stimulant adverse effects.
Read the full Guarana Glycerite Liquid Extract + Ephedrine, Guaifenesin (otc Drug) interactionEphedrine, Guaifenesin, Phenobarbital, TheophyllineMudrane GG
How Ephedrine, Guaifenesin, Phenobarbital, Theophylline interacts with Eleuthero & Guarana — through 2 ingredients. Tap an ingredient for the detail:
Guarana Glycerite Liquid ExtractPhenobarbital (luminal), Ephedrine +2 Major
Interaction Summary
Theoretically, guarana might reduce the effects of phenobarbital and increase the risk for convulsions.
Read the full Guarana Glycerite Liquid Extract + Ephedrine, Guaifenesin, Phenobarbital, Theophylline interactionEleuthero Glycerite Liquid ExtractCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, eleuthero might increase levels of drugs metabolized by CYP1A2.
Read the full Eleuthero Glycerite Liquid Extract + Ephedrine, Guaifenesin, Phenobarbital, Theophylline interactionEphedrine, Hydroxyzine, TheophyllineAmi Rax, Marax
How Ephedrine, Hydroxyzine, Theophylline interacts with Eleuthero & Guarana — through 2 ingredients. Tap an ingredient for the detail:
Guarana Glycerite Liquid ExtractStimulant Drugs, Theophylline +1 Major
Interaction Summary
Theoretically, concomitant use might increase stimulant adverse effects.
Read the full Guarana Glycerite Liquid Extract + Ephedrine, Hydroxyzine, Theophylline interactionEleuthero Glycerite Liquid ExtractCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, eleuthero might increase levels of drugs metabolized by CYP1A2.
Read the full Eleuthero Glycerite Liquid Extract + Ephedrine, Hydroxyzine, Theophylline interactionEphedrine, Phenobarbital, Potassium Iodide, TheophyllineMudrane, Quadrinal
How Ephedrine, Phenobarbital, Potassium Iodide, Theophylline interacts with Eleuthero & Guarana — through 1 ingredient. Tap an ingredient for the detail:
Guarana Glycerite Liquid ExtractPhenobarbital (luminal), Ephedrine +2 Major
Interaction Summary
Theoretically, guarana might reduce the effects of phenobarbital and increase the risk for convulsions.
Read the full Guarana Glycerite Liquid Extract + Ephedrine, Phenobarbital, Potassium Iodide, Theophylline interactionEphedrine, Phenobarbital, TheophyllineTedral
How Ephedrine, Phenobarbital, Theophylline interacts with Eleuthero & Guarana — through 1 ingredient. Tap an ingredient for the detail:
Guarana Glycerite Liquid ExtractStimulant Drugs, Theophylline +2 Major
Interaction Summary
Theoretically, concomitant use might increase stimulant adverse effects.
Read the full Guarana Glycerite Liquid Extract + Ephedrine, Phenobarbital, Theophylline interaction6-mercaptopurinePurinethol
How 6-mercaptopurine interacts with Eleuthero & Guarana — through 1 ingredient. Tap an ingredient for the detail:
Eleuthero Glycerite Liquid ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, eleuthero might interfere with immunosuppressive drugs because of its immunostimulant activity.
Read the full Eleuthero Glycerite Liquid Extract + 6-mercaptopurine interactionAbciximabReoPro
How Abciximab interacts with Eleuthero & Guarana — through 2 ingredients. Tap an ingredient for the detail:
Guarana Glycerite Liquid ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, guarana may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Guarana Glycerite Liquid Extract + Abciximab interactionEleuthero Glycerite Liquid ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, eleuthero may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Eleuthero Glycerite Liquid Extract + Abciximab interactionAbrocitinibCibinqo
How Abrocitinib interacts with Eleuthero & Guarana — through 2 ingredients. Tap an ingredient for the detail:
Guarana Glycerite Liquid ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, guarana may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Guarana Glycerite Liquid Extract + Abrocitinib interactionEleuthero Glycerite Liquid ExtractAnticoagulant/antiplatelet Drugs, Immunosuppressants +1 Moderate
Interaction Summary
Theoretically, eleuthero may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Eleuthero Glycerite Liquid Extract + Abrocitinib interactionAcalabrutinibCalquence
How Acalabrutinib interacts with Eleuthero & Guarana — through 1 ingredient. Tap an ingredient for the detail:
Eleuthero Glycerite Liquid ExtractCytochrome P450 3a4 (cyp3a4) Substrates, P-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, eleuthero might increase levels of drugs metabolized by CYP3A4.
Read the full Eleuthero Glycerite Liquid Extract + Acalabrutinib interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Eleuthero & Guarana — through 2 ingredients. Tap an ingredient for the detail:
Eleuthero Glycerite Liquid ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, eleuthero might have additive effects when used with antidiabetes drugs.
Read the full Eleuthero Glycerite Liquid Extract + Acarbose interactionGuarana Glycerite Liquid ExtractAntidiabetes Drugs Minor
Interaction Summary
Theoretically, taking guarana with antidiabetes drugs might interfere with blood glucose control.
Read the full Guarana Glycerite Liquid Extract + Acarbose interactionAcenocoumarolSintrom
How Acenocoumarol interacts with Eleuthero & Guarana — through 2 ingredients. Tap an ingredient for the detail:
Eleuthero Glycerite Liquid ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, eleuthero may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Eleuthero Glycerite Liquid Extract + Acenocoumarol interactionGuarana Glycerite Liquid ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, guarana may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Guarana Glycerite Liquid Extract + Acenocoumarol interactionAcetaminophenChildren's Tylenol, Children's Tylenol Meltaways, Tylenol, Tylenol Ex Strength
How Acetaminophen interacts with Eleuthero & Guarana — through 1 ingredient. Tap an ingredient for the detail:
Eleuthero Glycerite Liquid ExtractCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, eleuthero might increase levels of drugs metabolized by CYP1A2.
Read the full Eleuthero Glycerite Liquid Extract + Acetaminophen interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Eleuthero & Guarana — through 2 ingredients. Tap an ingredient for the detail:
Eleuthero Glycerite Liquid ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Anticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, eleuthero might increase levels of drugs metabolized by CYP1A2.
Read the full Eleuthero Glycerite Liquid Extract + Acetaminophen, Aspirin interactionGuarana Glycerite Liquid ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, guarana may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Guarana Glycerite Liquid Extract + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Eleuthero & Guarana — through 2 ingredients. Tap an ingredient for the detail:
Eleuthero Glycerite Liquid ExtractAnticoagulant/antiplatelet Drugs, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, eleuthero may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Eleuthero Glycerite Liquid Extract + Acetaminophen, Aspirin, Caffeine interactionGuarana Glycerite Liquid ExtractAnticoagulant/antiplatelet Drugs, Stimulant Drugs Moderate
Interaction Summary
Theoretically, guarana may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Guarana Glycerite Liquid Extract + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, Brompheniramine, PhenylpropanolamineDimetapp Cold and Flu
How Acetaminophen, Brompheniramine, Phenylpropanolamine interacts with Eleuthero & Guarana — through 2 ingredients. Tap an ingredient for the detail:
Guarana Glycerite Liquid ExtractStimulant Drugs, Phenylpropanolamine Moderate
Interaction Summary
Theoretically, concomitant use might increase stimulant adverse effects.
Read the full Guarana Glycerite Liquid Extract + Acetaminophen, Brompheniramine, Phenylpropanolamine interactionEleuthero Glycerite Liquid ExtractCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, eleuthero might increase levels of drugs metabolized by CYP1A2.
Read the full Eleuthero Glycerite Liquid Extract + Acetaminophen, Brompheniramine, Phenylpropanolamine interactionAcetaminophen, ButalbitalAxocet, Bancap, Bucet, Butex Forte, Esgic CF, Orbivan CF +5 more
How Acetaminophen, Butalbital interacts with Eleuthero & Guarana — through 1 ingredient. Tap an ingredient for the detail:
Eleuthero Glycerite Liquid ExtractCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, eleuthero might increase levels of drugs metabolized by CYP1A2.
Read the full Eleuthero Glycerite Liquid Extract + Acetaminophen, Butalbital interactionAcetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more
How Acetaminophen, Butalbital, Caffeine interacts with Eleuthero & Guarana — through 2 ingredients. Tap an ingredient for the detail:
Eleuthero Glycerite Liquid ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, eleuthero might increase levels of drugs metabolized by CYP1A2.
Read the full Eleuthero Glycerite Liquid Extract + Acetaminophen, Butalbital, Caffeine interactionGuarana Glycerite Liquid ExtractStimulant Drugs Moderate
Interaction Summary
Theoretically, concomitant use might increase stimulant adverse effects.
Read the full Guarana Glycerite Liquid Extract + Acetaminophen, Butalbital, Caffeine interactionAcetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
How Acetaminophen, Butalbital, Caffeine, Codeine interacts with Eleuthero & Guarana — through 2 ingredients. Tap an ingredient for the detail:
Eleuthero Glycerite Liquid ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, eleuthero might increase levels of drugs metabolized by CYP1A2.
Read the full Eleuthero Glycerite Liquid Extract + Acetaminophen, Butalbital, Caffeine, Codeine interactionGuarana Glycerite Liquid ExtractStimulant Drugs Moderate
Interaction Summary
Theoretically, concomitant use might increase stimulant adverse effects.
Read the full Guarana Glycerite Liquid Extract + Acetaminophen, Butalbital, Caffeine, Codeine interactionAcetaminophen, Butalbital, CodeineBancap w/ Codeine
How Acetaminophen, Butalbital, Codeine interacts with Eleuthero & Guarana — through 1 ingredient. Tap an ingredient for the detail:
Eleuthero Glycerite Liquid ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, eleuthero might increase levels of drugs metabolized by CYP1A2.
Read the full Eleuthero Glycerite Liquid Extract + Acetaminophen, Butalbital, Codeine interactionAcetaminophen, Butalbital, Codeine PhosphatePhrenilin #3
How Acetaminophen, Butalbital, Codeine Phosphate interacts with Eleuthero & Guarana — through 1 ingredient. Tap an ingredient for the detail:
Eleuthero Glycerite Liquid ExtractCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, eleuthero might increase levels of drugs metabolized by CYP2D6.
Read the full Eleuthero Glycerite Liquid Extract + Acetaminophen, Butalbital, Codeine Phosphate interactionAcetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with Eleuthero & Guarana — through 2 ingredients. Tap an ingredient for the detail:
Eleuthero Glycerite Liquid ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, eleuthero might increase levels of drugs metabolized by CYP1A2.
Read the full Eleuthero Glycerite Liquid Extract + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionGuarana Glycerite Liquid ExtractStimulant Drugs Moderate
Interaction Summary
Theoretically, concomitant use might increase stimulant adverse effects.
Read the full Guarana Glycerite Liquid Extract + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAcetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
How Acetaminophen, Caffeine, Codeine interacts with Eleuthero & Guarana — through 2 ingredients. Tap an ingredient for the detail:
Eleuthero Glycerite Liquid ExtractCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, eleuthero might increase levels of drugs metabolized by CYP2D6.
Read the full Eleuthero Glycerite Liquid Extract + Acetaminophen, Caffeine, Codeine interactionGuarana Glycerite Liquid ExtractStimulant Drugs Moderate
Interaction Summary
Theoretically, concomitant use might increase stimulant adverse effects.
Read the full Guarana Glycerite Liquid Extract + Acetaminophen, Caffeine, Codeine interactionAcetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
How Acetaminophen, Caffeine, Codeine, Salicylamide interacts with Eleuthero & Guarana — through 2 ingredients. Tap an ingredient for the detail:
Guarana Glycerite Liquid ExtractStimulant Drugs Moderate
Interaction Summary
Theoretically, concomitant use might increase stimulant adverse effects.
Read the full Guarana Glycerite Liquid Extract + Acetaminophen, Caffeine, Codeine, Salicylamide interactionEleuthero Glycerite Liquid ExtractCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, eleuthero might increase levels of drugs metabolized by CYP2D6.
Read the full Eleuthero Glycerite Liquid Extract + Acetaminophen, Caffeine, Codeine, Salicylamide interactionAcetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
How Acetaminophen, Caffeine, Dihydrocodeine interacts with Eleuthero & Guarana — through 2 ingredients. Tap an ingredient for the detail:
Eleuthero Glycerite Liquid ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates +1 Moderate
Interaction Summary
Theoretically, eleuthero might increase levels of drugs metabolized by CYP1A2.
Read the full Eleuthero Glycerite Liquid Extract + Acetaminophen, Caffeine, Dihydrocodeine interactionGuarana Glycerite Liquid ExtractStimulant Drugs Moderate
Interaction Summary
Theoretically, concomitant use might increase stimulant adverse effects.
Read the full Guarana Glycerite Liquid Extract + Acetaminophen, Caffeine, Dihydrocodeine interactionAcetaminophen, Caffeine, IsomethepteneMigralam
How Acetaminophen, Caffeine, Isometheptene interacts with Eleuthero & Guarana — through 2 ingredients. Tap an ingredient for the detail:
Guarana Glycerite Liquid ExtractStimulant Drugs Moderate
Interaction Summary
Theoretically, concomitant use might increase stimulant adverse effects.
Read the full Guarana Glycerite Liquid Extract + Acetaminophen, Caffeine, Isometheptene interactionEleuthero Glycerite Liquid ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, eleuthero might increase levels of drugs metabolized by CYP3A4.
Read the full Eleuthero Glycerite Liquid Extract + Acetaminophen, Caffeine, Isometheptene interactionAcetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
How Acetaminophen, Caffeine, Pyrilamine interacts with Eleuthero & Guarana — through 2 ingredients. Tap an ingredient for the detail:
Eleuthero Glycerite Liquid ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, eleuthero might increase levels of drugs metabolized by CYP1A2.
Read the full Eleuthero Glycerite Liquid Extract + Acetaminophen, Caffeine, Pyrilamine interactionGuarana Glycerite Liquid ExtractStimulant Drugs, Diuretic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might increase stimulant adverse effects.
Read the full Guarana Glycerite Liquid Extract + Acetaminophen, Caffeine, Pyrilamine interactionAcetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
How Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interacts with Eleuthero & Guarana — through 1 ingredient. Tap an ingredient for the detail:
Eleuthero Glycerite Liquid ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates +1 Moderate
Interaction Summary
Theoretically, eleuthero might increase levels of drugs metabolized by CYP1A2.
Read the full Eleuthero Glycerite Liquid Extract + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Eleuthero & Guarana with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Eleuthero & Guarana Glycerite Liquid Extract
Anticoagulant/Antiplatelet Drugs
Theoretically, eleuthero may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
In vitro and animal research shows that a constituent of eleuthero, dihydroxybenzoic acid, appears to inhibit platelet aggregation. Concomitant use with anticoagulant or antiplatelet drugs might increase the risk of bleeding. This effect has not been reported in humans.
Antidiabetes Drugs
Theoretically, eleuthero might have additive effects when used with antidiabetes drugs.
Animal research suggests that certain constituents of eleuthero have hypoglycemic activity in both healthy and diabetic animals. A small study in adults with type 2 diabetes also shows that taking eleuthero for 3 months can lower blood glucose levels. However, one very small study in healthy individuals shows that taking powdered eleuthero 3 grams, 40 minutes prior to a 75-gram oral glucose tolerance test, significantly increases postprandial blood glucose levels when compared with placebo. These contradictory findings might be due to patient-specific variability and variability in active ingredient ratios.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, eleuthero might increase levels of drugs metabolized by CYP1A2.
In vitro and animal research suggest that standardized extracts of eleuthero inhibit CYP1A2. This effect has not been reported in humans.
Cytochrome P450 2C9 (Cyp2C9) Substrates
Theoretically, eleuthero might increase levels of drugs metabolized by CYP2C9.
In vitro and animal research suggest that standardized extracts of eleuthero might inhibit CYP2C9. This effect has not been reported in humans.
Digoxin (Lanoxin)
Eleuthero might increase serum digoxin levels and increase the risk of side effects.
In one case report, a 74-year-old male who was stabilized on digoxin presented with an elevated serum digoxin level after starting an eleuthero supplement, without symptoms of toxicity. After stopping the supplement, serum digoxin levels returned to normal. It is not clear whether this was due to a pharmacokinetic interaction or to interference with the digoxin assay. Although the product was found to be free of digoxin and digitoxin, it was not tested for other contaminants.
Immunosuppressants
Theoretically, eleuthero might interfere with immunosuppressive drugs because of its immunostimulant activity.
Animal and in vitro research shows that eleuthero extracts have immunomodulatory effects, including increasing cellular and humoral activity.
P-Glycoprotein Substrates
Theoretically, eleuthero might increase levels of P-glycoprotein substrates.
In vitro research suggests that eleuthero can inhibit the multi-drug transporter protein, P-glycoprotein. However, it is too soon to tell if this is clinically important. This interaction has not been reported in humans.
Cytochrome P450 2D6 (Cyp2D6) Substrates
Theoretically, eleuthero might increase levels of drugs metabolized by CYP2D6.
In vitro and animal research suggest that standardized extracts of eleuthero might inhibit CYP2D6. However, research in healthy human volunteers has found that taking eleuthero 485 mg twice daily for 14 days does not inhibit CYP2D6 drug metabolism.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, eleuthero might increase levels of drugs metabolized by CYP3A4.
In vitro and animal research suggest that standardized extracts of eleuthero might inhibit CYP3A4. However, research in healthy human volunteers has found that taking eleuthero 485 mg twice daily for 14 days does not inhibit CYP3A4 drug metabolism.
Organic Anion-Transporting Polypeptide Substrates (Oatp)
Theoretically, eleuthero might decrease levels of drugs metabolized by OATP.
In vitro research suggests that eleuthero inhibits OATP2B1, which might reduce the bioavailability of oral drugs that are substrates of OATP2B1. Due to the weak inhibitory effect identified in this study, this interaction is not likely to be clinically significant.
Brand information
Manufacturer and brand details for Eleuthero & Guarana, from the product label.
TerraVita
See all TerraVita products- Name
- ZooScape LLC
- Phone Number
- 844-449-0444
- Web Address
- www.ZooScape.com
Eleuthero & Guarana by TerraVita: Common Questions
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Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Eleuthero & Guarana’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Eleuthero
Interacts with 1,140 drugsEleuthero is an herb traditionally used as an 'adaptogen' to fight fatigue, boost energy, and help the body handle stress. The scientific evidence behind these uses is limited and mixed, so...
Read the full Eleuthero monograph → Herb & supplement monographGuarana
Interacts with 655 drugsGuarana is an Amazonian seed that is naturally high in caffeine, which explains most of its stimulant and energy effects. While it may give a short-term boost in alertness and reduce fatigue...
Read the full Guarana monograph →Sources & How We Checked
Eleuthero & Guarana's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 138 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Eleuthero 24 references
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