Interactions on record — worth a quick check against your medications. Based on 2 of 5 ingredients. Check your meds →
Dietary supplement

Extra Strength Krill Oil 1000 mg Ingredients & Drug Interactions

by The Vitamin Shoppe

Extra Strength Krill Oil 1000 mg label
See full label image
Softgel Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Extra Strength Krill Oil 1000 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Extra Strength Krill Oil 1000 mg is a dietary supplement by The Vitamin Shoppe with 5 active ingredients. Its ingredients are commonly taken for antioxidant support, skin health and aging, eye health.Based on those ingredients, 838 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Astaxanthin, SuperbaBoost Krill Oil. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Extra Strength Krill Oil 1000 mg by The Vitamin Shoppe

Ask about any prescription or over-the-counter medication and we check it for interactions with Extra Strength Krill Oil 1000 mg by The Vitamin Shoppe — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Extra Strength Krill Oil 1000 mg by The Vitamin Shoppe

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 30, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 5 of its 5 active ingredients.
  • “Total Omega-3 Fatty Acids” is listed as a grouped ingredient — the label gives one combined amount (250 mg) without saying how much of each component you get.

This product contains 5 active ingredients centered on omega-3 fatty acids from krill. The two main ones — eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) — are the omega-3s themselves.

Astaxanthin is a naturally occurring pigment (and antioxidant) that comes from krill. The product also lists total omega-3 fatty acids and total phospholipids as active ingredients, along with SuperbaBoost Krill Oil as the krill extract base.

The softgel capsule itself contains inactive ingredients: bovine gelatin (the capsule material), purified water, sorbitol, glycerin, and a proprietary antioxidant blend.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: cardiovascular health.
  • We looked for evidence on: Cardiovascular disease (CVD), Heart failure, Hyperlipidemia, Hypertension, Hypertriglyceridemia, Stroke — and 4 related terms.
  • The closest evidence on file: Astaxanthin is rated "Insufficient Reliable Evidence To Rate" for Heart failure (Natural Medicines).
  • Also on file: Astaxanthin is rated "Insufficient Reliable Evidence To Rate" for Hyperlipidemia, Hypertension, Stroke.
  • Also on file: Krill Oil is rated "Insufficient Reliable Evidence To Rate" for Cardiovascular disease (CVD), Hyperlipidemia, Hypertension.

For dry eye, krill oil is rated Possibly Effective — meaning there's some evidence it may help, though more research would strengthen that claim. For astaxanthin, the evidence we hold is Insufficient Reliable Evidence To Rate it for age-related cognitive decline, age-related macular degeneration, aging skin, Alzheimer disease, athletic performance, or carpal tunnel syndrome.

Similarly, krill oil has insufficient evidence for aging skin, Alzheimer disease, cancer, high cholesterol, or cognitive function. The bottom line is that dry eye is the only condition with a meaningful evidence base for this product.

The evidence, ingredient by ingredient Astaxanthin Krill Oil

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Both astaxanthin and krill oil are generally well tolerated in studies, though long-term safety data for astaxanthin are limited. Krill oil has been studied at doses up to 4 grams daily.

The most common side effects from krill oil are gastrointestinal — bloating, diarrhea, fishy burps, flatulence, heartburn, nausea, and stomach discomfort. Astaxanthin may cause abdominal pain, diarrhea, and red-colored stools; at higher doses, severe stomach pain has been reported in a small number of cases.

Rarely, krill oil has caused headache, tiredness, and dizziness. For pregnancy, astaxanthin has not enough safety data, so the safety rating advises against use — talk it over with your doctor.

Krill oil also lacks enough reliable safety data in pregnancy; the same caution applies to breastfeeding for both ingredients. Additionally, avoid krill oil if you have a shellfish allergy, and use caution if you have a bleeding disorder.

Side effects, ingredient by ingredient Astaxanthin Krill Oil

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Astaxanthin, Krill Oil.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 839 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this product, double-check with your doctor or pharmacist if you're on anticoagulant or antiplatelet drugs (blood thinners like warfarin, clopidogrel, or aspirin at high doses) — krill oil may increase bleeding risk. If you take antidiabetes medications, confirm that adding krill oil won't lower your blood sugar too much.

Additionally, if you're on medications metabolized by CYP3A4 or CYP2B6 enzymes in your liver, astaxanthin may theoretically reduce their effectiveness — this effect hasn't been confirmed in humans, but it's worth discussing with your pharmacist.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

This product may be worth considering if you're looking at krill oil for dry eye, since that's the one condition with some evidence behind it. If you take blood thinners, diabetes medications, or drugs metabolized by your liver's CYP3A4 or CYP2B6 enzymes, you'll need to talk with your doctor or pharmacist before starting it — the interaction potential is real.

Pregnant or breastfeeding women and anyone with a shellfish allergy should check with their own healthcare provider first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 21, 2019.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Extra Strength Krill Oil 1000 mg, straight from the product label.

Brand The Vitamin Shoppe
Barcode (UPC) 766536036639
Net contents 30 Softgel(s)
Market status On market
Date entered into DSLD Nov 21, 2019
DSLD ID 208846
Product type Other Combinations
Supplement form Softgel Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Extra Strength Krill Oil 1000 mg by The Vitamin Shoppe, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
1 Softgel(s)
UPC/BARCODE
766536036639
IngredientAmount% DV
Calories10 Calorie(s)--
Eicosapentaenoic Acid140 mg--
Docosahexaenoic Acid65 mg--
Cholesterol20 mg7%
Total Fat1 Gram(s)1%
Astaxanthin70 mg--
Total Omega-3 Fatty Acids250 mg--
Total Phospholipids500 mg--
SuperbaBoost Krill Oil1000 mg--

Other ingredients: Bovine Gelatin, purified Water, Sorbitol, Glycerin, Proprietary Antioxidant Blend

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Cardiovascular health

Non-GMO Gluten-free

Formula

Omega fatty acids

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

Certified Sustainable Seafood MSC www.msc.org MSC-C-55281

Quality promise Tested & trusted

Precautions

Contains: Crustacean (Krill) and soy.

Warning: Consult your healthcare provider prior to use if you are pregnant, nursing, taking any medication or have any medical conditions.

Keep out of reach of children.

Tamper evident Do not use if outer seal is broken or missing.

Suggested/Recommended/Usage/Directions

Directions: Take one (1) softgel daily, preferably with a meal.

Storage

Store in a cool, dry place.

General Statements

From an MSC certified sustainable fishery. www.msc.org

Brand IP Statement(s)

SuperbaBoost is a trademark of the Aker Group.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Extra Strength Krill Oil 1000 mg by The Vitamin Shoppe label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Extra Strength Krill Oil 1000 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Extra Strength Krill Oil 1000 mg by The Vitamin Shoppe

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Astaxanthin

Interacts with
671 drugs
70 mg per serving

Astaxanthin is a reddish carotenoid pigment with strong antioxidant activity in the lab, and it is widely promoted for skin, eye, heart, and exercise...

Astaxanthin monograph & interactions

Total Omega-3 Fatty Acids

250 mg per serving
  • › Eicosapentaenoic Acid
  • › Docosahexaenoic Acid

Total Phospholipids

500 mg per serving

SuperbaBoost Krill Oil

Interacts with
208 drugs
1000 mg per serving

Krill oil is a source of omega-3 fatty acids (EPA and DHA) bound to phospholipids, which may help absorption. It is most studied for lowering triglyce...

SuperbaBoost Krill Oil monograph & interactions

Other (inactive) ingredients: Bovine Gelatin, Purified Water, Sorbitol, Glycerin, Proprietary Antioxidant Blend. These complete the product’s ingredient list but are not active constituents.

Interaction report

Extra Strength Krill Oil 1000 mg by The Vitamin Shoppe Drug Interactions

Want to check YOUR meds against Extra Strength Krill Oil 1000 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
838Drugs
838 Moderate

Ingredients driving the most interactions

Astaxanthin 671
SuperbaBoost Krill Oil 208

Individual Drug Interactions

The ingredients in Extra Strength Krill Oil 1000 mg interact with 838 drugs. Click any drug to see the details.

2 of the 5 ingredients in Extra Strength Krill Oil 1000 mg interact with drugs. Each result below shows which ingredient is responsible. Astaxanthin SuperbaBoost Krill Oil

Each ingredient & the kinds of drugs it affects

For each ingredient in Extra Strength Krill Oil 1000 mg with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Astaxanthin2 drug types · 671 drugs

Cytochrome P450 2B6 (Cyp2B6) Substrates

Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP2B6.
In vitro research shows that astaxanthin induces cytochrome CYP2B6 enzyme activity in human hepatocytes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
In vitro research shows that astaxanthin induces CYP3A4 enzyme activity in human hepatocytes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Astaxanthin full monograph & interactions

SuperbaBoost Krill Oil2 drug types · 208 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, krill oil may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Taking high doses of omega-3 fatty acids from fish oil can modestly decrease platelet aggregation. Since krill oil also contains these fatty acids, taking high doses of krill oil might also inhibit platelet aggregation. Theoretically, taking high doses of krill oil with antiplatelet or anticoagulant drugs might increase the risk of bleeding. However, the omega-3 content of krill oil is much lower than that of fish oil.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, taking krill oil with antidiabetes drugs might increase the risk of hypoglycemia.
Some research in animals and humans shows that krill oil might lower blood glucose levels. However, a small study shows that taking krill oil does not reduce blood glucose levels in patients with type 2 diabetes, most of whom were taking antidiabetes drugs.

Likelihood Possible Evidence B
SuperbaBoost Krill Oil full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Extra Strength Krill Oil 1000 mg, from the product label.

The Vitamin Shoppe

See all The Vitamin Shoppe products
Name
Vitamin Shoppe, Inc.
City
Secaucus
State
NJ
ZipCode
07094
Phone Number
1-866-293-3367
Web Address
www.vitaminshoppe.com
Pharmacist Counseling Corner

Extra Strength Krill Oil 1000 mg by The Vitamin Shoppe: Common Questions

Does Extra Strength Krill Oil 1000 mg by The Vitamin Shoppe interact with any medications?
Yes. Based on its ingredients, Extra Strength Krill Oil 1000 mg has a known interaction with 838 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Extra Strength Krill Oil 1000 mg contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is krill oil safe to take while I'm pregnant?
There isn't enough reliable safety data to know either way. Talk with your doctor or pharmacist before using it during pregnancy so you can make the right choice for you.
Can I take this if I have a shellfish allergy?
No. Since krill oil comes from krill (a type of shellfish), you should avoid this product if you have a shellfish allergy.
What are the most common side effects?
The most common side effects are gastrointestinal: bloating, diarrhea, fishy burps, flatulence, heartburn, nausea, and stomach discomfort. These tend to be milder with krill oil than with fish oil.
What is astaxanthin, and why is it in this product?
Astaxanthin is a natural pigment and antioxidant found in krill. It's included because krill naturally contains it as part of the whole-food source.
Will this help my cholesterol or blood sugar?
The evidence we have for krill oil on high cholesterol and blood sugar is insufficient to rate. Dry eye is the only condition with some evidence supporting krill oil's use.
Is there any concern if I'm on blood thinners?
Yes. High doses of omega-3 fatty acids in krill oil may theoretically increase your bleeding risk if you're taking anticoagulant or antiplatelet drugs — talk with your doctor or pharmacist before starting.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Extra Strength Krill Oil 1000 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Extra Strength Krill Oil 1000 mg label
Go deeper

The Full Monographs Behind Extra Strength Krill Oil 1000 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Astaxanthin

Interacts with 671 drugs

Astaxanthin is a reddish carotenoid pigment with strong antioxidant activity in the lab, and it is widely promoted for skin, eye, heart, and exercise benefits. Early human studies are promis...

Read the full Astaxanthin monograph → Herb & supplement monograph

Krill Oil

Interacts with 208 drugs

Krill oil is a source of omega-3 fatty acids (EPA and DHA) bound to phospholipids, which may help absorption. It is most studied for lowering triglycerides and supporting heart health, but t...

Read the full Krill Oil monograph →
Sources

Sources & How We Checked

Extra Strength Krill Oil 1000 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 16 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Astaxanthin 3 references
  1. Kupcinskas L, Lafolie P, Lignell A, et al. Efficacy of the natural antioxidant astaxanthin in the treatment of functional dyspepsia in patients with or without Helicobacter pylori infection: A prospective, randomized, double blind, and placebo-controlled
  2. Kistler, A., Liechti, H., Pichard, L., Wolz, E., Oesterhelt, G., Hayes, A., and Maurel, P. Metabolism and CYP-inducer properties of astaxanthin in man and primary human hepatocytes. Arch.Toxicol. 2002;75(11-12):665-675. PubMed
  3. Choi HD, Youn YK, Shin WG. Positive effects of astaxanthin on lipid profiles and oxidative stress in overweight subjects. Plant Foods Hum Nutr. 2011;66:363-369. PubMed

See these in context on the Astaxanthin monograph →

Krill Oil 13 references
  1. Leaf A. On the reanalysis of the GISSI-Prevenzione. Circulation 2002;105:1874-5. PubMed
  2. Connor WE. n-3 Fatty acids from fish and fish oil: panacea or nostrum? Am J Clin Nutr 2001;74;415-6. PubMed
  3. Calder PC. N-3 polyunsaturated fatty acids, inflammation and immunity: pouring oil on troubled waters or another fishy tale? Nutr Res 2001;21:309-41. DOI
  4. Bunea R, El Farrah K, Deutsch L. Evaluation of the effects of Neptune Krill Oil on the clinical course of hyperlipidemia. Altern Med Rev 2004;9:420-8.
  5. Sampalis F, Bunea R, Pelland MF, et al. Evaluation of the effects of Neptune Krill Oil on the management of premenstrual syndrome and dysmenorrhea. Altern Med Rev 2003;8:171-9.
  6. Harris WS, Miller M, Tighe AP, et al. Omega-3 fatty acids and coronary heart disease risk: clinical and mechanistic perspectives. Atherosclerosis 2008;197:12-24. PubMed
  7. Tandy S, Chung RW, Wat E, et al. Dietary krill oil supplementation reduces hepatic steatosis, glycemia, and hypercholesterolemia in high-fat-fed mice. J Agric Food Chem 10-14-2009;57:9339-45. PubMed
  8. Maki, K. C., Reeves, M. S., Farmer, M., Griinari, M., Berge, K., Vik, H., Hubacher, R., and Rains, T. M. Krill oil supplementation increases plasma concentrations of eicosapentaenoic and docosahexaenoic acids in overweight and obese men and women. Nutr.R PubMed
  9. Albert BB, Derraik JG, Brennan CM, et al. Supplementation with a blend of krill and salmon oil is associated with increased metabolic risk in overweight men. Am J Clin Nutr 2015;102(1):49-57.
  10. Berge K, Musa-Veloso K, Harwood M, Hoem N, Burri L. Krill oil supplementation lowers serum triglycerides without increasing low-density lipoprotein cholesterol in adults with borderline high or high triglyceride levels. Nutr Res 2014;34(2):126-33. PubMed
  11. Lobraico JM, DiLello LC, Butler AD, Cordisco ME, Petrini JR, Ahmadi R. Effects of krill oil on endothelial function and other cardiovascular risk factors in participants with type 2 diabetes, a randomized controlled trial. BMJ Open Diabetes Res Care. 2015 PubMed
  12. van der Wurff ISM, von Schacky C, Bergeland T, Zeegers MP, Kirschner PA, de Groot RHM. Krill oil supplementation's effect on school grades in typically developing adolescents. Prostaglandins Leukot Essent Fatty Acids 2023;191:102553. PubMed
  13. van der Wurff ISM, von Schacky C, Bergeland T, et al. Effect of 1 year krill oil supplementation on cognitive achievement of Dutch adolescents: A double-blind randomized controlled trial. Nutrients. 2019;11(6):1230. PubMed

See these in context on the Krill Oil monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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