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Dietary supplement

Feverfew 125 mg Ingredients & Drug Interactions

by Eclectic Herb

Feverfew 125 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Feverfew 125 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Feverfew 125 mg is a dietary supplement by Eclectic Herb with 1 active ingredient. Its ingredients are commonly taken for migraine prevention, headache, fever (traditional).Based on those ingredients, 929 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Feverfew, Freeze-Dried. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Feverfew 125 mg by Eclectic Herb

Ask about any prescription or over-the-counter medication and we check it for interactions with Feverfew 125 mg by Eclectic Herb — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Feverfew 125 mg by Eclectic Herb

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: freeze-dried feverfew at 125 mg per capsule. Freeze-drying concentrates the plant material by removing water, so you're getting the full profile of feverfew's compounds in a convenient capsule form.

The only other ingredient is hypromellose, which is the capsule material itself.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Feverfew product and its label doesn't state a use — see Feverfew's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence for feverfew isn't clear-cut yet. For tension headaches, prurigo nodularis (a skin condition), psoriasis, and rheumatoid arthritis, our data shows insufficient reliable evidence to rate whether it works.

That doesn't mean it's ineffective — it means the research so far hasn't been strong enough to say one way or the other. If you're considering it for any of these purposes, your pharmacist can walk you through what the current evidence suggests and whether a trial might be reasonable for you.

The evidence, ingredient by ingredient Feverfew

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Feverfew is generally well tolerated when taken short-term, but a few cautions apply. Gastrointestinal side effects like heartburn, nausea, diarrhea, constipation, abdominal pain, bloating, and flatulence can occur.

Chewing fresh feverfew leaves is more likely to cause mouth ulcers and tongue irritation than commercial capsule preparations are. Some people may experience skin rash or, rarely, allergic reactions.

If you've been taking feverfew for a long time and then stop suddenly, you might notice "post-feverfew syndrome" — anxiety, headaches, and insomnia — so tapering rather than stopping abruptly is worth discussing with us. Feverfew should be avoided during pregnancy because it may stimulate the uterus and its safety in pregnancy isn't established.

There isn't enough reliable safety information to recommend it while breastfeeding either.

Side effects, ingredient by ingredient Feverfew

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Feverfew.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 930 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with us before using this if you take blood thinners or antiplatelet drugs like warfarin, aspirin, or clopidogrel — feverfew may increase bleeding risk. You should also double-check any medications your liver breaks down, especially those metabolized by the CYP2C19, CYP2D6, CYP1A2, CYP2C9, CYP3A4, or CYP2C8 pathways, since feverfew may raise their levels.

Use the interaction checker below with your exact medication list.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Feverfew might be worth considering if you're exploring options for tension headaches or certain inflammatory conditions, but the evidence is still being built. The real question for you is whether any medications you're on could be affected by it — particularly blood thinners or drugs your liver metabolizes.

Check your prescriptions with us or use the tool on this page before you start.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Aug 22, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Feverfew 125 mg, straight from the product label.

Brand Eclectic Herb
Barcode (UPC) 023363309337
Net contents 90 Veg Cap(s)
Market status On market
Date entered into DSLD Aug 22, 2024
DSLD ID 316777
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Kosher, Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Feverfew 125 mg by Eclectic Herb, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Veg Cap(s)
Maximum serving Sizes:
3 Veg Cap(s)
Servings per container
90
UPC/BARCODE
023363309337
IngredientAmount% DV
Feverfew, Freeze-Dried125 mg--

Other ingredients: Hypromellose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Concentrated 3 1/2X through freeze-drying Freeze dried fresh for peak plant power Raw food Grown in the United States Naturally concentrated

No fillers Non GMO Gluten free

Vegan

Freeze-drying is the best method of preservation as it naturally concentrates the nutrients in the plant by removing only the water.

Nothing artificial - no fillers or additives.

Supports tension of the head & neck Small batch freeze dried

Formula

Whole herb

100% Kosher

Our feverfew is locally grown and fresh freeze-dried in-house in small batches.

FDA Disclaimer Statement

These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent disease.

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested use: Take 1-3 capsules per day.

Precautions

Keep out of reach of children. Consult your doctor about herbs with pregnancy, infants or prescription drugs.

Consult your doctor about herbs with pregnancy, infants or prescription drugs.

General Statements

@eclecticherb

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Feverfew 125 mg by Eclectic Herb label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Feverfew 125 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Feverfew 125 mg by Eclectic Herb

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Veg Cap(s) Dosage formCapsule Servings per container90 Amounts shown are per serving.

Feverfew, Freeze-Dried

Interacts with
929 drugs
125 mg per serving Form: Tanacetum parthenium, Freeze-dried, Tanacetum parthenium, Freeze-dried

Feverfew is a daisy-family herb best known for migraine prevention, where some studies suggest it may modestly lower how often migraines occur, though...

Feverfew, Freeze-Dried monograph & interactions

Other (inactive) ingredients: Hypromellose. These complete the product’s ingredient list but are not active constituents.

Interaction report

Feverfew 125 mg by Eclectic Herb Drug Interactions

Want to check YOUR meds against Feverfew 125 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
929Drugs
929 Moderate

Ingredients driving the most interactions

Feverfew, Freeze-Dried 929

Individual Drug Interactions

The ingredients in Feverfew 125 mg interact with 929 drugs. Click any drug to see the details.

1 of the 1 ingredient in Feverfew 125 mg interact with drugs. Each result below shows which ingredient is responsible. Feverfew, Freeze-Dried

Each ingredient & the kinds of drugs it affects

For each ingredient in Feverfew 125 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Feverfew, Freeze-Dried7 drug types · 929 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, feverfew might have additive effects and increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Laboratory research suggests that feverfew may inhibit platelet aggregation. Additionally, in one case report, a 36-year-old patient taking feverfew 2400 mg daily for 3 months experienced vaginal bleeding and a prolonged menstrual cycle, with a modest increase in partial thromboplastin time (PTT) and prothrombin time (PT).

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, feverfew might increase levels of drugs metabolized by CYP1A2.
Laboratory research shows that feverfew might inhibit CYP1A2. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, feverfew might increase levels of drugs metabolized by CYP2C19.
Laboratory research shows that feverfew might inhibit CYP2C19. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C8 (Cyp2C8) Substrates

Theoretically, feverfew might increase levels of drugs metabolized by CYP2C8.
Laboratory research shows that feverfew might inhibit CYP2C8. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, feverfew might increase levels of drugs metabolized by CYP2C9.
Laboratory research shows that feverfew might inhibit CYP2C9. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, feverfew might increase levels of drugs metabolized by CYP2D6.
Laboratory research shows that feverfew might inhibit CYP2D6. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, feverfew might increase levels of drugs metabolized by CYP3A4.
Laboratory research shows that feverfew might inhibit CYP3A4. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Feverfew, Freeze-Dried full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Feverfew 125 mg, from the product label.

Eclectic Herb

See all Eclectic Herb products
Name
Eclectic Herb
Street Address
755 NE 6th St.
City
Gresham
State
OR
ZipCode
97030
Phone Number
503-668-4120
Web Address
eclecticherb.com
Pharmacist Counseling Corner

Feverfew 125 mg by Eclectic Herb: Common Questions

Does Feverfew 125 mg by Eclectic Herb interact with any medications?
Yes. Based on its ingredients, Feverfew 125 mg has a known interaction with 929 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Feverfew 125 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
No — the safety data advises against feverfew during pregnancy because it may stimulate the uterus and safety isn't established. There also isn't enough reliable safety information for breastfeeding. Talk with your OB or midwife before considering it.
What side effects should I expect?
Most commonly, digestive upset: heartburn, nausea, diarrhea, constipation, abdominal pain, bloating, or gas. Skin rash can occur in sensitive people. If you chew fresh leaves instead of taking capsules, you're more likely to get mouth ulcers and tongue irritation. These side effects are generally mild, but if they bother you, let us know.
What happens if I stop taking it after using it for months?
Some people experience "post-feverfew syndrome" — anxiety, headaches, and insomnia — when they stop after long-term use. It's a good idea to taper off gradually rather than quit suddenly; we can help you plan that.
Does this actually work for headaches?
The evidence for tension headaches isn't clear yet — we don't have enough reliable research to say whether it works. That said, some people find it helpful, so a reasonable trial under your pharmacist's or doctor's eye might make sense for you.
Is this safe to take with my other medications?
That depends on what you're taking. Feverfew can interact with blood thinners and with many drugs your liver breaks down, potentially raising their levels. Use the interaction checker on this page with your full medication list, or come talk to us — we can review it together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Feverfew 125 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Feverfew 125 mg label
Go deeper

The Full Monographs Behind Feverfew 125 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Feverfew

Interacts with 929 drugs

Feverfew is a daisy-family herb best known for migraine prevention, where some studies suggest it may modestly lower how often migraines occur, though the evidence is mixed. It is generally...

Read the full Feverfew monograph →
Sources

Sources & How We Checked

Feverfew 125 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 18 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Feverfew 18 references
  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Awang DVC. Prescribing therapeutic feverfew (Tancetum pathrnium (L.) Schultz Bip., syn. Chrysanthemumparthenium (L.) Bernh). Int Med 1998;1:11-3.
  3. Heptinstall S, Groenewegen WA, Spangenberg P, Loesche W. Extracts of feverfew may inhibit platelet behaviour via neutralization of sulphydryl groups. J Pharm Pharmacol 1987;39:459-65. PubMed
  4. Heptinstall S, White A, Williamson L, Mitchell JR. Extracts of feverfew inhibit granule secretion in blood platelets and polymorphonuclear leucocytes. Lancet 1985;1:1071-4. PubMed
  5. Makheja AN, Bailey JM. A platelet phospholipase inhibitor from the medicinal herb feverfew (Tanacetum parthenium). Prostaglandins Leukot Med 1982;8:653-60.
  6. Groenewegen WA, Heptinstall S. A comparison of the effects of an extract of feverfew and parthenolide, a component of feverfew, on human platelet activity in-vitro. J Pharm Pharmacol 1990;42:553-7. PubMed
  7. Heptinstall S, Groenewegen WA, Spangenberg P, Losche W. Inhibition of platelet behaviour by feverfew: a mechanism of action involving sulphydryl groups. Folia Haematol Int Mag Klin Morphol Blutforsch 1988;115:447-9.
  8. Biggs MJ, Johnson ES, Persaud NP, Ratcliffe DM. Platelet aggregation in patients using feverfew for migraine. Lancet 1982;2:776. PubMed
  9. Lamminpaa A, Estlander T, Jolanki R, Kanerva L. Occupational allergic contact dermatitis caused by decorative plants. Contact Dermatitis 1996;34:330-5. PubMed
  10. Johnson ES, Kadam NP, Hylands DM, Hylands PJ. Efficacy of feverfew as prophylactic treatment of migraine. Br Med J (Clin Res Ed) 1985;291:569-73. PubMed
  11. Pittler MH, Ernst E. Feverfew for preventing migraine. Cochrane Database Syst Rev 2004;(1):CD002286. PubMed
  12. Ernst E, Pittler MH. The efficacy and safety of feverfew (Tanacetum parthenium L.): an update of a systematic review. Public Health Nutr 2000;3:509-14.
  13. Unger M, Frank A. Simultaneous determination of the inhibitory potency of herbal extracts on the activity of six major cytochrome P450 enzymes using liquid chromatography/mass spectrometry and automated online extraction. Rapid Commun Mass Spectrom 2004;1 PubMed
  14. Sil'vestrov VP, Kinitin AV, and Chesnokova, IV. [Immunological and metabolic disorders and the means for their correction in patients with chronic bronchitis]. Ter.Arkh. 1991;63:7-11.
  15. Cady RK, Goldstein J, Nett R, et al. A double-blind placebo-controlled pilot study of sublingual feverfew and ginger (LipiGesic M) in the treatment of migraine. Headache 2011;51:1078-86.
  16. Jovanovic, M. and Poljacki, M. [Compositae dermatitis]. Med Pregl. 2003;56(1-2):43-49. PubMed
  17. Burry, J. N. Compositae dermatitis in South Australia: contact dermatitis from Chrysanthemum parthenium. Contact Dermatitis 1980;6(6):445.
  18. Alenzi KA, Alharbi FH, Tawhari FM, Fradees GS. Alteration of Coagulation Test Results and Vaginal Bleeding Associated With the Use of Feverfew (Tanacetum parthenium). J Med Cases 2021;12(1):9-12.

See these in context on the Feverfew monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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