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Dietary supplement

Enzyme Complete DPP-IV with Isogest Ingredients & Drug Interactions

by Kirkman

Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

Enzyme Complete DPP-IV with Isogest is a dietary supplement by Kirkman with 3 active ingredients. Its ingredients are commonly taken for digestive support, bloating and gas, fat digestion.Based on those ingredients, 141 medications have a known interaction with it, the most serious rated moderate. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of Enzyme Complete DPP-IV with Isogest by Kirkman

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 15 active ingredients.
  • “Protein Digestion” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.
  • “Fat Digestion” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.
  • “Carbohydrate Digestion” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.

Enzyme Complete DPP-IV with Isogest contains 15 active ingredients, mostly digestive enzymes. The main ones are papain and bromelain, which break down protein; lipase, which breaks down fat; lactase, which breaks down milk sugar; and a mix of others — phytase, acid-stable protease, protease 6.0, and several carbohydrate-digesting enzymes (amylase, alpha-galactosidase, invertase) — plus isogest, which we could not check.

The capsule itself contains hypromellose, microcrystalline cellulose, maltodextrin, and water as inactive ingredients.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: Digestive enzyme support with DPP-IV activity.
  • We looked for evidence on: Dyspepsia, Lactose intolerance, Exercise-induced muscle soreness, Postoperative swelling, Sprains, Wound healing — and 3 related terms.
  • The strongest evidence on file: Lactase is rated "Effective" for Lactose intolerance (Natural Medicines).
  • Also on file: Papain is rated "Insufficient Reliable Evidence To Rate" for Exercise-induced muscle soreness, Wound healing.
  • Also on file: Lipase is rated "Insufficient Reliable Evidence To Rate" for Dyspepsia.

The data we hold shows evidence only for lactase, which is effective for lactose intolerance — meaning it helps people digest milk sugar if they don't produce enough of their own lactase enzyme. For papain, bromelain, lipase, phytase, the protease ingredients, and the other enzymes in this product, the evidence isn't established in our data.

Effectiveness for conditions like cancer, muscle soreness, burns, inflammatory bowel disease, and many others is rated as having insufficient reliable evidence to rate.

The evidence, ingredient by ingredient Lipase

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 6 of the 6 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 6 of 6.
  • General safety write-ups exist for 6 of 6.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Papain is generally tolerated as a food but supplements may irritate the digestive tract and cause allergic reactions in sensitive people — symptoms can include itchy watery eyes, runny nose, sneezing, abdominal cramps, and diarrhea. High doses orally may be unsafe and rarely can cause severe stomach inflammation or esophageal perforation.

Bromelain is generally well tolerated short-term with the most common side effects being diarrhea, flatulence, stomach upset, and headache; allergic reactions are possible. Lactase is likely safe in pregnancy and lactation.

Papain is possibly unsafe in pregnancy and should be avoided; bromelain should be avoided in both pregnancy and breastfeeding. For the other enzymes — lipase, phytase, and the proteases — there is limited or no safety data in pregnancy and breastfeeding, so check with your doctor or pharmacist before regular use if you're pregnant or nursing.

Side effects, ingredient by ingredient Lipase

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 6 matched ingredients can interact with medications — Papain, Bromelain.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 141 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you start, check with your doctor or pharmacist if you take warfarin (Coumadin) or any other blood thinner or antiplatelet drug — papain and bromelain may increase bleeding risk. If you take tetracycline antibiotics, bromelain might raise their levels, though human evidence is mixed.

No interactions are documented for the other ingredients we could check, but several we could not check for interactions at all.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This is a digestive enzyme blend best suited for people who want help breaking down protein, fat, and carbohydrates — and for those with lactose intolerance, lactase is proven effective. If you take warfarin or any blood thinner or antiplatelet medication, talk with your pharmacist or doctor before starting it, because papain and bromelain may increase bleeding risk.

Pregnant or breastfeeding people should also check with their doctor first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 7 of 15 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Dec 14, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Enzyme Complete DPP-IV with Isogest, straight from the product label.

Brand Kirkman
Barcode (UPC) 812325025060
Net contents 180 Capsule(s)
Market status On market
Date entered into DSLD Dec 14, 2023
DSLD ID 297036
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Enzyme Complete DPP-IV with Isogest by Kirkman, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
180
UPC/BARCODE
812325025060
IngredientAmount% DV
Papain0 NP--
Bromelain0 NP--
Lactase0 NP--
Lipase0 NP--
Cellulase0 NP--
Phytase0 NP--
Xylanase0 NP--
Amylase0 NP--
Alpha-Galactosidase0 NP--
Peptidase0 NP--
acid-stable Protease0 NP--
Diastase0 NP--
Protease 6.00 NP--
Protein Digestion0 NP--
Fat Digestion0 NP--
Carbohydrate Digestion0 NP--
Isogest0 NP--
Kirkman Proprietary Enzyme Blend230 mg--
Invertase0 NP--

Other ingredients: Hypromellose, Water, Microcrystalline Cellulose, Maltodextrin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Storage

Important: Store in a cool dry place and tightly capped.

Precautions

Keep out of the reach of children.

Caution: Enzymes may cause irritation to skin and soft tissue. Consult your physician if using in the presence of peptic ulcer.

Allergen Warning: Contains sulphites. Enzymes grown on fermentation media containing wheat and soy (may contain undetectable trace amounts).

Formulation

Free of: Milk, eggs, fish, shellfish, tree nuts, peanuts, wheat or soy

Hypoallergenic

Gluten-free

Seals/Symbols

Ultra Tested cGMP Certified Good Manufacturing Practice

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested Use: One capsule at the beginning of every meal or as directed by a physician.

See for yourself

Enzyme Complete DPP-IV with Isogest by Kirkman label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Enzyme Complete DPP-IV with Isogest by Kirkman

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container180 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Fat Digestion

0 NP per serving

Kirkman Proprietary Enzyme Blend

230 mg per serving
  • › Protein Digestion
  • › Carbohydrate Digestion

Other (inactive) ingredients: Hypromellose, Water, Microcrystalline Cellulose, Maltodextrin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Enzyme Complete DPP-IV with Isogest by Kirkman Drug Interactions

Want to check YOUR meds against Enzyme Complete DPP-IV with Isogest?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
141Drugs
122 Moderate 19 Minor

Ingredients driving the most interactions

Each ingredient & the kinds of drugs it affects

For each ingredient in Enzyme Complete DPP-IV with Isogest with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

The maker

Brand information

Manufacturer and brand details for Enzyme Complete DPP-IV with Isogest, from the product label.

Kirkman

See all Kirkman products
Name
Kirkman
City
Lake Oswego
State
OR
ZipCode
97035
Phone Number
(800) 245-8282
Web Address
www.kirkmangroup.com
Pharmacist Counseling Corner

Enzyme Complete DPP-IV with Isogest by Kirkman: Common Questions

Does Enzyme Complete DPP-IV with Isogest by Kirkman interact with any medications?
Yes. Based on its ingredients, Enzyme Complete DPP-IV with Isogest has a known interaction with 141 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Enzyme Complete DPP-IV with Isogest contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this help me digest food better if I don't have a digestive disorder?
The data we have only establishes that lactase works for lactose intolerance. For the other enzymes in this blend — papain, bromelain, lipase, and the rest — we don't have evidence they're effective for general digestion. Talk with your doctor about whether this product makes sense for you.
Can I take this if I'm pregnant?
Papain should be avoided in pregnancy because the data advises against it. Bromelain should also be avoided. For the other enzymes, there isn't enough safety data to say either way — check with your doctor or pharmacist for personalized advice.
Is this safe to breastfeed while taking?
Bromelain should be avoided while breastfeeding. Papain — not enough data exists, so it's best to avoid it too. Lactase is likely safe. For the others, safety data is limited or missing — talk with your doctor or pharmacist first.
What's papain, and why is it in here?
Papain is an enzyme from papaya that breaks down protein. It's included to help digest protein-rich foods. However, it can interact with blood thinners like warfarin, so let your pharmacist know if you take one.
Could this cause an allergic reaction?
Yes. Papain and bromelain can trigger allergic reactions in sensitive people — symptoms include itchy watery eyes, sneezing, runny nose, and abdominal cramps. If you have a known enzyme allergy or are sensitive to papaya or pineapple, mention it to your pharmacist before using.
What are the most common side effects?
Bromelain most commonly causes diarrhea, gas, stomach upset, and headache. Papain can cause digestive irritation and allergic reactions. Both are generally well tolerated when you take the right dose for the short term.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Enzyme Complete DPP-IV with Isogest is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Enzyme Complete DPP-IV with Isogest label
Go deeper

The Full Monographs Behind Enzyme Complete DPP-IV with Isogest’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Sources

Sources & How We Checked

Enzyme Complete DPP-IV with Isogest's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 42 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Papain 11 references
  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Shaw D, Leon C, Kolev S, Murray V. Traditional remedies and food supplements: a 5-year toxicological study (1991-1995). Drug Saf 1997;17:342-56.
  3. Shuttleworth D, Hill S, Marks R, Connelly DM. Relief of experimentally induced pruritus with a novel eutectic mixture of local anaesthetic agents. Br J Dermatol 1988;119:535-40.
  4. Mansfield LE, Ting S, Haverly RW, Yoo TJ. The incidence and clinical implications of hypersensitivity to papain in an allergic population, confirmed by blinded oral challenge. Ann Allergy 1985;55:541-3.
  5. Martin, T., Uhder, K., Kurek, R., Roeddiger, S., Schneider, L., Vogt, H. G., Heyd, R., and Zamboglou, N. Does prophylactic treatment with proteolytic enzymes reduce acute toxicity of adjuvant pelvic irradiation? Results of a double-blind randomized trial PubMed
  6. Walker-Renard, P. Update on the medicinal management of phytobezoars. Am J Gastroenterol. 1993;88(10):1663-1666.
  7. Tymoszuk D, Wiszniewska M, Walusiak-Skorupa J. Papain-induced occupational rhinoconjunctivitis and asthma - A case report. Med Pr 2016;67(1):109-12. PubMed
  8. Soto-Mera MT, López-Rico MR, Filgueira JF, et al. Occupational allergy to papain. Allergy 2000;55(10):983-4. PubMed
  9. Tarlo SM, Shaikh W, Bell B, et al. Papain-induced allergic reactions. Clin Allergy 1978;8(3):207-15. PubMed
  10. Baur X, König G, Bencze K, Fruhmann G. Clinical symptoms and results of skin test, RAST and bronchial provocation test in thirty-three papain workers: Evidence for strong immunogenic potency and clinically relevant proteolytic e?ects of airborne papain. C
  11. Novey HS, Keenan WJ, Fairshter RD, Wells ID, Wilson AF, Culver BD. Pulmonary disease in workers exposed to papain: clinico-physiological and immunological studies. Clin Allergy 1980;10(6):721-31. PubMed

See these in context on the Papain monograph →

Bromelain 19 references
  1. Nettis E, Napoli G, Ferrannini A, Tursi A. IgE-mediated allergy to bromelain. Allergy 2001;56:257-8. PubMed
  2. Taussig SJ, Batkin S. Bromelain, the enzyme complex of pineapple (Ananas comosus) and its clinical application. An update. J Ethnopharmacol 1988;22:191-203.. PubMed
  3. Bradbrook ID, Morrison PJ, Rogers HJ. The effect of bromelain on the absorption of orally administered tetracycline. Br J Clin Pharmacol 1978;6:552-4. PubMed
  4. Bush TM, Rayburn KS, Holloway SW, et al. Adverse interactions between herbal and dietary substances and prescription medications: a clinical survey. Altern Ther Health Med 2007;13:30-5.
  5. Brien S, Lewith G, Walker AF, et al. Bromelain as an adjunctive treatment for moderate-to-severe osteoarthritis of the knee: a randomized placebo-controlled pilot study. QJM 2006;99:841-50. PubMed
  6. Mori S, Ojima Y, Hirose T, et al. The clinical effect of proteolytic enzyme containing bromelain and trypsin on urinary tract infection evaluated by double blind method. Acta Obstet Gynaecol Jpn 1972;19:147-53.
  7. Glaser D, Hilberg T. The influence of bromelain on platelet count and platelet activity in vitro. Platelets 2006;17:37-41. PubMed
  8. Heinicke R M, van der Wal L, Yokoyama M. Effect of bromelain (Ananase) on human platelet aggregation. Experientia 1972;28:844-5. PubMed
  9. Gailhofer, G., Wilders-Truschnig, M., Smolle, J., and Ludvan, M. Asthma caused by bromelain: an occupational allergy. Clin Allergy 1988;18(5):445-450. PubMed
  10. Mattei, O., Fabri, G., and Farina, G. [Occupational health experience regarding four cases of asthma due to bromelain (author's transl)]. Medicina del Lavoro 1979;70(5):404-409.
  11. Galleguillos, F. and Rodriguez, J. C. Asthma caused by bromelin inhalation. Clin Allergy 1978;8(1):21-24. PubMed
  12. Perez-Camo I, Quirce S, Duran MA, and et al. Latex allergy: evidence of cross-reactivity with papain and bromelain [abstract]. Allergy 1996;51(suppl 31):48.
  13. Martin GJ, Ehrenreich J, and Asbell N. Bromelain: pineapple proteases with anti-edema activity. Exp Med Surg 1962;20:227-247.
  14. Kasemsuk T, Saengpetch N, Sibmooh N, Unchern S. Improved WOMAC score following 16-week treatment with bromelain for knee osteoarthritis. Clin Rheumatol. 2016 Oct;35(10):2531-40. PubMed
  15. Kutlu Ö, DemirbaS A, Elmas ÖF, Güvenç U, Metin A. Fixed drug eruption: a new side effect of bromelain. Contact Dermatitis 2020. Online ahead of print. PubMed
  16. Shoham Y, Shapira E, Haik J, et al. Bromelain-based enzymatic debridement of chronic wounds: Results of a multicentre randomized controlled trial. Wound Repair Regen 2021;29(6):899-907. PubMed
  17. Pfister P, Garcia Wendel PD, Kim BS, et al. Coagulation side effects of enzymatic debridement in burned patients. Burns 2022. PubMed
  18. Hasham S, Riyat H, Fletcher A, O'Boyle CP, Alexander S. To bleed or not to bleed? Case series and discussion of haemorrhage risk with enzymatic debridement in burn injuries. Scars Burn Heal 2023;9:20595131231168333. PubMed
  19. Leelakanok N, Petchsomrit A, Janurai T, Saechan C, Sunsandee N. Efficacy and safety of bromelain: A systematic review and meta-analysis. Nutr Health 2023. PubMed

See these in context on the Bromelain monograph →

Lactase 1 reference
  1. Laukkanen A, Ruoppi P, Remes S, Koistinen T, Mäkinen-Kiljunen S. Lactase-induced occupational protein contact dermatitis and allergic rhinoconjunctivitis. Contact Dermatitis. 2007;57(2):89-93. PubMed

See these in context on the Lactase monograph →

Lipase 1 reference
  1. Casper C, Hascoet JM, Ertl T, et al. Recombinant bile salt-stimulated lipase in preterm infant feeding: A randomized phase 3 study. PLoS One. 2016;11(5):e0156071. PubMed

See these in context on the Lipase monograph →

Phytase 7 references
  1. Lei XG, Weaver JD, Mullaney E, Ullah AH, Azain MJ. Phytase, a new life for an "old" enzyme. Annu Rev Anim Biosci. 2013;1:283-309. PubMed
  2. Smuts CM, Matsungo TM, Malan L, et al. Effect of small-quantity lipid-based nutrient supplements on growth, psychomotor development, iron status, and morbidity among 6- to 12-mo-old infants in South Africa: a randomized controlled trial. Am J Clin Nutr. 2 PubMed
  3. van Heemst RC, Sander I, Rooyackers J, et al. Hypersensitivity pneumonitis caused by occupational exposure to phytase. Eur Respir J. 2009;33(6):1507-9. PubMed
  4. Baur X, Melching-Kollmuss S, Koops F, Strassburger K, Zober A. IgE-mediated allergy to phytase -- a new animal feed additive. Allergy. 2002;57(10):943-5. PubMed
  5. Doekes G, Kamminga N, Helwegen L, Heederik D. Occupational IgE sensitisation to phytase, a phosphatase derived from Aspergillus niger. Occup Environ Med. 1999;56(7):454-9. PubMed
  6. Brnic M, Hurrell RF, Songré-Ouattara LT, et al. Effect of phytase on zinc absorption from a millet-based porridge fed to young Burkinabe children. Eur J Clin Nutr. 2017;71(1):137-141. PubMed
  7. Koshy JC, Sharabi SE, Feldman EM, Hollier LH Jr, Patrinely JR, Soparkar CN. Effect of dietary zinc and phytase supplementation on botulinum toxin treatments. J Drugs Dermatol. 2012;11(4):507-12.

See these in context on the Phytase monograph →

Proteolytic Enzymes (proteases) 3 references
  1. Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
  2. Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
  3. Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed

See these in context on the Proteolytic Enzymes (proteases) monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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