Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Estrosalus Ingredients & Drug Interactions

by Valentior

Estrosalus label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Estrosalus against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Estrosalus is a dietary supplement by Valentior with 4 active ingredients. Its ingredients are commonly taken for alcohol cravings and reduction, menopausal symptoms, heart and blood vessel health.Based on those ingredients, 917 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Actaea racemosa (Black Cohosh) root & rhizome ext., Isoflavones, Evening Primrose Oil. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Estrosalus by Valentior

Ask about any prescription or over-the-counter medication and we check it for interactions with Estrosalus by Valentior — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Estrosalus by Valentior

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 23, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 4 of its 4 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Estrosalus contains four active ingredients. Isoflavones (from kudzu) are plant compounds with hormone-like properties.

Black cohosh root and rhizome extract is a traditional herb for menopausal symptoms. Chasteberry fruit extract has been studied for menstrual and breast-related concerns.

Evening primrose oil is a fatty acid supplement. There are no inactive ingredients listed for this product.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: hormonal balance and skin health.
  • We looked for evidence on: Acne, Aging skin, Atopic dermatitis (eczema), Dysmenorrhea, Dry skin, Fibrocystic breast disease — and 4 related terms.
  • The strongest evidence on file: Black Cohosh is rated "Possibly Effective" for Menopausal symptoms (Natural Medicines).
  • Also on file: Vitex Agnus-castus is rated "Possibly Effective" for Mastalgia.
  • Also on file: Evening Primrose is rated "Likely Ineffective" for Mastalgia.

The evidence is mixed and often limited. Isoflavones are rated possibly effective for alcohol use disorder, but we hold insufficient evidence for hay fever, angina, and back pain.

Black cohosh is rated possibly effective for menopausal symptoms but has insufficient evidence for acne, sexual dysfunction, anxiety, and breast cancer-related hot flashes. Chasteberry is possibly effective for premenstrual syndrome and breast tenderness, but possibly ineffective for fractures and has insufficient evidence for aging skin, premenstrual dysphoric disorder, and anxiety.

Evening primrose oil is rated likely ineffective for breast tenderness and possibly ineffective for asthma; evidence is insufficient for acne, ADHD, and other uses. If you're considering this product for a specific condition, talk with your doctor or pharmacist about whether the evidence supports it for your situation.

The evidence, ingredient by ingredient Kudzu Black Cohosh Vitex Agnus-castus Evening Primrose

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

All four ingredients are generally well tolerated in short-term studies, but long-term safety data are limited across the board. Common side effects reported in trials include nausea, dizziness, headache, diarrhea, fatigue, and skin irritation—though these did not occur more often than placebo in many cases.

Black cohosh carries rare but serious concerns: cases of liver injury and, in one report, serotonin syndrome when combined with certain antidepressants. Black cohosh is rated possibly unsafe in pregnancy and lactation.

Isoflavones and chasteberry are rated unsafe or possibly unsafe in pregnancy due to hormone-like effects; avoid them during pregnancy and breastfeeding. Evening primrose oil is rated possibly safe during pregnancy and lactation, but medical guidance is wise.

If you're pregnant, nursing, or considering it, talk with your doctor or pharmacist before taking this product.

Side effects, ingredient by ingredient Kudzu Black Cohosh Vitex Agnus-castus Evening Primrose

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 4 of the 4 matched ingredients can interact with medications — Kudzu, Black Cohosh, Vitex Agnus-castus, Evening Primrose.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications; lithium.
  • For scale: 918 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Estrosalus, double-check if you take any serotonergic drugs (antidepressants or anti-anxiety medications)—there's a moderate risk of serotonin syndrome with black cohosh. Also check if you're on blood thinners or antiplatelet drugs, estrogen therapy or oral contraceptives, diabetes medications, lithium, antipsychotic or dopamine-related drugs, methotrexate, tamoxifen, or phenothiazines.

A conversation with your doctor or pharmacist is important before combining this product with any prescription medication.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Estrosalus is marketed for hormone-related concerns and contains ingredients with some evidence for menopausal and menstrual symptoms. However, the product interacts significantly with many common medications—including blood thinners, birth control, antidepressants, and diabetes drugs—and carries cautions about liver health and pregnancy safety.

This is not a simple supplement to add without checking your personal medications and health history. Talk it over with your doctor or pharmacist before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Sep 24, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Estrosalus, straight from the product label.

Brand Valentior
Barcode (UPC) 9348774000200
Net contents 30 Soft Capsule(s)
Market status On market
Date entered into DSLD Sep 24, 2021
DSLD ID 255993
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Estrosalus by Valentior, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
UPC/BARCODE
9348774000200
IngredientAmount% DV
Isoflavones100 mg--
Actaea racemosa (Black Cohosh) root & rhizome ext.264 mg--
Vitex agnus-castus (Chasteberry) fruit ext.400 mg--
Evening Primrose Oil500 mg--

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Hormonal balance Enhance skin health Antioxidant Made in Australia Benefits: Helps enhance/ promote skin health. Maintain/ support skin integrity and structure. Helps reduce occurrence of symptoms of acne. Antioxidant/ reduce free radicals formed in the body. Maintain/ support female healthy hormonal balance during the reproductive cycle and menopause. Decrease vaginal dryness. Decrease hot flushes, moodiness, mood swings and irritability associated with menopause. Helps reduce occurrence of pre-menstrual tension symptoms. Decrease menstrual cycle irregularity and irregular periods.

Suggested/Recommended/Usage/Directions

Dosage: Adults only: 1 capsule daily, or as directed by a healthcare professional.

Precautions

Caution: Always read the label. Follow the directions for use. If symptoms persist, talk to your health professional. Warnings: In very rare cases, black cohosh has been associated with liver failure. If you are experiencing yellowing of the skin or whites of the eyes, dark urine, nausea, vomiting, unusual tireness, weakness, stomach or abdominal pain, and/or loss of appetite, you should stop using this product and see your doctor. Vitex agnus-castus may affect hormones and medicines such as oral contraceptives. Consult your health professional before use.

Contains sulfites and soya bean products. Do not take this if allergic to any of its composition.

Do not use if cap seal is broken.

Keep out of reach of children.

Vitex agnus-castus may affect hormones and medicines such as oral contraceptives. Consult your health professional before use.

Storage

Storage: Store below 25 degrees C in a cool dry place away from heat and sunlight. Protect against moisture.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Estrosalus by Valentior label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Estrosalus label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Estrosalus by Valentior

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Isoflavones

Interacts with
584 drugs
100 mg per serving Form: Glycine max (Soya bean) seed germ ext.

Kudzu is a fast-growing vine whose root has long been used in traditional Chinese medicine and is now studied mostly for reducing alcohol intake. Earl...

Isoflavones monograph & interactions

Actaea racemosa (Black Cohosh) root & rhizome ext.

Interacts with
652 drugs
264 mg per serving

Black cohosh is a North American plant most often used to ease menopause symptoms like hot flashes, but the research is mixed and far from settled. It...

Actaea racemosa (Black Cohosh) root & rhizome ext. monograph & interactions

Vitex agnus-castus (Chasteberry) fruit ext.

Interacts with
121 drugs
400 mg per serving

Vitex (chasteberry) is an herbal remedy most often used for PMS and menstrual cycle problems, and the strongest evidence is for easing some PMS sympto...

Vitex agnus-castus (Chasteberry) fruit ext. monograph & interactions

Evening Primrose Oil

Interacts with
233 drugs
500 mg per serving

Evening primrose oil is a seed oil rich in gamma-linolenic acid (GLA), an omega-6 fatty acid, that is popularly used for skin conditions, PMS, and bre...

Evening Primrose Oil monograph & interactions
Interaction report

Estrosalus by Valentior Drug Interactions

Want to check YOUR meds against Estrosalus?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
917Drugs
794 Moderate 123 Minor

Ingredients driving the most interactions

Actaea racemosa (Black Cohosh) root & rhizome ext. 652
Isoflavones 584
Evening Primrose Oil 233
Vitex agnus-castus (Chasteberry) fruit ext. 121

Individual Drug Interactions

The ingredients in Estrosalus interact with 917 drugs. Click any drug to see the details.

4 of the 4 ingredients in Estrosalus interact with drugs. Each result below shows which ingredient is responsible. Actaea racemosa (Black Cohosh) root & rhizome ext. Isoflavones Evening Primrose Oil Vitex agnus-castus (Chasteberry) fruit ext.

Each ingredient & the kinds of drugs it affects

For each ingredient in Estrosalus with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Actaea racemosa (Black Cohosh) root & rhizome ext.7 drug types · 652 drugs

Atorvastatin (Lipitor)

Taking black cohosh with atorvastatin might increase the risk for elevated liver function tests.
In one case report, a patient taking atorvastatin (Lipitor) developed significantly elevated liver function enzymes after starting black cohosh 100 mg four times daily. Liver enzymes returned to normal when black cohosh was discontinued. It is unclear whether the elevated liver enzymes were due to black cohosh itself or an interaction between atorvastatin and black cohosh.

Likelihood Possible Evidence D
Cisplatin (Platinol-Aq)

Theoretically, black cohosh may reduce the clinical effects of cisplatin.
Animal research suggests that black cohosh might decrease the cytotoxic effect of cisplatin on breast cancer cells.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Some research suggests that black cohosh might inhibit CYP2D6, but there is conflicting evidence.
Some clinical research suggests that black cohosh might modestly inhibit CYP2D6 and increase levels of drugs metabolized by this enzyme. However, contradictory clinical research shows a specific black cohosh product (Remifemin, Enzymatic Therapy) 40 mg twice daily does not significantly inhibit metabolism of a CYP2D6 substrate in healthy study volunteers. Until more is known, use black cohosh cautiously in patients taking drugs metabolized by CYP2D6.

Likelihood Possible Evidence B
Estrogens

Theoretically, black cohosh may alter the effects of estrogen therapy.
Some research suggests that black cohosh has estrogenic effects. This may enhance or inhibit the effects of estrogen therapy.

Likelihood Possible Evidence D
Hepatotoxic Drugs

Theoretically, taking black cohosh with hepatotoxic drugs may increase the risk of liver damage.
There is concern that black cohosh might be linked to cases of liver failure and autoimmune hepatitis.

Likelihood Possible Evidence D
Serotonergic Drugs

Combining serotonergic drugs with black cohosh might cause additive serotonergic effects.
Black cohosh might increase the risk of serotonin syndrome when combined with other serotonergic drugs. Black cohosh acts as an agonist at several serotonin receptor subtypes and might interact with other serotonergic medications. In one case, a 55-year-old female who had been on stable treatment with sertraline 50 mg and duloxetine 60 mg daily developed serotonin syndrome after taking black cohosh extract 40 mg daily for 3 days.

Likelihood Possible Evidence D
Organic Anion-Transporting Polypeptide Substrates (Oatp)

Black cohosh may inhibit one form of OATP, OATP2B1, which could reduce the bioavailability and clinical effects of OATP2B1 substrates.
In vitro research shows that black cohosh modestly inhibits OATP2B1. OATPs are expressed in the small intestine and liver and are responsible for the uptake of drugs and other compounds into the body. Inhibition of OATP may reduce the bioavailability of oral drugs that are substrates of OATP.

Likelihood Possible Evidence D
Actaea racemosa (Black Cohosh) root & rhizome ext. full monograph & interactions

Isoflavones7 drug types · 584 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, kudzu may increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Kudzu isoflavones are reported to have antiplatelet activity.

Likelihood Possible Evidence D
Caffeine

Theoretically, taking kudzu with caffeine might increase levels of caffeine.
In healthy males injected with the kudzu constituent puerarin, caffeine clearance and metabolism is inhibited. This effect has been attributed to inhibition of cytochrome P450 1A2 (CYP1A2) enzyme, which is involved in caffeine metabolism. It is unclear if taking kudzu orally would have this same effect.

Likelihood Probable Evidence D
Estrogens

Theoretically, kudzu might alter the effects of estrogen therapy.
Some research suggests that kudzu has estrogenic effects. This may enhance or inhibit the effects of estrogen therapy.

Likelihood Possible Evidence B
Hepatotoxic Drugs

Theoretically, concomitant use might have additive hepatotoxic effects.
There is some concern that kudzu can adversely affect the liver.

Likelihood Possible Evidence D
Methotrexate (Trexall, Others)

Theoretically, taking kudzu with methotrexate might increase the risk of methotrexate toxicity.
Preclinical research suggests that kudzu extract greatly reduces the elimination and increases the toxicity of methotrexate. Kudzu might inhibit organic anion transporters (OATs) that are responsible for hepatobiliary and renal excretion of anions, similar to the interaction between methotrexate and non-steroidal anti-inflammatory drugs (NSAIDs).

Likelihood Possible Evidence D
Tamoxifen (Nolvadex)

Theoretically, kudzu might interfere with tamoxifen activity.
Some research suggests that kudzu may have estrogenic effects.

Likelihood Possible Evidence B
Antidiabetes Drugs

Theoretically, taking kudzu with antidiabetes drugs might increase the risk of hypoglycemia.
Kudzu might lower blood glucose levels and have additive effects in patients treated with antidiabetic agents. The dose of diabetes medications might need to be adjusted.

Likelihood Unlikely Evidence D
Isoflavones full monograph & interactions

Evening Primrose Oil5 drug types · 233 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, evening primrose oil may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Evening primrose oil contains gamma linolenic acid (GLA). There is preliminary clinical evidence that GLA can reduce platelet aggregation and prolong bleeding time.

Likelihood Possible Evidence D
Lithium

Theoretically, concomitant use of lithium with evening primrose oil might decrease lithium levels and effects.
In a case report, a patient on a stable dose of lithium for 10 years experienced a reduction in lithium levels after taking evening primrose oil 500 mg daily. Baseline levels were 0.69 mmol/L, which decreased to 0.37 mmol/L after 2 months and 0.23 mmol/L after 3 months of use. Lithium levels increased within 6 weeks of discontinuing evening primrose oil, to 0.73 mmol/L; no clinical effects were noted.

Likelihood Possible Evidence D
Lopinavir/Ritonavir (Kaletra)

Theoretically, evening primrose oil might increase the levels and effects of lopinavir.
In a case report, an HIV patient who took evening primrose oil (Efamol) along with lopinavir/ritonavir experienced an increase in serum levels of lopinavir to 15.2 mg/L. Six weeks after discontinuing evening primrose oil, levels of lopinavir returned to the normal range of 5-10 mg/L. When re-challenged with evening primrose oil for a week, the patient's lopinavir levels increased from 6.69 to 8.11 mg/L. It is suspected that evening primrose oil increases levels of lopinavir by inhibiting cytochrome P450 3A4 (CYP3A4), which metabolizes lopinavir. However, this effect has not been reported in other research.

Likelihood Possible Evidence D
Phenothiazines

Theoretically, taking evening primrose oil with phenothiazines might increase the risk of convulsions.
Evening primrose oil contains gamma-linolenic acid (GLA). There is some concern that taking supplements containing GLA might cause seizures, or lower the seizure threshold, when taken with phenothiazines. In one report, three patients with schizophrenia who had received phenothiazines developed EEG changes suggestive of temporal lobe epilepsy after starting treatment with GLA, although none experienced an actual seizure. In another report, two patients with schizophrenia who were stabilized on phenothiazines developed seizures when evening primrose oil 4 grams daily was added. One of these patients had a prior history of seizures. It is unclear whether evening primrose oil had any additive epileptogenic effects with the phenothiazines; there is no evidence that taking evening primrose oil alone causes seizures.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, evening primrose may increase the levels and clinical effects of CYP2C9 substrates.
In vitro research shows that linoleic acid, a constituent of evening primrose oil, inhibits CYP2C9.

Likelihood Possible Evidence D
Evening Primrose Oil full monograph & interactions

Vitex agnus-castus (Chasteberry) fruit ext.5 drug types · 121 drugs

Antipsychotic Drugs

Theoretically, vitex agnus-castus could interfere with the activity of antipsychotic drugs.
Vitex agnus-castus might interfere with the action of dopamine antagonists such as antipsychotic drugs due to its dopamine agonist effects.

Likelihood Possible Evidence D
Contraceptive Drugs

Theoretically, vitex agnus-castus could interfere with oral contraceptives.
Vitex agnus-castus might interfere with the efficacy of oral contraceptives due to possible hormone modulating activity.

Likelihood Possible Evidence B
Dopamine Agonists

Theoretically, vitex agnus-castus could interfere with dopamine agonists.
Vitex agnus-castus might potentiate the actions of dopaminergic agonists due to possible dopaminergic effects.

Likelihood Possible Evidence D
Estrogens

Theoretically, vitex agnus-castus could interfere with the activity of estrogens.
Vitex agnus-castus has hormone modulating activity that can interfere with the efficacy of hormone replacement therapy.

Likelihood Probable Evidence D
Metoclopramide (Reglan)

Theoretically, dopaminergic effects of vitex agnus-castus could interfere with metoclopramide.
Vitex agnus-castus might interfere with the action of dopamine antagonists such as metoclopramide due to its possible dopaminergic effects.

Likelihood Possible Evidence D
Vitex agnus-castus (Chasteberry) fruit ext. full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Estrosalus, from the product label.

Valentior

See all Valentior products
Name
Valentoir Pty Ltd
Street Address
Level 13, 50 Cavill Avenue
City
Surfers Paradise, QLD 4217
State
Australia
Web Address
www.valentior.com.au
Pharmacist Counseling Corner

Estrosalus by Valentior: Common Questions

Does Estrosalus by Valentior interact with any medications?
Yes. Based on its ingredients, Estrosalus has a known interaction with 917 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Estrosalus contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take Estrosalus if I'm pregnant or breastfeeding?
No. Isoflavones and chasteberry should be avoided in pregnancy because of hormone-like effects and insufficient safety data. Black cohosh is rated possibly unsafe for both pregnancy and breastfeeding. Evening primrose oil has less data against it in pregnancy and breastfeeding, but medical advice is still wise. Talk with your doctor or pharmacist before taking this product if you're pregnant, nursing, or planning to become pregnant.
What is black cohosh used for in this supplement?
Black cohosh is included for menopausal symptoms—it's the ingredient with the strongest evidence in that area, rated possibly effective. However, it carries cautions about liver health and interactions with serotonergic drugs like some antidepressants.
Does this product help with PMS or period-related breast pain?
Chasteberry in this product is rated possibly effective for premenstrual syndrome and breast tenderness. However, evidence for the other three ingredients in those conditions is either insufficient or not well established. Talk with your doctor about whether this product is a good fit for your specific symptoms.
What are the most common side effects?
The most frequently reported side effects in clinical trials are mild: nausea, dizziness, headache, diarrhea, fatigue, and skin irritation. These side effects did not occur more often than placebo in many studies, but they're worth knowing about. Serious side effects are rare but possible, particularly liver injury with black cohosh.
Is evening primrose oil safe to take long-term?
Short-term use is generally well tolerated, but we don't have strong long-term safety data. It does interact with blood thinners, lithium, and certain other medications, so medical guidance is wise if you plan extended use.
Can I take this if I'm on birth control?
No without talking to your doctor first. Both isoflavones and chasteberry have hormone-modulating activity that could theoretically interfere with oral contraceptives, meaning your birth control may be less effective. Check with your doctor or pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Estrosalus label
Go deeper

The Full Monographs Behind Estrosalus’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Kudzu

Interacts with 584 drugs

Kudzu is a fast-growing vine whose root has long been used in traditional Chinese medicine and is now studied mostly for reducing alcohol intake. Early research is promising for cutting back...

Read the full Kudzu monograph → Herb & supplement monograph

Black Cohosh

Interacts with 652 drugs

Black cohosh is a North American plant most often used to ease menopause symptoms like hot flashes, but the research is mixed and far from settled. It is generally well tolerated for short-t...

Read the full Black Cohosh monograph → Herb & supplement monograph

Vitex Agnus-castus

Interacts with 121 drugs

Vitex (chasteberry) is an herbal remedy most often used for PMS and menstrual cycle problems, and the strongest evidence is for easing some PMS symptoms. It is generally well tolerated by ma...

Read the full Vitex Agnus-castus monograph → Herb & supplement monograph

Evening Primrose

Interacts with 233 drugs

Evening primrose oil is a seed oil rich in gamma-linolenic acid (GLA), an omega-6 fatty acid, that is popularly used for skin conditions, PMS, and breast pain. The evidence behind most of th...

Read the full Evening Primrose monograph →
Sources

Sources & How We Checked

Estrosalus's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 145 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Kudzu 21 references
  1. Woo J, Lau E, Ho SC, et al. Comparison of Pueraria lobata with hormone replacement therapy in treating the adverse health consequences of menopause. Menopause 2003;10:352-61. PubMed
  2. Akita H, Sowa J, Makiura M, et al. Maculopapular drug eruption due to the Japanese herbal medicine Kakkonto (kudzu or arrowroot decoction). Contact Dermatitis 2003;48:348-9. PubMed
  3. Luo ZR, Zheng B. [Effect of Puerarin on platelet activating factors CD63 and CD62P, plasminogen activator inhibitor and C-reactive protein in patients with unstable angia pectoris]. Zhongguo Zhong Xi Yi Jie He Za Zhi 2001;21:31-3 .
  4. Lee KT, Sohn IC, Kim DH, et al. Hypoglycemic and hypolipidemic effects of tectorigenin and kaikasaponin III in the streptozotocin-lnduced diabetic rat and their antioxidant activity in vitro. Arch Pharm Res 2000;23:461-6.
  5. Yu Z, Zhang G, Zhao H. [Effects of Puerariae isoflavone on blood viscosity, thrombosis and platelet function]. Zhong Yao Cai 1997;20:468-9.
  6. Hsu FL, Liu IM, Kuo DH, et al. Antihyperglycemic effect of puerarin in streptozotocin-induced diabetic rats. J Nat Prod 2003;66:788-92. PubMed
  7. Chiang HM, Fang SH, Wen KC, et al. Life-threatening interaction between the root extract of Pueraria lobata and methotrexate in rats. Toxicol Appl Pharmacol 2005;209:263-8.
  8. Zheng, J., Chen, B., Jiang, B., Zeng, L., Tang, Z. R., Fan, L., and Zhou, H. H. The effects of puerarin on CYP2D6 and CYP1A2 activities in vivo. Arch Pharm Res 2010;33(2):243-246. PubMed
  9. Hsu, H. H., Chang, C. K., Su, H. C., Liu, I. M., and Cheng, J. T. Stimulatory effect of puerarin on alpha1A-adrenoceptor to increase glucose uptake into cultured C2C12 cells of mice. Planta Med 2002;68(11):999-1003.
  10. Zheng, G., Zhang, X., Zheng, J., Meng, Q., and Zheng, D. [Estrogen-like effects of puerarin and total isoflavones from Pueraria lobata]. Zhong.Yao Cai. 2002;25(8):566-568.
  11. Qi, B. L. and Qi, B. M. [Effect of the purariae-isofiavones on estrogen level in normal and ovariectomized rats]. Zhongguo Zhong.Yao Za Zhi. 2002;27(11):850-852.
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Black Cohosh 68 references
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  32. Hashemi H, Hasanpoor-Azghady SB, Farahani M, Amiri-Farahani L. Comparison of the effect of vaginal misoprostol and evening primrose oil capsule with misoprostol alone on the consequences of abortion in women with intrauterine fetal death: a randomized cli
  33. Ariana S, Amjadi N, Kazemi SN, Ahmadli Z. The Use of Evening Primrose Oil for Cervical Ripening in Low-Risk Women with Term Pregnancy: A Randomized Double-Blinded Controlled Trial. Complement Med Res 2024;31(3):215-221. PubMed

See these in context on the Evening Primrose monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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