EPA/DHA Guard Ingredients & Drug Interactions
by Perque
What is this page for?
First and foremost: checking EPA/DHA Guard against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
EPA/DHA Guard is a dietary supplement by Perque with 4 active ingredients. Its ingredients are commonly taken for vitamin c source, digestive support, flavoring and aromatherapy.Based on those ingredients, 1 medication has a known interaction with it, the most serious rated minor. The ingredients most likely to interact are Lemon Oil. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against EPA/DHA Guard by Perque
Ask about any prescription or over-the-counter medication and we check it for interactions with EPA/DHA Guard by Perque — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of EPA/DHA Guard by Perque
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This softgel contains 4 active ingredients: eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) — both omega-3 fatty acids sourced from fish — plus lemon oil and marine lipid oil. EPA and DHA are the two omega-3s that make up most fish oil supplements.
The inactive ingredients are lemon flavor oil and gelatin (the capsule shell).
Does it work?
Couldn't assess
We hold effectiveness data only for the lemon oil component, and the evidence for it is not established in our database. Lemon oil is rated as having insufficient reliable evidence for hay fever, anxiety, respiratory tract infections, high blood pressure, and kidney stones.
We have no effectiveness ratings on file for EPA, DHA, or marine lipid oil in this product.
How safe is it?
Well-documented data
Lemon oil as a food or drink is generally well tolerated in normal amounts. However, if you're using concentrated lemon supplements or essential oils (rather than food amounts), check with your doctor first — the safety data on medicinal doses and essential oils is limited.
In clinical trials, larger amounts of fresh lemon juice caused heartburn and stomach discomfort (epigastralgia) in a minority of people; in one study, 21% experienced heartburn and 8% experienced epigastralgia, compared to much lower rates in a placebo group. We have no pregnancy or lactation safety data on file for any of the ingredients in this product.
Meds to double-check
Minor interactions only
If you take itraconazole (Sporanox) — an antifungal medication — let your doctor or pharmacist know before using this product; the lemon oil may increase how much itraconazole your body absorbs. For all other medications, we have no documented interactions with the ingredients we could check, but that doesn't guarantee none exist — run your exact drugs through the tool on this page.
The bottom line
Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Only minor medication interactions are documented, and safety information is well characterized.
EPA/DHA Guard is an omega-3 supplement with lemon oil flavoring. If you take itraconazole for a fungal infection, mention this product to your doctor before starting it.
For anyone else, the main thing to watch is stomach upset if you're sensitive to lemon. Talk it over with your doctor or pharmacist before adding it to your routine, especially if you're on other medications.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Dec 26, 2020.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about EPA/DHA Guard, straight from the product label.
| Brand | Perque |
|---|---|
| Net contents | 120 Softgel(s) |
| Market status | On market |
| Date entered into DSLD | Dec 26, 2020 |
| DSLD ID | 240753 |
| Product type | Fat/fatty Acid |
| Supplement form | Softgel Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for EPA/DHA Guard by Perque, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Eicosapentaenoic Acid | 660 mg | -- |
| Docosahexaenoic Acid | 500 mg | -- |
| Lemon Oil | 40 mg | -- |
| Marine Lipid Oil | 1650 mg | -- |
Other ingredients: Lemon flavor Oil, Gelatin Shell
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions
Keep out of reach of children.
Do not use product if the tamper-resistant shrink band around the cap or the inner seal beneath the cap appears to have been tampered with or is missing.
Warning: Pregnant and nursing mothers need to check with their health professional before taking supplements.
Storage
Must be stored with cap on tightly in a cool, dry place.
General Statements
Uniquely Perque 100% active 100% natural 100% verified
Formulation
Does not contain: Citrus, MSG, wheat, gluten, corn, starch, sugar, soy, yeast, zein, sulfates, phosphates (other than coenzymes), preservatives, casein or other milk derivatives. NO GMO's; NO toxic minerals or metals
Supports healthy essential fat balance
Full disclosure label (no hidden or inactive ingredients)
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.
FDA Statement of Identity
Dietary Supplement
Suggested/Recommended/Usage/Directions
Directions: As a dietary supplement, take two (2) softgels a day or as directed by your health professional.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
EPA/DHA Guard by Perque label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in EPA/DHA Guard by Perque
These are the 4 active ingredients this product is made of. Select any to open its full monograph.
Serving size2 Softgel(s) Dosage formSoftgel Capsule Servings per container60 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Eicosapentaenoic Acid
Docosahexaenoic Acid
Lemon Oil
Interacts with1 drug
Lemon is a common citrus fruit that is a good source of vitamin C and citric acid, and it is widely used in food, drinks, and home remedies. While it...
Lemon Oil monograph & interactionsMarine Lipid Oil
Other (inactive) ingredients: Lemon flavor Oil, Gelatin Shell. These complete the product’s ingredient list but are not active constituents.
EPA/DHA Guard by Perque Drug Interactions
HelloPharmacist Interaction Report
EPA/DHA Guard by Perque contains lemon oil, which has one documented interaction we need to flag.
If you're taking itraconazole (Sporanox), an antifungal medication, the lemon oil in this product might theoretically increase how much of that drug your body absorbs, potentially raising its effects. This is a Minor interaction — worth mentioning to your doctor or pharmacist, but not an emergency concern.
Read the full breakdown — every affected drug type, severity by severity
We couldn't check the two main active ingredients in this product — eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) — because we hold no interaction data for them. Marine lipid oil also couldn't be checked against our database.
If you take itraconazole or any other medications, run them through the interaction checker on this page to be sure. Your doctor or pharmacist can also help you decide whether this product works for you alongside your current drugs.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against EPA/DHA Guard?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in EPA/DHA Guard interact with 1 drug. Click any drug to see the details.
1 of the 4 ingredients in EPA/DHA Guard interact with drugs. Each result below shows which ingredient is responsible. Lemon Oil
ItraconazoleSporanox, Sporanox Injection, Tolsura
How Itraconazole interacts with EPA/DHA Guard — through 1 ingredient. Tap an ingredient for the detail:
Lemon OilItraconazole (sporanox) Minor
Interaction Summary
Theoretically, taking itraconazole capsules or tablets with a beverage containing lemon might increase the levels and clinical effects of itraconazole.
Read the full Lemon Oil + Itraconazole interactionEach ingredient & the kinds of drugs it affects
For each ingredient in EPA/DHA Guard with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Lemon Oil
Itraconazole (Sporanox)
Theoretically, taking itraconazole capsules or tablets with a beverage containing lemon might increase the levels and clinical effects of itraconazole.
In one case report, dissolving itraconazole tablets in a small amount of specific beverages containing lemon prior to administration increased the level of itraconazole in a lung transplant patient. In this case, the increased bioavailability was desirable and was likely due to improved tablet dissolution in the acidic beverage.
Brand information
Manufacturer and brand details for EPA/DHA Guard, from the product label.
Perque
See all Perque products- Name
- Perque Integrative Health
- City
- Ashburn
- State
- VA
- ZipCode
- 20147
- Phone Number
- 800-525-7372
EPA/DHA Guard by Perque: Common Questions
Does EPA/DHA Guard by Perque interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
What are EPA and DHA?
Will lemon oil upset my stomach?
Is this safe to take during pregnancy or while breastfeeding?
Why should I avoid lemon supplements or essential oils without approval?
What are the inactive ingredients?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if EPA/DHA Guard is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind EPA/DHA Guard’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
EPA/DHA Guard's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 2 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Lemon 2 references
- Ruggenenti P, Caruso MR, Cortinovis M, et al. Fresh lemon juice supplementation for the prevention of recurrent stones in calcium oxalate nephrolithiasis: A pragmatic, prospective, randomised, open, blinded endpoint (PROBE) trial. EClinicalMedicine 2021;4 PubMed
- Umemura K, Katada Y, Nakagawa S, et al. Improved absorption of itraconazole tablet by co-administration with lemon beverages in a lung transplant recipient: A case report. J Infect Chemother 2022;28(8):1203-1207. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC