Interactions on record — worth a quick check against your medications. Based on 1 of 2 ingredients. Check your meds →
Dietary supplement

Endurance Ingredients & Drug Interactions

by PowerLife by Tony Horton

Endurance label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Endurance against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Endurance is a dietary supplement by PowerLife by Tony Horton with 2 active ingredients. Its ingredients are commonly taken for antioxidant support, skin health and aging, eye health.Based on those ingredients, 671 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Astaxanthin. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Endurance by PowerLife by Tony Horton

Ask about any prescription or over-the-counter medication and we check it for interactions with Endurance by PowerLife by Tony Horton — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Endurance by PowerLife by Tony Horton

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Endurance has two active ingredients. Astaxanthin is a carotenoid — a natural pigment found in certain seafood and algae — that acts as an antioxidant in your body.

The other active ingredient is elevATP, which we have no interaction data on file for. The capsule also contains several inactive ingredients: olive oil, hypromellose, glycine, rice husk, rice extract, gum arabic, sunflower oil, and silica.

These are standard excipients — binders and fillers that help hold the capsule together and aid absorption.

Does it work?

Insufficient evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Insufficient

There isn't enough reliable clinical evidence to rate this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: supports athletic performance and antioxidant protection.
  • We looked for evidence on: Athletic performance, Physical performance, Exercise-induced muscle damage, Exercise-induced muscle soreness, Fatigue, Endurance — and 2 related terms.
  • The closest evidence on file: Astaxanthin is rated "Insufficient Reliable Evidence To Rate" for Athletic performance (Natural Medicines).
  • Also on file: Astaxanthin is rated "Insufficient Reliable Evidence To Rate" for Exercise-induced muscle soreness, Fatigue, Physical performance, Exercise-induced muscle damage.

The evidence we hold doesn't establish that astaxanthin works for the conditions listed — including age-related cognitive decline, macular degeneration, skin aging, Alzheimer's disease, athletic performance, or carpal tunnel syndrome. All of those uses have insufficient reliable evidence to rate.

We have no effectiveness data on file for elevATP.

The evidence, ingredient by ingredient Astaxanthin

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Astaxanthin is generally well tolerated in studies, though long-term safety data are limited. The most common side effects from oral use are abdominal pain, diarrhea, and red-colored stools.

Trial data show a small number of people experienced increased bowel movements or red stool color at standard doses, and two patients on a much higher dose (40 mg daily, well above typical use) reported severe stomach or abdominal pain. There isn't enough safety data to recommend astaxanthin during pregnancy or while breastfeeding — talk with your pharmacist or doctor for personalized guidance if either applies to you.

Side effects, ingredient by ingredient Astaxanthin

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Astaxanthin.
  • The most serious interaction on file is rated Moderate.
  • For scale: 672 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Endurance, check whether you take any drugs metabolized by the CYP3A4 enzyme — astaxanthin may decrease their blood levels (Moderate severity). Also double-check any medications broken down by CYP2B6, which astaxanthin may affect the same way (Moderate severity).

We couldn't check elevATP for interactions.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with insufficient evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Endurance may be worth considering if you're looking for an antioxidant supplement, but the effectiveness evidence for its marketed uses isn't established in our data. The key thing: astaxanthin can theoretically lower levels of many common medications by speeding up how your liver breaks them down.

Check your prescriptions with the tool on this page before you start, and talk to your pharmacist if you take anything regularly.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 24, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Endurance, straight from the product label.

Brand PowerLife by Tony Horton
Net contents 30 Capsule(s)
Market status On market
Date entered into DSLD Oct 24, 2024
DSLD ID 323746
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Endurance by PowerLife by Tony Horton, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
30
IngredientAmount% DV
elevATP150 mg--
Astaxanthin6 mg--

Other ingredients: Olive Oil, Hypromellose, Glycine, Rice Husk, Rice extract, Gum Arabic, Sunflower Oil, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

High impact Supports antioxidant protection, athletic performance and body composition. Potent antioxidant Boost cellular energy

Vegan-Friendly

Non-GMO ingredients No artificial ingredients

FDA Statement of Identity

Dietary Supplement

Formula

Keto Keto-Friendly

6 mg Hawaiian Astaxanthin A powerful antioxidant that can support muscle development, and naturally boost energy levels. 150 mg elevATP Made of natural peat and apple polyphenols, can promote improved athletic performance and support your natural production of ATP-which your body uses for energy.

Brand IP Statement(s)

elevATP is a registered trademark of VDF FutureCeuticals, Inc. elevATP products are protected by US patent no. 9,327,005, used under license

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Endurance by PowerLife by Tony Horton label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Endurance label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Endurance by PowerLife by Tony Horton

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

ElevATP

150 mg per serving Form: Ancient Peat Extract, Apple Fruit Extract

Astaxanthin

Interacts with
671 drugs
6 mg per serving Form: Hawaiian Astaxanthin

Astaxanthin is a reddish carotenoid pigment with strong antioxidant activity in the lab, and it is widely promoted for skin, eye, heart, and exercise...

Astaxanthin monograph & interactions

Other (inactive) ingredients: Olive Oil, Hypromellose, Glycine, Rice Husk, Rice extract, Gum Arabic, Sunflower Oil, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

Endurance by PowerLife by Tony Horton Drug Interactions

Want to check YOUR meds against Endurance?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
671Drugs
671 Moderate

Ingredients driving the most interactions

Astaxanthin 671

Individual Drug Interactions

The ingredients in Endurance interact with 671 drugs. Click any drug to see the details.

1 of the 2 ingredients in Endurance interact with drugs. Each result below shows which ingredient is responsible. Astaxanthin

Each ingredient & the kinds of drugs it affects

For each ingredient in Endurance with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Astaxanthin2 drug types · 671 drugs

Cytochrome P450 2B6 (Cyp2B6) Substrates

Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP2B6.
In vitro research shows that astaxanthin induces cytochrome CYP2B6 enzyme activity in human hepatocytes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
In vitro research shows that astaxanthin induces CYP3A4 enzyme activity in human hepatocytes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Astaxanthin full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Endurance, from the product label.

PowerLife by Tony Horton

See all PowerLife by Tony Horton products
Name
PowerLife
Pharmacist Counseling Corner

Endurance by PowerLife by Tony Horton: Common Questions

Does Endurance by PowerLife by Tony Horton interact with any medications?
Yes. Based on its ingredients, Endurance has a known interaction with 671 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Endurance contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is astaxanthin?
Astaxanthin is a carotenoid — a natural pigment found in seafood and algae that acts as an antioxidant. It's the active ingredient in this product that interacts with medications.
Does astaxanthin actually improve athletic performance or brain health?
The evidence we hold doesn't establish that it works for athletic performance, cognitive decline, Alzheimer's disease, or other uses listed here. All are rated insufficient reliable evidence to rate.
What side effects might I get?
Astaxanthin is generally well tolerated. The most common effects are abdominal pain, diarrhea, and red-colored stools. A small number of trial participants experienced increased bowel movements or red stool color at standard doses.
Can I take this if I'm pregnant or breastfeeding?
There isn't enough safety data either way. Talk with your pharmacist or doctor — they can help you decide based on your individual situation.
What's elevATP, the other active ingredient?
It's the second active ingredient in this product, but we don't have interaction or effectiveness data on file for it. Your pharmacist can tell you more about what it does.
Does this product have fillers or other junk in it?
The capsule contains inactive ingredients — olive oil, hypromellose, glycine, rice husk, rice extract, gum arabic, sunflower oil, and silica — which are standard binders and excipients that help the capsule work.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Endurance is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Endurance label
Go deeper

The Full Monographs Behind Endurance’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Astaxanthin

Interacts with 671 drugs

Astaxanthin is a reddish carotenoid pigment with strong antioxidant activity in the lab, and it is widely promoted for skin, eye, heart, and exercise benefits. Early human studies are promis...

Read the full Astaxanthin monograph →
Sources

Sources & How We Checked

Endurance's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 3 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Astaxanthin 3 references
  1. Kupcinskas L, Lafolie P, Lignell A, et al. Efficacy of the natural antioxidant astaxanthin in the treatment of functional dyspepsia in patients with or without Helicobacter pylori infection: A prospective, randomized, double blind, and placebo-controlled
  2. Kistler, A., Liechti, H., Pichard, L., Wolz, E., Oesterhelt, G., Hayes, A., and Maurel, P. Metabolism and CYP-inducer properties of astaxanthin in man and primary human hepatocytes. Arch.Toxicol. 2002;75(11-12):665-675. PubMed
  3. Choi HD, Youn YK, Shin WG. Positive effects of astaxanthin on lipid profiles and oxidative stress in overweight subjects. Plant Foods Hum Nutr. 2011;66:363-369. PubMed

See these in context on the Astaxanthin monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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