Interactions on record — worth a quick check against your medications. Based on 5 of 10 ingredients. Check your meds →
Dietary supplement

Essential Digestive Enzymes 800 mg Ingredients & Drug Interactions

by Double Wood Supplements

Essential Digestive Enzymes 800 mg label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Essential Digestive Enzymes 800 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Essential Digestive Enzymes 800 mg is a dietary supplement by Double Wood Supplements with 10 active ingredients. Its ingredients are commonly taken for inflammation and swelling, sinus and nasal congestion, digestion support.Based on those ingredients, 141 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Bromelain, Papain. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Essential Digestive Enzymes 800 mg by Double Wood Supplements

Ask about any prescription or over-the-counter medication and we check it for interactions with Essential Digestive Enzymes 800 mg by Double Wood Supplements — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Essential Digestive Enzymes 800 mg by Double Wood Supplements

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 23, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 10 active ingredients.
  • “VitaZyme Digestive Enzyme Blend” is a proprietary blend — the label gives one combined amount (800 mg) without saying how much of each component you get.

This product contains 10 active ingredients, all digestive enzymes. Bromelain (from pineapple), papain (from papaya), and neutral bacterial protease are proteolytic enzymes — they break down protein.

Lipase breaks down fat, amylase and glucoamylase break down starches and carbohydrates, maltase breaks down malt sugar, lactase breaks down milk sugar, cellulase breaks down fiber, and invertase breaks down sucrose. The formula also includes several inactive ingredients: gelatin (capsule), microcrystalline cellulose, maltodextrin, potato dextrin, and silicon dioxide.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded its ingredients' overall clinical evidence instead.

Strong

Strong clinical evidence supports its ingredients for:

Why this rating?
  • The label markets general wellness (“supports healthy digestion”), not a specific health condition, so there is no single claim to grade against clinical-evidence data.
  • Since the label doesn't commit to one use, we graded the ingredients' overall clinical evidence instead.
  • On file: Lactose intolerance — rated "Effective" (Lactase) (Natural Medicines).

The evidence on most of these enzymes is limited. Lactase is effective for lactose intolerance — it helps people digest milk sugar.

For the other ingredients in this product, the effectiveness ratings in our data show insufficient reliable evidence to rate them for conditions like hay fever, burns, cancer, inflammatory bowel disease, or dyspepsia. That doesn't mean they don't work; it means the studies we have aren't strong enough to draw firm conclusions.

The evidence, ingredient by ingredient Bromelain Lipase Lactase Papain Proteolytic Enzymes (proteases)

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 5 of the 5 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 5 of 5.
  • General safety write-ups exist for 5 of 5.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Bromelain is generally well tolerated short-term, though long-term safety data is sparse. The most common side effects are diarrhea, flatulence, stomach upset, and headache.

Papain is also generally tolerated at normal doses but may cause allergic reactions in sensitive people; high doses carry a rare risk of severe stomach damage. Lipase has no reported adverse effects in adults but should be used only under medical guidance if you have serious digestive conditions.

Lactase is generally well tolerated. Neutral bacterial protease may cause digestive upset or allergic reactions in some people.

Bromelain and papain are not recommended in pregnancy — bromelain has insufficient safety data and papain is considered possibly unsafe. Lactase is likely safe in pregnancy.

For lipase and neutral bacterial protease, safety data during pregnancy is sparse or absent; check with your doctor. Safety data during breastfeeding is limited for all ingredients except lactase (for which it's likely safe); ask your doctor or pharmacist before use.

Side effects, ingredient by ingredient Bromelain Lipase Lactase Papain Proteolytic Enzymes (proteases)

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 5 matched ingredients can interact with medications — Papain, Bromelain.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 141 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your doctor or pharmacist before taking this product if you use warfarin (a blood thinner) — papain may dangerously increase its effect. Also confirm if you take any blood thinners or antiplatelet drugs (like aspirin or clopidogrel), as bromelain may raise bleeding risk.

If you're on a tetracycline antibiotic, ask about the bromelain interaction as well.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with strong clinical evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

This product is a broad-spectrum enzyme blend, most useful if you have lactose intolerance (lactase is effective for that). If you take blood thinners, antiplatelet drugs, or warfarin, or if you're on tetracycline antibiotics, talk to your doctor or pharmacist before starting it — the bromelain and papain may interfere with how these medications work.

If you're pregnant or breastfeeding, discuss this product with your healthcare provider first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 10 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Sep 24, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Essential Digestive Enzymes 800 mg, straight from the product label.

Brand Double Wood Supplements
Barcode (UPC) 859793007952
Net contents 180 Capsule(s)
Market status On market
Date entered into DSLD Sep 24, 2021
DSLD ID 255590
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Essential Digestive Enzymes 800 mg by Double Wood Supplements, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
90
UPC/BARCODE
859793007952
IngredientAmount% DV
Bromelain0 NP--
Lipase0 NP--
Lactase0 NP--
Cellulase0 NP--
Invertase0 NP--
VitaZyme Digestive Enzyme Blend800 mg--
Papain0 NP--
Glucoamylase0 NP--
Amylase0 NP--
Maltase0 NP--
neutral Bacterial Protease0 NP--

Other ingredients: Gelatin, Microcrystalline Cellulose, Maltodextrin, Potato Dextrin, Silicon Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Product Information: Contains 10 Essential Digestive Enzymes including Glucoamylase, Amylase, Bromelain, Cellulase, Invertase, Lactase, Neutral Bacterial Protease, Papain, Lipase, Maltase. This digestive enzyme blend supports healthy digestive function by supporting breakdown of fats, carbohydrates, and protein as well as supporting optimal nutrient absorption.

800 mg per serving Contains 10 Essential Digestive Enzymes

Suggested/Recommended/Usage/Directions

Suggested Use As a supplement, take 1 serving (2 capsules) per day. It can be taken in the morning or night, with or without food.

Storage

Storage: Store in a cool, dark place. Do not freeze or expose to moisture or heat above room temperature.

Precautions

Warning: Consult your physician before use.

Do not use Essential Digestive Enzymes if you are pregnant, nursing, or under 18 years of age.

Do not use Essential Digestive Enzymes if you are pregnant, nursing, or under 18 years of age.

Discontinue use and consult your doctor immediately if any adverse reactions occur. Do not use Essential Digestive Enzymes and operate heavy machinery until you know how it affects you.

Keep out of reach of children.

Do not exceed 6 capsules per day.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Seals/Symbols

Proudly Made in USA

Formulation

Made with Non-GMO ingredients Gluten free

Supports healthy digestive function

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Essential Digestive Enzymes 800 mg by Double Wood Supplements label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Essential Digestive Enzymes 800 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Essential Digestive Enzymes 800 mg by Double Wood Supplements

These are the 10 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container90 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

VitaZyme Digestive Enzyme Blend

800 mg per serving

Other (inactive) ingredients: Gelatin, Microcrystalline Cellulose, Maltodextrin, Potato Dextrin, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

Essential Digestive Enzymes 800 mg by Double Wood Supplements Drug Interactions

Want to check YOUR meds against Essential Digestive Enzymes 800 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
141Drugs
122 Moderate 19 Minor

Ingredients driving the most interactions

Bromelain 141
Papain 2

Individual Drug Interactions

The ingredients in Essential Digestive Enzymes 800 mg interact with 141 drugs. Click any drug to see the details.

2 of the 10 ingredients in Essential Digestive Enzymes 800 mg interact with drugs. Each result below shows which ingredient is responsible. Bromelain Papain

Each ingredient & the kinds of drugs it affects

For each ingredient in Essential Digestive Enzymes 800 mg with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Bromelain2 drug types · 141 drugs

Anticoagulant/Antiplatelet Drugs

Bromelain may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
There is one case report of a patient experiencing minor bruising while taking bromelain with naproxen. Bromelain is thought to have antiplatelet activity. Whether this interaction is of concern with topical bromelain is unclear. Interference with coagulation of burn wounds has been reported in a patient receiving bromelain-based enzymatic debridement. However, observational research has found that topical bromelain debridement is not associated with increases or decreases in laboratory markers of coagulation when compared with surgical debridement.

Likelihood Possible Evidence D
Tetracycline Antibiotics

Theoretically, bromelain might increase levels of tetracycline antibiotics.
Laboratory research suggests that bromelain might increase the absorption of tetracycline antibiotics. However, a study in healthy adults reported no difference in tetracycline plasma levels when a 500 mg dose was taken with or without bromelain 80 mg.

Likelihood Possible Evidence B
Bromelain full monograph & interactions

Papain1 drug type · 2 drugs

Warfarin (Coumadin)

Theoretically, papain might increase the effects and side effects of warfarin.
In one case report, a patient previously stable on warfarin was found to have an international normalization ratio (INR) of 7.4, which was attributed to ingestion of a supplement containing papain from papaya extract.

Likelihood Possible Evidence D
Papain full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Essential Digestive Enzymes 800 mg, from the product label.

Double Wood Supplements

See all Double Wood Supplements products
Name
Double Wood LLC
Street Address
3510 Scotts Ln Ste 219
City
Philadelphia
State
PA
ZipCode
19129-1573
Web Address
www.doublewoodsupplements.com
Pharmacist Counseling Corner

Essential Digestive Enzymes 800 mg by Double Wood Supplements: Common Questions

Does Essential Digestive Enzymes 800 mg by Double Wood Supplements interact with any medications?
Yes. Based on its ingredients, Essential Digestive Enzymes 800 mg has a known interaction with 141 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Essential Digestive Enzymes 800 mg contains 10 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this safe if I'm pregnant?
Bromelain and papain are not recommended in pregnancy — bromelain lacks sufficient safety data, and papain is considered possibly unsafe. Lactase is likely safe. For the other enzymes, safety data is missing or limited. Talk with your doctor before using this product during pregnancy.
Can I take this while breastfeeding?
Lactase is likely safe. For bromelain, papain, lipase, neutral bacterial protease, and the others, safety data during breastfeeding is sparse or absent. Ask your doctor or pharmacist before use.
Does lactase in this product actually work for lactose intolerance?
Yes — lactase is rated as effective for lactose intolerance. It breaks down lactose (milk sugar) so your body can digest it. The amount in this blend may vary, so check the label for the specific lactase dose.
What are these enzymes supposed to do?
They're digestive enzymes that break down different types of food: bromelain and papain break down protein, lipase breaks down fat, amylase breaks down starches, lactase breaks down milk sugar, and cellulase breaks down fiber. Together they're meant to support overall digestion.
What are the most common side effects?
Diarrhea, flatulence, stomach upset, and headache are the main ones reported, mostly from bromelain. Allergic reactions are possible in sensitive people, especially to bromelain and papain. Most people tolerate digestive enzymes well at standard doses.
Can I take this long-term?
Bromelain's long-term safety is not well studied. The other enzymes either have limited safety data over time or are generally well tolerated in the short term. If you're planning regular use, talk with your doctor or pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Essential Digestive Enzymes 800 mg label
Go deeper

The Full Monographs Behind Essential Digestive Enzymes 800 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Bromelain

Interacts with 141 drugs

Bromelain is a group of protein-digesting enzymes from pineapple that people take mainly for inflammation, swelling, and sinus problems. Some early studies are promising, but the overall evi...

Read the full Bromelain monograph → Herb & supplement monograph

Lipase

Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy for people who cannot make enough of their...

Read the full Lipase monograph → Herb & supplement monograph

Lactase

Lactase is a digestive enzyme supplement that helps people who lack enough natural lactase break down lactose, the sugar in milk and dairy. It can reduce gas, bloating, cramping, and diarrhe...

Read the full Lactase monograph → Herb & supplement monograph

Papain

Interacts with 2 drugs

Papain is a protein-digesting enzyme from the papaya plant that is used in digestive supplements and some topical products. While it has clear food and laboratory uses, strong human evidence...

Read the full Papain monograph → Herb & supplement monograph

Proteolytic Enzymes (proteases)

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...

Read the full Proteolytic Enzymes (proteases) monograph →
Sources

Sources & How We Checked

Essential Digestive Enzymes 800 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 35 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Bromelain 19 references
  1. Nettis E, Napoli G, Ferrannini A, Tursi A. IgE-mediated allergy to bromelain. Allergy 2001;56:257-8. PubMed
  2. Taussig SJ, Batkin S. Bromelain, the enzyme complex of pineapple (Ananas comosus) and its clinical application. An update. J Ethnopharmacol 1988;22:191-203.. PubMed
  3. Bradbrook ID, Morrison PJ, Rogers HJ. The effect of bromelain on the absorption of orally administered tetracycline. Br J Clin Pharmacol 1978;6:552-4. PubMed
  4. Bush TM, Rayburn KS, Holloway SW, et al. Adverse interactions between herbal and dietary substances and prescription medications: a clinical survey. Altern Ther Health Med 2007;13:30-5.
  5. Brien S, Lewith G, Walker AF, et al. Bromelain as an adjunctive treatment for moderate-to-severe osteoarthritis of the knee: a randomized placebo-controlled pilot study. QJM 2006;99:841-50. PubMed
  6. Mori S, Ojima Y, Hirose T, et al. The clinical effect of proteolytic enzyme containing bromelain and trypsin on urinary tract infection evaluated by double blind method. Acta Obstet Gynaecol Jpn 1972;19:147-53.
  7. Glaser D, Hilberg T. The influence of bromelain on platelet count and platelet activity in vitro. Platelets 2006;17:37-41. PubMed
  8. Heinicke R M, van der Wal L, Yokoyama M. Effect of bromelain (Ananase) on human platelet aggregation. Experientia 1972;28:844-5. PubMed
  9. Gailhofer, G., Wilders-Truschnig, M., Smolle, J., and Ludvan, M. Asthma caused by bromelain: an occupational allergy. Clin Allergy 1988;18(5):445-450. PubMed
  10. Mattei, O., Fabri, G., and Farina, G. [Occupational health experience regarding four cases of asthma due to bromelain (author's transl)]. Medicina del Lavoro 1979;70(5):404-409.
  11. Galleguillos, F. and Rodriguez, J. C. Asthma caused by bromelin inhalation. Clin Allergy 1978;8(1):21-24. PubMed
  12. Perez-Camo I, Quirce S, Duran MA, and et al. Latex allergy: evidence of cross-reactivity with papain and bromelain [abstract]. Allergy 1996;51(suppl 31):48.
  13. Martin GJ, Ehrenreich J, and Asbell N. Bromelain: pineapple proteases with anti-edema activity. Exp Med Surg 1962;20:227-247.
  14. Kasemsuk T, Saengpetch N, Sibmooh N, Unchern S. Improved WOMAC score following 16-week treatment with bromelain for knee osteoarthritis. Clin Rheumatol. 2016 Oct;35(10):2531-40. PubMed
  15. Kutlu Ö, DemirbaS A, Elmas ÖF, Güvenç U, Metin A. Fixed drug eruption: a new side effect of bromelain. Contact Dermatitis 2020. Online ahead of print. PubMed
  16. Shoham Y, Shapira E, Haik J, et al. Bromelain-based enzymatic debridement of chronic wounds: Results of a multicentre randomized controlled trial. Wound Repair Regen 2021;29(6):899-907. PubMed
  17. Pfister P, Garcia Wendel PD, Kim BS, et al. Coagulation side effects of enzymatic debridement in burned patients. Burns 2022. PubMed
  18. Hasham S, Riyat H, Fletcher A, O'Boyle CP, Alexander S. To bleed or not to bleed? Case series and discussion of haemorrhage risk with enzymatic debridement in burn injuries. Scars Burn Heal 2023;9:20595131231168333. PubMed
  19. Leelakanok N, Petchsomrit A, Janurai T, Saechan C, Sunsandee N. Efficacy and safety of bromelain: A systematic review and meta-analysis. Nutr Health 2023. PubMed

See these in context on the Bromelain monograph →

Lipase 1 reference
  1. Casper C, Hascoet JM, Ertl T, et al. Recombinant bile salt-stimulated lipase in preterm infant feeding: A randomized phase 3 study. PLoS One. 2016;11(5):e0156071. PubMed

See these in context on the Lipase monograph →

Lactase 1 reference
  1. Laukkanen A, Ruoppi P, Remes S, Koistinen T, Mäkinen-Kiljunen S. Lactase-induced occupational protein contact dermatitis and allergic rhinoconjunctivitis. Contact Dermatitis. 2007;57(2):89-93. PubMed

See these in context on the Lactase monograph →

Papain 11 references
  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Shaw D, Leon C, Kolev S, Murray V. Traditional remedies and food supplements: a 5-year toxicological study (1991-1995). Drug Saf 1997;17:342-56.
  3. Shuttleworth D, Hill S, Marks R, Connelly DM. Relief of experimentally induced pruritus with a novel eutectic mixture of local anaesthetic agents. Br J Dermatol 1988;119:535-40.
  4. Mansfield LE, Ting S, Haverly RW, Yoo TJ. The incidence and clinical implications of hypersensitivity to papain in an allergic population, confirmed by blinded oral challenge. Ann Allergy 1985;55:541-3.
  5. Martin, T., Uhder, K., Kurek, R., Roeddiger, S., Schneider, L., Vogt, H. G., Heyd, R., and Zamboglou, N. Does prophylactic treatment with proteolytic enzymes reduce acute toxicity of adjuvant pelvic irradiation? Results of a double-blind randomized trial PubMed
  6. Walker-Renard, P. Update on the medicinal management of phytobezoars. Am J Gastroenterol. 1993;88(10):1663-1666.
  7. Tymoszuk D, Wiszniewska M, Walusiak-Skorupa J. Papain-induced occupational rhinoconjunctivitis and asthma - A case report. Med Pr 2016;67(1):109-12. PubMed
  8. Soto-Mera MT, López-Rico MR, Filgueira JF, et al. Occupational allergy to papain. Allergy 2000;55(10):983-4. PubMed
  9. Tarlo SM, Shaikh W, Bell B, et al. Papain-induced allergic reactions. Clin Allergy 1978;8(3):207-15. PubMed
  10. Baur X, König G, Bencze K, Fruhmann G. Clinical symptoms and results of skin test, RAST and bronchial provocation test in thirty-three papain workers: Evidence for strong immunogenic potency and clinically relevant proteolytic e?ects of airborne papain. C
  11. Novey HS, Keenan WJ, Fairshter RD, Wells ID, Wilson AF, Culver BD. Pulmonary disease in workers exposed to papain: clinico-physiological and immunological studies. Clin Allergy 1980;10(6):721-31. PubMed

See these in context on the Papain monograph →

Proteolytic Enzymes (proteases) 3 references
  1. Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
  2. Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
  3. Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed

See these in context on the Proteolytic Enzymes (proteases) monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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