Major interaction on record — check this product against your medications before combining. Check your meds →
Dietary supplement

Feverfew & Guarana Ingredients & Drug Interactions

by TerraVita

Feverfew & Guarana label
See full label image
Liquid Category: Botanical
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Feverfew & Guarana against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Feverfew & Guarana is a dietary supplement by TerraVita with 1 active ingredient. Its ingredients are commonly taken for migraine prevention, headache, fever (traditional).Based on those ingredients, 1,212 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Feverfew & Guarana Glycerite Liquid Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Feverfew & Guarana by TerraVita

Ask about any prescription or over-the-counter medication and we check it for interactions with Feverfew & Guarana by TerraVita — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Feverfew & Guarana by TerraVita

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 30, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 2 active ingredients.
  • “Feverfew & Guarana Glycerite Liquid Extract” is listed as a grouped ingredient — the label gives one combined amount (0.13 mL) without saying how much of each component you get.

Feverfew & Guarana contains two active ingredients: guarana glycerite liquid extract and feverfew glycerite liquid extract. Guarana is a plant source of caffeine and is included for its stimulant properties.

Feverfew is a traditional herbal ingredient. The product also contains glycerin as an inactive ingredient.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

The label doesn't state a purpose we can grade — see each ingredient's own graded uses on its monograph instead.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence we hold does not establish that guarana is effective for cancer-related anorexia, anxiety, athletic performance, cancer-related fatigue, or chemotherapy-related fatigue — all are rated insufficient reliable evidence. Similarly, feverfew evidence is insufficient for tension headache, prurigo nodularis, psoriasis, or rheumatoid arthritis.

This product's effectiveness for any specific condition is not established in our data.

The evidence, ingredient by ingredient Feverfew Guarana

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Guarana is generally well tolerated in small amounts, but its high caffeine content can cause problems with overuse — the most common side effects are stomach burning and nausea, though it can also cause dizziness, insomnia (especially in children), nervousness, restlessness, tremors, headache, anxiety, and agitation. In rare cases, caffeine can trigger anaphylaxis in sensitive individuals.

Feverfew is generally well tolerated short-term but can cause abdominal pain, bloating, constipation, diarrhea, flatulence, heartburn, nausea, and skin rash in some people. Stopping feverfew after long-term use may cause "post-feverfew syndrome," with symptoms including anxiety, headaches, and insomnia.

Due to guarana's high caffeine content, it should be avoided during pregnancy. Guarana's caffeine passes into breast milk and is best avoided or limited while breastfeeding.

Feverfew is possibly unsafe in pregnancy (it may stimulate the uterus) and should be avoided — safety data while breastfeeding is not reliable enough, so it is best avoided then too.

Side effects, ingredient by ingredient Feverfew Guarana

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Feverfew, Guarana.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications; lithium.
  • For scale: 1,213 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check with your own pharmacist or doctor if you take ephedrine or other stimulants (Major risk), valproate, carbamazepine, or felbamate (seizure medications), disulfiram (alcohol dependence), dipyridamole (used before stress tests), fluvoxamine (an antidepressant), clozapine (an antipsychotic), blood thinners or antiplatelet drugs, or any medication metabolized by the liver pathways CYP2C19, CYP2D6, CYP1A2, CYP2C9, CYP3A4, or CYP2C8 — the product may interfere with how these drugs work or raise their levels.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no assessable stated purpose. Major medication interactions have been identified, and safety information is well characterized.

This product combines two herbal extracts with a number of documented interactions, most notably with stimulants, seizure medications, and blood thinners. If you take any prescription medications — especially for seizures, mood, blood clotting, or stimulant-related conditions — check this product with your own doctor or pharmacist before starting.

The caffeine content and pregnancy/breastfeeding precautions also mean it's not for everyone.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 22, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Feverfew & Guarana, straight from the product label.

Brand TerraVita
Barcode (UPC) 064435224721
Net contents 1 Fluid Ounce(s); 30 mL
Market status On market
Date entered into DSLD Nov 22, 2022
DSLD ID 279929
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Feverfew & Guarana by TerraVita, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
25 Drop(s)
Maximum serving Sizes:
40 Drop(s)
Servings per container
227
UPC/BARCODE
064435224721
IngredientAmount% DV
Guarana Glycerite Liquid Extract0 NP--
Feverfew Glycerite Liquid Extract0 NP--
Feverfew & Guarana Glycerite Liquid Extract0.13 mL--

Other ingredients: Glycerin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

Copyright 2018 TerraVita - Distributed by ZooScape LLC, All Rights Reserved.

Formula

Glycerite liquid extract (1:5)

Formulation

Alcohol free No flavor

Suggested/Recommended/Usage/Directions

Suggested Use: Take 25-40 drops of extract in a small amount of warm water 3-4 times daily. Shake well before using.

Precautions

Keep away from children.

Do not use if safety seal around cap is broken or missing.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Feverfew & Guarana by TerraVita label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Feverfew & Guarana label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Feverfew & Guarana by TerraVita

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size25 Drop(s) Dosage formLiquid Servings per container227 Amounts shown are per serving.

Feverfew & Guarana Glycerite Liquid Extract

Interacts with
929 drugs
0.13 mL per serving

Feverfew is a daisy-family herb best known for migraine prevention, where some studies suggest it may modestly lower how often migraines occur, though...

Feverfew & Guarana Glycerite Liquid Extract monograph & interactions

Other (inactive) ingredients: Glycerin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Feverfew & Guarana by TerraVita Drug Interactions

Want to check YOUR meds against Feverfew & Guarana?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,212Drugs
8 Major 1,086 Moderate 118 Minor

Ingredients driving the most interactions

Feverfew & Guarana Glycerite Liquid Extract 929

Individual Drug Interactions

The ingredients in Feverfew & Guarana interact with 1,212 drugs. Click any drug to see the details.

1 of the 1 ingredient in Feverfew & Guarana interact with drugs. Each result below shows which ingredient is responsible. Feverfew & Guarana Glycerite Liquid Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Feverfew & Guarana with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Feverfew & Guarana Glycerite Liquid Extract7 drug types · 929 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, feverfew might have additive effects and increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Laboratory research suggests that feverfew may inhibit platelet aggregation. Additionally, in one case report, a 36-year-old patient taking feverfew 2400 mg daily for 3 months experienced vaginal bleeding and a prolonged menstrual cycle, with a modest increase in partial thromboplastin time (PTT) and prothrombin time (PT).

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, feverfew might increase levels of drugs metabolized by CYP1A2.
Laboratory research shows that feverfew might inhibit CYP1A2. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, feverfew might increase levels of drugs metabolized by CYP2C19.
Laboratory research shows that feverfew might inhibit CYP2C19. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C8 (Cyp2C8) Substrates

Theoretically, feverfew might increase levels of drugs metabolized by CYP2C8.
Laboratory research shows that feverfew might inhibit CYP2C8. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, feverfew might increase levels of drugs metabolized by CYP2C9.
Laboratory research shows that feverfew might inhibit CYP2C9. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, feverfew might increase levels of drugs metabolized by CYP2D6.
Laboratory research shows that feverfew might inhibit CYP2D6. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, feverfew might increase levels of drugs metabolized by CYP3A4.
Laboratory research shows that feverfew might inhibit CYP3A4. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Feverfew & Guarana Glycerite Liquid Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Feverfew & Guarana, from the product label.

TerraVita

See all TerraVita products
Name
ZooScape LLC
Phone Number
844-449-0444
Web Address
www.ZooScape.com
Pharmacist Counseling Corner

Feverfew & Guarana by TerraVita: Common Questions

Does Feverfew & Guarana by TerraVita interact with any medications?
Yes. Based on its ingredients, Feverfew & Guarana has a known interaction with 1,212 medications, including 8 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Feverfew & Guarana contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while pregnant?
No — guarana's high caffeine content should be avoided during pregnancy, and feverfew is possibly unsafe in pregnancy because it may stimulate the uterus and its safety is not established. Talk with your doctor or pharmacist about whether this product is right for you.
What about breastfeeding?
Guarana's caffeine passes into breast milk and is best avoided or limited while breastfeeding. Feverfew doesn't have enough reliable safety data, so it should be avoided too. Discuss your options with your own doctor or pharmacist.
What are the most common side effects?
Guarana's most common side effects are stomach burning and nausea. Feverfew's are abdominal pain, bloating, constipation, diarrhea, flatulence, heartburn, and nausea. Both can cause dizziness and other nervous-system effects like insomnia and anxiety.
Will this help with (anxiety/fatigue/headaches)?
We don't have reliable evidence that either ingredient is effective for those conditions. The data we hold rates the evidence as insufficient.
Is this safe to take long-term?
Guarana is generally tolerated in small amounts but its high caffeine content makes large or prolonged doses risky. Feverfew is generally well tolerated short-term, but stopping it after long-term use can cause "post-feverfew syndrome" — symptoms like anxiety, headaches, and insomnia. Talk with your doctor or pharmacist about your specific situation.
What's in this product besides the main ingredients?
The product contains glycerin as an inactive ingredient (a common ingredient in liquid supplements).

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Feverfew & Guarana label
Go deeper

The Full Monographs Behind Feverfew & Guarana’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Feverfew

Interacts with 929 drugs

Feverfew is a daisy-family herb best known for migraine prevention, where some studies suggest it may modestly lower how often migraines occur, though the evidence is mixed. It is generally...

Read the full Feverfew monograph → Herb & supplement monograph

Guarana

Interacts with 655 drugs

Guarana is an Amazonian seed that is naturally high in caffeine, which explains most of its stimulant and energy effects. While it may give a short-term boost in alertness and reduce fatigue...

Read the full Guarana monograph →
Sources

Sources & How We Checked

Feverfew & Guarana's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 132 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Guarana 114 references
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Feverfew 18 references
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