Fenugreek Ingredients & Drug Interactions
by Herbal Hills
What is this page for?
First and foremost: checking Fenugreek against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Fenugreek is a dietary supplement by Herbal Hills with 1 active ingredient. Its ingredients are commonly taken for blood sugar control, boosting breast milk supply, high cholesterol.Based on those ingredients, 389 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Fenugreek seed extract & Fenugreek seed powder blend. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Fenugreek by Herbal Hills
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AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Fenugreek by Herbal Hills
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: a blend of fenugreek seed extract and fenugreek seed powder. Fenugreek is a legume seed used traditionally in cooking and herbal medicine.
The capsule itself is made from HPMC (a plant-based capsule material) and contains silicon dioxide as an inactive ingredient.
Does it work?
Moderate evidence
Fenugreek is possibly effective for sexual dysfunction and for dysmenorrhea (menstrual cramps), based on the evidence we have on file. It's also possibly effective for type 2 diabetes — clinical research shows it can lower fasting blood sugar and post-meal blood sugar levels in adults with diabetes.
That said, 'possibly effective' means the evidence supports some benefit, but more research would strengthen the case.
How safe is it?
Well-documented data
Fenugreek seed is generally well tolerated in food amounts, but supplement doses can cause side effects. The most common are digestive — abdominal pain, bloating, diarrhea, indigestion, gas, and nausea — and low blood sugar (hypoglycemia).
Rarely, severe allergic reactions including throat swelling (angioedema), airway constriction (bronchospasm), and anaphylaxis have been reported. Avoid medicinal doses during pregnancy, as supplement amounts may affect the uterus.
If you're breastfeeding and considering fenugreek to boost milk supply, the evidence is limited — discuss it with your doctor or pharmacist first. One note: if fenugreek is taken during pregnancy or shortly before delivery, the newborn may develop an unusual body odor that can be confused with maple syrup urine disease; this does not appear to cause long-term harm.
Meds to double-check
Moderate interaction found
Before you take fenugreek, check with your doctor or pharmacist if you're on blood thinners (anticoagulants) or antiplatelet drugs like warfarin or clopidogrel, diabetes medications, theophylline, metoprolol or other blood pressure medications, seizure medications like phenytoin, or sildenafil. Fenugreek may alter how these drugs work.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.
Fenugreek may help with sexual function, menstrual cramps, and blood sugar control in type 2 diabetes — but it interacts with a long list of medications, especially blood thinners, diabetes drugs, and heart and seizure medications. If you take any prescription or over-the-counter drugs, check them against this product before starting.
Talk it over with your doctor or pharmacist to make sure it's right for you.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jul 25, 2017.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Fenugreek, straight from the product label.
| Brand | Herbal Hills |
|---|---|
| Barcode (UPC) | 8906068413566 |
| Net contents | 120 Vegi Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Jul 25, 2017 |
| DSLD ID | 75043 |
| Product type | Botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Halal |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Fenugreek by Herbal Hills, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Fenugreek seed extract & Fenugreek seed powder blend | 500 mg | -- |
Other ingredients: Silicon Dioxide, HPMC Capsule
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity
Dietary Supplement
General Statements
Mfg. Lic. No.: PD/AYU/002/10
(An ISO 22000:2005 Certified Company)
Back to nature
Joint health support
~ Pure ~ Natural ~ Effective
Fenugreek has an immense healing power & is considered to be very effective anti-inflammatory herb & may help relieve symptoms related to pain due to exercise & normal overuse. Being rich in dietary fiber, it supports glucose metabolism and help elevate prolactin level.
Contents based on standard raw material as per ayurvedic text
Brand IP Statement(s)
Product name: Methihills
Seals/Symbols
JAS-ANZ ICS ISO 22000:2005 Reg. No.: RH91/7301
GMP Good Manufacturing Practice
Halal India www.halalindia.com
Storage
Store in a cool dry place away from direct sunlight.
Precautions
Keep out of reach of children.
Do not use if inner seal is broken or missing.
Caution: Pregnant or lactating women are advised to consume herbal products under the advice of the healthcare practitioner.
Formula
Standardized extract / 8% Saponins, 5% Bitter
Suggested/Recommended/Usage/Directions
Directions For Use: As a dietary supplement take 1 capsule twice daily, preferably after meals. For better results it should be taken with warm water.
FDA Disclaimer Statement
These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Fenugreek by Herbal Hills label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Fenugreek by Herbal Hills
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Amounts shown are per serving.
Fenugreek seed extract & Fenugreek seed powder blend
Interacts with389 drugs
Fenugreek is a common kitchen spice that is also taken as a supplement, mainly for blood sugar, cholesterol, and to support breast milk production. So...
Fenugreek seed extract & Fenugreek seed powder blend monograph & interactionsOther (inactive) ingredients: Silicon Dioxide, HPMC Capsule. These complete the product’s ingredient list but are not active constituents.
Fenugreek by Herbal Hills Drug Interactions
HelloPharmacist Interaction Report
Fenugreek by Herbal Hills does interact with medications, and the interactions are all Moderate in severity.
Through its fenugreek seed extract and powder, this product can have additive effects with blood thinners (anticoagulants) and antiplatelet drugs — meaning it may increase bleeding risk when combined with them. The most serious documented case involved warfarin (Coumadin), where a patient's blood-thinning effect (INR) increased when fenugreek was added.
Read the full breakdown — every affected drug type, severity by severity
The product can also lower blood sugar (hypoglycemia) when combined with diabetes medications, reduce the effectiveness of theophylline (a breathing medication), and interact with clopidogrel (Plavix) by potentially affecting how your body activates it. Additionally, fenugreek may have blood-pressure-lowering effects that add to metoprolol (a heart and blood pressure medication), and animal research suggests it could decrease levels of phenytoin (a seizure medication) and sildenafil (Viagra).
Altogether, these interactions span 389 individual medications. If you take any prescription or over-the-counter medication — especially blood thinners, diabetes drugs, heart or blood pressure medications, seizure medications, or anything for breathing — check your exact medications with the tool on this page before you start.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Fenugreek?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Fenugreek interact with 389 drugs. Click any drug to see the details.
1 of the 1 ingredient in Fenugreek interact with drugs. Each result below shows which ingredient is responsible. Fenugreek seed extract & Fenugreek seed powder blend
AbciximabReoPro
How Abciximab interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Fenugreek Seed Extract & Fenugreek Seed Powder BlendAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Fenugreek Seed Extract & Fenugreek Seed Powder Blend + Abciximab interactionAbrocitinibCibinqo
How Abrocitinib interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Fenugreek Seed Extract & Fenugreek Seed Powder BlendAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Fenugreek Seed Extract & Fenugreek Seed Powder Blend + Abrocitinib interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Fenugreek Seed Extract & Fenugreek Seed Powder BlendAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, fenugreek seed might have additive hypoglycemic effects when used with antidiabetes drugs.
Read the full Fenugreek Seed Extract & Fenugreek Seed Powder Blend + Acarbose interactionAcenocoumarolSintrom
How Acenocoumarol interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Fenugreek Seed Extract & Fenugreek Seed Powder BlendAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Fenugreek Seed Extract & Fenugreek Seed Powder Blend + Acenocoumarol interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Fenugreek Seed Extract & Fenugreek Seed Powder BlendAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Fenugreek Seed Extract & Fenugreek Seed Powder Blend + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Fenugreek Seed Extract & Fenugreek Seed Powder BlendAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Fenugreek Seed Extract & Fenugreek Seed Powder Blend + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, IbuprofenCombogesic
How Acetaminophen, Ibuprofen interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Fenugreek Seed Extract & Fenugreek Seed Powder BlendAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Fenugreek Seed Extract & Fenugreek Seed Powder Blend + Acetaminophen, Ibuprofen interactionAcetohexamideDymelor
How Acetohexamide interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Fenugreek Seed Extract & Fenugreek Seed Powder BlendAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, fenugreek seed might have additive hypoglycemic effects when used with antidiabetes drugs.
Read the full Fenugreek Seed Extract & Fenugreek Seed Powder Blend + Acetohexamide interactionAcetylsalicylic AcidEntrophen
How Acetylsalicylic Acid interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Fenugreek Seed Extract & Fenugreek Seed Powder BlendAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Fenugreek Seed Extract & Fenugreek Seed Powder Blend + Acetylsalicylic Acid interactionAlbiglutideTanzeum
How Albiglutide interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Fenugreek Seed Extract & Fenugreek Seed Powder BlendAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, fenugreek seed might have additive hypoglycemic effects when used with antidiabetes drugs.
Read the full Fenugreek Seed Extract & Fenugreek Seed Powder Blend + Albiglutide interactionAlogliptinNesina
How Alogliptin interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Fenugreek Seed Extract & Fenugreek Seed Powder BlendAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, fenugreek seed might have additive hypoglycemic effects when used with antidiabetes drugs.
Read the full Fenugreek Seed Extract & Fenugreek Seed Powder Blend + Alogliptin interactionAlogliptin, MetforminKazano
How Alogliptin, Metformin interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Fenugreek Seed Extract & Fenugreek Seed Powder BlendAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, fenugreek seed might have additive hypoglycemic effects when used with antidiabetes drugs.
Read the full Fenugreek Seed Extract & Fenugreek Seed Powder Blend + Alogliptin, Metformin interactionAlogliptin, PioglitazoneOseni
How Alogliptin, Pioglitazone interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Fenugreek Seed Extract & Fenugreek Seed Powder BlendAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, fenugreek seed might have additive hypoglycemic effects when used with antidiabetes drugs.
Read the full Fenugreek Seed Extract & Fenugreek Seed Powder Blend + Alogliptin, Pioglitazone interactionAlteplase, TpaActilyse, Activase
How Alteplase, Tpa interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Fenugreek Seed Extract & Fenugreek Seed Powder BlendAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Fenugreek Seed Extract & Fenugreek Seed Powder Blend + Alteplase, Tpa interactionAluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium HydroxideAscriptin Codeine #2
How Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Fenugreek Seed Extract & Fenugreek Seed Powder BlendAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Fenugreek Seed Extract & Fenugreek Seed Powder Blend + Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interactionAluminum Hydroxide, Aspirin, Magnesium HydroxideAscriptin
How Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Fenugreek Seed Extract & Fenugreek Seed Powder BlendAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Fenugreek Seed Extract & Fenugreek Seed Powder Blend + Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interactionAnacaulase-bcdbNexoBrid
How Anacaulase-bcdb interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Fenugreek Seed Extract & Fenugreek Seed Powder BlendAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Fenugreek Seed Extract & Fenugreek Seed Powder Blend + Anacaulase-bcdb interactionAnagrelideAgrylin
How Anagrelide interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Fenugreek Seed Extract & Fenugreek Seed Powder BlendAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Fenugreek Seed Extract & Fenugreek Seed Powder Blend + Anagrelide interactionAnisindioneMiradon
How Anisindione interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Fenugreek Seed Extract & Fenugreek Seed Powder BlendAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Fenugreek Seed Extract & Fenugreek Seed Powder Blend + Anisindione interactionAntidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) InhibitorGlyxambi
How Antidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) Inhibitor interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Fenugreek Seed Extract & Fenugreek Seed Powder BlendAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, fenugreek seed might have additive hypoglycemic effects when used with antidiabetes drugs.
Read the full Fenugreek Seed Extract & Fenugreek Seed Powder Blend + Antidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) Inhibitor interactionAntithrombin IiiThrombate III
How Antithrombin Iii interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Fenugreek Seed Extract & Fenugreek Seed Powder BlendAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Fenugreek Seed Extract & Fenugreek Seed Powder Blend + Antithrombin Iii interactionApixabanEliquis
How Apixaban interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Fenugreek Seed Extract & Fenugreek Seed Powder BlendAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Fenugreek Seed Extract & Fenugreek Seed Powder Blend + Apixaban interactionArgatrobanArgatroban
How Argatroban interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Fenugreek Seed Extract & Fenugreek Seed Powder BlendAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Fenugreek Seed Extract & Fenugreek Seed Powder Blend + Argatroban interactionAspirinAngettes 75, ASA, Asaphen, Aspirin, Caprin, Cartia +8 more
How Aspirin interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Fenugreek Seed Extract & Fenugreek Seed Powder BlendAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Fenugreek Seed Extract & Fenugreek Seed Powder Blend + Aspirin interactionAspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium HydroxideAscriptin Codeine #3
How Aspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium Hydroxide interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Fenugreek Seed Extract & Fenugreek Seed Powder BlendAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Fenugreek Seed Extract & Fenugreek Seed Powder Blend + Aspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium Hydroxide interactionAspirin, ButalbitalAxotal
How Aspirin, Butalbital interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Fenugreek Seed Extract & Fenugreek Seed Powder BlendAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Fenugreek Seed Extract & Fenugreek Seed Powder Blend + Aspirin, Butalbital interactionAspirin, Butalbital, CaffeineFiorinal
How Aspirin, Butalbital, Caffeine interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Fenugreek Seed Extract & Fenugreek Seed Powder BlendAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Fenugreek Seed Extract & Fenugreek Seed Powder Blend + Aspirin, Butalbital, Caffeine interactionAspirin, Butalbital, Caffeine, Codeine PhosphateFiorinal w/ Codeine
How Aspirin, Butalbital, Caffeine, Codeine Phosphate interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Fenugreek Seed Extract & Fenugreek Seed Powder BlendAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Fenugreek Seed Extract & Fenugreek Seed Powder Blend + Aspirin, Butalbital, Caffeine, Codeine Phosphate interactionAspirin, Butalbital, Caffeine, PhenacetinMarnal
How Aspirin, Butalbital, Caffeine, Phenacetin interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Fenugreek Seed Extract & Fenugreek Seed Powder BlendAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Fenugreek Seed Extract & Fenugreek Seed Powder Blend + Aspirin, Butalbital, Caffeine, Phenacetin interactionAspirin, CaffeineAnacin
How Aspirin, Caffeine interacts with Fenugreek — through 1 ingredient. Tap an ingredient for the detail:
Fenugreek Seed Extract & Fenugreek Seed Powder BlendAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Fenugreek Seed Extract & Fenugreek Seed Powder Blend + Aspirin, Caffeine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Fenugreek with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Fenugreek seed extract & Fenugreek seed powder blend
Anticoagulant/Antiplatelet Drugs
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Some of the constituents in fenugreek have antiplatelet effects in animal and in vitro research. However, common fenugreek products might not contain sufficient concentrations of these constituents for clinical effects. A clinical study in patients with coronary artery disease or diabetes shows that taking fenugreek seed powder 2.5 grams twice daily for 3 months does not affect platelet aggregation, fibrinolytic activity, or fibrinogen levels .
Antidiabetes Drugs
Theoretically, fenugreek seed might have additive hypoglycemic effects when used with antidiabetes drugs.
Clinical research shows that fenugreek seed can reduce fasting blood glucose and 2-hour postprandial glucose levels in adults with type 2 diabetes.
Clopidogrel (Plavix)
Theoretically, fenugreek seed might alter the clinical effects of clopidogrel by inhibiting its conversion to the active form.
Animal research shows that fenugreek seed 200 mg/kg daily for 14 days increases the maximum serum concentration of clopidogrel by 21%. It is unclear how this affects the pharmacokinetics of the active metabolite of clopidogrel; however, this study found that concomitant use of fenugreek seed and clopidogrel prolonged bleeding time by an additional 11%.
Metoprolol (Toprol)
Theoretically, fenugreek seed might have additive hypotensive effects when used with metoprolol.
Animal research shows that fenugreek seed 300 mg/kg daily for 2 weeks decreases systolic and diastolic blood pressure by 9% and 11%, respectively, when administered alone, and by 15% and 22%, respectively, when given with metoprolol 10 mg/kg.
Phenytoin (Dilantin)
Theoretically, fenugreek might decrease plasma levels of phenytoin.
Animal research shows that taking fenugreek seeds for 1 week decreases maximum concentrations and the area under the curve of a single dose of phenytoin by 44% and 72%, respectively. This seems to be related to increased clearance. So far, this interaction has not been reported in humans.
Sildenafil (Viagra)
Theoretically, concurrent use of sildenafil and fenugreek might reduce levels and therapeutic effects of sildenafil.
Animal research shows that taking fenugreek seeds for 1 week reduces maximum concentrations and the area under the curve of a single dose of sildenafil by 27% and 48%, respectively. So far, this interaction has not been reported in humans.
Theophylline
Theoretically, fenugreek may reduce the levels and clinical effects of theophylline.
Animal research shows that fenugreek 50 grams daily for 7 days reduces the maximum serum concentration (Cmax) of theophylline by 28% and the area under the plasma drug concentration-time curve (AUC) by 22%.
Warfarin (Coumadin)
Theoretically, fenugreek might have additive effects with warfarin and increase the international normalized ratio (INR).
Some fenugreek constituents have antiplatelet effects, although these might not be present in concentrations that are clinically significant. In one case report, a patient taking warfarin experienced an increased INR when starting to take fenugreek in combination with boldo.
Antihypertensive Drugs
Fenugreek may also have an additive effect on blood pressure-lowering medications. Studies on animals have shown that fenugreek seed can decrease both systolic and diastolic blood pressure by up to 22% when combined with metoprolol. Therefore, it is essential to monitor your blood pressure regularly if you are taking fenugreek and metoprolol together or any other antihypertensive drugs.
Brand information
Manufacturer and brand details for Fenugreek, from the product label.
Herbal Hills
See all Herbal Hills products- Name
- Isha Agro Developers Pvt. Ltd.
- Street Address
- 55-A/B, Lonavala Co-op. Indl. Est. Ltd.
- City
- Nangargaon, Lonavala, Taluka-Maval, Dist. Pune,
- State
- Maharashtra
- ZipCode
- 410401
- Web Address
- 0091 22 2868 6868
Fenugreek by Herbal Hills: Common Questions
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Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Fenugreek is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Fenugreek’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Fenugreek's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 30 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Fenugreek 30 references
- Madar Z, Thorne R. Dietary fiber. Prog Food Nutr Sci 1987;11:153-74.
- Sharma RD, Raghuram TC, Rao NS. Effect of fenugreek seeds on blood glucose and serum lipids in type I diabetes. Eur J Clin Nutr 1990;44:301-6.
- Patil SP, Niphadkar PV, Bapat MM. Allergy to fenugreek (Trigonella foenum graecum). Ann Allergy Asthma Immunol 1997;78:297-300. PubMed
- Lambert J, Cormier J. Potential interaction between warfarin and boldo-fenugreek. Pharmacotherapy 2001;21:509-12. PubMed
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
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