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Dietary supplement

Fadogia Agrestis with Tongkat Ali Ingredients & Drug Interactions

by aSquared Nutrition

Fadogia Agrestis with Tongkat Ali label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Fadogia Agrestis with Tongkat Ali against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Fadogia Agrestis with Tongkat Ali is a dietary supplement by aSquared Nutrition with 2 active ingredients. Its ingredients are commonly taken for low testosterone or low libido in men, male fertility support, athletic performance and muscle strength.Based on those ingredients, 248 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Tongkat Ali Root Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Fadogia Agrestis with Tongkat Ali by aSquared Nutrition

Ask about any prescription or over-the-counter medication and we check it for interactions with Fadogia Agrestis with Tongkat Ali by aSquared Nutrition — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Fadogia Agrestis with Tongkat Ali by aSquared Nutrition

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This product has 2 active ingredients: Tongkat Ali Root Extract and Fadogia Agrestis Stem Extract. Tongkat Ali has been traditionally used to support sexual desire and may increase testosterone levels in aging males; the evidence for that use is rated possibly effective.

Fadogia agrestis is included for athletic performance and sexual function, though reliable evidence for either is not yet established. The capsule itself is made from methylcellulose, an inactive ingredient.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded its ingredients' overall clinical evidence instead.

Moderate

Some clinical evidence supports its ingredients for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredients' overall clinical evidence instead.
  • On file: Sexual desire — rated "Possibly Effective" (Eurycoma Longifolia) (Natural Medicines).

Tongkat Ali is rated possibly effective for sexual desire. The evidence for athletic performance is rated possibly ineffective, and there isn't enough reliable evidence yet to rate it for back pain, osteoporosis, or diabetes.

Fadogia agrestis lacks established evidence — we don't have solid data on whether it works for athletic performance, erectile dysfunction, or the other uses it's marketed for.

The evidence, ingredient by ingredient Eurycoma Longifolia Fadogia Agrestis

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Tongkat Ali is generally well tolerated in short-term studies, but long-term safety and the quality of different products are uncertain. A concern is that if it raises testosterone levels too high, you could see acne, insulin resistance, liver damage, and other testosterone-related side effects.

Fadogia agrestis has very limited human safety data, and animal studies hint at possible harm to the testicles, liver, and kidneys — this is a real caution. During pregnancy, the safety data for Tongkat Ali advises against it; for Fadogia agrestis, no safety data exist so it should be avoided.

During breastfeeding, neither ingredient has reliable safety information, so both should be avoided. If you're pregnant, planning to become pregnant, or breastfeeding, talk with your doctor or pharmacist before starting this product.

Side effects, ingredient by ingredient Eurycoma Longifolia Fadogia Agrestis

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Eurycoma Longifolia.
  • The most serious interaction on file is rated Moderate.
  • For scale: 248 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you start, make sure to check any heart or blood pressure medications you take — propranolol specifically has a Moderate interaction. Also flag any medications your liver breaks down through CYP1A2, CYP2C19, or CYP2A6 pathways, and let us know if you're taking testosterone replacement therapy.

Use the medication checker on this page to be sure.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

This product is geared toward men interested in sexual function and athletic performance. If you take propranolol or any blood pressure or heart medication, or if you're on testosterone replacement, check with your pharmacist first — interactions are documented.

Pregnant women and breastfeeding mothers should avoid it entirely. Talk with your pharmacist about your specific medications before you begin.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 18, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Fadogia Agrestis with Tongkat Ali, straight from the product label.

Brand aSquared Nutrition
Barcode (UPC) X0035DBJF5
Net contents 120 Capsule(s)
Market status On market
Date entered into DSLD Jul 18, 2023
DSLD ID 295346
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Fadogia Agrestis with Tongkat Ali by aSquared Nutrition, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
60
UPC/BARCODE
X0035DBJF5
IngredientAmount% DV
Tongkat Ali Root Extract400 mg--
Fadogia agrestis Stem Extract1000 mg--

Other ingredients: Methylcellulose Capsule

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested use: Take 2 capsules per day with a meal, or as directed by your healthcare professional.

Precautions

Caution: Do not exceed the recommended dose.

Not for use by children under 18 years of age.

Pregnant or nursing mothers, individuals taking any medications, individuals with a known medical condition, and individuals planning a medical procedure should consult a physician before using this or any dietary supplement.

Keep out of the reach of children.

Do not use if safety seal is damaged or missing.

Seals/Symbols

Sourced From A GMP Certified Facility Good Manufacturing Practice Quality Assured

USA Formulated

General Statements

Please recycle

Storage

Store in a cool, dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Formulation

Ultra strength Made with natural ingredients

Third-party tested Supports energy levels

No preservatives

Formula

Enhanced with Tongkat Ali

Asquared Nutrition is proud to offer an ultra strength Fadogia Agrestis supplement enhanced with Tongkat Ali. Our formula contains 1000 mg of Fadogia Agrestis and 400 mg of Tongkat Ali per serving.

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Fadogia Agrestis with Tongkat Ali by aSquared Nutrition label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Fadogia Agrestis with Tongkat Ali label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Fadogia Agrestis with Tongkat Ali by aSquared Nutrition

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Tongkat Ali Root Extract

Interacts with
248 drugs
400 mg per serving

Eurycoma longifolia (tongkat ali) is a Southeast Asian herb most popular for supporting testosterone, libido, and male fertility, with some small huma...

Tongkat Ali Root Extract monograph & interactions

Fadogia agrestis Stem Extract

No known
interactions
1000 mg per serving

Fadogia agrestis is a West African shrub marketed as a testosterone booster, but human evidence is essentially nonexistent and what we know comes most...

Fadogia agrestis Stem Extract monograph & interactions

Other (inactive) ingredients: Methylcellulose Capsule. These complete the product’s ingredient list but are not active constituents.

Interaction report

Fadogia Agrestis with Tongkat Ali by aSquared Nutrition Drug Interactions

Want to check YOUR meds against Fadogia Agrestis with Tongkat Ali?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
248Drugs
3 Moderate 245 Minor

Ingredients driving the most interactions

Tongkat Ali Root Extract 248

Individual Drug Interactions

The ingredients in Fadogia Agrestis with Tongkat Ali interact with 248 drugs. Click any drug to see the details.

1 of the 2 ingredients in Fadogia Agrestis with Tongkat Ali interact with drugs. Each result below shows which ingredient is responsible. Tongkat Ali Root Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Fadogia Agrestis with Tongkat Ali with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Tongkat Ali Root Extract5 drug types · 248 drugs

Propranolol (Inderal)

Eurycoma longifolia can reduce the levels and clinical effects of propranolol.
A small clinical study in healthy persons shows that taking a single dose of a water-based Eurycoma longifolia extract 200 mg, in combination with a single dose of propranolol 80 mg, reduces the propranolol area under the curve (AUC) by 29%, reduces the peak concentration by 42%, and increases time to peak concentration by 86% when compared with control. Since the elimination half-life of propranolol did not change, it seems that Eurycoma longifolia alters the kinetics of propranolol by decreasing its absorption in the gut, and not by altering its metabolism. It is not known if separating administration will prevent this interaction.

Likelihood Probable Evidence A
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, Eurycoma longifolia might increase levels CYP1A2 substrates.
In vitro research suggests that methanolic Eurycoma longifolia root extract weakly inhibits CYP1A2 enzymes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2A6 (Cyp2A6) Substrates

Theoretically, Eurycoma longifolia might increase levels of CYP2A6 substrates.
In vitro research suggests that methanolic Eurycoma longifolia root extract weakly inhibits CYP2A6 enzymes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, Eurycoma longifolia might increase levels of CYP2C19 substrates.
In vitro research suggests that methanolic Eurycoma longifolia root extract weakly inhibits CYP2C19 enzymes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Testosterone

Theoretically, Eurycoma longifolia may further increase levels of testosterone.
A clinical study in aging males with testosterone levels below 300 ng/dL shows that taking a specific water extract of Eurycoma longifolia roots (Physta; Biotropics Malaysia) 100-200 mg daily with breakfast for 12 weeks increases total testosterone levels by 8% to 11% when compared with placebo. It is unclear whether this increase would occur in individuals with normal testosterone levels.

Likelihood Possible Evidence D
Tongkat Ali Root Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Fadogia Agrestis with Tongkat Ali, from the product label.

aSquared Nutrition

See all aSquared Nutrition products
Name
aSquared Brands LLC
Street Address
382 NE 191st Street, #98406
City
Miami
State
Florida
ZipCode
33179
Phone Number
1-800-557-4120
Pharmacist Counseling Corner

Fadogia Agrestis with Tongkat Ali by aSquared Nutrition: Common Questions

Does Fadogia Agrestis with Tongkat Ali by aSquared Nutrition interact with any medications?
Yes. Based on its ingredients, Fadogia Agrestis with Tongkat Ali has a known interaction with 248 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Fadogia Agrestis with Tongkat Ali contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does Tongkat Ali actually improve sexual desire?
The evidence is rated possibly effective for sexual desire, meaning some research supports it but the data aren't definitive. Results vary, and quality and dose matter.
Can this product raise my testosterone too much?
Yes — Tongkat Ali can increase testosterone levels. If it raises yours beyond the normal range, you risk acne, insulin resistance, liver damage, and other testosterone-related side effects. If you're concerned about your levels, talk to your doctor.
What's the deal with Fadogia agrestis safety?
Human safety data are scarce, and animal studies suggest possible damage to the testicles, liver, and kidneys. That's why we don't know enough yet to say it's safe long-term.
Is this safe while I'm breastfeeding?
No — neither ingredient has reliable safety data for breastfeeding, so it's best to avoid it. Talk with your pharmacist or doctor if you're nursing.
Will this work for athletic performance?
Tongkat Ali is rated possibly ineffective for athletic performance, and Fadogia agrestis doesn't have enough evidence to rate. This isn't the product to choose if that's your main goal.
Can I take this with propranolol?
Not without checking first — Tongkat Ali reduces propranolol levels by about 29%, which could make the medication less effective at controlling your heart rate or blood pressure. Your doctor or pharmacist needs to know before you start.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Fadogia Agrestis with Tongkat Ali is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Fadogia Agrestis with Tongkat Ali label
Go deeper

The Full Monographs Behind Fadogia Agrestis with Tongkat Ali’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Eurycoma Longifolia

Interacts with 248 drugs

Eurycoma longifolia (tongkat ali) is a Southeast Asian herb most popular for supporting testosterone, libido, and male fertility, with some small human studies suggesting possible benefits....

Read the full Eurycoma Longifolia monograph → Herb & supplement monograph

Fadogia Agrestis

Fadogia agrestis is a West African shrub marketed as a testosterone booster, but human evidence is essentially nonexistent and what we know comes mostly from a few small rat studies. Animal...

Read the full Fadogia Agrestis monograph →
Sources

Sources & How We Checked

Fadogia Agrestis with Tongkat Ali's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Eurycoma Longifolia 4 references
  1. Salman SA, Amrah S, Wahab MS, et al. Modification of propranolol's bioavailability by Eurycoma longifolia water-based extract. J Clin Pharm Ther 2010;35:691-6. PubMed
  2. Tambi MI, Imran MK, Henkel RR. Standardised water-soluble extract of Eurycoma longifolia, Tongkat ali, as testosterone booster for managing men with late-onset hypogonadism? Andrologia 2011 Jun 15. doi: 10.1111/j.1439-0272.2011.01168.x. [Epub ahead of pri PubMed
  3. Han YM, Kim IS, Rehman SU, Choe K, Yoo HH. In vitro evaluation of the effects of Eurycoma longifolia extract on CYP-mediated drug metabolism. Evid Based Complement Alternat Med 2015;2015:631329.
  4. Chinnappan SM, George A, Pandey P, Narke G, Choudhary YK. Effect of Eurycoma longifolia standardised aqueous root extract-Physta ® on testosterone levels and quality of life in ageing male subjects: a randomised, double-blind, placebo-controlled multicent

See these in context on the Eurycoma Longifolia monograph →

Fadogia Agrestis 2 references
  1. Dietary Supplements: What You Need to Know — NIH Office of Dietary Supplements Source
  2. Using Dietary Supplements Wisely — NIH NCCIH Source

See these in context on the Fadogia Agrestis monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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