Fenugreek Ingredients & Drug Interactions
by Hawaii Pharm
What is this page for?
First and foremost: checking Fenugreek against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Fenugreek is a dietary supplement by Hawaii Pharm with 1 active ingredient. Its ingredients are commonly taken for blood sugar control, boosting breast milk supply, high cholesterol.Based on those ingredients, 389 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Fenugreek Fruit Extract, Dry. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Fenugreek by Hawaii Pharm
Ask about any prescription or over-the-counter medication and we check it for interactions with Fenugreek by Hawaii Pharm — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Fenugreek by Hawaii Pharm
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: fenugreek fruit extract in dried form. It's a liquid preparation made with alcohol, water, and glycerin as inactive ingredients.
Does it work?
Moderate evidence
Fenugreek is listed as possibly effective for sexual dysfunction and dysmenorrhea (severe period cramping), and possibly effective for helping manage diabetes. The evidence in our data supports these uses, though the strength of evidence isn't the same for each condition.
How safe is it?
Well-documented data
Fenugreek is generally well tolerated in food amounts, but supplement doses may cause side effects. Common ones include stomach pain, bloating, diarrhea, indigestion, gas, low blood sugar (hypoglycemia), and nausea.
Rare but serious allergic reactions — including anaphylaxis — have been reported. Fenugreek may also affect your uterus, so medicinal use during pregnancy is advised against.
If you're breastfeeding and interested in using fenugreek to boost milk supply, the evidence is limited — talk it over with your doctor or pharmacist first. One oddity worth knowing: fenugreek can cause an unusual body odor in both adults and children, sometimes confused with maple syrup urine disease.
Meds to double-check
Moderate interaction found
Before you take this, double-check with your pharmacist or doctor if you're on blood thinners like warfarin or antiplatelet drugs like clopidogrel; diabetes medications; theophylline (for asthma or breathing); the seizure drug phenytoin; the blood pressure drug metoprolol; or sildenafil for erectile dysfunction. All of these have documented moderate interactions with fenugreek.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.
Fenugreek may help with sexual function, period pain, or blood sugar control, but it has moderate interactions with blood thinners, diabetes drugs, and several other medications. If you're on any prescription medications — especially for bleeding, diabetes, heart, or seizures — check with your own doctor or pharmacist before starting this.
Pregnant people should avoid it.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Oct 24, 2023.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Fenugreek, straight from the product label.
| Brand | Hawaii Pharm |
|---|---|
| Barcode (UPC) | 840253621733 |
| Net contents | 4 Fluid Ounce(s); 120 mL |
| Market status | On market |
| Date entered into DSLD | Oct 24, 2023 |
| DSLD ID | 301583 |
| Product type | Botanical |
| Supplement form | Liquid |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Fenugreek by Hawaii Pharm, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Fenugreek Fruit Extract, Dry | 983 mg | -- |
Other ingredients: Alcohol, Water, Glycerin
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)
Hawaii Pharm Herbal Extract Highest quality since 2008
Suggested/Recommended/Usage/Directions
Suggested use: Shake well before using. For adults add about 20-30 drops (0.7-1 mL, one full squeeze of the dropper bulb) to some juice or water, up to 4 times a day.
Precautions
Warning: We recommend to seek expert medical advice before taking.
Do not use if you are allergic to any ingredients.
Consult your physician before giving to children under 18, during pregnancy, if nursing or taking medications.
Consult your physician before giving to children under 18, during pregnancy, if nursing or taking medications.
May affect the ability to drive and operate machinery. May have contraindications, can cause side effects and adverse reactions. Do not use if seal is broken or missing.
Keep out of the reach of children!
Storage
Store in a cool dry place.
Seals/Symbols
cGMP Made in compliance with cGMP 21 CFR 111 in an FDA registered and inspected facility.
Organic Alcohol Based USA Made in United States of America
FDA Disclaimer Statement
This product has not been evaluated by the FDA and is not intended to diagnose, treat, cure or prevent any disease.
General Statements
Scan this QR-code to get 15% discount on your next purchase. Limited time deal.
Formula
Trigonella foenum-graecum
Organic Alcohol Based
Formulation
Only natural ingredients Purity is laboratory tested and verified
All the raw materials are gluten-free by their nature No artificial colors, flavors, or preservatives
Not tested on animals
Organic Alcohol Based
Made in USA, Hawaii
FDA Statement of Identity
Herbal Supplement
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Fenugreek by Hawaii Pharm label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Fenugreek by Hawaii Pharm
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size0.7 mL Dosage formLiquid Servings per container120 Amounts shown are per serving.
Fenugreek Fruit Extract, Dry
Interacts with389 drugs
Fenugreek is a common kitchen spice that is also taken as a supplement, mainly for blood sugar, cholesterol, and to support breast milk production. So...
Fenugreek Fruit Extract, Dry monograph & interactionsOther (inactive) ingredients: Alcohol, Water, Glycerin. These complete the product’s ingredient list but are not active constituents.
Fenugreek by Hawaii Pharm Drug Interactions
HelloPharmacist Interaction Report
Fenugreek by Hawaii Pharm interacts with a significant number of medications.
The ingredient fenugreek fruit extract has documented interactions with blood thinners and antiplatelet drugs (the most serious concern), diabetes medications, heart and blood pressure drugs, seizure medications, and erectile dysfunction drugs. The most serious interaction is with blood thinners like warfarin, where fenugreek may increase bleeding risk by raising your INR (international normalized ratio) — a measure of how thin your blood is.
Read the full breakdown — every affected drug type, severity by severity
Fenugreek may also add to the blood-thinning effects of antiplatelet drugs like clopidogrel (Plavix) and could lower blood sugar too much if you're taking diabetes medications. It may reduce how well theophylline (an asthma/breathing medication) works by lowering its levels in your blood.
Similarly, it could reduce the effectiveness of the seizure drug phenytoin and the erectile dysfunction drug sildenafil. Animal research also shows it may have additive blood pressure-lowering effects with metoprolol.
Altogether, these interactions span 389 individual medications. If you take any blood thinners, diabetes drugs, heart or blood pressure medications, seizure medications, theophylline, or sildenafil, run them through the medication interaction checker on this page before you start fenugreek.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Fenugreek?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Fenugreek interact with 389 drugs. Click any drug to see the details.
1 of the 1 ingredient in Fenugreek interact with drugs. Each result below shows which ingredient is responsible. Fenugreek Fruit Extract, Dry
AbciximabReoPro
How Abciximab interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Fenugreek Fruit Extract, DryAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Fenugreek Fruit Extract, Dry + Abciximab interactionAbrocitinibCibinqo
How Abrocitinib interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Fenugreek Fruit Extract, DryAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Fenugreek Fruit Extract, Dry + Abrocitinib interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Fenugreek Fruit Extract, DryAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, fenugreek seed might have additive hypoglycemic effects when used with antidiabetes drugs.
Read the full Fenugreek Fruit Extract, Dry + Acarbose interactionAcenocoumarolSintrom
How Acenocoumarol interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Fenugreek Fruit Extract, DryAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Fenugreek Fruit Extract, Dry + Acenocoumarol interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Fenugreek Fruit Extract, DryAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Fenugreek Fruit Extract, Dry + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Fenugreek Fruit Extract, DryAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Fenugreek Fruit Extract, Dry + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, IbuprofenCombogesic
How Acetaminophen, Ibuprofen interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Fenugreek Fruit Extract, DryAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Fenugreek Fruit Extract, Dry + Acetaminophen, Ibuprofen interactionAcetohexamideDymelor
How Acetohexamide interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Fenugreek Fruit Extract, DryAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, fenugreek seed might have additive hypoglycemic effects when used with antidiabetes drugs.
Read the full Fenugreek Fruit Extract, Dry + Acetohexamide interactionAcetylsalicylic AcidEntrophen
How Acetylsalicylic Acid interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Fenugreek Fruit Extract, DryAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Fenugreek Fruit Extract, Dry + Acetylsalicylic Acid interactionAlbiglutideTanzeum
How Albiglutide interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Fenugreek Fruit Extract, DryAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, fenugreek seed might have additive hypoglycemic effects when used with antidiabetes drugs.
Read the full Fenugreek Fruit Extract, Dry + Albiglutide interactionAlogliptinNesina
How Alogliptin interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Fenugreek Fruit Extract, DryAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, fenugreek seed might have additive hypoglycemic effects when used with antidiabetes drugs.
Read the full Fenugreek Fruit Extract, Dry + Alogliptin interactionAlogliptin, MetforminKazano
How Alogliptin, Metformin interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Fenugreek Fruit Extract, DryAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, fenugreek seed might have additive hypoglycemic effects when used with antidiabetes drugs.
Read the full Fenugreek Fruit Extract, Dry + Alogliptin, Metformin interactionAlogliptin, PioglitazoneOseni
How Alogliptin, Pioglitazone interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Fenugreek Fruit Extract, DryAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, fenugreek seed might have additive hypoglycemic effects when used with antidiabetes drugs.
Read the full Fenugreek Fruit Extract, Dry + Alogliptin, Pioglitazone interactionAlteplase, TpaActilyse, Activase
How Alteplase, Tpa interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Fenugreek Fruit Extract, DryAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Fenugreek Fruit Extract, Dry + Alteplase, Tpa interactionAluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium HydroxideAscriptin Codeine #2
How Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Fenugreek Fruit Extract, DryAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Fenugreek Fruit Extract, Dry + Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interactionAluminum Hydroxide, Aspirin, Magnesium HydroxideAscriptin
How Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Fenugreek Fruit Extract, DryAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Fenugreek Fruit Extract, Dry + Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interactionAnacaulase-bcdbNexoBrid
How Anacaulase-bcdb interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Fenugreek Fruit Extract, DryAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Fenugreek Fruit Extract, Dry + Anacaulase-bcdb interactionAnagrelideAgrylin
How Anagrelide interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Fenugreek Fruit Extract, DryAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Fenugreek Fruit Extract, Dry + Anagrelide interactionAnisindioneMiradon
How Anisindione interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Fenugreek Fruit Extract, DryAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Fenugreek Fruit Extract, Dry + Anisindione interactionAntidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) InhibitorGlyxambi
How Antidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) Inhibitor interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Fenugreek Fruit Extract, DryAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, fenugreek seed might have additive hypoglycemic effects when used with antidiabetes drugs.
Read the full Fenugreek Fruit Extract, Dry + Antidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) Inhibitor interactionAntithrombin IiiThrombate III
How Antithrombin Iii interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Fenugreek Fruit Extract, DryAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Fenugreek Fruit Extract, Dry + Antithrombin Iii interactionApixabanEliquis
How Apixaban interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Fenugreek Fruit Extract, DryAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Fenugreek Fruit Extract, Dry + Apixaban interactionArgatrobanArgatroban
How Argatroban interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Fenugreek Fruit Extract, DryAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Fenugreek Fruit Extract, Dry + Argatroban interactionAspirinAngettes 75, ASA, Asaphen, Aspirin, Caprin, Cartia +8 more
How Aspirin interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Fenugreek Fruit Extract, DryAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Fenugreek Fruit Extract, Dry + Aspirin interactionAspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium HydroxideAscriptin Codeine #3
How Aspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium Hydroxide interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Fenugreek Fruit Extract, DryAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Fenugreek Fruit Extract, Dry + Aspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium Hydroxide interactionAspirin, ButalbitalAxotal
How Aspirin, Butalbital interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Fenugreek Fruit Extract, DryAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Fenugreek Fruit Extract, Dry + Aspirin, Butalbital interactionAspirin, Butalbital, CaffeineFiorinal
How Aspirin, Butalbital, Caffeine interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Fenugreek Fruit Extract, DryAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Fenugreek Fruit Extract, Dry + Aspirin, Butalbital, Caffeine interactionAspirin, Butalbital, Caffeine, Codeine PhosphateFiorinal w/ Codeine
How Aspirin, Butalbital, Caffeine, Codeine Phosphate interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Fenugreek Fruit Extract, DryAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Fenugreek Fruit Extract, Dry + Aspirin, Butalbital, Caffeine, Codeine Phosphate interactionAspirin, Butalbital, Caffeine, PhenacetinMarnal
How Aspirin, Butalbital, Caffeine, Phenacetin interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Fenugreek Fruit Extract, DryAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Fenugreek Fruit Extract, Dry + Aspirin, Butalbital, Caffeine, Phenacetin interactionAspirin, CaffeineAnacin
How Aspirin, Caffeine interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Fenugreek Fruit Extract, DryAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Fenugreek Fruit Extract, Dry + Aspirin, Caffeine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Fenugreek with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Fenugreek Fruit Extract, Dry
Anticoagulant/Antiplatelet Drugs
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Some of the constituents in fenugreek have antiplatelet effects in animal and in vitro research. However, common fenugreek products might not contain sufficient concentrations of these constituents for clinical effects. A clinical study in patients with coronary artery disease or diabetes shows that taking fenugreek seed powder 2.5 grams twice daily for 3 months does not affect platelet aggregation, fibrinolytic activity, or fibrinogen levels .
Antidiabetes Drugs
Theoretically, fenugreek seed might have additive hypoglycemic effects when used with antidiabetes drugs.
Clinical research shows that fenugreek seed can reduce fasting blood glucose and 2-hour postprandial glucose levels in adults with type 2 diabetes.
Clopidogrel (Plavix)
Theoretically, fenugreek seed might alter the clinical effects of clopidogrel by inhibiting its conversion to the active form.
Animal research shows that fenugreek seed 200 mg/kg daily for 14 days increases the maximum serum concentration of clopidogrel by 21%. It is unclear how this affects the pharmacokinetics of the active metabolite of clopidogrel; however, this study found that concomitant use of fenugreek seed and clopidogrel prolonged bleeding time by an additional 11%.
Metoprolol (Toprol)
Theoretically, fenugreek seed might have additive hypotensive effects when used with metoprolol.
Animal research shows that fenugreek seed 300 mg/kg daily for 2 weeks decreases systolic and diastolic blood pressure by 9% and 11%, respectively, when administered alone, and by 15% and 22%, respectively, when given with metoprolol 10 mg/kg.
Phenytoin (Dilantin)
Theoretically, fenugreek might decrease plasma levels of phenytoin.
Animal research shows that taking fenugreek seeds for 1 week decreases maximum concentrations and the area under the curve of a single dose of phenytoin by 44% and 72%, respectively. This seems to be related to increased clearance. So far, this interaction has not been reported in humans.
Sildenafil (Viagra)
Theoretically, concurrent use of sildenafil and fenugreek might reduce levels and therapeutic effects of sildenafil.
Animal research shows that taking fenugreek seeds for 1 week reduces maximum concentrations and the area under the curve of a single dose of sildenafil by 27% and 48%, respectively. So far, this interaction has not been reported in humans.
Theophylline
Theoretically, fenugreek may reduce the levels and clinical effects of theophylline.
Animal research shows that fenugreek 50 grams daily for 7 days reduces the maximum serum concentration (Cmax) of theophylline by 28% and the area under the plasma drug concentration-time curve (AUC) by 22%.
Warfarin (Coumadin)
Theoretically, fenugreek might have additive effects with warfarin and increase the international normalized ratio (INR).
Some fenugreek constituents have antiplatelet effects, although these might not be present in concentrations that are clinically significant. In one case report, a patient taking warfarin experienced an increased INR when starting to take fenugreek in combination with boldo.
Antihypertensive Drugs
Fenugreek may also have an additive effect on blood pressure-lowering medications. Studies on animals have shown that fenugreek seed can decrease both systolic and diastolic blood pressure by up to 22% when combined with metoprolol. Therefore, it is essential to monitor your blood pressure regularly if you are taking fenugreek and metoprolol together or any other antihypertensive drugs.
Brand information
Manufacturer and brand details for Fenugreek, from the product label.
Hawaii Pharm
See all Hawaii Pharm products- Name
- Hawaii Pharm LLC
- Street Address
- 510 Sumner St. Ste. 613
- City
- Honolulu
- State
- HI
- ZipCode
- 96817
- Phone Number
- 888-854-2924
- Web Address
- www.hawaiipharm.com
Fenugreek by Hawaii Pharm: Common Questions
Does Fenugreek by Hawaii Pharm interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Will fenugreek help my blood sugar if I have diabetes?
What are the most common side effects?
Can I take this while pregnant?
Is fenugreek safe for breastfeeding?
Will this help with sexual dysfunction?
Why does fenugreek cause body odor?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Fenugreek is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Fenugreek’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Fenugreek's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 30 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Fenugreek 30 references
- Madar Z, Thorne R. Dietary fiber. Prog Food Nutr Sci 1987;11:153-74.
- Sharma RD, Raghuram TC, Rao NS. Effect of fenugreek seeds on blood glucose and serum lipids in type I diabetes. Eur J Clin Nutr 1990;44:301-6.
- Patil SP, Niphadkar PV, Bapat MM. Allergy to fenugreek (Trigonella foenum graecum). Ann Allergy Asthma Immunol 1997;78:297-300. PubMed
- Lambert J, Cormier J. Potential interaction between warfarin and boldo-fenugreek. Pharmacotherapy 2001;21:509-12. PubMed
- Bordia A, Verma SK, Srivastava KC. Effect of ginger (Zingiber officinale Rosc.) and fenugreek (Trigonella foenumgraecum L.) on blood lipids, blood sugar and platelet aggregation in patients with coronary artery disease. Prostaglandins Leukot Essent Fatty PubMed
- Yalcin SS, Tekinalp G, Ozalp I. Peculiar odor of traditional food and maple syrup urine disease. Pediatr Int 1999;41:108-9. PubMed
- Sewell AC, Mosandl A, Bohles H. False diagnosis of maple syrup urine disease owing to ingestion of herbal tea. N Engl J Med 1999;341:769.. PubMed
- Abdo MS, al-Kafawi AA. Experimental studies on the effect of Trigonella foenum-graecum (abstract). Planta Med 1969;17:14-8.
- Gupta A, Gupta R, Lal B. Effect of Trigonella foenum-graecum (fenugreek) seeds on glycaemic control and insulin resistance in type 2 diabetes mellitus: a double blind placebo controlled study. J Assoc Physicians India 2001;49:1057-61.
- Gabay MP. Galactogogues: medications that induce lactation. J Hum Lact 2002;18:274-9. PubMed
- Chevassus H, Gaillard JB, Farret A, et al. A fenugreek seed extract selectively reduces spontaneous fat intake in overweight subjects. Eur J Clin Pharmacol 2010;66(5):449-55. PubMed
- Turkyilmaz C, Onal E, Hirfanoglu IM, et al. The effect of galactagogue herbal tea on breast milk production and short-term catch-up of birth weight in the first week of life. J Altern Complement Med 2011;17(2):139-42. PubMed
- Swafford S, Berens P. Effect of fenugreek on breast milk volume. Abstract presented at: 5th International Meeting of the Academy of Breastfeeding Medicine; September 11-13,2000, Tucson, Arizona.
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