Femarelle Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Femarelle against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Femarelle is a dietary supplement by Se-cure Pharmaceuticals with 2 active ingredients. Its ingredients are commonly taken for constipation and digestive health, high cholesterol, heart health.Based on those ingredients, 597 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Flax. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Femarelle by Se-cure Pharmaceuticals
Ask about any prescription or over-the-counter medication and we check it for interactions with Femarelle by Se-cure Pharmaceuticals — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Femarelle by Se-cure Pharmaceuticals
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
Femarelle has 2 active ingredients: flaxseed and tofu extract. Flaxseed is a whole seed rich in fiber, omega-3 fatty acids, and compounds called lignans — plant substances with possible hormone-like properties.
Tofu extract is included for its role in the formula, though we have no detailed data on file about its function. The capsule itself is made of cellulose, an inert ingredient.
Does it work?
Not established
Flaxseed is possibly effective for high cholesterol, possibly effective for diabetes, possibly effective for mastalgia (breast pain), possibly effective for high blood pressure, and possibly effective for constipation — meaning there's some evidence but it's not definitive. We have no effectiveness data on file for tofu extract.
How safe is it?
Well-documented data
Flaxseed is generally well tolerated as a food, but at supplement doses it carries some caution. The most common side effects are bloating, diarrhea, and other digestive complaints — especially at higher doses.
Starting with small amounts and drinking plenty of water can help. Rare but serious allergic reactions like anaphylaxis are possible.
The supplement doses may have hormone-like effects, so you should get your doctor's approval before using it. Pregnancy safety is rated possibly unsafe for flaxseed, so discuss it with your doctor if you're pregnant or planning to be.
There isn't enough reliable safety information for supplement doses while breastfeeding, so talk with your pharmacist or doctor before taking it.
Meds to double-check
Moderate interaction found
Before you take Femarelle, double-check with your pharmacist if you use blood thinners or antiplatelet drugs (like warfarin or clopidogrel) — flaxseed may increase bleeding risk. Also flag blood pressure medications, diabetes drugs, antibiotics, or estrogen-based hormone therapies, as flaxseed may add to or reduce their effects.
The bottom line
Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.
Femarelle might appeal to you if you're looking at natural support for cholesterol, blood sugar, blood pressure, or constipation — flaxseed has some evidence for each. But if you take blood thinners, diabetes pills, blood pressure medications, antibiotics, or hormone therapy, you'll need to check with your pharmacist first.
Start with a small dose to see how your digestion handles it.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 25, 2014.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Femarelle, straight from the product label.
| Brand | Se-cure Pharmaceuticals |
|---|---|
| Net contents | 56 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Jun 25, 2014 |
| DSLD ID | 34225 |
| Product type | Botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Kosher, Menopause, Seniors/Mature (>50 Years) - Women ONLY |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Femarelle by Se-cure Pharmaceuticals, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Flax | 108 mg | -- |
| Tofu extract | 322 mg | -- |
Other ingredients: Cellulose capsules
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation
Femarelle(R) contains no estrogen and is not an isoflavone extract.
Suggested/Recommended/Usage/Directions
Suggested Use: A dietary supplement for the relief of menopausal symptoms and to support bone mineral content.* Recommended intake: 1 capsule, twice daily morning and evening; can be taken with or without food.
Precautions
Warnings: If you are pregnant, nursing or taking prescription drugs, consult your healthcare practitioner prior to use.
Do not use if seal is cut, torn or broken.
General Statements
Capsules are individually sealed in blister packs.
MADE IN ISRAEL
Storage
Store in a cool dry place.
FDA Statement of Identity
DIETARY SUPPLEMENT
Formula
A Natural SERM for Menopuse & Bone Health*
Kosher
Clinically proven relief of menopausal symptoms and promotion of bone health.*
FDA Disclaimer Statement
Studies have shown that Femarelle(R) alleviates menopausal symptoms and promotes bone health.*
* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Brand IP Statement(s)
Femarelle(R) is a high-quality product using standardized ingredients produced in consistent batches, and manufactured according to strict manufacturing practices:
Published clinical studies have shown that Femarelle(R) alleviates menopausal symptoms such as hot flashes, sleep disturbances, night sweats, joint and muscle discomfort.
Furthermore, Femarelle(R) supports bone mineral density and promotes bone health.*
Seals/Symbols
ISO 14001:2004 IQC Institute of Quality & Control Certified Environmental Management System
ISO 9001:2008 IQC Institute of Quality & Control Certified Environmental Management System
G.M.P Good Manufacturing Practices
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Femarelle by Se-cure Pharmaceuticals label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Femarelle by Se-cure Pharmaceuticals
These are the 2 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container56 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Flax
Interacts with597 drugs
Flaxseed is a nutritious food rich in fiber, omega-3 fats (ALA), and plant compounds called lignans. It is most reliably helpful for constipation and...
Flax monograph & interactionsTofu extract
Other (inactive) ingredients: Cellulose capsules. These complete the product’s ingredient list but are not active constituents.
Femarelle by Se-cure Pharmaceuticals Drug Interactions
HelloPharmacist Interaction Report
Femarelle by Se-cure Pharmaceuticals contains flaxseed, which interacts with several medication types.
The most serious concern is with blood thinners and antiplatelet drugs (medications that prevent clotting): flaxseed may add to their effect and raise your bleeding risk, and some clinical evidence suggests flaxseed can decrease how platelets clump together.
Read the full breakdown — every affected drug type, severity by severity
Flaxseed also has moderate interactions with blood pressure medications, diabetes drugs, antibiotics, and hormone therapies. With blood pressure drugs, it may lower your pressure further and cause dizziness or lightheadedness.
With diabetes medications, it could increase the risk of low blood sugar (hypoglycemia). Antibiotics might change how your body processes flaxseed's active compounds.
And flaxseed contains plant compounds (lignans) with mild hormone-like effects that might reduce how well estrogen medications work.
We could not check tofu extract — we hold no interaction data for it. Altogether, these interactions span 594 individual medications.
Please use the medication checker below with your exact prescriptions before you start.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Femarelle?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Femarelle interact with 597 drugs. Click any drug to see the details.
1 of the 2 ingredients in Femarelle interact with drugs. Each result below shows which ingredient is responsible. Flax
AmoxicillinAmix, Amoram, Amoxident, Amoxil Capsules, Amoxil Injection, Galenamox +3 more
How Amoxicillin interacts with Femarelle — through 1 ingredient. Tap an ingredient for the detail:
FlaxAntibiotic Drugs Moderate
Interaction Summary
Theoretically, antibiotics might interfere with the metabolism of flaxseed constituents, which could potentially alter the effects of flaxseed.
Read the full Flax + Amoxicillin interactionAmoxicillin VeterinaryBiomox
How Amoxicillin Veterinary interacts with Femarelle — through 1 ingredient. Tap an ingredient for the detail:
FlaxAntibiotic Drugs Moderate
Interaction Summary
Theoretically, antibiotics might interfere with the metabolism of flaxseed constituents, which could potentially alter the effects of flaxseed.
Read the full Flax + Amoxicillin Veterinary interactionAmoxicillin, Clavulanate PotassiumAugmentin, Augmentin '125/31 SF', Augmentin '250/62 SF', Augmentin XR, Augmentin-Duo 400/57, Clavulin
How Amoxicillin, Clavulanate Potassium interacts with Femarelle — through 1 ingredient. Tap an ingredient for the detail:
FlaxAntibiotic Drugs Moderate
Interaction Summary
Theoretically, antibiotics might interfere with the metabolism of flaxseed constituents, which could potentially alter the effects of flaxseed.
Read the full Flax + Amoxicillin, Clavulanate Potassium interactionAmoxicillin, Omeprazole Magnesium, RifabutinTalicia
How Amoxicillin, Omeprazole Magnesium, Rifabutin interacts with Femarelle — through 1 ingredient. Tap an ingredient for the detail:
FlaxAntibiotic Drugs Moderate
Interaction Summary
Theoretically, antibiotics might interfere with the metabolism of flaxseed constituents, which could potentially alter the effects of flaxseed.
Read the full Flax + Amoxicillin, Omeprazole Magnesium, Rifabutin interactionAmphotericin, TetracyclineMysteclin-F
How Amphotericin, Tetracycline interacts with Femarelle — through 1 ingredient. Tap an ingredient for the detail:
FlaxAntibiotic Drugs Moderate
Interaction Summary
Theoretically, antibiotics might interfere with the metabolism of flaxseed constituents, which could potentially alter the effects of flaxseed.
Read the full Flax + Amphotericin, Tetracycline interactionAmpicillinOmnipen, Omnipen-N, Penbritin, Principen, Rimacillin
How Ampicillin interacts with Femarelle — through 1 ingredient. Tap an ingredient for the detail:
FlaxAntibiotic Drugs Moderate
Interaction Summary
Theoretically, antibiotics might interfere with the metabolism of flaxseed constituents, which could potentially alter the effects of flaxseed.
Read the full Flax + Ampicillin interactionAmpicillin, SulbactamUnasyn
How Ampicillin, Sulbactam interacts with Femarelle — through 1 ingredient. Tap an ingredient for the detail:
FlaxAntibiotic Drugs Moderate
Interaction Summary
Theoretically, antibiotics might interfere with the metabolism of flaxseed constituents, which could potentially alter the effects of flaxseed.
Read the full Flax + Ampicillin, Sulbactam interactionAnacaulase-bcdbNexoBrid
How Anacaulase-bcdb interacts with Femarelle — through 1 ingredient. Tap an ingredient for the detail:
FlaxAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, using flaxseed in combination with anticoagulant or antiplatelet drugs might have additive effects and increase the risk of bleeding.
Read the full Flax + Anacaulase-bcdb interactionAnagrelideAgrylin
How Anagrelide interacts with Femarelle — through 1 ingredient. Tap an ingredient for the detail:
FlaxAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, using flaxseed in combination with anticoagulant or antiplatelet drugs might have additive effects and increase the risk of bleeding.
Read the full Flax + Anagrelide interactionAnisindioneMiradon
How Anisindione interacts with Femarelle — through 1 ingredient. Tap an ingredient for the detail:
FlaxAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, using flaxseed in combination with anticoagulant or antiplatelet drugs might have additive effects and increase the risk of bleeding.
Read the full Flax + Anisindione interactionAntidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) InhibitorGlyxambi
How Antidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) Inhibitor interacts with Femarelle — through 1 ingredient. Tap an ingredient for the detail:
FlaxAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, flaxseed might have additive effects when used with antidiabetes drugs and increase the risk for hypoglycemia.
Read the full Flax + Antidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) Inhibitor interactionAntithrombin IiiThrombate III
How Antithrombin Iii interacts with Femarelle — through 1 ingredient. Tap an ingredient for the detail:
FlaxAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, using flaxseed in combination with anticoagulant or antiplatelet drugs might have additive effects and increase the risk of bleeding.
Read the full Flax + Antithrombin Iii interactionApixabanEliquis
How Apixaban interacts with Femarelle — through 1 ingredient. Tap an ingredient for the detail:
FlaxAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, using flaxseed in combination with anticoagulant or antiplatelet drugs might have additive effects and increase the risk of bleeding.
Read the full Flax + Apixaban interactionAprocitentanTryvio
How Aprocitentan interacts with Femarelle — through 1 ingredient. Tap an ingredient for the detail:
FlaxAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, flaxseed might have additive effects when used with antihypertensive drugs and increase the risk of hypotension.
Read the full Flax + Aprocitentan interactionArgatrobanArgatroban
How Argatroban interacts with Femarelle — through 1 ingredient. Tap an ingredient for the detail:
FlaxAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, using flaxseed in combination with anticoagulant or antiplatelet drugs might have additive effects and increase the risk of bleeding.
Read the full Flax + Argatroban interactionAspirinAngettes 75, ASA, Asaphen, Aspirin, Caprin, Cartia +8 more
How Aspirin interacts with Femarelle — through 1 ingredient. Tap an ingredient for the detail:
FlaxAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, using flaxseed in combination with anticoagulant or antiplatelet drugs might have additive effects and increase the risk of bleeding.
Read the full Flax + Aspirin interactionAspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium HydroxideAscriptin Codeine #3
How Aspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium Hydroxide interacts with Femarelle — through 1 ingredient. Tap an ingredient for the detail:
FlaxAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, using flaxseed in combination with anticoagulant or antiplatelet drugs might have additive effects and increase the risk of bleeding.
Read the full Flax + Aspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium Hydroxide interactionAspirin, ButalbitalAxotal
How Aspirin, Butalbital interacts with Femarelle — through 1 ingredient. Tap an ingredient for the detail:
FlaxAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, using flaxseed in combination with anticoagulant or antiplatelet drugs might have additive effects and increase the risk of bleeding.
Read the full Flax + Aspirin, Butalbital interactionAspirin, Butalbital, CaffeineFiorinal
How Aspirin, Butalbital, Caffeine interacts with Femarelle — through 1 ingredient. Tap an ingredient for the detail:
FlaxAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, using flaxseed in combination with anticoagulant or antiplatelet drugs might have additive effects and increase the risk of bleeding.
Read the full Flax + Aspirin, Butalbital, Caffeine interactionAspirin, Butalbital, Caffeine, Codeine PhosphateFiorinal w/ Codeine
How Aspirin, Butalbital, Caffeine, Codeine Phosphate interacts with Femarelle — through 1 ingredient. Tap an ingredient for the detail:
FlaxAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, using flaxseed in combination with anticoagulant or antiplatelet drugs might have additive effects and increase the risk of bleeding.
Read the full Flax + Aspirin, Butalbital, Caffeine, Codeine Phosphate interactionAspirin, Butalbital, Caffeine, PhenacetinMarnal
How Aspirin, Butalbital, Caffeine, Phenacetin interacts with Femarelle — through 1 ingredient. Tap an ingredient for the detail:
FlaxAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, using flaxseed in combination with anticoagulant or antiplatelet drugs might have additive effects and increase the risk of bleeding.
Read the full Flax + Aspirin, Butalbital, Caffeine, Phenacetin interactionAspirin, CaffeineAnacin
How Aspirin, Caffeine interacts with Femarelle — through 1 ingredient. Tap an ingredient for the detail:
FlaxAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, using flaxseed in combination with anticoagulant or antiplatelet drugs might have additive effects and increase the risk of bleeding.
Read the full Flax + Aspirin, Caffeine interactionAspirin, Caffeine, Codeine PhosphateAnacin w/ Codeine
How Aspirin, Caffeine, Codeine Phosphate interacts with Femarelle — through 1 ingredient. Tap an ingredient for the detail:
FlaxAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, using flaxseed in combination with anticoagulant or antiplatelet drugs might have additive effects and increase the risk of bleeding.
Read the full Flax + Aspirin, Caffeine, Codeine Phosphate interactionAspirin, Caffeine, Dihydrocodeine BitartrateSynalgos DC
How Aspirin, Caffeine, Dihydrocodeine Bitartrate interacts with Femarelle — through 1 ingredient. Tap an ingredient for the detail:
FlaxAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, using flaxseed in combination with anticoagulant or antiplatelet drugs might have additive effects and increase the risk of bleeding.
Read the full Flax + Aspirin, Caffeine, Dihydrocodeine Bitartrate interactionAspirin, Caffeine, Dover's PwdAcedoval, Dovacet
How Aspirin, Caffeine, Dover's Pwd interacts with Femarelle — through 1 ingredient. Tap an ingredient for the detail:
FlaxAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, using flaxseed in combination with anticoagulant or antiplatelet drugs might have additive effects and increase the risk of bleeding.
Read the full Flax + Aspirin, Caffeine, Dover's Pwd interactionAspirin, Caffeine, HydrocodoneDamason-P
How Aspirin, Caffeine, Hydrocodone interacts with Femarelle — through 1 ingredient. Tap an ingredient for the detail:
FlaxAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, using flaxseed in combination with anticoagulant or antiplatelet drugs might have additive effects and increase the risk of bleeding.
Read the full Flax + Aspirin, Caffeine, Hydrocodone interactionAspirin, Caffeine, Isobutylallylbarbituric Acid, PhenacetinLanorinal
How Aspirin, Caffeine, Isobutylallylbarbituric Acid, Phenacetin interacts with Femarelle — through 1 ingredient. Tap an ingredient for the detail:
FlaxAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, using flaxseed in combination with anticoagulant or antiplatelet drugs might have additive effects and increase the risk of bleeding.
Read the full Flax + Aspirin, Caffeine, Isobutylallylbarbituric Acid, Phenacetin interactionAspirin, Caffeine, OrphenadrineInvagesic, Invagesic Forte, Norgesic, Norgesic Forte, Orphengesic, Orphengesic Forte
How Aspirin, Caffeine, Orphenadrine interacts with Femarelle — through 1 ingredient. Tap an ingredient for the detail:
FlaxAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, using flaxseed in combination with anticoagulant or antiplatelet drugs might have additive effects and increase the risk of bleeding.
Read the full Flax + Aspirin, Caffeine, Orphenadrine interactionAspirin, Caffeine, Phenacetin, PropoxypheneMargesic Comp. 65
How Aspirin, Caffeine, Phenacetin, Propoxyphene interacts with Femarelle — through 1 ingredient. Tap an ingredient for the detail:
FlaxAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, using flaxseed in combination with anticoagulant or antiplatelet drugs might have additive effects and increase the risk of bleeding.
Read the full Flax + Aspirin, Caffeine, Phenacetin, Propoxyphene interactionAspirin, Calcium Carbonate, Magnesium Carbonate, Magnesium OxideBufferin
How Aspirin, Calcium Carbonate, Magnesium Carbonate, Magnesium Oxide interacts with Femarelle — through 1 ingredient. Tap an ingredient for the detail:
FlaxAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, using flaxseed in combination with anticoagulant or antiplatelet drugs might have additive effects and increase the risk of bleeding.
Read the full Flax + Aspirin, Calcium Carbonate, Magnesium Carbonate, Magnesium Oxide interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Femarelle with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Flax
Antibiotic Drugs
Theoretically, antibiotics might interfere with the metabolism of flaxseed constituents, which could potentially alter the effects of flaxseed.
Some potential benefits of flaxseed are thought to be due to its lignan content. Secoisolariciresinol diglucoside (SDG), a major lignan precursor, is found in high concentrations in flaxseed. SDG is converted by bacteria in the colon to the lignans enterolactone and enterodiol. Antibiotics alter the flora of the colon, which could theoretically alter the metabolism of flaxseed.
Anticoagulant/Antiplatelet Drugs
Theoretically, using flaxseed in combination with anticoagulant or antiplatelet drugs might have additive effects and increase the risk of bleeding.
Some clinical evidence suggests that the oil contained in flaxseed can decrease platelet aggregation.
Antidiabetes Drugs
Theoretically, flaxseed might have additive effects when used with antidiabetes drugs and increase the risk for hypoglycemia.
Some clinical research suggests that flaxseed can lower blood glucose levels.
Antihypertensive Drugs
Theoretically, flaxseed might have additive effects when used with antihypertensive drugs and increase the risk of hypotension.
Clinical research shows that daily flaxseed consumption, especially for longer than 12 weeks, modestly reduces blood pressure.
Estrogens
Theoretically, taking flaxseed might decrease the effects of estrogens.
Flaxseed contains lignans with mild estrogenic and possible antiestrogenic effects. The lignans seem to compete with circulating endogenous estrogen and might reduce estrogen binding to estrogen receptors, resulting in an anti-estrogen effect. It is unclear if this effect transfers to exogenously administered estrogens.
Brand information
Manufacturer and brand details for Femarelle, from the product label.
Se-cure Pharmaceuticals
See all Se-cure Pharmaceuticals products- Name
- IFS
- Street Address
- 4346 Belgium Blvd
- City
- Kansas City
- State
- MO
- ZipCode
- 64150-1704
Femarelle by Se-cure Pharmaceuticals: Common Questions
Does Femarelle by Se-cure Pharmaceuticals interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Will this cause bloating or gas?
Is it safe if I'm pregnant?
Can I use it while breastfeeding?
Does it really lower cholesterol?
What does tofu extract do in this formula?
How much can I safely take per day?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Femarelle is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Femarelle’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Femarelle's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 37 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Flaxseed 37 references
- Kolonel LN, Nomura AM, Cooney RV. Dietary fat and prostate cancer: current status. J Natl Cancer Inst 1999;91:414-28. PubMed
- Ramon JM, Bou R, Romea S, et al. Dietary fat intake and prostate cancer risk: a case-control study in Spain. Cancer Causes Control 2000;11:679-85. PubMed
- Thompson LU, Rickard SE, Cheung F, et al. Variability in anticancer lignan levels in flaxseed. Nutr Cancer 1997;27:26-30. PubMed
- Nordstrom DC, Honkanen VE, Nasu Y, et al. Alpha-linolenic acid in the treatment of rheumatoid arthritis. A double-blind, placebo-controlled and randomized study: flaxseed vs. safflower seed. Rheumatol Int 1995;14:231-4. PubMed
- Cunnane SC, Ganguli S, Menard C, et al. High alpha-linolenic acid flaxseed (Linum usitatissimum): some nutritional properties in humans. Br J Nutr 1993;69:443-53.
- Clark WF, Parbtani A, Huff MW, et al. Flaxseed: a potential treatment for lupus nephritis. Kidney Int 1995;48:475-80. PubMed
- Cunnane SC, Hamadeh MJ, Liede AC, et al. Nutritional attributes of traditional flaxseed in healthy young adults. Am J Clin Nutr 1995;61:62-8. PubMed
- De Stefani E, Deneo-Pellegrini H, Boffetta P, et al. Alpha-linolenic acid and risk of prostate cancer: a case-control study in Uruguay. Cancer Epidemiol Biomarkers Prev 2000;9:335-8.
- Giovannucci E, Rimm EB, Colditz GA, et al. A prospective study of dietary fat and risk of prostate cancer. J Natl Cancer Inst 1993;85:1571-9. PubMed
- Clark WF, Kortas C, Heidenheim P, et al. Flaxseed in lupus nephritis: a two-year nonplacebo-controlled crossover study. J Am Coll Nutr 2001;20:143-8. PubMed
- Serraino M, Thompson LU. The effect of flaxseed supplementation on early risk markers for mammary carcinogenesis. Cancer Lett 1991;60:135-42. PubMed
- Rickard SE, Yuan YV, Thompson LU. Plasma insulin-like growth factor I levels in rats are reduced by dietary supplementation of flaxseed or its lignan secoisolariciresinol diglycoside. Cancer Lett 2000;161:47-55. PubMed
- Mousavi Y, Adlercreutz H. Enterolactone and estradiol inhibit each other's proliferative effect on MCF-7 breast cancer cells in culture. J Steroid Biochem Mol Biol 1992;41:615-9.. PubMed
- Adlercreutz H, Fotsis T, Bannwart C, et al. Determination of urinary lignans and phytoestrogen metabolites, potential antiestrogens and anticarcinogens, in urine of women on various habitual diets. J Steroid Biochem 1986;25:791-7.. PubMed
- Rose DP. Dietary fiber and breast cancer. Nutr Cancer 1990;13:1-8.. PubMed
- Lemay A, Dodin S, Kadri N, et al. Flaxseed dietary supplement versus hormone replacement therapy in hypercholesterolemic menopausal women. Obstet Gynecol 2002;100:495-504.. DOI
- Brooks JD, Ward WE, Lewis JE, et al. Supplementation with flaxseed alters estrogen metabolism in postmenopausal women to a greater extent than does supplementation with an equal amount of soy. Am J Clin Nutr 2004;79:318-25.. PubMed
- Laaksonen DE, Laukkanen JA, Niskanen L, et al. Serum linoleic and total polyunsaturated fatty acids in relation to prostate and other cancers: a population-based cohort study. Int J Cancer 2004;111:444-50.. PubMed
- Dodin S, Lemay A, Jacques H, et al. The effects of flaxseed dietary supplement on lipid profile, bone mineral density, and symptoms in menopausal women: a randomized, double-blind, wheat germ placebo-controlled clinical trial. J Clin Endocrinol Metab 2005 PubMed
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