Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Fenugreek Plus Ingredients & Drug Interactions

by Metagenics

Fenugreek Plus label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Fenugreek Plus against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Fenugreek Plus is a dietary supplement by Metagenics with 3 active ingredients. Its ingredients are commonly taken for blood sugar support, diabetes, digestive complaints.Based on those ingredients, 1,105 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Gymnema Leaf Extract, Fenugreek seed extract, Bitter Melon Fruit Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Fenugreek Plus by Metagenics

Ask about any prescription or over-the-counter medication and we check it for interactions with Fenugreek Plus by Metagenics — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Fenugreek Plus by Metagenics

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 30, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 3 of its 3 active ingredients.
  • “Gymnema Leaf Extract” is listed as a grouped ingredient — the label gives one combined amount (100 mg) without saying how much of each component you get.

Fenugreek Plus contains 3 active ingredients: bitter melon fruit extract, fenugreek seed extract, and gymnema leaf extract. Bitter melon has been used traditionally to support healthy blood sugar, while fenugreek seed is often included for sexual function and menstrual comfort.

Gymnema leaf extract is included for additional metabolic support. The capsule also contains inactive ingredients—hypromellose, microcrystalline cellulose, silica, magnesium stearate, and croscarmellose sodium—which are fillers and binders that hold the supplement together.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: herbal support for healthy glucose metabolism.
  • We looked for evidence on: Diabetes, Hyperlipidemia, Impaired glucose tolerance (prediabetes), Metabolic syndrome, Obesity, Blood sugar control — and 2 related terms.
  • The strongest evidence on file: Fenugreek is rated "Possibly Effective" for Diabetes (Natural Medicines).
  • Also on file: Fenugreek is rated "Insufficient Reliable Evidence To Rate" for Hyperlipidemia, Obesity, Impaired glucose tolerance (prediabetes), Metabolic syndrome.
  • Also on file: Bitter Melon is rated "Insufficient Reliable Evidence To Rate" for Diabetes, Obesity.

The evidence for what this product does depends on the ingredient. Fenugreek seed shows possibly effective evidence for sexual dysfunction and for helping manage diabetes—clinical studies show it can lower fasting blood sugar and post-meal glucose levels in people with type 2 diabetes.

Bitter melon, on the other hand, has insufficient evidence for any of the conditions it's traditionally used for, including diabetes, constipation, liver disease, and amenorrhea—the studies so far don't give us a clear answer either way. We hold no effectiveness data on gymnema leaf extract.

The evidence, ingredient by ingredient Bitter Melon Fenugreek Gymnema

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Bitter melon is generally well tolerated as food, but supplement doses may lower blood sugar and cause stomach upset. The most common side effects from bitter melon in studies are gastrointestinal—heartburn, nausea, vomiting, diarrhea, constipation, flatulence, and belly discomfort occurred in about 3% to 16% of people taking it.

Rare serious effects include severe low blood sugar (hypoglycemic coma) and seizures in children. One case report linked long-term use (600–1200 mg daily) to kidney function decline that improved after the supplement was stopped.

Fenugreek seed is generally well tolerated in food amounts, but supplement doses may cause belly pain, bloating, diarrhea, indigestion, gas, and nausea. Rare serious effects include severe allergic reactions—bronchospasm (airway constriction), angioedema (deep tissue swelling), and shock.

Fenugreek is considered likely unsafe in pregnancy because supplement amounts may affect the uterus; it is possibly safe while breastfeeding, though evidence is limited and you should discuss it with your doctor or pharmacist first. One side effect worth knowing: fenugreek consumed during or near delivery may cause a newborn to have an unusual body odor that could be confused with maple syrup urine disease, though this doesn't appear to cause long-term harm.

Side effects, ingredient by ingredient Bitter Melon Fenugreek Gymnema

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Fenugreek, Bitter Melon.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 571 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take Fenugreek Plus, double-check with your doctor or pharmacist if you're on any of these: blood thinners or antiplatelet drugs (warfarin, clopidogrel, or other anticoagulants), antidiabetes drugs, theophylline (an asthma medication), metoprolol (a heart drug), phenytoin (a seizure medication), sildenafil (an erectile dysfunction drug), or cancer drugs that are P-glycoprotein substrates. All of these have Moderate-severity interactions documented with one or both of the bitter melon and fenugreek ingredients in this product.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Fenugreek Plus may be worth considering if you're interested in blood sugar support or sexual function, but the evidence is strongest only for fenugreek's role in diabetes and sexual health—bitter melon's effectiveness isn't yet clear. If you take any blood thinners, diabetes medications, heart drugs, or seizure medications, you need to check this with your own doctor or pharmacist before you start, because the interactions are documented and could affect how your drugs work.

Talk it over with your healthcare provider to make sure this product is right for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Sep 25, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Fenugreek Plus, straight from the product label.

Brand Metagenics
Barcode (UPC) 755571800060
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Sep 25, 2023
DSLD ID 295709
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Fenugreek Plus by Metagenics, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
30
UPC/BARCODE
755571800060
IngredientAmount% DV
Total Carbohydrates1 Gram(s)1%
Bitter Melon Fruit Extract152 mg--
Fenugreek seed extract1 Gram(s)--
Gymnema Leaf Extract100 mg--
Gymnemic Acids25 mg--

Other ingredients: Hypromellose, Microcrystalline Cellulose, Silica, Magnesium Stearate, Croscarmellose Sodium

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Fenugreek Plus features concentrates of three highly valued herbs traditionally used to support healthy glucose metabolism. The unique, odorless extract of fenugreek is highly concentrated for ease of use.

Suggested/Recommended/Usage/Directions

Directions: Take two capsules twice daily with six to eight ounces of water before meals, or as directed by your healthcare practitioner.

Formulation

This product is non-GMO, gluten free, and vegetarian.

Non GMO Project Verified nongmoproject.org GFCO.org (Gluten-Free Certification Organization)

Herbal support for healthy glucose metabolism

Brand IP Statement(s)

This product is non-GMO, gluten free, and vegetarian.

Precautions

Caution: If you are being treated for heart disease, diabetic, taking medication, or if pregnant or nursing, consult your healthcare practitioner before use.

Keep out of the reach of children.

Practitioner exclusive

Seals/Symbols

Non GMO Project Verified nongmoproject.org GFCO.org (Gluten-Free Certification Organization)

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Fenugreek Plus by Metagenics label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Fenugreek Plus label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Fenugreek Plus by Metagenics

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Bitter Melon Fruit Extract

Interacts with
282 drugs
152 mg per serving

Bitter melon is a tropical fruit eaten as food and used in traditional medicine, most often for blood sugar control. While some small studies hint it...

Bitter Melon Fruit Extract monograph & interactions

Fenugreek seed extract

Interacts with
389 drugs
1 Gram(s) per serving Form: Galactomannan

Fenugreek is a common kitchen spice that is also taken as a supplement, mainly for blood sugar, cholesterol, and to support breast milk production. So...

Fenugreek seed extract monograph & interactions

Gymnema Leaf Extract

Interacts with
851 drugs
100 mg per serving Form: Gymnema sylvestre leaf extract

Gymnema is an Ayurvedic herb best known for possibly helping lower blood sugar and reducing the taste of sweetness on the tongue. Some early human stu...

Gymnema Leaf Extract monograph & interactions
  • › Gymnemic Acids

Other (inactive) ingredients: Hypromellose, Microcrystalline Cellulose, Silica, Magnesium Stearate, Croscarmellose Sodium. These complete the product’s ingredient list but are not active constituents.

Interaction report

Fenugreek Plus by Metagenics Drug Interactions

Want to check YOUR meds against Fenugreek Plus?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,105Drugs
587 Moderate 518 Minor

Ingredients driving the most interactions

Gymnema Leaf Extract 851
Fenugreek seed extract 389
Bitter Melon Fruit Extract 282

Individual Drug Interactions

The ingredients in Fenugreek Plus interact with 1,105 drugs. Click any drug to see the details.

3 of the 3 ingredients in Fenugreek Plus interact with drugs. Each result below shows which ingredient is responsible. Gymnema Leaf Extract Fenugreek seed extract Bitter Melon Fruit Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Fenugreek Plus with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Gymnema Leaf Extract6 drug types · 851 drugs

Antidiabetes Drugs

Theoretically, taking gymnema with antidiabetes drugs might increase the risk of hypoglycemia.
Gymnema reduces blood glucose levels in some human and animal research. In human studies, it has been shown to enhance the blood glucose lowering effects of hypoglycemic drugs. However, other research in adults with prediabetes or metabolic syndrome suggests that gymnema does not reduce fasting levels of blood glucose. Until more is known, monitor blood glucose levels closely.

Likelihood Probable Evidence B
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, gymnema might increase levels of drugs metabolized by CYP1A2.
Animal and in vitro research shows that gymnema can inhibit the CYP1A2 enzyme. In one animal study, oral administration of gymnema for 7 days increased the plasma concentrations of phenacetin, a CYP1A2 substrate, by about 1.4-fold and reduced the clearance of phenacetin by about 29%.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, gymnema might increase or decrease levels of drugs metabolized by CYP2C9.
Animal research shows that gymnema can induce the CYP2C9 enzyme. In one animal study, gymnema caused a 2.4-fold increase in the clearance of tolbutamide, a CYP2C9 substrate, in rats. In vitro research also shows that gymnema can inhibit CYP2C9.

Likelihood Possible Evidence D
Phenacetin

Theoretically, taking gymnema with phenacetin might increase the levels of phenacetin.
Animal research shows that gymnema, administered orally for 7 days, decreases the clearance of phenacetin in a dose-dependent manner by about 21% to 29% and increases plasma levels about 1.3- to 1.4-fold when compared to control.

Likelihood Possible Evidence D
Tolbutamide (Orinase)

Theoretically, taking gymnema with tolbutamide might the decrease levels of tolbutamide.
Animal research shows that gymnema, administered orally for 7 days, increases the clearance of tolbutamide by 2.4-fold when compared to control.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, gymnema might increase levels of drugs metabolized by CYP3A4.
One in vitro study using rat liver microsomes shows that gymnema can modestly inhibit the CYP3A4 enzyme. However, other in vitro research using human liver microsomes shows that gymnema does not affect CYP3A4 activity. Animal research also shows that gymnema does not alter the function of CYP3A4. In one study in rats, oral administration of gymnema for 7 days did not alter the clearance of amlodipine, a CYP3A4 substrate.

Likelihood Unlikely Evidence D
Gymnema Leaf Extract full monograph & interactions

Fenugreek seed extract9 drug types · 389 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Some of the constituents in fenugreek have antiplatelet effects in animal and in vitro research. However, common fenugreek products might not contain sufficient concentrations of these constituents for clinical effects. A clinical study in patients with coronary artery disease or diabetes shows that taking fenugreek seed powder 2.5 grams twice daily for 3 months does not affect platelet aggregation, fibrinolytic activity, or fibrinogen levels .

Likelihood Unlikely Evidence B
Antidiabetes Drugs

Theoretically, fenugreek seed might have additive hypoglycemic effects when used with antidiabetes drugs.
Clinical research shows that fenugreek seed can reduce fasting blood glucose and 2-hour postprandial glucose levels in adults with type 2 diabetes.

Likelihood Probable Evidence B
Clopidogrel (Plavix)

Theoretically, fenugreek seed might alter the clinical effects of clopidogrel by inhibiting its conversion to the active form.
Animal research shows that fenugreek seed 200 mg/kg daily for 14 days increases the maximum serum concentration of clopidogrel by 21%. It is unclear how this affects the pharmacokinetics of the active metabolite of clopidogrel; however, this study found that concomitant use of fenugreek seed and clopidogrel prolonged bleeding time by an additional 11%.

Likelihood Possible Evidence D
Metoprolol (Toprol)

Theoretically, fenugreek seed might have additive hypotensive effects when used with metoprolol.
Animal research shows that fenugreek seed 300 mg/kg daily for 2 weeks decreases systolic and diastolic blood pressure by 9% and 11%, respectively, when administered alone, and by 15% and 22%, respectively, when given with metoprolol 10 mg/kg.

Likelihood Probable Evidence B
Phenytoin (Dilantin)

Theoretically, fenugreek might decrease plasma levels of phenytoin.
Animal research shows that taking fenugreek seeds for 1 week decreases maximum concentrations and the area under the curve of a single dose of phenytoin by 44% and 72%, respectively. This seems to be related to increased clearance. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Sildenafil (Viagra)

Theoretically, concurrent use of sildenafil and fenugreek might reduce levels and therapeutic effects of sildenafil.
Animal research shows that taking fenugreek seeds for 1 week reduces maximum concentrations and the area under the curve of a single dose of sildenafil by 27% and 48%, respectively. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Theophylline

Theoretically, fenugreek may reduce the levels and clinical effects of theophylline.
Animal research shows that fenugreek 50 grams daily for 7 days reduces the maximum serum concentration (Cmax) of theophylline by 28% and the area under the plasma drug concentration-time curve (AUC) by 22%.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, fenugreek might have additive effects with warfarin and increase the international normalized ratio (INR).
Some fenugreek constituents have antiplatelet effects, although these might not be present in concentrations that are clinically significant. In one case report, a patient taking warfarin experienced an increased INR when starting to take fenugreek in combination with boldo.

Likelihood Possible Evidence D
Antihypertensive Drugs

Fenugreek may also have an additive effect on blood pressure-lowering medications. Studies on animals have shown that fenugreek seed can decrease both systolic and diastolic blood pressure by up to 22% when combined with metoprolol. Therefore, it is essential to monitor your blood pressure regularly if you are taking fenugreek and metoprolol together or any other antihypertensive drugs.

Likelihood Possible Evidence C
Fenugreek seed extract full monograph & interactions

Bitter Melon Fruit Extract3 drug types · 282 drugs

Antidiabetes Drugs

Taking bitter melon with antidiabetes drugs might increase the risk of hypoglycemia.
Bitter melon can lower blood glucose levels and might have additive effects when used with antidiabetes drugs. This might increase the risk of hypoglycemia in some patients. Monitor blood glucose levels closely.

Likelihood Probable Evidence B
P-Glycoprotein Substrates

Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Bitter melon might inhibit the p-glycoprotein (P-gp) intestinal pump and increase intracellular levels of P-gp substrates. In vitro research in intestinal cells shows that 1-monopalmitin, a constituent of bitter melon, increases levels of daunomycin, a P-gp substrate. Additionally, drinking bitter melon juice has been associated with a case of acute pancreatitis in a patient who had been taking pazopanib, a P-gp substrate, for 8 years. Researchers theorize that inhibition of P-gp led to increased levels of pazopanib, resulting in pazopanib-induced pancreatitis.

Likelihood Possible Evidence D
Pazopanib (Votrient)

Theoretically, bitter melon might increase levels of pazopanib, potentially increasing the risk of adverse effects.
In one case, a 65-year-old patient taking pazopanib for 8 years for renal cell carcinoma experienced signs and symptoms consistent with acute pancreatitis 4 days after drinking bitter melon juice at a dose of 100-150 mL daily. The patient's symptoms, amylase levels, and lipase levels improved upon discontinuation of bitter melon and pazopanib. Pazopanib treatment was re-initiated with no further evidence of pancreatitis. Researchers theorize that inhibition of P-glycoprotein by bitter melon led to increased levels of pazopanib, a P-glycoprotein substrate, resulting in pazopanib-induced pancreatitis.

Likelihood Possible Evidence D
Bitter Melon Fruit Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Fenugreek Plus, from the product label.

Metagenics

See all Metagenics products
Name
Metagenics
City
Gig Harbor
State
WA
ZipCode
98332
Phone Number
800 692 9400
Web Address
metagenics.com
Pharmacist Counseling Corner

Fenugreek Plus by Metagenics: Common Questions

Does Fenugreek Plus by Metagenics interact with any medications?
Yes. Based on its ingredients, Fenugreek Plus has a known interaction with 1,105 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Fenugreek Plus contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take Fenugreek Plus if I'm pregnant or breastfeeding?
Bitter melon is traditionally avoided in pregnancy because supplement amounts may cause uterine effects and other harm; the safety data advises against medicinal use during pregnancy. For breastfeeding, there isn't enough reliable safety information about bitter melon, so it's best avoided. Fenugreek is considered likely unsafe in pregnancy because supplement doses may affect the uterus, but it is possibly safe while breastfeeding (many people use it to boost milk supply)—however, evidence is limited, so talk with your doctor or pharmacist first to weigh the pros and cons for your situation.
What are the most common side effects of this product?
The most common side effects are gastrointestinal and mild: heartburn, nausea, vomiting, diarrhea, constipation, gas, and belly discomfort. These occurred in a small number of trial participants (roughly 3% to 16% for bitter melon). Both ingredients can also cause abdominal pain and bloating. Serious side effects are rare, but they include severe allergic reactions (especially from fenugreek) and very low blood sugar if combined with diabetes medications.
Does Fenugreek Plus actually work for diabetes?
Fenugreek seed shows possibly effective evidence for helping manage blood sugar in type 2 diabetes—clinical studies show it can lower fasting blood sugar and post-meal glucose levels. Bitter melon, which is also in this product, does not have enough reliable evidence yet to say whether it works for diabetes. If you have diabetes, talk with your doctor or pharmacist before adding this supplement, especially because both ingredients can lower blood sugar and may increase the risk of hypoglycemia if you're already on diabetes medication.
What is gymnema leaf extract used for in this product?
Gymnema leaf extract is included for additional metabolic support, but we don't hold effectiveness data for it in our database, so I can't tell you what the evidence says about how well it works.
Does this product have any fillers?
Yes, the capsule contains inactive ingredients: hypromellose, microcrystalline cellulose, silica, magnesium stearate, and croscarmellose sodium. These are standard excipients that help bind and preserve the supplement.
What is bitter melon supposed to do?
Bitter melon is traditionally used to support healthy blood sugar and has been studied for diabetes, constipation, liver disease, and several other conditions, but the evidence isn't strong enough yet to say reliably whether it works for any of these uses.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Fenugreek Plus label
Go deeper

The Full Monographs Behind Fenugreek Plus’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Bitter Melon

Interacts with 282 drugs

Bitter melon is a tropical fruit eaten as food and used in traditional medicine, most often for blood sugar control. While some small studies hint it may modestly lower blood sugar, the evid...

Read the full Bitter Melon monograph → Herb & supplement monograph

Fenugreek

Interacts with 389 drugs

Fenugreek is a common kitchen spice that is also taken as a supplement, mainly for blood sugar, cholesterol, and to support breast milk production. Some early research is encouraging for blo...

Read the full Fenugreek monograph → Herb & supplement monograph

Gymnema

Interacts with 851 drugs

Gymnema is an Ayurvedic herb best known for possibly helping lower blood sugar and reducing the taste of sweetness on the tongue. Some early human studies are encouraging for blood sugar sup...

Read the full Gymnema monograph →
Sources

Sources & How We Checked

Fenugreek Plus's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 60 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Bitter Melon 18 references
  1. Leatherdale B, Panesar RK, Singh G, et al. Improvement in glucose tolerance due to Momordica charantia. Br Med J (Clin Res Ed) 1981;282:1823-4.
  2. Welihinda J, et al. Effect of Momordica charantia on the glucose tolerance in maturity onset diabetes. J Ethnopharmacol 1986;17:277-82. PubMed
  3. Srivastava Y, Venkatakrishna-Bhatt H, Verma Y, et al. Antidiabetic and adaptogenic properties of Momordica charantia extract: An experimental and clinical evaluation. Phytother Res 1993;7:285-9.
  4. Baldwa VS, Bhandari CM, Pangaria A, Goyal RK. Clinical trial in patients with diabetes mellitus of an insulin-like compound obtained from plant sources. Ups J Med Sci 1977;82:39-41. PubMed
  5. Aslam M, Stockley IH. Interaction between curry ingredient (karela) and drug (chlorpropamide). Lancet 1979:1:607. PubMed
  6. Ahmad N, Hassan MR, Halder H, Bennoor KS. Effect of Momordica charantia (Karolla) extracts on fasting and postprandial serum glucose levels in NIDDM patients (abstract). Bangladesh Med Res Counc Bull 1999;25:11-3.
  7. Basch E, Gabardi S, Ulbricht C. Bitter melon (Momordica charantia): a review of efficacy and safety. Am J Health Syst Pharm 2003;60:356-9. PubMed
  8. Yin RV, Lee NC, Hirpara H, Phung OJ. T. The effect of bitter melon (Mormordica charantia) in patients with diabetes mellitus: s systematic review and meta-analysis. Nutr Diabetes. 2014;4:e145.
  9. Rahman IU, Khan RU, Rahman KU, Bashir M. Lower hypoglycemic but higher antiatherogenic effects of bitter melon than glibenclamide in type 2 diabetic patients. Nutr J. 2015;14:13. PubMed
  10. Alam MA, Uddin R, Subhan N, Rahman MM, Jain P, Reza HM. Beneficial role of bitter melon supplementation in obesity and related complications in metabolic syndrome. J Lipids. 2015;2015:496169. PubMed
  11. Konishi T, Satsu H, Hatsugai Y, et al. Inhibitory effect of a bitter melon extract on the P-glycoprotein activity in intestinal Caco-2 cells. Br J Pharmacol. 2004;143(3):379-87. PubMed
  12. Peter EL, Kasali FM, Deyno S, et al. Momordica charantia L. lowers elevated glycaemia in type 2 diabetes mellitus patients: Systematic review and meta-analysis. J Ethnopharmacol. 2019;231:311-24. doi: 10.1016/j.jep.2018.10.033. PubMed
  13. Cortez-Navarrete M, Martínez-Abundis E, Pérez-Rubio KG, González-Ortiz M, Méndez-Del Villar M. Momordica charantia administration improves insulin secretion in type 2 diabetes mellitus. J Med Food. 2018;21(7):672-7. doi: 10.108
  14. Kim SK, Jung J, Jung JH, et al. Hypoglycemic efficacy and safety of Momordica charantia (bitter melon) in patients with type 2 diabetes mellitus. Complement Ther Med. 2020 Aug;52:102524. doi: 10.1016/j.ctim.2020.102524. PubMed
  15. Unsal O, Sütcüoglu O, Yazici O. Dangerous interaction of bitter melon (Momordica charantia) with pazopanib: a case of acute pancreatitis. J Oncol Pharm Pract 2022;28(2):486-8.
  16. Bae W, Kim S, Choi J, et al. Acute interstitial nephritis associated with ingesting a Momordica charantia extract: a case report. Medicine (Baltimore) 2021;100(27):e26606. PubMed
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See these in context on the Fenugreek monograph →

Gymnema 12 references
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Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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